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Microplastic pollution poses a growing threat to ecosystems globally, necessitating sustainable solutions. This study explores upcycling microplastics into graphene as a promising approach Traditional methods like pyrolysis and catalytic carbonization are slow and compromise graphene quality. Flash Joule heating is fast but energy‐intensive and hard to control. In contrast, atmospheric pressure microwave plasma (APMP) synthesis, the proposed technique, offers a one‐step, environmentally friendly alternative. APMP operates at relatively lower temperatures, reducing energy consumption and providing precise control over process parameters. This study demonstrates that polyethylene microplastics from waste dropper bottles can be efficiently transformed into graphene using APMP synthesis. Raman spectroscopy of synthesized material reveals a spectrum characteristic of graphene‐based materials, with indications of defects and the presence of oxygen content. X‐ray diffraction illustrates the characteristic graphitic lattice, with a slightly larger interlayer spacing attributed to intercalated functional groups. X‐ray photoelectron spectroscopy confirms sp2 hybridized carbon as the major component. High‐resolution transmission electron microscopy provides insights into the multilayered structure and variations in interlayer spacing. The as‐synthesized pristine graphene exhibits nearly ten times greater efficiency in adsorbing perfluorooctanoic acid compared to the oxidized form of graphene, although it is slightly less effective than graphene‐based nanocomposites. [ABSTRACT FROM AUTHOR]

Sea vessels and artificial sea‐based structures are severely affected by biofouling, i.e., the formation of deposits of living and dead marine organisms that belong to different species and range in size from unicellular bacteria to multicellular seaweed and mussels. This is a significant engineering problem since they essentially alter the geometry of the hull, increasing friction and reducing the speed of vessels, thus increasing the cost and environmental footprint of transportation. Given the scale of global transportation reaches several billion tons per year, the socioeconomic consequences of the reduction in transit speed and increased consumption of fuel continue to drive researchers and engineers to develop strategies to combat the processes of marine biofouling. Many types of antifouling paints, coatings, and materials that have been designed and tested, and in some instances used commercially, suffer from shortcomings ranging from environmental toxicity to limited efficiency and durability. In this review article, a brief overview of the traditional antifouling materials is presented and recent achievements in the design of advanced antifouling materials based on such nanomaterials as graphene, nanotubes, nanoparticles, and more complex nanostructures are discussed. These materials exhibit excellent antifouling properties and candrive a breakthrough in how marine biofouling is tackled. [ABSTRACT FROM AUTHOR]

As data processing volume increases, the limitations of traditional computers and the need for more efficient computing methods become evident. Neuromorphic computing mimics the brain's low‐power and high‐speed computations, making it crucial in the era of big data and artificial intelligence. One significant development in this field is the memristor, a device that exhibits neuromorphic tendencies. The performance of memristive devices and circuits relies on the materials used, with graphene being a promising candidate due to its unique properties. Researchers are investigating graphene‐based memristors for large‐scale, sustainable fabrication. Herein, progress in the development of graphene‐based memristive neuromorphic devices and circuits is highlighted. Graphene and its common fabrication methods are discussed. The fabrication and production of graphene‐based memristive devices are reviewed and comparisons are provided among graphene‐ and nongraphene‐based memristive devices. Next, a detailed synthesis of the devices utilizing graphene‐based memristors is provided to implement the basic building blocks of neuromorphic architectures, that is, synapses, and neurons. This is followed by reviewing studies building graphene memristive spiking neural networks (SNNs). Finally, insights on the prospects of graphene‐based neuromorphic memristive systems including their device‐ and network‐level challenges and opportunities are given. [ABSTRACT FROM AUTHOR]

Atmospheric pressure microwave plasma has the lead in synthesizing freestanding and scalable graphene within seconds without the need for high vacuum and temperature. However, the process is limited in utilizing chemical sources for synthesis, such as methane and ethanol. Herein, the usage of an extract of a sustainable precursor, that is, Melaleuca alternifolia, commonly known as tea tree, is for the first time reported to synthesize graphene nanosheets in atmospheric pressure microwave plasma. The synthesis is carried out in a single step at a remarkably low microwave power of 200 W. The morphology, structure, and electrochemical properties of graphene are studied using state‐of‐the‐art characterization techniques such as Raman spectroscopy, X‐ray diffraction, transmission electron microscopy (TEM) and electrochemical impedance spectroscopy. The TEM images reveal the presence of a combination of nanostructures such as nano‐horns, nano‐rods, or nano‐onions consisting of multi‐layer graphitic architectures. An excellent sensing capability of as‐synthesized graphene is demonstrated through the detection of diuron herbicide. A commendable linear range of 20 µm to 1 mm and a limit of detection of 5 µm of diuron is recorded. [ABSTRACT FROM AUTHOR]

A classical symmetrical carrier‐based digital Average Current Mode (ACM) control has two sampling choices, peak point and valley point, to control the average inductor current. If it is employed to regulate the DC‐DC boost converter, there will be a difference in the dynamic performance at peak and valley point sampling instants because of discontinuous output voltage ripple due to Equivalent Series Resistance (ESR) of the output capacitor. Therefore, this paper investigates the effect of sampling instant on the dynamic performance of the PWM DC‐DC boost converter in consideration of capacitor ESR. The small‐signal transfer functions of a boost converter for both sampling positions are prominent to analyze each sampling impact on its dynamics. They are derived by using discrete‐time modeling. Further, the choices of sampling instant are investigated related to the RHP zero elimination, voltage stability, and peak‐to‐peak ripple current of the DC‐DC boost converter. The boost converter has improved stability performance by synchronizing the ADC sampling at starting position (valley point) of the symmetrical carrier signal, as evident by the analytical and hardware results of both sampling techniques working from 25% to 100% load working conditions. [ABSTRACT FROM AUTHOR]

Summary: This paper presents the digital realization of the fractional‐order PI (FOPI) controller fractional integrator element using the improved constant phase approximation method. A new pole‐zero rationalization approach is proposed within the bandwidth of the Bode phase plot. The voltage source inverter fed induction motor fractional‐order model has been identified. A novel mathematical FOPI controller design procedure for the identified FO plant model has been proposed. The designed FOPI controller fractional integrator element is implemented using the constant phase approximation method. A detailed comparative performance study of the proposed approximation method with the existing Charef, Oustaloup, and refined Oustaloup methods has been carried out using the Bode, Nyquist, and Nichols plots. The proposed FOPI controller is placed in the speed feedback loop of the rotor field‐oriented control algorithm of IM. To confirm the proposed FOPI controller approximation method's robustness, a hardware study is carried out on the laboratory hardware‐in‐loop (HIL) platform. In addition, variation in the number of pole‐zero pair's effect on the speed tracking performance, robustness against parameter and load variations are also analyzed. [ABSTRACT FROM AUTHOR]

