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Introduction: The prognosis of diffuse large B‐cell lymphoma (DLBCL) patients with refractory or multiply relapsed (R/R) disease is disappointing. Pixantrone is currently approved as third or fourth line regimen, with encouraging results, even if long‐term follow‐up data are limited. Methods: In this post‐hoc analysis of our observational study, we retrospectively investigated disease outcome and clinical characteristics of 16 R/R DLBCL patients who achieved a complete response with pixantrone. Results: Pixantrone was administered as third or fourth line in 12/16 (75%) and 4/16 (25%) cases. After a median follow‐up of 24 months, 14/16 patients (87.5%) were alive (causes of death were progressive disease and secondary acute myeloid leukemia, one case each). Median progression‐free survival was 23.8 months, median duration of response was 17.8 months and median overall survival (OS) was not reached (2‐years OS was 84%). A significant proportion of patients achieved a long‐lasting response >12 months (7/16 cases). Response to prior therapy did not influence long‐term remission after pixantrone. Conclusion: In this real‐life experience, pixantrone demonstrated long‐term efficacy in a cohort of R/R DLBCL cases who had previously received at least two prior regimens; many of whom had characteristics associated with poor prognosis. [ABSTRACT FROM AUTHOR]

However, cervical spine CT and dorsal-cervical-magnetic resonance imaging were performed showing an osteolytic lesion in the right C1 lateral mass, invading the anterior arc, the para-vertebral muscles and above the occipito-cervical junction (Fig. b). GLO:HWR/01sep19:ans14691-fig-0001.jpg PHOTO (COLOR): (a) Abdominal computed tomography (CT) (axial section) identified a large mass in the right lobe of the liver with infiltration of the right and middle hepatic veins (red arrow). (b) Cervical spine CT (axial section) showed an osteolytic lesion in the right C1 lateral mass, invading the anterior arc, the para-vertebral muscles and above the occipito-cervical junction (red box). [Extracted from the article]

ABSTRACT Bois Noir is an emergent disease of grapevine that has been associated to a phytoplasma belonging to the XII-A stolbur group. In plants, phytoplasmas have been found mainly in phloem sieve elements, from where they spread moving through the pores of plates, accumulating especially in source leaves. To examine the expression of grapevine genes involved in sucrose transport and metabolism, phloem tissue, including sieve element/companion cell complexes and some parenchyma cells, was isolated from healthy and infected leaves by means of laser microdissection pressure catapulting (LMPC). Site-specific expression analysis dramatically increased sensitivity, allowing us to identify specific process components almost completely masked in whole-leaf analysis. Our findings showed decreased phloem loading through inhibition of sucrose transport and increased sucrose cleavage activity, which are metabolic changes strongly suggesting the establishment of a phytoplasma-induced switch from carbohydrate source to sink. The analysis focused at the infection site also showed a differential regulation and specificity of two pathogenesis-related thaumatin-like genes ( TL4 and TL5) of the PR-5 family. [ABSTRACT FROM AUTHOR]