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To enrich the crystal growth strategies for the booming applications concerning lattice structure, a preferred facet‐growth method is proposed for solvothermal synthesis of target (BiO)2CO3 in the two‐phase system. The dominant crystal phase can be regulated from α‐Fe2O3 to (BiO)2CO3 by properly increasing dosage of Bi feedstock, and the optimized composite is composed of (BiO)2CO3 nanocrystal (≈10 nm) and amorphous iron oxide (defined as "FOB‐50"). Based on experimental characterizations and theoretical calculations, the highly matched lattice between (006)/(0012) facets of α‐Fe2O3 and {010} facet group of (BiO)2CO3 involving orientation of Fe─O─Fe bond and Bi─O─Bi bond is verified to facilitate the interaction between the above facets, resulting in preferred growth of {010} dominated by (040) facet in (BiO)2CO3 and its composites. The structural merits can not only enable the FOB‐50‐based electrodes to achieve a high capacity and unprecedentedly stable cyclic performances for 1500 cycles/a long time‐span of 32 months as anode materials, but also ensure the full‐cell to well inherit the electrochemical features of the cathode in potassium ion batteries (PIBs). This work can provide new insight into lattice regulation for bismuth‐based materials and expand their application as electrodes for high performance PIBs and lithium ion batteries. [ABSTRACT FROM AUTHOR]

Background Aims Methods and Procedures Outcomes and Results Conclusions and Implications WHAT THIS PAPER ADDS What is already known on this subject What this study adds to existing knowledge What are the clinical implications of this work? Dysphagia services have only recently been formalised within Chinese health services. There has been no comprehensive evaluation of all aspects of dysphagia services practice in China.To provide a profile for the dysphagia practice in China by assessing various facets of dysphagia services.This is a survey study carried out from December 2022 to May 2023 online in China. One hundred fifty‐nine respondents comprising doctors, nurses or therapists involved in the field of dysphagia rehabilitation completed a questionnaire via Sojump. The questionnaire included dichotomous (e.g., yes/no) and multiple‐choice questions related to participants' general information and their provision of dysphagia management services. Results were analysed descriptively and the differences among different levels of hospitals were analysed.Approximately two‐thirds of hospitals (67.9%) started dysphagia services within the last 5 years. A significant difference in the initiation of dysphagia rehabilitation was observed across different hospital levels (χ2  = 32.70;p < 0.001). Routine dysphagia screening was a standard practice in most hospitals (71.7%), with the most frequently employed screening method being the water swallow test (95.6%). Clinical swallowing evaluation emerged as the preferred initial assessment method (80.5%) and the most utilised assessment method (91.8%). Video fluoroscopic swallow study and flexible endoscopic evaluation swallowing were used by 22.7% and 12.6% of respondents. A significant difference was observed in the choice of assessment methods across hospitals of different levels (χ2 = 43.397; p < 0.001). The majority of respondents (53.5%) primarily employed rehabilitation as the main intervention method (76%–100%). Most respondents indicated that they would reevaluate patients after treatment (74.8%) and reported routine follow‐up with patients (60.4%).Despite the relatively recent development of dysphagia management in China, the practice patterns uncovered in this study are broadly consistent with Chinese guidelines and consensus. However, the use of instrumental assessments remains low, resulting in a lack of objective evaluation of patient conditions and outcomes. There is a need for policy and resource support in the field of dysphagia rehabilitation in China. Assessment and treatment methods for dysphagia are various across different patients, medical facilities and settings. There has been no comprehensive evaluation of all aspects of dysphagia rehabilitation practice in China. The study assessed various facets of dysphagia rehabilitation in China through an online survey. We found that the relatively recent development of dysphagia management in China, but the practice patterns uncovered in this study are broadly consistent with Chinese guidelines and consensus. Variations in practice patterns between hospitals of different levels may be attributed to resource constraints and patient needs. Besides, while rehabilitation exercises are the primary intervention method for dysphagia in China, the assessment largely centres on clinical swallowing evaluation. The use of instrumental assessments remains low, resulting in a lack of objective evaluation of patient conditions and outcomes. The study assessed various facets of dysphagia rehabilitation in China, and the results indicate that the use of instrumental assessments needs to be improved and there is a need for policy and resource support in the field of dysphagia rehabilitation in China. [ABSTRACT FROM AUTHOR]

