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Premise: The expected concomitant increase in multiple stressors such as herbivory and drought may threaten peatland ecosystems. How Sphagnum, the ecological engineers of peatlands, responds to combined stressors remains largely unexplored. Here we aimed to clarify resource allocations in Sphagnum during concomitant herbivory and drought. Methods: S. magellanicum and S. fuscum were exposed to drought and herbivory together or separately in laboratory experiments and analyzed for growth (biomass production and net photosynthetic rate), defense (phenolics in leachates and phenolics in extraction) and nonstructural carbohydrates (soluble sugar and starch) in relation to untreated controls. Results: Herbivory and drought had significant interactive effects on Sphagnum growth and defense. In both species, drought without herbivory reduced the phenolics in leachate, but with herbivory increased phenolics, indicating a synergistic effect between herbivory and drought on Sphagnum defense. Both stressors significantly decreased biomass production, with the combined stress having a more negative effect. Interestingly, a growth–defense trade‐off was found in the drought treatment of both Sphagnum species, but disappeared in the wet treatment. Conversely, a trade‐off between soluble sugars and phenolics was found in the wet but not in the drought treatment, suggesting that soluble sugars may play a role in inducing the defense and hence mask the growth–defense trade‐off in peat mosses. Conclusions: Our results emphasize that predicting the impact of combined stressors on peat moss traits is complex and challenging. Future models should account for the effects of multiple environmental stressors to guide peatland conservation under climate warming. [ABSTRACT FROM AUTHOR]

Optoelectronic neuromorphic devices based on oxide semiconductors have been potentially investigated to mimic the functions of human visual synapses. However, the challenge comes from the wide bandgap characteristics of numerous oxide semiconductors, which restricts the response range of the device under ultra‐violet (UV) region. Strategies for widening the response range are mostly focused on artificially generating the defect states, however, most of them results in mimicking the tetrachromatic visual system from UV to visible light range. To be used for industries such as robotics, or autonomous vehicles, mimicking the tetrachromatic vision system should be overcome up to near‐infrared (NIR) region. Here, a facile solution processed indium‐gallium‐zinc‐oxide and silver oxide structured optoelectronic synaptic transistor is fabricated not only to mimic the function of human synapses, but to overcome the tetrachromatic human visual system up to the NIR region. The device not only showed photoresponse characteristics under the entire 405 to 830 nm wavelength region, but also showed significant synaptic behaviors with over 512 conduction states under a reasonable incident light power density of 4.5 mW cm−2. The results will offer a useful facile method for fabricating optoelectronic synaptic transistors that can overcome the tetrachromatic vision systems. [ABSTRACT FROM AUTHOR]

In times of prolonged economic doldrums across the globe, multinational firms (MNFs) offshoring blunders can undermine their competitiveness in the marketplace. To help the MNF formulate a more resilient offshoring strategy and identify the most desirable offshoring destination, this article aims to identify dynamic risk factors that significantly hinder the efficiency of offshoring and then measure specific offshoring risks over time using two different versions of data envelopment analysis (DEA) models and Malmquist productivity index (MPI). After assessing the degree of risk resiliency of the offshoring host countries over extended periods and then conducting Tobit regression analysis to identify key factors that significantly influence offshoring risks, we found that the host country's logistics efficiency (i.e., logistics performance index [LPI]) and domestic market size were critical indicators of offshoring success in that country. Since low‐cost sourcing countries (LCCs) tend to have relatively low LPIs and smaller domestic market sizes, they are not attractive offshoring destinations. This finding defies conventional wisdom. This article is one of the first longitudinal studies to assess the comprehensive risk resilience of 87 different offshoring destinations (countries) during multiple periods (6‐year span). [ABSTRACT FROM AUTHOR]

The depletion of the ozone layer over the last four decades has increased Earth's exposure to ultraviolet (UV) radiation, posing significant health risks. Indium‐Gallium‐Zinc‐Oxide (IGZO) phototransistors have emerged as promising UV detection candidates, boasting a wide bandgap (>3 eV), low off‐current, high on‐current, and stability. However, previous efforts to enhance the photoresponse of IGZO phototransistors focused on visible light absorption layers, neglecting UV detection. Here, zinc oxide (ZnO) nanoparticles (NPs) as an absorption layer in IGZO TFTs for UV phototransistors are introduced. IGZO/ZnO TFTs exhibit robust photoresponsivity for UV light below 360 nm, showcasing rejection ratios (Ruv / Rvis) of 20 258, 62 261, 193 649, and 401 582 for wavelengths of 360, 340, 320, and 300 nm, respectively. The combination of IGZO's wide bandgap with ZnO NPs proves effective for detecting UV light below 360 nm, even at low incident light intensities (15 µW cm−2). Enhanced photoresponse characteristics are confirmed via ultraviolet photoelectron spectroscopy. This research highlights the potential of IGZO materials for UV phototransistors and introduces a novel perspective on the utilization of an additional absorption layer traditionally employed for the conventional extension into the visible light range. [ABSTRACT FROM AUTHOR]

Lithium polysulfides (LiPSs) are pivotal intermediates involved in all the cathodic reactions in lithium–sulfur (Li−S) batteries. Elucidating the solvation structure of LiPSs is the first step for rational design of electrolyte and improving Li−S battery performances. Herein, we investigate the solvation structure of LiPSs and find that Li salt anions tend to enter the first solvation sheath of LiPSs and form contact ion pairs in electrolyte. The anion‐involved solvation structure of LiPSs significantly influences the intrinsic kinetics of the sulfur redox reactions. In particular, the LiPS solvation structure modified by lithium bis(fluorosulfonyl)imide endows Li−S batteries with reduced polarization and enhanced rate performances under high sulfur areal loading and lean electrolyte volume conditions. This work updates the fundamental understanding of the solvation chemistry of LiPSs and highlights electrolyte engineering for promoting the performances of Li−S batteries. [ABSTRACT FROM AUTHOR]

The research on the deviations caused by different resolutions is relevant to the study of spatial scale effects. In 2018, spatial interpolations were performed using the removal ratios of the TN, NH4‐N, and NO3‐N of the layers of different resolutions, respectively. Based on the mean and the standard deviation, the area, shape, and position were obtained for four levels related to the removal ratios of the three nitrogen forms. The linear and 6th function fitting methods were used to reveal the differences in nitrogen removal in wetland water at different spatial resolutions. The results showed that a resolution of 25 times the original was the key scale of the spatial effects. Due to the fact that 52 of the 72 functions did not reach a significant level (P < 0.05), the spatial scale effect of the nitrogen removal was mainly characterized by disorderly fluctuations. The results have a certain extrapolation value for the analysis of spatial scale effects. Practitioner Points: The resolution difference was not sufficient to change the spatial pattern of the geographic phenomena.The resolution of 25 times the original was the important scale for determining spatial effects.When studying the spatial scale effects caused by differences in resolution, it was necessary to comprehensively consider various resolutions. [ABSTRACT FROM AUTHOR]