Low‐ and negative‐value (waste) products represent a valuable resource. Its use as a source for the fabrication of high value materials represents a lucrative pathway to increasing sustainability and decreasing the economic cost of various industries. Thermochemical methods for the valorization of biowaste and low‐value natural products are simple and cheap yet sufficiently efficient to deliver significant economic benefits. Plasma‐based methods represent another family of technologies for waste‐to‐value conversion. The nanostructure nucleation and growth in plasmas involve a complex set of physical and chemical processes that occur in bulk plasma and on surfaces. The choice between these two types of technology assumes a complex optimization that takes into account several factors including the cost of precursors; initial outlay and operating cost of equipment; the cost of labor; the cost of production engineering including the research and development efforts for designing the industrial technology, which is typically higher for the plasma‐based systems, and so on. In this article a technology level comparison of thermochemical and plasma‐based techniques for the valorization of raw and waste biomass, where the intent is to use the resulting products for environmental remediation, energy storage, optoelectronics, and biomedical applications, is presented. [ABSTRACT FROM AUTHOR]

Summary: This paper presents the fractional‐order voltage‐source‐inverter‐controlled induction machine (FO‐VSI‐IM) model extraction and integration to improve the closed‐loop speed control performance of variable speed drives. In the operating range of variable speed drive, it is susceptible to load disturbance and speed tracking error. This paper provides the practical approach to obtain the fractional‐order model of VSI‐fed induction motor (IM) drive by using PWM signal injection technique. The injected PWM signals and speed encoder response signals are recorded using the dSPACE 1104 platform. This model is used in constructing the closed‐loop speed control of VSI‐IM with designed integer‐order PI speed controller. The comparative performance is evaluated for FO‐VSI‐IM and integer‐order voltage‐source‐inverter‐controlled induction machine (IO‐VSI‐IM) with feed‐forward gain variations and load disturbances. It is observed that the robust speed tracking capability with the controller designed using the FO‐VSI‐IM model over the controller with IO‐VSI‐IM model under load disturbances. The improvement in speed tracking with less control effort in the FO‐VSI‐IM model is advantageous in field‐oriented control (FOC) drives. [ABSTRACT FROM AUTHOR]

Bacterial infection of chronic wounds is a major healthcare problem that affects the quality of life of millions of patients worldwide and leads to a substantial healthcare cost burden. This project focused on the manufacture of a potential wound healing agent. Plasma polymers from oregano secondary metabolites (PP‐OSMs) were fabricated by radiofrequency plasma‐enhanced chemical vapor deposition (RF‐PECVD) in continuous and pulse plasma modes at room temperature. The surface, biocompatibility, and antibacterial properties of the PP‐OSMs were investigated. Polymers fabricated by RF‐PECVD retained the functional groups of OSMs, promoted human dermal fibroblast adhesion, inhibited Staphylococcus aureus attachment, and eliminated Pseudomonas aeruginosa. The PP‐OSM coatings are potential candidates for use in medical applications where cell biocompatibility and antibacterial properties are required. [ABSTRACT FROM AUTHOR]

Introduction: Eventration of the diaphragm results in impaired respiratory mechanics, which leads to symptoms of dyspnea. Robotic diaphragmatic plication is a recently reported technique that has had good immediate outcomes. The aim of this study was to describe our transthoracic and transabdominal plication techniques and to analyze the safety, efficacy, and feasibility of robotic diaphragmatic plication in an Indian setting. Methods: This retrospective study was conducted at a large tertiary care center in a dedicated thoracic surgery unit. To measure the efficacy of plication, we administered a pulmonary function test to each patient at baseline and 6 months postoperatively and then compared the results. Results: Eighteen patients underwent robotic diaphragmatic plication during the study period. Of these 18 patients, 12 underwent surgery via a transabdominal approach, and 6 underwent surgery via a transthoracic approach. Surgery was completed robotically in 17 patients. The comparison of the preoperative and postoperative pulmonary function test results showed that the mean ± SD increase in forced expiratory volume in 1 second (FEV1) was 19.9 ± 22.0% (P =.002) and the mean increase in FEV1/forced vital capacity was 5.7 ± 2.5 % (P =.225), indicating a significant improvement in FEV1 after surgery. Conclusion: Robotic diaphragmatic plication can be performed transthoracically or transabdominally with good surgical outcomes. It is safe, effective, and feasible. [ABSTRACT FROM AUTHOR]

Aim: We aimed to explore the association between South Asian ethnicity and complications of type 1 diabetes, and whether this is affected by migration. Methods: In this retrospective cohort study, data on diabetes control and complications were obtained for South Asians in India (South AsiansIndia, n = 2592) and the UK (South AsiansUK, n = 221) and white Europeans in the UK (n = 1431). Multivariable logistic regression was used to identify associations between ethnicity and diabetic kidney disease, retinopathy and neuropathy adjusting for age, sex, BMI, disease duration, HbA1c, blood pressure (BP) and cholesterol. Results: South AsiansIndia had significantly greater adjusted odds of diabetic kidney disease [odds ratio (OR) 5.0, 95% confidence intervals (CI) 3.6–7.1] and retinopathy (OR 1.8, 95% CI 1.2–2.5), but lower odds of neuropathy (OR 0.5, 95% CI 0.4–0.6) than white Europeans. South AsiansIndia had significantly greater adjusted odds of diabetic kidney disease (OR 3.0, 95% 1.8–5.3) than South AsiansUK, but there was no significant difference in the odds of other complications. Conclusions: In this hypothesis‐generating study, we report that South Asian ethnicity is associated with greater risk of diabetic kidney disease and retinopathy, and lower risk of neuropathy than white European ethnicity. Part of the excess diabetic kidney disease risk is reduced in South AsiansUK. These associations cannot be accounted for by differences in vascular risk factors. Our findings in South Asians with type 1 diabetes mirror previous findings in type 2 diabetes and now need to be validated in a study of the effect of ethnicity on type 1 diabetes complications where healthcare is provided in the same setting. What's new?: The impact of South Asian ethnicity and migration on the natural history of type 1 diabetes is not well understood.South Asians in India have a greater risk of retinopathy and diabetic kidney disease and lower risk of neuropathy than white Europeans in the UK. The excess risk of diabetic kidney disease is mitigated for South Asians in the UK.These associations persist despite adjusting for classical risk factors for microvascular complications such as glycaemic control, blood pressure, disease duration or markers of insulin resistance.The results call for us to be particularly vigilant for the complications of type 1 diabetes in South Asians. [ABSTRACT FROM AUTHOR]