The utilization of single atoms (SAs) as trifunctional electrocatalyst for nitrogen reduction, oxygen reduction, and oxygen evolution reactions (NRR, ORR, and OER) is still a formidable challenge. Herein, we devise one‐pot synthesized palladium SAs stabilized on nitrogen‐doped carbon palladium SA electrocatalyst (Pd‐SA/NC) as efficient trifunctional electrocatalyst for NRR, ORR, and OER. Pd‐SA/NC performs a robust catalytic activity toward NRR with faradaic efficiency of 22.5% at −0.25 V versus reversible hydrogen electrode (RHE), and the relative Pd utilization efficiency is enhanced by 17‐fold than Pd‐NP/NC. In addition, the half‐wave potential reaches 0.876 V versus RHE, amounting to a 58‐time higher mass activity than commercial Pt/C. Moreover, the overpotential at 10 mA cm−2 is as low as 287 mV for Pd‐SA/NC, outperforming the commercial IrO2 by 360 times in turnover frequency at 1.6 V versus RHE. Accordingly, the assembled rechargeable zinc‐air battery (ZAB) achieves a maximum power density of 170 mW cm−2, boosted by 2.3 times than Pt/C–IrO2. Two constructed ZABs efficiently power the NRR‐OER system to electrochemically generate ammonia implying its superior trifunctionality. [ABSTRACT FROM AUTHOR]

Snap‐through bistability was widely exploited for rapid hopping in micro‐electro‐mechanical systems and soft robots. However, considerable energy input was required to trigger the transition between discrete buckling states blocked by potential wells. Here a dynamic buckling mechanism of a buckled blister constrained inside an outer ring is explored for eliciting rotary actuation via a localized change of curvature in the blister. Due to rotational invariance of the buckled blister, lower energy supply is required to initiate the snap‐through of buckling compared to conventional bistable mechanism. The controllability in rotational speed and output torque of the bimetallic blister‐based rotator inside a rigid stator is exhibited, and the locomotion is demonstrated with two elastic rings via localized pneumatic actuators. With broad choices of stimulus and material for rings, the findings illustrate the promising potential of two nested rings to create active motions for diverse applications including gearless motors, peristaltic pumps, and locomotive robots. [ABSTRACT FROM AUTHOR]

During CO2 storage in deep saline aquifers, the presence of residual water has an important influence on the storage efficiency and safety. In this study, natural rock cores taken from deep reservoirs in the Ordos Basin and Fukang, Xinjiang are used as research objects. Nine groups of core‐flooding experiments are performed under different CO2/N2 gas mixture ratios to study the influence of rock properties (mineral composition, permeability, porosity and pore structure) on the residual water. Furthermore, the geophysical and chemical properties of rock cores are analyzed by X‐ray diffraction, electron microscopy, field emission scanning electron microscopy and piezoelectric mercury method. The results show that residual water saturation is a quantitative power function of drainage time. The residual water saturation is positively correlated with the total amount of quartz and feldspar and increases with increasing permeability. Moreover, both the average and median pore throat radius show a strong inverse correlation with irreducible residual water saturation; as these radius increase, the residual water saturation decreases. In contrast, the porosity and maximum pore throat radius display a weaker correlation with irreducible residual water saturation. This study is of great value for engineering practices such as the site selection of CO2 storage projects in saline aquifer and improvement of CO2 storage efficiency. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background and Aims: Liver injury is one of the common complications of paraquat (PQ) poisoning, but whether the degree of liver injury is related to patient prognosis is still controversial. This study aimed to investigate whether liver injury was a risk factor for death in PQ‐poisoned patients. Methods: We conducted a retrospective cohort study of PQ‐poisoned patients from the past 10 years (2011–2020) from a large tertiary academic medical centre in China. PQ‐poisoned patients were divided into a normal liver function group (n = 580) and a liver injury group (n = 60). Propensity score matching (PSM) analysis was then performed. Results: A total of 640 patients with PQ poisoning were included in this study. To reduce the impact of bias, dose of PQ, urinary PQ concentration and time from poisoning to hospital admission were matched between the two groups. A 3:1 PSM analysis was performed, ultimately including 240 patients. Compared with the normal liver function group, patients in the liver injury group were older, had a higher R value ([ALT/ULN]/[ALP/ULN]) (p <.001) and had a higher mortality rate. Cox regression analysis showed that there was no significant association between alanine aminotransferase, alkaline phosphatase, total bilirubin levels and hazard of death, but age, PQ dose, creatine kinase isoenzyme, creatine kinase, white blood cell count, neutrophil percentage and lymphocyte percentage were associated with mortality in patients with PQ poisoning. Conclusions: The occurrence of liver injury within 48 h after PQ poisoning was a risk factor for mortality, and such liver injury was likely of a hepatocellular nature. Age, PQ dose, creatine kinase isoenzyme and white blood cell count were positively correlated with mortality, while creatine kinase, percentage of neutrophils and lymphocytes were inversely correlated. [ABSTRACT FROM AUTHOR]