Lithium–sulfur (Li–S) batteries promise high‐energy‐density potential to exceed the commercialized lithium‐ion batteries but suffer from limited cycling lifespan due to the side reactions between lithium polysulfides (LiPSs) and Li metal anodes. Herein, a three‐way electrolyte with ternary solvents is proposed to enable high‐energy‐density and long‐cycling Li–S pouch cells. Concretely, ternary solvents composed of 1,2‐dimethoxyethane, di‐isopropyl sulfide, and 1,3,5‐trioxane are employed to guarantee smooth cathode kinetics, inhibit the parasitic reactions, and construct a robust solid electrolyte interphase, respectively. The cycling lifespan of Li–S coin cells with 50 µm Li anodes and 4.0 mg cm−2 sulfur cathodes is prolonged from 88 to 222 cycles using the three‐way electrolyte. Nano‐heterogeneous solvation structure of LiPSs and organic‐rich solid electrolyte interphase are identified to improve the cycling stability of Li metal anodes. Consequently, a 3.0 Ah‐level Li–S pouch cell with the three‐way electrolyte realizes a high energy density of 405 Wh kg−1 and undergoes 27 cycles. This work affords a three‐way electrolyte recipe for suppressing the side reactions of LiPSs and inspires rational electrolyte design for practical high‐energy‐density and long‐cycling Li–S batteries. [ABSTRACT FROM AUTHOR]

Gestational hypoxia adversely affects uterine artery function, increasing complications. However, an effective therapy remains unidentified. Here, we show in rodent uterine arteries that hypoxic pregnancy promotes hypertrophic remodelling, increases constrictor reactivity via protein kinase C signalling, and triggers compensatory dilatation via nitric oxide‐dependent mechanisms and stimulation of large conductance Ca2+‐activated K+‐channels. Maternal in vivo oral treatment with the mitochondria‐targeted antioxidant MitoQ in hypoxic pregnancy normalises uterine artery reactivity and prevents vascular remodelling. From days 6–20 of gestation (term ∼22 days), female Wistar rats were randomly assigned to normoxic or hypoxic (13–14% O2) pregnancy ± daily maternal MitoQ treatment (500 µm in drinking water). At 20 days of gestation, maternal, placental and fetal tissue was frozen to determine MitoQ uptake. The uterine arteries were harvested and, in one segment, constrictor and dilator reactivity was determined by wire myography. Another segment was fixed for unbiased stereological analysis of vessel morphology. Maternal administration of MitoQ in both normoxic and hypoxic pregnancy crossed the placenta and was present in all tissues analysed. Hypoxia increased uterine artery constrictor responses to norepinephrine, angiotensin II and the protein kinase C activator, phorbol 12,13‐dibutyrate. Hypoxia enhanced dilator reactivity to sodium nitroprusside, the large conductance Ca2+‐activated K+‐channel activator NS1619 and ACh via increased nitric oxide‐dependent mechanisms. Uterine arteries from hypoxic pregnancy showed increased wall thickness and MitoQ treatment in hypoxic pregnancy prevented all effects on uterine artery reactivity and remodelling. The data support mitochondria‐targeted therapy against adverse changes in uterine artery structure and function in high‐risk pregnancy. Key points: Dysfunction and remodelling of the uterine artery are strongly implicated in many pregnancy complications, including advanced maternal age, maternal hypertension of pregnancy, maternal obesity, gestational diabetes and pregnancy at high altitude.Such complications not only have immediate adverse effects on the growth of the fetus, but also they can also increase the risk of cardiovascular disease in the mother and offspring. Despite this, there is a significant unmet clinical need for therapeutics that treat uterine artery vascular dysfunction in adverse pregnancy.Here, we show in a rodent model of gestational hypoxia that in vivo oral treatment of the mitochondria‐targeted antioxidant MitoQ protects against uterine artery vascular dysfunction and remodelling, supporting the use of mitochondria‐targeted therapy against adverse changes in uterine artery structure and function in high‐risk pregnancy. [ABSTRACT FROM AUTHOR]

Background and Objective. Approximately 50% of acute ischemic stroke (AIS) patients who achieve complete recanalization after endovascular therapy (EVT) experience unfavorable outcomes that are potentially partially attributed to incomplete microvascular reperfusion, which can possibly be improved by antiplatelet treatment. This study aimed to evaluate the effect of periprocedural tirofiban on AIS patients who achieved complete recanalization with EVT. Methods. Anterior circulation large-vessel occlusion stroke patients who achieved complete recanalization after EVT were retrospectively analyzed. Patients were dichotomized into tirofiban and nontirofiban groups and compared. Propensity score matching (PSM) was used to balance baseline confounders. 3-month functional independence (modified Rankin scale: 0–2), any intracranial hemorrhage (ICH), symptomatic ICH (sICH), arterial reocclusion, in-hospital mortality, and 3-month mortality were evaluated. Results. This study included 303 patients with 118 and 185 in the nontirofiban and tirofiban groups, respectively. After PSM, 85 couples with balanced baseline characteristics were generated. 49 (57.6%) and 36 patients (42.4%) in the tirofiban and nontirofiban groups achieved functional independence at 3 months with a significant difference (risk ratio: 1.361, 95% confidence interval: 1.001–1.852, P = 0.046). However, there was no significant difference between the tirofiban and nontirofiban groups in terms of the other outcomes (all P > 0.05). Conclusions. In anterior circulation, large-vessel occlusion AIS patients who achieved complete recanalization with EVT, periprocedural tirofiban may improve the functional outcomes and does not appear to increase the rate of ICH and sICH. [ABSTRACT FROM AUTHOR]

Lithium–sulfur (Li–S) batteries promise great potential as high‐energy‐density energy storage devices. However, the parasitic reactions between lithium polysulfides (LiPSs) and Li metal anodes render limited cycling lifespan of Li–S batteries. Herein, an organic‐rich solid electrolyte interphase (SEI) is constructed to inhibit the LiPS parasitic reactions and achieve long‐cycling Li–S batteries. Concretely, 1,3,5‐trioxane is introduced as a reactive co‐solvent that decomposes on Li anode surfaces and contributes organic components to the SEI. The as‐constructed organic‐rich SEI effectively inhibits the LiPS parasitic reactions and protects working Li metal anodes. Consequently, the cycling lifespan of Li–S coin cells with 50 µm Li anodes and 4.0 mg cm−2 sulfur cathodes is prolonged from 130 to 300 cycles by the organic‐rich SEI. Furthermore, the organic‐rich SEI enables a 3.0 Ah‐level Li–S pouch cell to achieve a high energy density of 400 Wh kg−1 and stable 26 cycles. This study affords an effective organic‐rich SEI to inhibit the LiPS parasitic reactions and inspires rational SEI design to achieve long‐cycling Li–S batteries. [ABSTRACT FROM AUTHOR]

Lithium manganese oxides are considered as promising cathodes for lithium‐ion batteries due to their low cost and available resources. Layered LiMnO2 with orthorhombic or monoclinic structure has attracted tremendous interest thanks to its ultrahigh theoretical capacity (285 mAh g−1) that almost doubles that of commercialized spinel LiMn2O4 (148 mAh g−1). However, LiMnO2 undergoes phase transition to spinel upon cycling cause by the Jahn‐Teller effect of the high‐spin Mn3+. In addition, soluble Mn2+ generates from the disproportionation of Mn3+ and oxygen release during electrochemical processes may cause poor cycle performance. To address the critical issues, tremendous efforts have been made. This paper provides a general review of layered LiMnO2 materials including their crystal structures, synthesis methods, structural/elemental modifications, and electrochemical performance. In brief, first the crystal structures of LiMnO2 and synthetic methods have been summarized. Subsequently, modification strategies for improving electrochemical performance are comprehensively reviewed, including element doping to suppress its phase transition, surface coating to resist manganese dissolution into the electrolyte and impede surface reactions, designing LiMnO2 composites to improve electronic conductivity and Li+ diffusion, and finding compatible electrolytes to enhance safety. At last, future efforts on the research frontier and practical application of LiMnO2 have been discussed. [ABSTRACT FROM AUTHOR]