ABSTRACT: This study aimed to produce graphitic‐polymer nanocomposite thin films via the swift heavy ion irradiation of polyterpenol thin films synthesized from an environmentally sustainable precursor by radio‐frequency plasma enhanced chemical vapor deposition. Atomic force microscopy and scanning electron microscopy revealed fluence‐dependent surface restructuring of the thin films leading to the formation of interconnected island structures, with no discernible delamination from the underlying aluminum substrate. Raman spectroscopy confirmed the development of D and G peaks associated with graphitic materials, whilst Fourier transform infrared spectroscopy indicated retention of the plasma polymer's chemical functionalities (including hydroxyl groups) within the material after irradiation. Graphitic‐polymer nanocomposite films prepared by this dry and solvent‐free process have numerous potential applications in biological assay, organic electronics, and membrane technology. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46498. [ABSTRACT FROM AUTHOR]

ABSTRACT Polymers derived from natural, minimally-processed materials have recently emerged as a more sustainable alternative to synthetic polymers, with promising applications in biocompatible and biodegradable devices. Plasma-enhanced deposition is well-suited to one-step, fast, and efficient synthesis of highly crosslinked inert polymers directly from natural resources, however, fabrication of biologically active polymers remains a challenge. Plasma processing parameters influence the properties such as surface energy, roughness, morphology, and chemical composition of deposited polymers and thus their final applications. This article reports on the important role of substrate temperature ( TS) in the chemical composition, wettability, refractive index, and crosslinking density of plasma polymers derived from terpenoids. Experiments are conducted as a function of deposition power Pd, and substrate temperature, TS. TS varied from 40 to 280 °C and is externally controlled. Atomic force microscopy analysis reveals the change in deposition mechanism attributed to shadowing effect at higher TS and Pd. Increase in band gap ( Eg) with high Ts deposition for terpenoid based plasma polymers is observed. Swelling behavior analyzed by in situ ellipsometry affirms the enhanced crosslink density with increasing deposition rate. Fourier transform infrared analysis exhibits the formation of additional chemical moieties with increasing TS. Increase in deposition rate with increasing TS at higher Pd supports the theory of direct incorporation of depositing particles as dominant mechanism of plasma polymerization in this study. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45771. [ABSTRACT FROM AUTHOR]

Maturity-onset diabetes of the young ( MODY) is a genetically heterogeneous monogenic form of diabetes characterized by onset of diabetes below 25 years of age, autosomal dominant mode of inheritance and primary defect in insulin secretion. Mutations in the gene ( HNF1A) encoding transcription factor hepatocyte nuclear factor 1A ( HNF-1A) results in one of the most common forms of MODY ( MODY3). HNF-1A is mainly enriched in pancreatic β-cells and hepatocytes and important for organ development and normal pancreatic function. We here report on the functional interrogation of eight missense HNF1A mutations associated with MODY3 in South Indian subjects, and the contributing effect of common variant ( S487N) within HNF1A. Of the eight mutations, three mutations (p. R171G, p. G245R and p. R263H), in particular, affected HNF-1A function in transfected HeLa cells by reducing both transcriptional activity and nuclear localization, possibly due to disruption of the integrity of the three dimensional structure. The common variant p.S487N contributed further to the loss-of-function of p. R271Q (p. R271Q+p. S487N double mutant), in vitro, on both activity and localization. Our data on the first functional study of HNF1A mutations in South India subjects confers that the defect of the HNF-1A mutant proteins are responsible for MODY3 diabetes in these patients. [ABSTRACT FROM AUTHOR]

The purpose of this study is to provide a broad idea about current control scheme and equilibrating voltages in DC-link capacitors of the neutral-point clamped multilevel inverter (NPC-MLI), using an innovative hexagonal space vector hysteresis current control (SVHCC) scheme. The main ideology is to force the literal current vector to reach the reference current vector through an appropriate voltage vector selection sequence. This proposed scheme defines two hexagonal hysteresis bands encompassing the error vector, as a first step. With respect to the error vector location, the selection of the adjacent vector is acted to minimise the error vector. In addition to the error vector selection, the capacitor voltage is also equilibrated by controlling the degree of freedom available in selecting the switching vectors. The SVHCC scheme is intelligent in performing modulation depth dependent selection of switching vectors between the groups namely closest three vector and preferred three vector (PTV). This scheme balances the DC-link capacitors' voltages within a tolerance limit for any value of modulation index. The proposed scheme is asserted through MATLAB/Simulink software. The superiority of the proposed technique is validated through the 2 kW NPC-MLI supported with SPARTAN III 3AN -XC3S400 field programmable gate array. [ABSTRACT FROM AUTHOR]

Aims To assess young healthy men from rural India, who had normal or low birth weights, using magnetic resonance spectroscopy to determine the potential differences in ectopic fat storage between birth weight groups, and to determine if ectopic fat storage was associated with insulin resistance in this population. Methods A total of 54 lean men with normal birth weight and 49 lean men with low birth weight (age range 18-22 years) from rural India were recruited. All the men underwent anthropometry, magnetic resonance spectroscopy, a hyperinsulinaemic-euglycaemic clamp and a dual-energy X-ray absorptiometry. Results The median (interquartile range) values for hepatic cellular lipids, intramyocellular lipids and extramyocellular lipids, measured using magnetic resonance spectroscopy were 0.76 (0.1-1.8)%, 1.27 (1.0-2.3)% and 1.89 (1.3-3.2)%, respectively, for the normal birth weight group and 0.4 (0.1-1.3)%, 1.38 (0.9-2.2)% and 2.07 (1.2-2.8)%, respectively, for the low birth weight group ( P > 0.05). No difference in ectopic fat storage was observed between the low and normal birth weight groups, with or without adjustment for age and total fat percentage. Homeostatic model assessment of insulin resistance values were not associated with hepatic cellular, intramyocellular or extramyocellular lipid content in any of the groups. Total fat percentage was the only independent predictor of intramyocellular and extramyocellular lipid content. Conclusion Young and lean men from rural India with low birth weight were not observed to have ectopic fat storage in the liver or muscle, and the amount of liver and muscle fat was unrelated to insulin resistance. Older age and/or an urban affluent lifestyle may be required to show a potential role of ectopic fat storage on insulin resistance in Indian people with low or normal birth weight. [ABSTRACT FROM AUTHOR]