Recurrent spontaneous abortion (RSA) has a complex pathogenesis with an increasing prevalence and is one of the most intractable clinical challenges in the field of reproductive medicine. Quercetin (QCT) is an effective active ingredient extracted from Semen Cuscutae and Herba Taxilli used in traditional Chinese medicine for tonifyng the kidneys and promoting fetal restoration. Although QCT helps improve adverse pregnancy outcomes, the specific mechanism remains unclear. The trophoblast cell line HTR‐8/SVneo cultured in vitro was treated with different concentrations of QCT, and the cell counting kit‐8 assay, wound healing assay, transwell assay, and western blotting were used to evaluate the effects and mechanisms of QCT on the proliferation, migration, and invasion of HTR‐8/SVneo cells, respectively. To assess the expression levels of miR‐149‐3p and AKT serine/threonine kinase 1 (AKT1), quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blotting analysis were performed. A dual‐luciferase reporter assay was used to investigate the potential regulatory relationship between miR‐149‐3p and AKT1. Our results showed that QCT promoted the proliferation, migration, and invasion of trophoblast cells, promoted the expression of MMP2, MMP9, and vimentin, and downregulated the expression of E‐cadherin. Mechanistically, QCT downregulated the expression of miR‐149‐3p and upregulated the expression of AKT1, and miR‐149‐3p directly targets AKT1, negatively regulating its expression. Overexpression of miR‐149‐3p and silencing of AKT1 counteracted the promotional effects of QCT on trophoblast proliferation, migration, and invasion. Taken together, QCT regulates the migration and invasion abilities of HTR‐8/SVneo cells through the miR‐149‐3p/AKT1 axis, which may provide a promising therapeutic approach for RSA. [ABSTRACT FROM AUTHOR]

The dissolution/shuttling of sodium polysulfides, coupled with sodium dendrites growth, severely compromises the lifespan and stability of room temperature sodium–sulfur (RT Na–S) batteries. Herein, it proposes employing a functionalized porous ZIF‐based membrane (PZM) to address these two challenges. First, the metal ions embedded within the zeolitic imidazolate framework chemically bind with polysulfide anions, curtailing their detrimental shuttling. Second, the tailored porous structure of the membrane ensures a selective and uniform pathway for sodium ions, significantly reducing non‐uniform deposition and curbing dendritic sodium growth. Third, the intrinsically non‐combustible nature of the ZIF‐based membrane acts as a fortification against thermal outbursts and electrolyte decomposition. Implementing this polysulfide‐resistant, dendrite‐inhibiting and flame‐retardant PZM with a standard S/C cathode leads to the creation of a robust separator with lean electrolyte RT Na–S battery. This configuration may impart a novel perspective for the advancement and enhancement of RT Na–S battery systems. [ABSTRACT FROM AUTHOR]