A recent publication in the journal Nature by Hu et al. explores the potential of activating the stimulators of interferon genes (STING) pathway to prevent dormant metastasis in lung adenocarcinoma (LUAD). The study reveals that the dynamic changes in STING activation during the transition of cancer cells from quiescent to reawakened states influence immune surveillance and can effectively prevent the progression of metastasis. The authors identify the STING pathway as a novel checkpoint that plays a pivotal role in modulating the interaction between metastatic tumor seeds and the immune system. This research provides a promising therapeutic avenue for preventing disease recurrence in LUAD patients. [Extracted from the article]

Reactive‐transport models (RTMs) have been an integral part of the safety case and design optimization for the nuclear waste repository in Finland. Such highly resolved, internally complex RTMs tend to be computationally demanding, thus their design is often a compromise between representativeness and computational efficiency. A modeling strategy is presented, demonstrating how a 2D simplified model can be constructed based upon and calibrated against a geometrically realistic 3D RTM. Key geometrical parameters of the 2D model are consistent with the 3D model, and the 2D model is verified by a series of benchmarks for various designs and conditions of the repository. Overall, the 2D model is proven suitable for fast scoping calculations, as (1) it reduces the mesh elements by 16 times and shortens the run time by about 40 times; (2) it has much more flexible remeshing possibilities; and (3) it provides highly consistent results with the 3D model. [ABSTRACT FROM AUTHOR]

Recycling of molybdenum isotopes in continental subduction zones remains debated. In this contribution, we re‐visit the Mo isotope compositions of the Sailipu post‐collisional ultrapotassic rocks in the Himalaya‐southern Tibet orogen. These ultrapotassic rocks have very varying δ98/95Mo values of −0.66 to −0.07‰ and Mo/Ce ratios of 0.0008–0.005, which are lower than those of mid‐ocean ridge basalts (MORB; δ98/95Mo = −0.20 ± 0.06‰, and Mo/Ce = 0.03) and oceanic subduction‐related (i.e., mantle source involving fluids, residual slab, or oceanic sediments) magmatic rocks (e.g., modern arc lavas, Cenozoic OIB‐type basalts in eastern China and the central Mariana Trough basalts in the back‐arc basin, syn‐collisional andesitic rocks in southern Tibet). Combined with the light Mo isotopes of the Himalayan schists and gneisses, we suggest that the light Mo isotopic signature of the Sailipu ultrapotassic rocks is derived from subducted Indian continental crust. This is consistent with the extremely low δ11B (−17.4 to −9.7‰) and B/Nb (0.16–1) values and enriched Sr‐Nd‐Pb isotopes of the Sailipu ultrapotassic rocks. Thus, this study reveals the recycling of light Mo‐B isotopes during continental subduction and demonstrates that Mo‐B isotopes can effectively distinguish between continental and oceanic subduction. Plain Language Summary: Mo isotope systematics have been widely applied in the study of tracing recycled crustal materials, and abundant researches have proposed that heavy Mo isotopic compositions of arc‐mafic magma can be ascribed to slab‐dehydrated fluids. However, in continental subduction zones, the origin of the light Mo isotopes of post‐collisional mafic rocks (oceanic sediments during prior oceanic subduction vs. subducted continental crust) remains controversial, hindering our understanding of the recycling of continental crustal materials. In this study, we report new Mo isotope data of post‐collisional ultrapotassic rocks in the Lhasa block of the southern Tibetan plateau. We have used Mo isotope data along with B‐Sr‐Nd‐Pb isotopes of these ultrapotassic rocks, in combination with Mo‐B‐Sr‐Nd‐Pb isotopes of the Himalayan crustal rocks (e.g., gneisses and schists) to trace the crustal components in the post‐collisional mantle beneath southern Tibet. We concluded that the light Mo and B isotope compositions in southern Tibet were derived from subducted Indian continental crust rather than Neo‐Tethyan oceanic sediments. Thus, this study not only reveals the recycling of light Mo‐B isotopes in this typical collision orogen (i.e., Himalaya‐Tibet orogen) but also shows the potential in discriminating between oceanic subduction metasomatism and continental subduction metasomatism. Key Points: Post‐collisional ultrapotassic rocks in southern Tibet have extremely light Mo and B isotope compositionsThese light Mo‐B isotope features are derived from subducted Indian continental crustMo‐B isotopes have the potential to discriminate between oceanic and continental subduction [ABSTRACT FROM AUTHOR]

We present a comparison of atmospheric transport models that simulate carbonyl sulfide (COS). This is part II of the ongoing Atmospheric Transport Model Inter‐comparison Project (TransCom–COS). Differently from part I, we focus on seven model intercomparison by transporting two recent COS inversions of NOAA surface data within TM5‐4DVAR and LMDz models. The main goals of TransCom‐COS part II are (a) to compare the COS simulations using the two sets of optimized fluxes with simulations that use a control scenario (part I) and (b) to evaluate the simulated tropospheric COS abundance with aircraft‐based observations from various sources. The output of the seven transport models are grouped in terms of their vertical mixing strength: strong and weak mixing. The results indicate that all transport models capture the meridional distribution of COS at the surface well. Model simulations generally match the aircraft campaigns HIAPER Pole‐To‐Pole Observations (HIPPO) and Atmospheric Tomography Mission (ATom). Comparisons to HIPPO and ATom demonstrate a gap between observed and modeled COS over the Pacific Ocean at 0–40°N, indicating a potential missing source in the free troposphere. The effects of seasonal continental COS uptake by the biosphere, observed on HIPPO and ATom over oceans, is well reproduced by the simulations. We found that the strength of the vertical mixing within the column as represented in the various atmospheric transport models explains much of the model to model differences. We also found that weak‐mixing models transporting the optimized flux derived from the strong‐mixing TM5 model show a too strong seasonal cycle at high latitudes. Plain Language Summary: Carbonyl sulfide (COS) is a significant sulfur‐containing trace gas in the atmosphere, which makes it important for studying climate change. One of the reasons it is worth investigating is because plants take up COS in a similar way as CO2 during photosynthesis. However, the atmospheric sources and sinks of COS are not well understood. To address this knowledge gap, we evaluated the state‐of‐the‐art optimized surface COS fluxes from the inverse models TM5‐4DVAR and LMDz, and then seven atmospheric transport models were used to simulate COS mole fractions by transporting the optimized fluxes under the TransCom‐COS protocol. The results showed good agreement between the simulated COS and COS observations on independent platforms. The study also revealed that COS drawdown due to plant uptake can be observed over Pacific and Atlantic Oceans. However, discrepancies between the model simulations and observations were mainly found in free troposphere, emphasizing the need for further investigation into COS chemistry and model transport differences. These findings provide important reference for further investigation of COS global distribution and budget analysis. Key Points: Simulations in seven models propagating optimized carbonyl sulfide (COS) fluxes derived from two inversions agree with independent observationsSimulated and observed COS drawdowns are captured in boundary layer over the Pacific and Atlantic Oceans due to plant uptake over landsWeak vertical mixing models using fluxes optimized from the fast‐mixing TM5 model overestimate the COS seasonal amplitude at high latitudes [ABSTRACT FROM AUTHOR]