Successful collaboration between new product development ( NPD) teams maintained by competitors (so-called horizontal NPD collaboration) requires the use of formal modes of management control that simultaneously coordinate the teams' interdependent development activities and encourage their cooperative behavior. Nevertheless, prior theoretical and empirical research suggests that formal control modes required to improve coordination may also drive uncooperative, opportunistic behavior. To help managers in horizontal NPD collaborations select appropriate control modes, this study draws on organizational theory of management control and develops a conceptual framework that specifies the impact of one partner's use of input, process, and output controls on the other partner's perception of coordination effectiveness and cooperative behavior. The results of a scenario-based experiment with 110 expert practitioners show that managers perceive the competitor's use of input control as harmful and process control as helpful for achieving coordination effectiveness. Moreover, managers respond positively to the competitor's use of input control and negatively to the competitor's use of output control when it comes to cooperative behavior. Together, the results indicate that no single mode of formal management control simultaneously enhances both coordination and cooperative behavior in horizontal NPD collaborations. [ABSTRACT FROM AUTHOR]

In this paper a new algorithm is presented to calculate the poles and zeros to approximate a fractional order (FO) differintegral ( s± α, α∈(0,1)) by a rational function on a finite frequency band ω∈( ω l, ω h). The constant phase property of the FO differintegral is the basis for development of the algorithm. Interlacing of real poles and zeros is used to achieve the constant phase. The calculations are done using the asymptotic Bode phase plot. A brief investigation is made to get a good approximation for the Bode phase plot. Two design parameters are introduced to keep the average phase close to the desired phase angle and to keep the error within the allowed bounds. A study is done to empirically understand the relationship between the error and the design parameters. The results thus obtained help in the further calculations. The algorithm is computationally simple and inexpensive, and gives a fairly good approximation of fractance frequency response on the specified frequency band. [ABSTRACT FROM AUTHOR]

Understanding the polymerization mechanism of a precursor is indispensable to enhance the requisite material properties. In situ mass spectroscopy and X-ray photoelectron spectroscopy is used in this study to understand the RF plasma polymerization of γ-terpinene. High-resolution mass spectra positive ion mass spectrometry data of the plasma phase demonstrates the presence of oligomeric species of the type [M+H]+ and [2M+H]+, where M represents a unit of the starting material. In addition, there is abundant fragmented species, with most dominant being [M+] (136 m/ z), C10H13+ (133 m/ z), C9H11+ (119 m/ z), and C7H9+ (93 m/ z). The results reported in this manuscript enables to comprehend the relationship between the degree of incorporation of oxygen and the rate of deposition with the input RF power. [ABSTRACT FROM AUTHOR]

ABSTRACT Plasma polymerized γ-terpinene (pp−GT) thin films are fabricated using RF plasma polymerization. MIM structures are fabricated and using the capacitive structures dielectric properties of the material is studied. The dielectric constant values are found to be in good agreement with those determined from ellipsometric data. At a frequency of 100 kHz, the dielectric constant varies with RF deposition power, from 3.69 (10 W) to 3.24 (75 W). The current density-voltage ( J−V) characteristics of pp-GT thin films are investigated as a function of RF deposition power at room temperature to determine the resistivity and DC conduction mechanism of the films. At higher applied voltage region, Schottky conduction is the dominant DC conduction mechanism. The capacitance and the loss tangent are found to be frequency dependent. The conductivity of the pp−GT thin films is found to decrease from 1.39 × 10−12 S/cm (10 W) to 1.02 × 10−13 S/cm (75 W) and attributed to the change in the chemical composition and structure of the polymer. The breakdown field for pp-GT thin films increases from 1.48 MV/cm (10 W) to 2 MV/cm (75 W). A single broad relaxation peak is observed indicating the contribution of multiple relaxations to the dielectric response for temperature dependent J−V. The distribution of these relaxation times is determined through regularization methods. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42318. [ABSTRACT FROM AUTHOR]

Aims To assess geographic differences in the association between BMI, blood pressure and lipid levels with impaired glucose regulation among young adults from various geographical regions. Methods This was a cross-sectional study including data from 6987 participants aged ≤ 30 years from India, Singapore, Australia, Greenland, Kenya and Tanzania. Impaired glucose regulation was determined by the 75-g oral glucose tolerance test. For each geographical region, BMI, blood pressure and lipids were examined and compared between participants with normal glucose tolerance and those with impaired glucose regulation. Multiple logistic regression models were used to assess the association between risk factors and impaired glucose regulation. Results Indian and East African people had a higher prevalence of impaired glucose regulation compared with participants from other regions, despite their lower BMI. Compared with the other regions, blood pressure was lower among Indian and Singaporean people but higher in those from Greenland. Greenlanders had the highest, while Indian and East-African people, had the lowest level of HDL cholesterol. BMI was positively associated with impaired glucose regulation in all regions, and there were no statistically significant geographic differences. In the Indian, Singaporean and Australian participants, there was a positive association between blood pressure and impaired glucose regulation. Triglycerides were positively associated with and HDL cholesterol had no association with impaired glucose regulation in all geographical regions. Conclusions Higher BMI and triglyceride levels were positively associated with prevalent impaired glucose regulation in all geographical regions. There were geographic differences in the association between impaired glucose regulation and blood pressure and lipids, probably reflecting environmental and genetic factors. [ABSTRACT FROM AUTHOR]