M‐series molecules are one kind of promising acceptor‐donor‐acceptor (A‐D‐A)‐type acceptors for constructing high‐performance organic solar cells (OSCs). However, their power conversion efficiencies (PCEs) are lagging behind that of current state‐of‐the‐art OSCs, limited by the relatively low fill factor (FF) and photocurrent. Herein, combined strategies of layer‐by‐layer (LBL) deposition and interface engineering are conducted to systematically improve light utilization and thus PCEs for M36‐based OSCs. Through choosing a proper processing solvent, a PCE of 17.3% with an FF of 77.9% is achieved for the resulting LBL devices, much higher than those (15.9%/74.0%) from the blend‐casting devices. The improvement is assigned to the favorable morphological evolution that facilitates carrier generation and transport as well as reduces charge recombination. More importantly, light‐harvesting of the active layers can be enhanced upon employing a self‐assembled monolayer of (2‐(9H‐carbazol‐9‐yl)ethyl)phosphonic acid (2PACz) instead of the widely used PEDOT:PSS as the hole‐selecting layer, due to the decreased parasitic absorption of the former. Consequently, 2PACz‐based LBL devices exhibit significantly increased photocurrent, affording a PCE up to 18.2%, which is the highest among the reported A‐D‐A‐type acceptor‐based OSCs. These results deliver important strategies to enhance the performance of OSCs and thus highlight the great potential of M‐series acceptors for practical applications. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: The strategy of removable glycosylation modification was used to overcome the low‐efficiency problem encountered in the chemical synthesis of the mirror‐image D‐version of the immunoglobulin (Ig)‐like domain of tropomyosin receptor kinase A (DlgCTrkA), a protein molecule needed for mirror‐image screening of D‐peptide ligands targeting this cell membrane receptor. It was found that O‐linked‐β‐N‐acetyl‐D‐glucosamine (O‐GlcNAc) modification at DSer312, or DSer320 can significantly improve the efficiency of DlgCTrkA synthesis and folding, while O‐GlcNAc modification at DSer330 showed barely any improvement. This study provides a new example demonstrating the power of the removable glycosylation modification strategy in the chemical synthesis and folding of difficult‐to‐obtain proteins. It also presents evidence that removable glycosylation modification at different sites would significantly affect the efficiency of protein folding promoted by this strategy. [ABSTRACT FROM AUTHOR]

Acute lung injury (ALI) poses a significant and escalating medical challenge, where precise diagnosis and timely intervention hold utmost importance in halting its deterioration. Nevertheless, persistent obstacles arise from the lack of agents proficient in both real‐time diagnosis and efficient mitigation of ALI. Here, a biocatalytic and second near‐infrared (NIR‐II) fluorescence‐illuminating nanoplatform is designed to simultaneously facilitate real‐time monitoring and robust inflammation alleviation in ALI. The study first develops a new aggregation‐induced emission luminogen with trifluoromethyl substitutions, which simultaneously increase NIR‐II emission wavelength and fluorescence brightness. The molecular probe is further integrated into biocatalytic hollow ceria nanostructures, and cloaked with pre‐activated macrophage membranes for targeted inflammation intervention. Upon inhalation administration in ALI mice, the theranostic nanoagents leverage the bright NIR‐II emission and active inflammation‐tropic properties for in vivo sensitive NIR‐II imaging of ALI, which also facilitates real‐time tracking of the nanoagents' distribution and dynamic fate within pneumonia milieu. Concurrently, the catalytic prowess of the nanoplatforms efficaciously scavenges excess reactive oxygen species, dampens proinflammatory cytokines, and promotes macrophage repolarization, substantially alleviating acute lung damage. The multifaceted nanoplatform integrates NIR‐II bioimaging with nanocatalysis‐mediated immunoregulation, offering a versatile and promising approach for addressing the intricate challenges posed by acute inflammation diseases. [ABSTRACT FROM AUTHOR]