COVID-19 is a viral infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) that first emerged in Wuhan, China, in late 2019 and rapidly escalated into a global pandemic.[1] As of June 2023, it has resulted in the death of over six million individuals (https://www.who.int/emergencies/diseases/novel-coronavirus-2019). Recently, publicly available data sets encompassing larger sample sizes for both COVID-19 and stroke have been made accessible.[7] Lastly, previous MR studies have been constrained by a limited number of instrumental variables (IVs), resulting in a restricted ability to elucidate causal effects. Infection with critically ill COVID-19 increases the risk of cardioembolic stroke. [Extracted from the article]

The origins of Cenozoic granites in the Himalaya are key to understanding the evolution of the Himalayan orogen. However, it is unclear whether these granites represent primary melts, and the nature of their magma source is controversial. Here, we present a systematic element and Sr–Nd–B–Mo isotope study of Cenozoic granites from the Yardoi area in the eastern Tethyan Himalaya, China. These granites can be divided into two groups: mid‐Eocene porphyritic two‐mica granites with low SiO2 contents (65.9−69.6 wt.%) and adakitic geochemical signatures, and mid‐Eocene to Miocene equigranular granites with high SiO2 contents (71.6−75.5 wt.%). The high‐SiO2 granites (HSG) have similar Sr−Nd isotope compositions to the low‐SiO2 granites (LSG), but they have distinct δ11B values of −19.4‰ to −11.4‰ and −10.6‰ to −6.89‰. This indicates that the two groups have different sources, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metasedimentary rocks with less enriched Nd isotope compositions. The δ98/95Mo of the LSG and HSG are highly variable with values of −0.68‰ to 0.12‰ and −1.13‰ to 0.46‰, respectively. δ11B values of the HSG correlate positively with δ98/95Mo and Sr/Y values and correlate negatively with K2O, Rb, Zr, and Rb/Sr, reflecting the addition of external metamorphic fluids during anatexis of the metapelites. The B–Mo isotope data robustly suggest source‐controlled compositional diversity of the Himalayan granites, which could provide clues to the physical and geochemical responses during the evolution of a large orogen. Plain Language Summary: Partial melts derived from crustal anatexis exhibit large compositional diversity. The relative influence of source compositions and magmatic differentiation on such heterogeneity is a subject of ongoing debate. B−Mo isotopes have the potential to trace the source compositions of crustal magmas. In this study, we present whole‐rock geochemical and B–Mo isotopic compositions of Cenozoic granites in the eastern Tethyan Himalaya. Samples with diverse mineralogical and geochemical features and ages (mid‐Eocene, early Oligocene, and Miocene) were investigated and can be divided into low‐SiO2 granites (LSG) and high‐SiO2 granites (HSG). Boron isotopes reveal different source compositions for the two groups, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metapelites. B–Mo isotopes combined with the variations in element contents/ratios provide evidence for the involvement of external fluids during the formation of the HSG. Our new data suggest that the geochemical diversity of anatectic melts is dominated by the nature of the source, including source lithology and fluid effects. This implies that the Himalayan granites could be potentially in tracing the thermal and tectonic evolution of the Himalayan orogen. Key Points: Boron isotopes reveal different source compositions for the Himalayan Cenozoic granitesB–Mo isotopes provide evidence for the involvement of external fluids during crustal anatexisHimalayan Cenozoic granites can potentially trace the evolution of a large orogen [ABSTRACT FROM AUTHOR]

Aims: The significance of the correlation of computed tomography (CT)–based cerebral small vessel disease (SVD) markers with the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)‐related intracerebral hemorrhage (ICH) remains uncertain. Thus, this study aimed to explore the relationship between SVD markers and short‐term outcomes of CAA‐ICH. Methods: A total of 183 patients with CAA‐ICH admitted to the Xuanwu Hospital, and Beijing Fengtai You'anmen Hospital, from 2014 to 2021 were included. The multivariate logistic regression analysis was performed to identify the correlation between SVD markers based on CT and clinical outcomes at 7‐day and 90‐day. Results: Of the 183 included patients, 66 (36%) were identified with severe SVD burden. The multivariate analysis showed that the total SVD burden, white matter lesion (WML) grade, and brain atrophy indicator were independent risk factors for unfavorable outcomes at 90‐day. The brain atrophy indicator was independently associated with mortality at 90‐day. Severe cortical atrophy was significantly associated with early neurological deterioration. Conclusions: The neuroimaging profiles of SVD based on CT in patients with CAA‐ICH might predict the short‐term outcome more effectively. Further studies are required to validate these findings and identify modifiable factors for preventing CAA‐ICH development. [ABSTRACT FROM AUTHOR]

We present a comparison of atmospheric transport model (ATM) simulations for carbonyl sulfide (COS), within the framework of the atmospheric tracer transport model intercomparison project "TransCom‐COS." Seven ATMs participated in the experiment and provided simulations of COS mixing ratios over the years 2010–2018, using state‐of‐the‐art surface fluxes for various components of the COS budget: biospheric sink, oceanic source, sources from fire and industry. The main goal of TransCom‐COS is to investigate the impact of the transport uncertainty and emission distribution in simulating the spatio‐temporal variability of tropospheric COS mixing ratios. A control case with seasonal surface fluxes of COS was constructed. The results indicate that the COS mixing ratios are underestimated by at least 50 parts per trillion (ppt) in the tropics, pointing to a missing tropical source. In summer, the mixing ratios are overestimated by at least 50 ppt above 40°N, pointing to a likely missing sink in the high northern latitudes. Regarding the latitudinal profile, the model spread is greater than 60 ppt above 40°N in boreal summer. Regarding the seasonal amplitude, the model spread reaches 50 ppt at 6 out of 15 sites, compared to an observed seasonal amplitude of 100 ppt. All models simulated a too late minimum by at least 2–3 months at two high northern‐latitude sites, likely owing to errors in the seasonal cycle in the ocean emissions. This study highlighted the shortcomings in the COS global budget that need to be resolved before using COS as a photosynthesis tracer. Plain Language Summary: In this study, we evaluate the state‐of‐the‐art fluxes for various components of the carbonyl sulfide (COS) budget: biospheric sink, oceanic source, sources from fire and industry. A control case with seasonal surface fluxes of COS was constructed. Seven atmospheric transport models provided simulations of COS mixing ratios. Then, the simulated mixing ratios were evaluated against atmospheric measurements at several surface sites. Results show that all models fail to capture the observed latitudinal distribution and that the model spread is small compared to the model‐observation mismatch. In summer, the overestimated mixing ratios above 40°N point to a likely missing sink in the high northern latitudes. The underestimated mixing ratios in the tropics point to a missing tropical source. This study highlighted the shortcomings in the COS global budget that need to be resolved before using COS as a photosynthesis tracer. Key Points: The model‐observation mismatch suggests there is a missing source in the tropics and a missing sink in the high northern latitude in summerAt northern latitude sites, the model spread in seasonal amplitude reaches 50 ppt compared to a mean seasonal amplitude of about 100 pptThe diurnal rectifier effect is small, decreasing the seasonal amplitude by up to 20% at continental sites [ABSTRACT FROM AUTHOR]