The objective of this study is to evaluate disease modifying efficacy and safety of a standardized extract of Trigonella foenum-graecum L, Fenugreek (IBHB) (family Fabaceae) as a nutritional adjuvant to Levo-dopa (L-Dopa) in Parkinson's disease (PD) patients. We conducted double-blind placebo-controlled proof of concept clinical study of IBHB capsules (300 mg, twice daily) with matching placebo for 6 months of period in 50 patients of PD stabilized on L-Dopa therapy. The efficacy outcome measures were the scores of Unified Parkinson's Disease Rating Scale (UPDRS - total and its subsections), and Hoehn and Yahr (H&Y) staging at baseline and end of 6-months treatment duration. Safety evaluation included haematology, biochemistry, urinalysis parameters and adverse event monitoring. Total UPDRS scores in IBHB treatment (0.098%) showed slower rise as opposed to steep rise (13.36%) shown by placebo. Further, Clinically Important Difference for total UPDRS scores and scores of motor subsection of UPDRS was found to be 5.3 and 4.8, respectively, in favour of IBHB treatment. Similar improvement was shown by IBHB in terms of H&Y staging as compared with placebo. IBHB was found to have excellent safety and tolerability profile. In conclusion, IBHB can be useful adjuvant treatment with L-Dopa in management of PD patients. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Biomedical research enterprises require a large number of core facilities and resources to supply the infrastructure necessary for translational research. Maintaining the financial viability and promoting efficiency in an academic environment can be particularly challenging for medical schools and universities. The Indiana Clinical and Translational Sciences Institute sought to improve core and service programs through a partnership with the Indiana University Kelley School of Business. The program paired teams of Masters of Business Administration students with cores and programs that self-identified the need for assistance in project management, financial management, marketing, or resource efficiency. The projects were developed by CTSI project managers and business school faculty using service-learning principles to ensure learning for students who also received course credit for their participation. With three years of experience, the program demonstrates a successful partnership that improves clinical research infrastructure by promoting business best practices and providing a valued learning experience for business students. [ABSTRACT FROM AUTHOR]

We conducted a randomised trial comparing lidocaine 2% gel with proparacaine 0.5% eye drops in children having elective squint surgery. One hundred and forty children aged between 3 and 14 years were recruited. The requirement for intra-operative fentanyl and postoperative ibuprofen was significantly less in the lidocaine group compared with the proparacaine group (1 (1.7%) vs 12 (18.5%), p = 0.002 and 16 (27.6%) 38 (58.5%), p = 0.001, respectively). The incidence of postoperative nausea and vomiting was significantly less in the lidocaine group compared with the proparacaine group (6 (10.3%) vs 16 (24.6%), p = 0.04). There were no differences between the groups in terms of incidence and severity of the oculocardiac reflex. We conclude that, compared with proparacaine 0.5% eye drops, a single application of lidocaine 2% gel improves peri-operative analgesia and reduces the incidence of postoperative nausea and vomiting in elective paediatric squint surgery. [ABSTRACT FROM AUTHOR]

Aims To identify real-world factors affecting adherence to insulin therapy in patients with Type 1 or Type 2 diabetes mellitus. Methods A literature search was conducted in PubMed and EMBASE in November 2011 to identify studies reporting factors associated with adherence/non-adherence to insulin therapy in adults with Type 1 or Type 2 diabetes. Results Seventeen studies were identified; six used self-reported measures and 11 used calculated measures of adherence. Most (13/17) were conducted exclusively in the USA. Four categories of factors associated with non-adherence were identified: predictive factors for non-adherence, patient-perceived barriers to adherence, type of delivery device and cost of medication. For predictive factors and patient-perceived barriers, only age, female sex and travelling were associated with non-adherence in more than one study. Fear of injections and embarrassment of injecting in public were also cited as reasons for non-adherence. Conversely, adherence was improved by initiating therapy with, or switching to, a pen device (in four studies), and by changing to an insurance scheme that lowered the financial burden on patients (in two studies). Conclusions Adherence to insulin therapy is generally poor. Few factors or patient-perceived barriers were consistently identified as predictive for non-adherence, although findings collectively suggest that a more flexible regimen may improve adherence. Switching to a pen device and reducing patient co-payments appear to improve adherence. Further real-world studies are warranted, especially in countries other than the USA, to identify factors associated with non-adherence and enable development of strategies to improve adherence to insulin therapy. [ABSTRACT FROM AUTHOR]

Aim This study was designed to assess the efficacy and safety of the dipeptidyl peptidase IV inhibitor gemigliptin ( LC15-0444) 50 mg versus placebo in patients with type 2 diabetes. Methods We conducted a 24-week, randomized, double-blind, placebo-controlled phase III trial in 182 patients (74 from Korea and 108 from India) with type 2 diabetes. After an initial 2 weeks of a diet and exercise programme followed by 2 weeks of a single-blind placebo run-in period, eligible patients were randomized to gemigliptin 50 mg or placebo, receiving the assigned treatment for 24 weeks. HbA1c and fasting plasma glucose ( FPG) were measured periodically, and oral glucose tolerance test was performed at baseline and weeks 12 and 24. Results At week 24, gemigliptin treatment led to significant reductions in HbA1c measurements compared to placebo (adjust mean after subtracting the placebo effect size: −0.71%, 95% confidence interval: −1.04 to −0.37%). A significantly greater proportion of patients achieved an HbA1c <7% with gemigliptin than with placebo. The placebo-subtracted FPG change from baseline at week 24 was −19.80 mg/ dl. The overall incidence rates for adverse events were similar in the gemigliptin and placebo groups. Conclusions This study showed the efficacy and safety of gemigliptin 50 mg administered once daily as a monotherapy for type 2 diabetes patients. [ABSTRACT FROM AUTHOR]

Mutations in the pancreatic ATP sensitive K+ channel proteins [sulfonyluea receptor 1 ( SUR1) and inward rectifier K+ channel Kir6.2 (Kir6.2), encoded by ATP-binding cassette transporter subfamily C member 8 ( ABCC8) and potassium channel J11 ( KCNJ11), respectively], are the most common cause of neonatal diabetes. We describe the clinical presentation and molecular characterization of Asian Indian children with neonatal diabetes mellitus and monogenic syndromes of diabetes. We sequenced KCNJ11, ABCC8 and insulin ( INS) genes in 33 unrelated Indian probands with onset of diabetes below one year of age. A total of 12 mutations were identified which included ABCC8 mutations in seven, KCNJ11 mutations in three and INS mutations in two children. The Asp212Tyr mutation in ABCC8 was novel. We also detected two novel mutations ( Val67Met and Leu19Arg) in children with syndromic forms of diabetes like Berardinelli Seip syndrome [1-acyl- sn-glycerol-3-phosphate acyltransferase beta ( AGPAT2)] and Fanconi Bickel syndrome [solute carrier family 2A2 ( SLC2A2)]. Children carrying the KCNJ11 ( Cys42Arg, Arg201Cys) and ABCC8 ( Val86Ala, Asp212Tyr) mutations have been successfully switched over from insulin therapy to oral sulfonylurea. Our study is the first large genetic screening study of neonatal diabetes in India. [ABSTRACT FROM AUTHOR]