ABSTRACT Background Objective Methods Results Conclusions Whether pain, jaw function and quality of life are correlated with disc positions is controversial, and similar studies evaluating disc positions by magnetic resonance imaging (MRI) are very limited.This study evaluated the pain, mandibular function and quality of life of the temporomandibular disorders (TMDs) patients with different disc positions according to MRI, and the relationship among them.Three hundred and thirty‐five participants were included. Patients completed questionnaires included the Numeric Rating Scale (NRS), Jaw Functional Limitation Scale 8‐item (JFLS‐8), the Generalised Anxiety Disorder 7‐item (GAD‐7), Patient Health Questionnaire 9‐item (PHQ‐9) and Oral Health Impact Profile for TMD (OHIP‐TMD). MRI was conducted to evaluate these diagnoses, resulting in the identification of three distinct categories: normal positioning (NP), disc displacement with reduction (DDwR) and disc displacement without reduction (DDwoR).Participants had the mean age of 28.55 ± 11.10 years (80.90% women). DDwR and DDwoR had a higher percentage of females compared with NP. Significant differences existed among patients in all questionnaires. The DDwoR group had significantly the highest pain, functional limitation and the worst quality of life. Moreover, they experienced the most difficulties in chewing tough foods, yawning, experiencing pain and psychological discomfort. Moreover, the multivariate regression showed that age, female gender, diagnosis as DDwoR, GAD‐7 and PHQ‐9 were significantly linked to higher functional limitation. Worse quality of life was associated with age, diagnosis as DDwoR, GAD‐7 and PHQ‐9.Among patients with different disc positions, DDwoR showed the highest pain, functional limitation and the worst quality of life. Also, NP showed a proportion of chronic pain. Physical pain, psychological discomfort and chewing tough food were regarded as the most impaired. Women who experience anxiety and depression tended to have a higher propotion of dysfunction and a lower quality of life. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusion Paediatric traumatic duodenal hematoma is a rare type of blunt abdominal injury for which treatment strategies are controversial. This study aimed to evaluate the application value of nonoperative management of paediatric duodenal hematoma caused by trauma.A retrospective analysis was conducted on patients with duodenal hematoma with a confirmed history of abdominal trauma admitted to our hospital between January 2010 and December 2022. General patient information, including age, sex, cause of injury, clinical manifestations, and treatment outcomes, was recorded.A total of 11 cases were included in this study, with 6 males and 5 females. School‐age children (≥6 years) accounted for 72.7% (8/11) of the cases. Bicycle handlebar injuries accounted for 63.6% (7/11) of cases. Among these cases, 5 (45.5%) were classified as American Association for the Surgery of Trauma grade I, while the remaining were classified as grade II. The median history time was 1 day (range: 2 h–12 days). All patients were successfully treated using non‐operative methods. The median time to oral feeding after injury was 17 days (range: 9–32 days). Oral feeding was initiated within 2 weeks in 2 patients (18.2%), within 3 weeks in 6 patients (54.5%), and within 4 weeks in 10 patients (90.9%).Paediatric traumatic duodenal hematoma is more common in school‐aged children, mainly due to bicycle handlebar injuries. Nonoperative treatment is proven to be safe and effective, with duodenal obstruction symptoms typically resolving within 4 weeks. [ABSTRACT FROM AUTHOR]

Separating n‐butene and iso‐butene through adsorption represents a viable and energy‐efficient strategy. However, developing porous adsorbents that can effectively discern the subtle differences between these isomers remains a significant challenge. This study demonstrates that a zinc‐based coordination network (CALF‐20) exhibits a slight pore expansion with increasing temperature, creating nanochannels that preferentially adsorb n‐butene over iso‐butene. This unique temperature‐dependent dynamic behavior enables effective sieving of n‐butene from iso‐butene within the temperature range of 273 to 423 K, a phenomenon not previously observed. Notably, CALF‐20 exhibits the highest n‐butene adsorption capacity (2.62 mmol g−1) and the highest selectivity ratio (14.7) among sieving materials reported to date for n‐butene isomers. Modeling calculations show that dynamic factors play a significant role in achieving such high adsorption separation capabilities. At medium temperatures, the initial separation of n‐butene and iso‐butene is achievable, which may provide a foundation for the future design of adsorbents intended to achieve efficient separation of n‐butene/iso‐butene under comparable temperature conditions. In the future, the intricate structure dynamics and enhanced capacity for molecular recognition will offer a new pathway for developing advanced sieving materials. [ABSTRACT FROM AUTHOR]

Summary: Background: Azithromycin (AZ) is a widely used antibiotic. The aim of this study was to characterise the clinical features, outcomes, and HLA association in patients with drug‐induced liver injury (DILI) due to AZ. Methods: The clinical characteristics of individuals with definite, highly likely, or probable AZ‐DILI enrolled in the US Drug‐Induced Liver Injury Network (DILIN) were reviewed. HLA typing was performed using an Illumina MiSeq platform. The allele frequency (AF) of AZ‐DILI cases was compared to population controls, other DILI cases, and other antibiotic‐associated DILI cases. Results: Thirty cases (4 definite, 14 highly likely, 12 probable) of AZ‐DILI were enrolled between 2004 and 2022 with a median age of 46 years, 83% white, and 60% female. Median duration of AZ treatment was 5 days. Latency was 18.5 days. 73% were jaundiced at presentation. The injury pattern was hepatocellular in 60%, cholestatic in 27%, and mixed in 3%. Ten cases (33%) were severe or fatal; 90% of these were hepatocellular. Two patients required liver transplantation. One patient with chronic liver disease died of hepatic failure. Chronic liver injury developed in 17%, of which 80% had hepatocellular injury at onset. HLA‐DQA1*03:01 was significantly more common in AZ‐DILI versus population controls and amoxicillin‐clavulanate DILI cases (AF: 0.29 vs. 0.11, p = 0.001 and 0.002, respectively). Conclusion: Azithromycin therapy can lead to rapid onset of severe hepatic morbidity and mortality in adult and paediatric populations. Hepatocellular injury and younger age were associated with worse outcomes. HLA‐DQA1*03:01 was significantly more common in AZ cases compared to controls. [ABSTRACT FROM AUTHOR]