Facile evaluation of oxygen reduction reaction (ORR) kinetics for electrocatalysts is critical for sustainable fuel‐cell development and industrial H2O2 production. Despite great success in ORR studies using mainstream strategies, such as the membrane electrode assembly, rotation electrodes, and advanced surface‐sensitive spectroscopy, the time and spatial distribution of reactive oxygen species (ROS) intermediates in the diffusion layer remain unknown. Using time‐dependent electrochemiluminescence (Td‐ECL), we report an intermediate‐oriented method for ORR kinetics analysis. Owing to multiple ultrasensitive stoichiometric reactions between ROS and the ECL emitter, except for electron transfer numbers and rate constants, the potential‐dependent time and spatial distribution of ROS were successfully obtained for the first time. Such exclusively uncovered information would guide the development of electrocatalysts for fuel cells and H2O2 production with maximized activity and durability. [ABSTRACT FROM AUTHOR]

Plant cells contain only small amounts of mitochondrial DNA (mtDNA), with the genomic information shared among multiple mitochondria. The biological relevance and molecular mechanism underlying this hallmark of plant cells has been unclear. Here, we report that Arabidopsis thaliana plants exhibited significantly reduced growth and mitochondrial dysfunction when the mtDNA copy number was increased to the degree that each mitochondrion possessed DNA. The amounts of mitochondrion‐encoded transcripts increased several fold in the presence of elevated mtDNA levels. However, the efficiency of RNA editing decreased with this excess of mitochondrion‐encoded transcripts, resulting in impaired assembly of mitochondrial complexes containing mtDNA‐encoded subunits, such as respiratory complexes I and IV. These observations indicate the occurrence of nuclear–mitochondrial incompatibility in the cells with increased amounts of mtDNA and provide an initial answer to the fundamental question of why plant cells have much lower mtDNA levels than animal cells. We propose that keeping mtDNA levels low moderates nuclear–mitochondrial incompatibility and that this may be a crucial factor driving plant cells to restrict the copy numbers of mtDNA. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to explore the effect of different administration routes of a low dose of tirofiban on acute ischemic stroke (AIS) patients with successful recanalization after endovascular treatment (EVT). Methods: This is a cohort study that retrospectively analyzed data of patients with AIS who underwent EVT and achieved successful recanalization from a prospective registry. Eligible patients were divided into three groups according to their use of tirofiban. Propensity score matching (PSM) was used to balance baseline bias. Safety outcomes included any intracranial hemorrhage (ICH) and symptomatic ICH (sICH). Efficacy outcomes included arterial reocclusion, in‐hospital mortality, 3‐month mortality, and 3‐month functional outcomes. Results: We included 821 patients with 306 in the no tirofiban group, 202 in the IA + IV tirofiban group, and 313 in the IV tirofiban group. After PSM, each group included 101 patients with balanced baseline characteristics. There was no difference between the IV tirofiban group and the no tirofiban group in terms of safety and efficacy outcomes (all p > 0.05). Compared with no tirofiban, IA + IV tirofiban group did not increase ICH (30.7% vs. 37.6%, p > 0.05) and sICH (6.9% vs. 17.8%, p > 0.05) whereas reduced 3‐month mortality (14.3% vs. 28.7%, p < 0.05) and improved 3‐month modified Rankin Scale (median 3 vs. 4, p < 0.05). Conclusions: A low dose of tirofiban, regardless of their administration routes, was safe for AIS patients who achieved successful recanalization with EVT, whereas only IA + IV tirofiban improved clinical outcomes. [ABSTRACT FROM AUTHOR]

Object: The long‐term functional outcome of cerebral amyloid angiopathy‐related hemorrhage (CAAH) patients is unclear. We sought to assess the long‐term functional outcome of CAAH and determine the prognostic factors associated with unfavorable outcomes. Methods: We enrolled consecutive CAAH patients from 2014 to 2020 in this observational study. Baseline characteristics and clinical outcomes were presented. Multivariable logistic regression analysis was performed to identify the prognostic factors associated with long‐term outcome. Results: Among the 141 CAAH patients, 76 (53.9%) achieved favorable outcomes and 28 (19.9%) of them died at 1‐year follow‐up. For the longer‐term follow‐up with a median observation time of 19.0 (interquartile range, 12.0–26.5) months, 71 (50.4%) patients obtained favorable outcomes while 33 (23.4%) died. GCS on admission (OR, 0.109; 95% CI, 0.021–0.556; p = 0.008), recurrence of ICH (OR, 2923.687; 95% CI, 6.282–1360730.14; p = 0.011), WML grade 3–4 (OR, 31.007; 95% CI, 1.041–923.573; p = 0.047), severe central atrophy (OR, 4220.303; 95% CI, 9.135–1949674.84; p = 0.008) assessed by CT was identified as independent predictors for long‐term outcome. Interpretation: Nearly 50% of CAAH patients achieved favorable outcomes at long‐term follow‐up. GCS, recurrence of ICH, WML grade and cerebral atrophy were identified as independent prognostic factors of long‐term outcome. [ABSTRACT FROM AUTHOR]

Artificial photocatalysis offers a clean approach for producing H2O2. However, the poor selectivity and activity of H2O2 production hamper traditional industrial applications and emerging photodynamic therapy (PDT)/chemodynamic therapy (CDT). Herein, we report a C5N2 photocatalyst with a conjugated C=N linkage for selective and efficient non‐sacrificial H2O2 production in both normoxic and hypoxic systems. The strengthened delocalization of π‐electrons by linkers in C5N2 downshifted the band position, thermodynamically eliminating side H2 evolution reaction and kinetically promoting water oxidation. As a result, C5N2 had a competitive solar‐to‐chemical conversion efficiency of 0.55 % in overall H2O2 production and exhibited by far the highest activity under hypoxic conditions (698 μM h−1). C5N2 was further applied to hypoxic PDT/CDT with outstanding performance in apparent cancer cell death and synchronous bioimaging. The study sheds light on the photosynthesis of H2O2 by carbon nitrides for health applications. [ABSTRACT FROM AUTHOR]

Nuanxin capsule (NX), an in-hospital preparation of Guangdong Provincial Hospital of Chinese Medicine, has been used in heart failure (HF) treatment for 15 years, but its mechanism and protective effect have not been investigated. This study was aimed at exploring the mechanism and protective effect of NX on HF treatment via network pharmacology analysis and experimental validation. Network pharmacology analysis predicted that NX was involved in the regulation of response to apoptotic process and hypoxia via protecting cellular damage and mitochondrial dysfunction against chronic hypoxia. Its mechanism may be involved in the regulation of the PI3K-Akt signaling pathway, HIF-1 signaling pathway, AMPK signaling pathway, and MAPK signaling pathway. Experimental validation indicated that NX was capable of improving cellular viability, restoring cellular morphology, and suppressing cellular apoptosis cellular. NX also exerted cardioprotection by inhibiting mitochondrial membrane potential injury and protecting mitochondrial respiratory and energy metabolism in a chronic hypoxia cellular model, which was consistent with the results of network pharmacology prediction. In addition, the screened active compounds of NX did have a good binding with their key targets, indicating NX may exert protective effect through multicompounds and multitargets. In conclusion, NX had a protective effect on HF through cellular and mitochondrial protection against chronic hypoxia via multicompounds, multitargets, and multipathways, and its mechanism may be involved in modulating the PI3K-Akt signaling pathway, HIF-1 signaling pathway, AMPK signaling pathway, and MAPK signaling pathway. [ABSTRACT FROM AUTHOR]

