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The article discusses the value and potential pitfalls of using morphometric analysis of magnetic resonance imaging (MRI) in epilepsy, particularly in patients with first unprovoked seizures. The Morphometric Analysis Program (MAP) can help detect focal cortical dysplasia (FCD) in MRI-negative patients, potentially converting a nonlesional MRI into a lesional one. The commentary emphasizes the importance of cross-correlations and clinical concordance in interpreting MAP results, highlighting the need for expert interpretation and consideration of multiple imaging outputs. The authors caution against solely relying on MAP findings without considering clinical semiology and electroencephalographic (EEG) data, as epilepsy remains a clinical diagnosis that requires careful evaluation. [Extracted from the article]

Most theoretical models of arousal/regulatory function emphasise the maintenance of homeostasis; consistent with this, most previous research into arousal has concentrated on examining individuals' recovery following the administration of experimentally administered stressors. Here, we take a different approach: we recorded day‐long spontaneous fluctuations in autonomic arousal (indexed via electrocardiogram, heart rate variability and actigraphy) in a cohort of 82 typically developing 12‐month‐old infants while they were at home and awake. Based on the aforementioned models, we hypothesised that extreme high or low arousal states might be more short‐lived than intermediate arousal states. Our results suggested that, contrary to this, both low‐ and high‐arousal states were more persistent than intermediate arousal states. The same pattern was present when the data were viewed over multiple epoch sizes from 1 s to 5 min; over 10–15‐minute time‐scales, high‐arousal states were more persistent than low‐ and intermediate states. One possible explanation for these findings is that extreme arousal states have intrinsically greater hysteresis; another is that, through 'metastatic' processes, small initial increases and decreases in arousal can become progressively amplified over time. Rather than exclusively using experimental paradigms to study recovery, we argue that future research should also use naturalistic data to study the mechanisms through which states can be maintained or amplified over time. [ABSTRACT FROM AUTHOR]

Background: Previous research has suggested that children exposed to more early‐life stress show worse mental health outcomes and impaired cognitive performance in later life, but the mechanisms subserving these relationships remain poorly understood. Method: Using miniaturised microphones and physiological arousal monitors (electrocardiography, heart rate variability and actigraphy), we examined for the first time infants' autonomic reactions to environmental stressors (noise) in the home environment, in a sample of 82 12‐month‐old infants from mixed demographic backgrounds. The same infants also attended a laboratory testing battery where attention‐ and emotion‐eliciting stimuli were presented. We examined how children's environmental noise exposure levels at home related to their autonomic reactivity and to their behavioural performance in the laboratory. Results: Individual differences in total noise exposure were independent of other socioeconomic and parenting variables. Children exposed to higher and more rapidly fluctuating environmental noise showed more unstable autonomic arousal patterns overall in home settings. In the laboratory testing battery, this group showed more labile and short‐lived autonomic changes in response to novel attention‐eliciting stimuli, along with reduced visual sustained attention. They also showed increased arousal lability in response to an emotional stressor. Conclusions: Our results offer new insights into the mechanisms by which environmental noise exposure may confer increased risk of adverse mental health and impaired cognitive performance during later life. [ABSTRACT FROM AUTHOR]

The use of the molecular imprinting technique to produce polymers with high specificity for a given 'molecular template' has undergone a rapid and expansive evolution since the inception of the idea over half a century ago. It was only a matter of time before the seemingly inevitable 'marriage' of this concept with another modern research obsession, the generation of 'smart' polymers, capable of reacting quickly, accurately and reproducibly to changes in their environment. Many advances have since been made, concerning the quality and diversity of these systems and polymers responsive to temperature, pH and a host of other environmental cues now exist. This article provides a succinct overview of the process and outcomes of 'smart' molecular imprinting, followed by a detailed assessment of recent developments and applications in such field. [ABSTRACT FROM AUTHOR]