1. Stereoselective Synthesis of Key Skeleton of Mohangic Acids A‐E.
- Author
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Mondal, Joyanta, Guchhait, Sandip, Sharma, Himangshu, and Goswami, Rajib Kumar
- Subjects
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HECK reaction , *COUPLING reactions (Chemistry) , *NATURAL products , *SKELETON , *MOLECULES - Abstract
The key skeleton that could allow to access structurally intriguing mohangic acids A−E has been synthesized in stereoselective manner. The salient features of this synthesis include Evans syn‐aldol reaction to construct the C‐11 and C‐12 centers, HWE olefination to construct C14−C15 bond, Evans asymmetric methylation to install C‐14 center and Crimmins acetate aldol to generate C‐15 center whereas Wittig and Takai olefinations to prepare the C8–C9 & C6–C7 alkenes, respectively, and Heck reaction to couple C1–C5 & C6–C17 segments of the molecules. The developed route is highly modular and useful for accessing diverse natural product like molecules for future investigations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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