The study on the characteristic and the parameterization of cloud droplet effective radius (re) is important for the optimization of warm cloud microphysical schemes in numerical models. Based on numerical simulations combined with the four aircraft observations of stratiform warm clouds in Jiangxi, China, this work investigated their microphysical properties, focusing on the evolutionary pattern and the parameterization of re, as well as the correlation between re and the number concentration (Nc) of cloud droplet and liquid water path (LWP). It is found that there is a negative correlation between re and Nc, and the rate of the decrease could be increased by 2–4 times with a strengthening of collision‐coalescence process. What's more, the direct introduction of collision‐coalescence is conducted based on the existing re parameterization schemes, and the results show that it can perform well in most of collision‐coalescence intensities. It is also found that LWP is positively correlated with re when re is less than 12 μm, after which the relationship changes to a negative correlation due to the impact of rainfall intensity. Plain Language Summary: The bin microphysical scheme can reproduce the microphysical structures of warm cloud, combined with aircraft observations to investigate the microphysics within warm clouds. This work analyzes the evolution characteristics and the parameterization of effective radius in warm clouds based on bin microphysics simulations. Thereafter, the impact of these cloud microphysical quantities to liquid water path (LWP) are also researched. The results show that the rate of effective radius decrease with number concentration can be intensified by collision‐coalescence intensity, and an effective radius parameterization scheme related to collision‐coalescence is proposed based on the existing parameterization schemes. The variation pattern of LWP with effective radius is linked to the critical radius for rainfall intensity. Above all, the effective radius variation pattern depends largely on collision‐coalescence intensity and can affect LWP a lot. These findings are important for understanding warm cloud microphysical parameterization and improving climate assessment. Key Points: The relation between the effective radius and cloud droplet number concentration greatly influenced by collision‐coalescence intensityAn effective radius parameterization scheme which is directly related to collision‐coalescence is considered based on the existing schemesLiquid water path has different relationship with number and effective radius of cloud droplets, also affected by the rainfall intensity [ABSTRACT FROM AUTHOR]

The mechanism and function of the expression of Schwann characteristics by nevus cells in the mature zone of the dermis are unknown. Early growth response 3 (EGR3) induces Schwann cell‐like differentiation of melanoma cells by simulating the process of nevus maturation, which leads to a strong phenotypic transformation of the cells, including the formation of long protrusions and a decrease in cell motility, proliferation, and melanin production. Meanwhile, EGR3 regulates the levels of myelin protein zero (MPZ) and collagen type I alpha 1 chain (COL1A1) through SRY‐box transcription factor 10 (SOX10)‐dependent and independent mechanisms, by binding to non‐strictly conserved motifs, respectively. Schwann cell‐like differentiation demonstrates significant benefits in both in vivo and clinical studies. Finally, a CD86‐P2A‐EGR3 recombinant mRNA vaccine is developed which leads to tumor control through forced cell differentiation and enhanced immune infiltration. Together, these data support further development of the recombinant mRNA as a treatment for cancer. [ABSTRACT FROM AUTHOR]

