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The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore concentration, excitation power and spectral similarity. This study investigates the diagnosis of early cervical cancer using FLIM and a neural network extreme learning machine classifier. A concurrently high sensitivity and specificity of 92.8% and 80.2%, respectively, were achieved. The results suggest that the proposed technique can be used to supplement the traditional histopathological examination of early cervical cancer. (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

ABSTRACT Spectroscopic optical coherence tomography is used to monitor fibroblast cell proliferation in silk fibroin (SF) scaffolds. Time points of 1, 3, and 5-weeks are chosen to give sufficient time for the fibroblasts to proliferate before harvesting. Fibroblasts and their distribution in the SF scaffolds are clearly differentiated in the spectroscopic images. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2587-2594, 2013 [ABSTRACT FROM AUTHOR]

Optical coherence tomography (OCT) was used to monitor various flexor tendon states including tendon at rest, normal tendons during loading, tendon microstructural damage post loading, and healing tendons at 0, 3, and 8 weeks time points.Potential uses include assessing microstructural damage, monitoring the quality of suture repair, and tendon healing. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:990-995, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27514 [ABSTRACT FROM AUTHOR]