Type 2 diabetes mellitus (T2DM) is one of the leading causes of morbidity and mortality. While all ethnic groups are affected, the prevalence of T2DM in South Asians, both in their home countries and abroad, is extremely high and is continuing to rise rapidly. Innate biological susceptibilities coupled with rapid changes in physical activity, diet, and other lifestyle behaviors are contributing factors propelling the increased burden of disease in this population. The large scope of this problem calls for investigations into the cause of increased susceptibility and preventative efforts at both the individual and population level that are aggressive, culturally sensitive, and start early. In this review, we outline the biological and environmental factors that place South Asians at elevated risk for T2DM, compared with Caucasian and other ethnic groups. [ABSTRACT FROM AUTHOR]

Anuradha S, Radha V, Mohan V. Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes. Variants in hepatocyte nuclear factor 4A ( HNF4A) cause maturity onset diabetes of the young (MODY 1). The objective of the study was to screen the coding and the promoter regions of HNF4A mutations in 87 unrelated South Indian subjects with clinically diagnosed MODY with severe forms of diabetes referred to a tertiary diabetes centre. In addition, we looked at the association of common polymorphisms in HNF4 A gene in subjects with MODY ( n = 199), early onset type 2 diabetes (T2DM) ( n = 505), late onset T2DM ( n = 287) and normal glucose tolerance (NGT) ( n = 247). We identified three novel mutations in the P2 promoter region of HNF4A, namely -1009 G/C, -129 T/C and -79 C/T. Co-segregation with diabetes was noted with the -1009 G/C and -129 T/C in one MODY family. We also studied eight single nucleotide polymorphisms (SNPs) of HNF4A gene. The frequency of the minor allele of the rs2144908 was significantly higher in subjects with MODY (p < 0.01) and that of rs736823 was significantly higher in early onset T2DM (p = 0.001). Minor allele frequency of rs1884614 and rs2071197 was significantly lower in early onset T2DM when compared to NGT subjects (p < 0.01). Minor allele frequency of Val255Met was significantly lower in MODY, early onset T2DM and late onset T2DM compared to NGT subjects (p < 0.01). This is the first report of MODY 1 mutations from India and shows that 3.4% of clinically diagnosed MODY subjects have MODY 1. In addition, we report SNPs of HNF4A that are both susceptible to, and protective against, MODY and early onset T2DM. [ABSTRACT FROM AUTHOR]

Diabet. Med. 27, 1226-1232 (2010) Aims Risk of Type 2 diabetes varies by ethnicity, but whether ethnicity remains important among those who have impaired glucose tolerance or impaired fasting glucose is uncertain. Whether the effect of thiazolidinedione treatment on diabetes prevention in persons with non-diabetic dysglycaemia varies by ethnicity is also not known. We addressed these questions using data collected in the DREAM trial. Methods A 2-by-2 factorial double-blind randomized controlled trial to compare the effects of rosiglitazone and ramipril on the primary outcome of diabetes or death in persons meeting criteria for impaired glucose tolerance or impaired fasting glucose. The effect of these interventions by ethnicity was estimated using Cox regression analysis. Results Of 5269 adults, 2365 were randomly assigned to rosiglitzone and 2634 to placebo. South Asians showed a higher hazard for the primary outcome compared with Europeans (hazard ratio, 95% confidence interval 2.21, 1.41-3.47) adjusted for age, gender, BMI, waist-hip ratio and geographic region. A lesser increase in risk was seen in Black people (1.37, 1.04-1.81). A significant reduction in risk of the primary outcome with rosiglitazone treatment assignment was seen in all ethnic groups, but the treatment effect significantly differed by ethnicity ( P = 0.0242), with South Asians experiencing a smaller, and Latinos a larger preventive effect. Conclusions Ethnicity is an important risk factor for Type 2 diabetes in dysglycaemic persons. All ethnic groups experienced a large significant reduction in diabetes risk because of rosiglitazone. The magnitude of this reduction differed by ethnicity. Given the post hoc nature of this analysis, further confirmation of these findings is needed. [ABSTRACT FROM AUTHOR]

Trigonella foenum (TF) has long been used in the traditional Indian systems of medicine for the treatment of various ailments. The objective was to study the anabolic and androgenic activity of the furostanol glycosides fraction of Trigonella foenum-graecum (Fenu-FG) in immature castrated male Wistar rats. It was also aimed to investigate the effect of Fenu-FG on testicular histology in non-castrated immature rats. The animals (55 ± 5 g) were castrated. The rats were treated with either vehicle, testosterone (10 mg/kg s.c. bi-weekly) or Fenu-FG (10 and 35 mg/kg p.o.) once daily for 4 weeks. At the end of the study, blood was withdrawn, serum testosterone and BUN were measured. Animals were killed and reproductive organs were excised and weighed. Fenu-FG (35 mg/kg p.o.) and testosterone (10 mg/kg, s.c. biweekly) increased the weight of the levator ani muscle as well as body weight. Fenu-FG (10 or 35 mg/kg p.o.) did not change the testosterone level in castrated rats. Histopathological examination of the testis of non-castrated rats treated with Fenu-FG (10, 35 mg/kg p.o.) showed normal architecture of the testis. Fenu-FG (35 mg/kg p.o.) showed anabolic activity without androgenic activity. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

This research develops a conceptual model for predicting success of process improvement projects as a result of knowledge-creation practices employed in the projects. The model is empirically examined in the context of Six Sigma black belt projects. New scales are developed to measure explicit- and tacit-knowledge-creation practices in process improvement. Data is gathered via a cross-sectional sample, and the hypotheses are tested using hierarchical regression. Our results support the notion that knowledge-creation practices influence the success of process improvement projects. Specifically, the inclusion of softer, people-oriented practices for capturing tacit knowledge explains a significant amount of variance in project success, as much as the more analytically focused practices that capture explicit knowledge. This research offers practical insights about the influence of practices that project managers use to create new knowledge by capturing explicit and tacit knowledge, and seeks to advance theoretical understanding of process improvement. [Copyright &y& Elsevier]