Highly efficient inter‐conversion of different types of energy is the core of science and technology. Among them, electrochemiluminescence (ECL), an emission of light excited by electrochemical reactions, has drawn attention as a powerful tool across diverse fields in addressing global energy, environment, and health challenges. Nonetheless, the ECL efficiency (ΦECL) of most luminophores in aqueous solutions is low, significantly hampering their broad applications. Along this line, developing ECL luminophores with high ΦECL and understanding the associated intrinsic factors is highly envisioned. Herein, taking carbon nitride (CN) with rigid 2D backbones as an emerging model luminophore, it is reported that the orbital delocalization is a unified and quantifiable factor for its ΦECL. Behind the complicated transformation of molecular structures of cyano‐terminal groups and triazine/heptazine basal frameworks, the orbital delocalization of CN is found to be generally improved at an elevated condensation temperature. Such intrinsic evolution in electronic structure favored the electron injection in excitation and follow‐up photon emission in ECL for CN. As a result, the cathodic ΦECL of CN is remarkably improved to a new milestone of 24‐fold greater than the previous record. [ABSTRACT FROM AUTHOR]

The Yangtze River Estuary (YRE) plays an important role in the conservation of fishery resources in the Yangtze River basin, and the Chinese government has established a special fishing ban management area at the YRE. To assess effects of the fishing ban, survey design and appropriate effort need to be determined and implemented. This study used long‐term trawl survey data of the YRE (2004–2017) to explore the effects of survey effort (8–30 continuous survey stations selected by systematic and stratified sampling) on precision and accuracy of estimates of abundance of different fishery groups in the YRE. Estimated precision for a given number of survey stations varied by season and fishery group. Precision of systematic sampling fluctuated with the number of stations. Precision of stratified sampling with a proportional allocation scheme gradually increased with the number of survey stations. We suggest including 15–20 survey stations for all fishery groups sampled using the examined sampling methods.This study provides a research reference for selecting the survey effort (number of survey stations) for a fishery‐independent survey in the YRE under the backgroud of conservation. [ABSTRACT FROM AUTHOR]

The Industrial Internet has grown rapidly in recent years, and attacks against the Industrial Internet have also increased. When compared with the traditional Internet, the industrial Internet has a more complex network structure, and the traditional graph neural network attack behavior detection model cannot well adapt to the complex network environment. To make the model better adapt to the complex network environment, this paper proposes the E-minBatch GraphSAG model. First, the application layer source port and source IP address is used as source nodes, the application layer target port and target IP address are used as target nodes, and the remaining traffic information is used as edge information to complete the construction of the graph structure data, and then the constructed graph structure data is presampled to select the edge information that needs to be aggregated next, followed by using the AGG aggregation function to aggregate the information in the domain generated by the presampling process. Finally, the information of two adjacent nodes is aggregated as edge information to classify the edges. Increase the number of IP addresses in the UNSW-NB15 dataset, and then use it for model training and testing. The experimental results show that the accuracy of the model reaches 99.49% in a relatively complex network environment. In this paper, the E-minBatch GraphSAG model is presented in an attempt to solve the problem of attack detection in the complex industrial Internet environment. [ABSTRACT FROM AUTHOR]

Objective: To observe expression of CD38, a key modulator of nicotinamide dinucleotide (NAD+) metabolism in mice with knee osteoarthritis, and protective effect of CD38 inhibition during the osteoarthritis (OA) development. Method: The destabilization of the medial meniscus (DMM) model was performed in mice to mimic the process of OA. Immunofluorescence of CD38 was performed to evaluate its response during the OA process. Limb bud‐derived mesenchymal cells were isolated for micromass culture. 100 nM or 1 μM CD38 inhibitor (78c) treatment for 14 days and CD38 sgRNA infection were then used to explore the effects of chondrogenic differentiation via Alcian blue staining. The expressions of chondrogenic markers were detected using RT‐PCR and Western blot. To explore the protective effect of CD38 inhibitor on cartilage degradation during OA in vivo, a CD38 inhibitor was injected into the knee joint after DMM operations. Micro‐CT analysis and Safranin O‐fast green staining were used to evaluate subchondral bone micro‐architecture changes and cartilage degeneration. Results: Compared to the control group, the CD38 expression in superficial cartilage was obviously increased in DMM group (P < 0.05). During the normal chondrogenic differentiation, the extracellular matrix formed and expression of Sox9, Col2, aggrecan increased apparently while CD38 expression decreased, which could be reversed with ablation of CD38 in limb bud‐derived mesenchymal cells. Consistent with findings in vitro, CD38 blockage via CD38 inhibitor injection protected against osteosclerosis in medial subchondral bone and cartilage degeneration in DMM‐induced experimental mice. Compared to the Sham group, DMM mice showed significantly increased values of BV and BV/TV in subchondral bone (P < 0.05) and Mankin score, which could be rescued by 78c treatment (P < 0.05). Also the CD38 inhibitor contributed to homeostasis of anabolism and catabolism by upregulating Sox9, Col2, aggrecan and downregulating Runx2, Col10 and Mmp13. Conclusion: This study primarily implicates CD38 as an important regulator of chondrogenic differentiation. Inhibition of CD38 demonstrated protection against cartilage degeneration, which suggests that CD38 could be a potential therapeutic target for OA. [ABSTRACT FROM AUTHOR]