Background Age is associated with both impaired glucose and insulin metabolism. To what extent the age-related changes in insulin resistance (IR) and β-cell function contribute to the increase in prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) is less known, and this is investigated in this study. Methods This study included 6610 men and 7664 women of different ethnic groups aged 30-69 years. IR and β-cell function were examined by the homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-B). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression analysis adjusting for body mass index and study. Results In Chinese men, the ORs (95% CIs) for IFG were 2.69 (1.70, 4.26), 2.51 (1.49, 4.21) and 2.89 (1.68, 4.97), respectively, in age groups of 40-49, 50-59 and 60-69 years compared with 30-39 years ( p < 0.001 for trend); the corresponding figures for IGT were 1.73 (1.25, 2.38), 2.54 (1.78, 3.63) and 3.57 (2.46, 5.19) ( p < 0.001 for trend). Similar trends for IGT were observed also in Chinese women and other ethnic groups, but not for IFG in Mauritius Indian and Creole men. Adjustment for HOMA-IR and HOMA-B reduced the ORs in all age groups of all ethnicities for both IFG and IGT, but the risk gradient between age groups remained particularly for the IGT. Conclusions The age-related increase in glucose intolerance may not be fully explained by the defect in HOMA-IR and HOMA-B. As HOMA-IR and HOMA-B are only surrogate measures of insulin sensitivity and insulin secretion, the results need to be further investigated. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The article presents a study on the solubility and adhesion characteristics of organic polymer thin films produced from Lavandula angustifolia essential oil using radio frequency plasma polymerization. The study shows that the polymers are monopolar in nature. It also suggests that the polymers will resist solubilization from the solvents explored. It concludes that the adhesion quality of the thin film improves with radio frequency power.

We examine the content of continuous improvement strategies and identify infrastructure decision areas that are important for continuous improvement initiatives. We present a framework of infrastructure based on the idea that continuous improvement can serve as a dynamic capability when it includes a comprehensive organizational context. Further, we study continuous improvement initiatives in five companies to investigate the practices used by them in each of the decision areas of our framework. This research adds to the conceptual understanding of continuous improvement and results in grounded propositions about critical areas of infrastructure for continuous improvement. [Copyright &y& Elsevier]

Background Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes. Methods Cross-sectional data of 10 374 men and 12 552 women aged 30-74 years from 14 cohorts, representing seven populations of Asian origin were jointly analysed. Multivariable adjusted linear regression analyses with standardized regression coefficients (β) were performed to estimate relationships between lipids and plasma glucose. Results Within each glucose category, fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides (TGs), total cholesterol (TC), TC to high-density lipoprotein (HDL) ratio and non-HDL cholesterol (non-HDL-C) ( p < 0.05 in most of the ethnic groups) and inversely associated with HDL-C ( p < 0.05 in some, but not all, of the populations). The association of lipids with 2-h plasma glucose (2hPG) followed a similar pattern as that for the FPG, except that an inverse relationship between HDL-C and glucose was more commonly observed for 2hPG than for FPG among different ethnic groups. Conclusions Hyperglycaemia is associated with adverse lipid profiles in Asians without a prior history of diabetes. The 2hPG appears to be more closely associated with lipid profiles than does FPG. When assessing the risk of cardiovascular disease, the association of the dyslipidaemia with intermediate hyperglycaemia needs to be considered. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

This article reports on legal issues of privacy related to radio frequency identification (RFID) technology. RFID technology can track personal movements through common things such as credit cards, automobile license plates, anti-theft devices in clothes, and prescription medicine. The article discusses issues of consumer privacy and individual control over the release of personal or sensitive information. Information is also presented on the capabilities of RFID technology, its legal and economic aspects, and behavior economics.

Aim To highlight the regional difference in the prevalence of diabetes mellitus (DM) and to explore determinants in variability in the Indian industrial population. Methods A cross-sectional survey was carried out among the employees and their family members (10 930 individuals, mean age 39.6 years, 6764 male) of eleven medium-to-large industries from diverse sites in India, using a stratified random sampling technique. Information on behavioural, clinical and biochemical risk factors of DM was obtained, through standardized instruments. DM was diagnosed when fasting blood glucose was ≥ 7.0 mmol/l and/or individuals took drug treatment for DM. Multiple logistic regression analysis was carried out to identify the potential predictors of DM. Result In the 20 to 69-year-old age group, the crude prevalence of DM and impaired fasting glucose was 10.1 and 5.3%, respectively. Urban sites had a higher prevalence and awareness of DM status. Individuals in the lower education group had a high prevalence of DM (11.6%). In diabetic subjects, 38.4% were unaware that they had diabetes. Waist-circumference-to-height ratio had a higher DM predictive power than waist circumference and body mass index. The risk factors associated with overall prevalence of DM were: age, sex, low-education level, family history of DM, hypertension and overweight/obesity. Interaction of risk factors was observed only in urban high-prevalence sites. Conclusion There are wide regional variations in the prevalence of DM in India. The high burden of undetected diabetes, even in settings with universal access to on-site health care, highlights the need for innovative prevention and control strategies. [ABSTRACT FROM AUTHOR]

The article offers information on a study which described the synthesis of sodium-ion conducting polymer electrolytes based on poly(vinyl alcohol) complexed with sodium bromide with a solution-casting method. A review of the related literature is given. Methods utilized include x-ray diffraction for determining the structure of these films and Fourier transform infrared spectroscopy for determining the complexation of the salt with polymer.