Camellia osmantha is a new species of the genus Camellia and is an economically important ornamental plant. Its activity and ingredients are less studied than other Camellia plants. This study investigated the antithrombotic effect and chemical components of C. osmantha fruit cores using platelet aggregation assays and coagulation function tests. The cores of C. osmantha fruits were extracted with ethanol to obtain a crude extract. The extract was dissolved in water and further eluted with different concentrations of methanol on an MCI resin column to obtain three fractions. These samples were used for antithrombotic activity tests and phytochemical analysis. The results showed that the extract and its fractions of C. osmantha have strong antithrombotic activity, significantly reducing the platelet aggregation rate and prolonging the thrombin time (TT). The total saponins, flavonoids, and polyphenols in the active fractions may be responsible for the antithrombotic activity. The chemical constituents were analyzed by ultra‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS). Twenty‐three compounds were identified rapidly and accurately. Among them, ellagic acid, naringenin, and quercetin 3‐O‐glucuronide may be important antithrombotic constituents. Furthermore, interactions between these compounds and the P2Y1 receptor were investigated via molecular modeling, because the P2Y1 receptor is a key drug target of antiplatelet aggregative activity. The molecular docking results suggested that these compounds could combine tightly with the P2Y1R protein. Our results showed that C. osmantha fruit cores are rich in polyphenols, flavonoids, and saponins, which can be developed into a promising antithrombotic functional beverage for the prevention and treatment of cardiovascular and cerebrovascular diseases. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate microvascular alterations with optical coherence tomography angiography (OCTA) in eyes with non‐arteritic anterior ischaemic optic neuropathy (NAION) and the unaffected fellow eyes. Design: Systematic review and meta‐analysis. Methods: A comprehensive literature search was conducted in the PubMed and Embase databases through 6 September 2020, to identify the studies on NAION and the unaffected fellow eyes using OCTA. Eligible studies and data of interest were extracted and analysed by RevMan Software v. 5.4 and Stata Software v.14.0. The weighted mean differences and 95% confidence intervals were used to assess the strength of the association. Results: Seventeen observational comparative studies, including 379 eyes with NAION, 175 unaffected contralateral eyes and 470 eyes of healthy controls, were identified. Compared to those of the healthy controls, the perfusion density (PD) of radial peripapillary capillary (RPC) and peripapillary superficial capillary plexus (ppSCP) of NAION were significantly lower. Moreover, the PD of the macular SCP (mSCP) in NAION was significantly reduced in the whole image, superior quadrant and temporal quadrant, while the macular deep capillary plexus (mDCP) showed a decreasing PD only within the whole image. Between unaffected fellow eyes and healthy eyes, significant differences of PD were demonstrated in the whole image and some peripapillary regions of the RPC and ppSCP. Conclusion: Our results suggested that compared to those of healthy controls, the eyes affected by NAION and unaffected fellow eyes demonstrated significant microvascular impairments in different regions. Between acute and non‐acute NAION, macular OCTA parameters showed different characteristic patterns. [ABSTRACT FROM AUTHOR]

Gully development is an important topic in the evolution of modern geomorphology. The study of the development process of gullies is key to understanding the genesis, mechanism and spatial differentiation of loess geomorphology. This study explored the mechanism of the development process of gullies whilst taking into account the erosion characteristics of the gully head area, gully slope area and gully bed area. Based on geographic cellular automata (Geo‐CA), the transition rules were interacted with the fundamental hydraulic principles for gully evolution simulation. Different sediment transfer rules apply to the gully slope area and gully bed area. A simulation model of the loess gully evolution was constructed and implemented based on the loess simulation small watershed. The superior performance of the model was demonstrated by the accuracy evaluation of the model structure and the comparative analysis of the modelling results. Moreover, the model was validated by natural watershed data, and the analytical results indicated the feasibility of the model. [ABSTRACT FROM AUTHOR]

Intraplantar injection of formalin produces persistent spontaneous nociception and hyperalgesia. The underlying mechanism, however, remains unclear. The present study was, therefore, designed to determine the roles of peripheral group III metabotropic glutamate receptors (mGluRs) in formalin‐evoked spontaneous nociception. Pre‐treatment with intraplantar injections of L‐serine‐O‐phosphate (L‐SOP), a group III mGluRs agonist, significantly inhibited formalin‐induced nociceptive behaviours and decreased Fos production in the spinal dorsal horn. The inhibitory effects of L‐SOP were abolished completely by pre‐treatment with the group III mGluR antagonist (RS)‐a‐methylserine‐O‐phosphate (M‐SOP). These data suggest that the activation of group III mGluRs in the periphery may play a differential role in formalin‐induced nociception. In addition, L‐SOP decreased the formalin‐induced upregulation of tumour necrosis factor‐α (TNF‐α) as well as interleukine‐1β (IL‐1β) expression in the spinal cord, suggesting that activation of peripheral group III mGluRs reduces formalin‐induced nociception through inhibition of the pro‐inflammatory cytokines in the spinal cord. Therefore, the agonists acting peripheral group III mGluRs possess therapeutic effectiveness in chronic pain. [ABSTRACT FROM AUTHOR]

Summary: Staphylococcus xylosus (S. xylosus)‐induced cow mastitis is an extremely serious clinical problem. However, antibiotic therapy does not successfully treat S. xylosus infection because these bacteria possess a strong biofilm formation ability, which significantly reduces the efficacy of antibiotic treatments. In this study, we developed ceftiofur‐loaded chitosan grafted with β‐cyclodextrins (CD‐g‐CS) nanoparticles (CT‐NPs) using host–guest interaction. These positively charged nanoparticles improved bacterial internalization, thereby significantly improving the effectiveness of antibacterial treatments for planktonic S. xylosus. Moreover, CT‐NPs effectively inhibited biofilm formation and eradicated mature biofilms. After mammary injection in a murine model of S. xylosus‐induced mastitis, CT‐NPs significantly reduced bacterial burden and alleviated inflammation, thereby achieving optimized therapeutic efficiency for S. xylosus infection. In conclusion, this treatment strategy could improve the efficiency of antibiotic therapeutics and shows great potential in the treatment of S. xylosus infections. [ABSTRACT FROM AUTHOR]

Biological inspiration evaluation has been widely acknowledged as one of the most important phases in biologically inspired design (BID) as it substantially determines the direction of the following‐up design activities. However, it is inherently an interdisciplinary assessment, which includes both the engineering domain and the biological systems. Due to the lack of knowledge at the early stage of product design, the risk assessments mainly depend on experts' subjective judgments, which values are vague, imprecise, and even inconsistent. How to objectively evaluate the biological inspiration under such uncertain and interdisciplinary scenarios remains an open issue. To bridge such gaps, this study proposes a fuzzy rough number extended multi‐criteria group decision‐making (MCGDM) to evaluate the biological inspiration for BID. A fuzzy rough number is introduced to represent the individual decision maker's risk assessment and aggregate respective evaluation values within the decision‐making group. A fuzzy rough number extended decision‐making trial and evaluation laboratory is presented to determine the criteria weights and a fuzzy rough number extended multi‐attribute ideal real comparative analysis is proposed to rank the candidate biological inspirations. Experimental results and comparative analysis validate the superiority of the proposed MCGDM in handling the subjectivity and uncertainty in biological inspiration evaluation. [ABSTRACT FROM AUTHOR]

The present study provides the length–weight relationships (LWRs) for common estuarine fish species collected from the Yangtze River Estuary by bottom trawl from 2017 to 2021. The net port width of bottom trawl net was 6 m, and the mesh size was 20 mm. This study provides new information on LWRs for three species in FishBase. Also, this study updates the information on the maximum length for three species. [ABSTRACT FROM AUTHOR]

An artificial anal sphincter is a device to help patients with fecal incontinence rebuild the ability to control the excrement through the anus. In this article, an artificial anal sphincter based on a novel clamping mechanism (AASNCM) is proposed to improve the safety and reliability. The AASNCM, which is powered by a transcutaneous energy transfer system, consists of a novel clamping mechanism, a receiving coil and a control unit. According to design requirements, the novel clamping mechanism model was established. After that, its kinematics and dynamics were analyzed. The results of force tests on the prototype AASNCM show that the maximum values of clamping force and expanding force are 15.859 and 31.029 N, respectively. Comparing the experimental results with theoretical analysis, a good match can be concluded. Finally, in vitro experiments were conducted, and have verified the safety and reliability of the proposed AASNCM. [ABSTRACT FROM AUTHOR]