It is well known that by improving mitochondrial bioenergetics, Coenzyme Q_{10} improves the systolic function in heart failure. The aim of this study was to see whether it benefits the diastolic dysfunction in hypertrophic cardiomyopathy (HCM) cases since diastolic relaxation also requires energy like the systole. 200~mg/day of CoQ_{10} was added to the conventional treatment in 46 patients with HCM diagnosed clinically and by echocardiography and by excluding cases of long standing hypertension. A comparable group of 41 age/sex matched cases received only conventional therapy. There was a significant improvement in the parameters like NYHA class &ges; 1, in quality of life (QOL) on 6 minutes walk test, in diastolic dysfunction by &ges; 1 parameter and in MR &ges; 1 grade. Post treatment echocardiogram showed significant reduction in left ventricular outflow tract (LVOT) gradient &ges; 15 mm Hg in obstructive cases (12 out of 46) in the treatment group. The mean interventricular septal thickness (IVS) showed a 22.4% reduction (p < 0.005). The mean posterior wall thickness showed a 23.1% reduction (p < 0.005). No patient in the treatment Group had ventricular tachycardia (VT) whereas 4 cases in the control group had VT. In both groups 1 patient was lost due to sudden cardiac death (SCD). [ABSTRACT FROM AUTHOR]

This paper empirically examines the acquisition of a technology from a source outside the firm and its incorporation into a new or existing operational process. We refer to this key activity in process innovation as external technology integration. This paper develops a conceptual framework of external technology integration based on organizational information processing theory and technology management literature. The primary hypothesis underlying the conceptual framework is that external technology integration will be most successful when the level of interaction between the source of the technology and recipient of the technology is appropriately matched, or fit, to the characteristics of the technology to be integrated. The conceptual framework also develops other hypotheses relating to contextual factors that may also influence the success of external technology integration. A cross-sectional survey methodology is employed to test the four hypotheses of the conceptual framework, with the results indicating strong support for the fit hypothesis and general support for the contextual hypotheses. The paper closes with a discussion of the implications of this study for both theory and practice. [Copyright &y& Elsevier]

Aims: The aims of the study were to compare the recently evolved Indian Diabetes Risk Score (IDRS), in subjects with different grades of glucose intolerance and to evaluate its usefulness as an indicator of cardiovascular risk in Asian Indians, a high risk group for diabetes and coronary artery disease (CAD). Methods: The data for the present study were obtained from the Phase 3 (n = 2350, response rate: 90.4%) of the Chennai Urban Rural Epidemiology Study, a population-based study done in Chennai, the largest city in southern India. IDRS was developed based on multiple logistic regression analysis using four simple parameters namely age, abdominal obesity, family history of type 2 diabetes and physical activity. In all subjects, family history of diabetes was obtained, and details on physical activity were assessed using a validated questionnaire. Subjects with an IDRS of <30 was categorized as low risk, 30–50 as medium risk and those with ≥60 as high risk for diabetes. Biochemical and anthropometric measurements were done using standardized procedures. Minnesota coding was used to grade 12-lead electrocardiogram. Results: The mean IDRS increased significantly with worsening glucose intolerance [normal glucose tolerance (NGT) subjects: 48 ± 17, impaired glucose tolerance (IGT): 57 ± 16, newly diagnosed diabetics (NDD): 61 ± 15 and known diabetics (KD): 68 ± 12; p for trend <0.001]. Among NGT group, the prevalence of cardiovascular risk factors increased progressively in low-, medium- to high-risk score groups; hypertension: 9.4, 22.1 and 38.2% (p for trend: < 0.001), hypertriglyceridemia: 8.8, 19.9 and 25.3% (p for trend: < 0.001), hypercholesterolemia: 7.2, 20.3 and 34.9% (p for trend: < 0.001) and metabolic syndrome: 1.8, 14.6 and 30.3% (p for trend: < 0.001), respectively. The prevalence of CAD was also significantly higher in individuals with high risk compared with those with low risk (p = 0.030) and the medium risk (p = 0.050) in the NGT group. Conclusions: The results suggest that in Asian Indians, (i) the diabetes risk score increases with increasing glucose intolerance, and (ii) it can serve as an effective indicator of metabolic syndrome and cardiovascular risk even among subjects with NGT. [ABSTRACT FROM AUTHOR]

Aims The aim of the study was to investigate the association of serum adiponectin levels with the Pro12Ala polymorphism of the peroxisome proliferator activated receptor-γ ( PPARG) gene in Asian Indians. Methods We selected 400 diabetic subjects, 200 with the Pro12Pro genotype (100 male and 100 female) and 200 with the Pro12Ala genotype (100 male and 100 female) and 400 age- and sex-matched normal glucose tolerance subjects with similar genotype profiles from the Chennai Urban Rural Epidemiology Study. Fasting serum adiponection levels were measured using radioimmunoassay. The Pro12Ala polymorphism was genotyped by PCR–restriction fragment length polymorphism using BstUI. Results All clinical and biochemical parameters were similar in the subjects with the Pro12Pro and Pro12Ala genotypes. There was no significant difference in serum adiponectin values between subjects with the Pro12Pro and Pro12Ala genotypes (males 5.4 vs. 5.8 µg/ml, P = 0.546; females 6.9 vs. 7.2 µg/ml, P = 0.748). Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 µg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 µg/ml, P = 0.622). Conclusion The Pro12Ala polymorphism of the PPARG gene is not associated with serum adiponectin levels in Asian Indians. [ABSTRACT FROM AUTHOR]

AIM: To compare the prevalence of metabolic syndrome (MS) using the World Health Organisation (WHO), Adult Treatment Panel III (ATPIII) and International Diabetes Federation (IDF) criteria of MS in an urban south Indian population, and their ability to identify coronary artery disease (CAD) in males and females. METHODS: Chennai Urban Rural Epidemiology Study (CURES) is one of the largest epidemiological studies on diabetes carried out in India, in which 26 001 individuals aged >/=20 years were screened using systematic random sampling method. Every tenth subject recruited in Phase 1 of CURES was requested to participate in Phase 3, and the response rate was 90.4%. An oral glucose tolerance test (OGTT) was performed in all individuals except self-reported diabetic subjects. Anthropometric measurements and lipid estimations were done in all subjects and the prevalence of MS estimated using the three criteria. Diagnosis of CAD, made by resting 12 lead ECG, was compared by the three criteria of MS. RESULTS: MS was identified in 546 subjects (23.2%) by WHO criteria, 430 subjects (18.3%) by ATPIII criteria and 607 subjects (25.8%) by IDF criteria. Only 224 of these subjects were identified by all the three criteria. There was an increased risk of probable CAD in MS subjects diagnosed by WHO criteria (odds ratio (OR) 3.86, 95% Confidence Interval (CI), 2.37-6.29, p < 0.001), compared to ATPIII criteria (OR 2.19, 95% CI 1.30-3.67, p < 0.05) and IDF criteria (OR 1.90, 95% CI 1.16-3.12, p < 0.05). The WHO criteria marked out a much higher population for CAD risk compared to ATPIII and IDF criteria in males, but not in females. CONCLUSION: In Asian Indians, the WHO, ATPIII and IDF criteria of MS identify different individuals. The WHO criteria identify a greater number of CAD subjects in males, but not in females. Copyright (c) 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]