Keywords: angiotensin-converting enzyme II; chronic rhinosinusitis; coronavirus disease 2019; inferior turbinate; interferon; sinus EN angiotensin-converting enzyme II chronic rhinosinusitis coronavirus disease 2019 inferior turbinate interferon sinus 1565 1568 4 05/17/21 20210501 NES 210501 Coronavirus disease 2019 (COVID-19) is a primary acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast to the sinus mucosa, we found that ACE2 expression was comparable in IT samples from non-CRS controls, CRSsNP patients, and CRSwNP patients (Figure 1C,D). The reduced expression of IFN-stimulated genes in the sinus mucosa of patients with CRS has also been reported by other groups, indicating that patients with CRS may have a deficient local anti-viral defense.7 IFN response deficits may limit the entry of SARS-CoV-2 by downregulating ACE2 expression. [Extracted from the article]

This may be the reason that the AR prevalence in our cohort (9.8%) was higher than those previously reported in Chinese COVID-19 patients (0%-1.8%).4,5 The prevalence of AR in our COVID-19 cohort is comparable to that in general populations in Wuhan (9.7%).6 In addition, we did not find any association between AR comorbidity and disease severity in COVID-19 patients. Keywords: allergic rhinitis; angiotensin-converting enzyme II; coronavirus disease 2019; cytokine; epithelial cell EN allergic rhinitis angiotensin-converting enzyme II coronavirus disease 2019 cytokine epithelial cell 906 910 5 03/09/21 20210301 NES 210301 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affects more than 17 million of people and results in more than 666 000 deaths all over the world. In PSM analysis, we were able to match 109 patients without AR to 109 patients with AR at a ratio of 1:1 (Table S3). [Extracted from the article]

Introduction and Aims. Bile acids play an essential role in the progression of nonalcoholic fatty liver disease (NAFLD). This study was aimed at investigating the association of the serum glycocholic acid- (GCA-) to-total bile acid (TBA) ratio with NAFLD in the general population. Materials and Methods. A total of 6708 subjects (2859 cases with NAFLD and 3849 controls) were enrolled in the development cohort and additional 1568 subjects (784 cases with NAFLD and 784 controls) in an independent validation cohort. Demographic characteristics and biochemical data were compared between subjects with NAFLD and controls. Multivariate logistic regression analysis was performed to determine the association of the GCA-to-TBA ratio with NAFLD. A novel model incorporating the GCA-to-TBA ratio was developed for screening NAFLD from the general population. Results. The serum TBA and GCA levels were significantly higher in subjects with NAFLD than in those without NAFLD (2.8 (2.0-4.2) μmol/L vs. 2.5 (1.8-3.7) μmol/L and 1.30 (1.10-1.53) μg/mL vs. 1.28 (1.08-1.50) μg/mL, respectively, all p ≤ 0.01), whereas the serum GCA-to-TBA ratio was significantly lower in subjects with NAFLD than in subjects without NAFLD (0.44 (0.33-0.60) vs. 0.48 (0.36-0.64), p ≤ 0.01). Logistic regression analysis showed that the GCA-to-TBA ratio was independently associated with NAFLD after adjustment for confounding factors (odds ratio: 0.81, 95% confidence interval (CI): 0.71-0.92, p ≤ 0.01). The area under the receiver operating characteristic curve of the novel developed GCA-to-TBA ratio score model in discriminating NAFLD was 0.84 (95% CI: 0.83-0.85) in the development cohort and was 0.91 (95% CI: 0.36-0.65) in the validation cohort. Conclusion. The serum GCA-to-TBA ratio is independently associated with NAFLD. A simple novel model incorporating the GCA-to-TBA ratio score has a good performance in discriminating NAFLD from the general population. [ABSTRACT FROM AUTHOR]

Background: Cold‐inducible RNA‐binding protein (CIRP) is a newly identified damage‐associated molecular pattern molecule. Its roles beyond promoting inflammation and in human diseases are poorly understood. This study aimed to investigate the involvement of CIRP in chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: Immunohistochemistry, quantitative RT‐PCR, and ELISA were used to detect the expression of CIRP and matrix metalloproteinases (MMPs) in sinonasal mucosal samples and nasal secretions. Human nasal epithelial cells (HNECs) and THP‐1 cells, a human monocytic/macrophage cell line, were cultured to explore the regulation of CIRP expression and MMP expression. Results: Cytoplasmic CIRP expression in nasal epithelial cells and CD68+ macrophages in sinonasal tissues, and CIRP levels in nasal secretions were significantly increased in both patients with eosinophilic and noneosinophilic CRSwNP as compared to those in control subjects. IL‐4, IL‐13, IL‐10, IL‐17A, TNF‐α, Dermatophagoides pteronyssinus group 1, and lipopolysaccharide induced the production and secretion of CIRP from HNECs and macrophages differentiated from THP‐1 cells. CIRP promoted MMP2, MMP7, MMP9, MMP12, and vascular endothelial growth factor A (VEGF‐A) production from HNECs, macrophages differentiated from THP‐1 cells, and polyp tissues, which was inhibited by the blocking antibody for Toll‐like receptor 4, but not advanced glycation end products. The expression of MMPs and VEGF‐A in tissues correlated with CIRP levels in nasal secretions in patients with CRSwNP. Conclusions: The upregulated production and release of CIRP from nasal epithelial cells and macrophages may contribute to the edema formation in both eosinophilic and noneosinophilic CRSwNP by inducing MMP and VEGF‐A production from epithelial cells and macrophages. [ABSTRACT FROM AUTHOR]

Background: The impacts of chronic airway diseases on coronavirus disease 2019 (COVID‐19) are far from understood. Objective: To explore the influence of asthma and chronic obstructive pulmonary disease (COPD) comorbidity on disease expression and outcomes, and the potential underlying mechanisms in COVID‐19 patients. Methods: A total of 961 hospitalized COVID‐19 patients with a definite clinical outcome (death or discharge) were retrospectively enrolled. Demographic and clinical information were extracted from the medical records. Lung tissue sections from patients suffering from lung cancer were used for immunohistochemistry study of angiotensin‐converting enzyme II (ACE2) expression. BEAS‐2B cell line was stimulated with various cytokines. Results: In this cohort, 21 subjects (2.2%) had COPD and 22 (2.3%) had asthma. After adjusting for confounding factors, COPD patients had higher risk of developing severe illness (OR: 23.433; 95% CI 1.525‐360.135; P <.01) and acute respiratory distress syndrome (OR: 19.762; 95% CI 1.461‐267.369; P =.025) than asthmatics. COPD patients, particularly those with severe COVID‐19, had lower counts of CD4+ T and CD8+ T cells and B cells and higher levels of TNF‐α, IL‐2 receptor, IL‐10, IL‐8, and IL‐6 than asthmatics. COPD patients had increased, whereas asthmatics had decreased ACE2 protein expression in lower airways, compared with that in control subjects without asthma and COPD. IL‐4 and IL‐13 downregulated, but TNF‐α, IL‐12, and IL‐17A upregulated ACE2 expression in BEAS‐2B cells. Conclusion: Patients with asthma and COPD likely have different risk of severe COVID‐19, which may be associated with different ACE2 expression. [ABSTRACT FROM AUTHOR]