For decades, many marine animals have been considered to exhibit cosmopolitan or transoceanic distribution. This situation is prevalent in Asia, where many species were collected and named by American or European experts in the 1700s to early 1900s. Using the windowpane oysters Placuna—a small genus of bivalves with five recognized species—we show that careful analysis is required to reassess the validity of these species. Currently, only two species of Placuna (P. placenta and P. ephippium) widely reported in the Indo‐Pacific region have been recorded from Chinese coastal waters. Here, we described two new species of Placuna from China. Placuna vitream sp. nov. can be distinguished from P. placenta by its larger ridge angle. Phylogenetic analysis using five gene fragments fully supported that P. vitream sp. nov. is a sister to the specimen from Singapore identified as P. placenta and more distant from other Placuna species with available molecular data. Besides, based on subfossil shells, we describe Placuna aestuaria sp. nov. that differs from its congeneric species by its broad hinge, medium ridge angle, and nearly straight ridges. Finally, we suggest a combination of hinge structure and ridge angle that can be used for identifying Placuna species and preparing a key to this genus. Our findings of two new species expand the diversity of Placuna and prompt reassessment of the many presumably widely distributed marine species in Asia. [ABSTRACT FROM AUTHOR]

Background: Infertility affects 186 million people worldwide, with male factors contributing to 50% of infertility cases. Semen analysis is a key for diagnosing male factor infertility, but sperm parameters can be influenced by ejaculatory abstinence (EA) duration. Shortening or prolonging EA can impact on semen quality and assisted reproductive technology (ART) outcomes, but the optimal EA duration remains unclear, particularly for infertility patients. Objectives: This study conducts a comprehensive meta‐analysis to explore the impact of varying abstinence durations on semen quality and fertility outcomes. Methods: Three English database (PubMed, Embase, and Cochrane Central Register of Controlled Trials) as well as four Chinese database (China National Knowledge Infrastructure, Chinese Scientific Journals database, WanFang database, and Chinese Biomedical Literature database) were searched from 2000 to August 2023. The classical meta‐analysis and "one‐stage" dose–response meta‐analysis were conducted to compare the associations of different abstinence durations (short‐term abstinence vs. long‐term abstinence) on semen quality in healthy adult and different type of infertile patients. Results: There were 85 eligible studies were finally included. The meta‐analysis of volume (mean difference [MD] = −0.95 mL, 95% confidence interval [CI]: −1.16 to −0.74 mL), total sperm count (TSC) (MD = −102.45×106, 95% CI: −117.98×106 to −86.91×106), sperm concentration (SC) (MD = −11.88×106/mL, 95% CI: −18.96×106/mL to −4.80×106/mL), DNA fragmentation index (DFI) (MD = −2.37%, 95% CI: −4.73% to −0.01%) in healthy men showed a significant decrease with different abstinence durations (short‐term abstinence vs. long‐term abstinence). The meta‐analysis of infertile men showed significant decrease in volume in various subgroups (MD range: −0.73 to −1.17 mL) with P < 0.01; TSC (MD = −61.93×106, 95% CI: −88.84×106 to −35.01×106), SC (MD = −5.39×106/mL, 95% CI: −9.97×106 to −0.81×106/mL), DFI (MD = −5.63%, 95% CI: −10.19% to −1.06%) in unexplained infertility subgroup; significant increase in viability (MD = 6.14%, 95% CI: 3.61% to 8.68%) in the unexplained infertility subgroup. The dose–response meta‐analysis showed that TSC in oligozoospermia showed a nonlinear increase (coefficient from 3.38 to −5.76, P from 0.02 to 0.22) and the truncation point was around the 4th to 5th abstinence day. The percentage of progressive motile sperm (PR) in asthenozoospermia showed a significant decrease (coefficient = −2.39, 95% CI: −4.28 to −0.50). For fertility outcomes of different ARTs, only the clinical pregnancy rate (CPR) in the intrauterine insemination (IUI) subgroup showed a significant decrease around the 3rd day (coefficient = 0.85, 95% CI: 0.75 to 0.97). Conclusions: Short‐term abstinence may be associated with limited improvements in semen quality in healthy men but could be more beneficial for infertile men, especially within the first 4 days of abstinence. Caution is urged in making definitive conclusions about the causal relationship between abstinence time and semen quality changes due to potential confounding and interactions. [ABSTRACT FROM AUTHOR]

The coordination environment is crucial to the electrocatalytic activity of single‐atom catalysts (SACs). Although substituting N atoms in traditional transition metal‐nitrogen (TM‐N4) configuration with other non‐metal atoms has been reported, its specific role in sulfur electrochemical reactions has not been sufficiently investigated. Herein, a Co‐P2N2 SACs configuration is fabricated to investigate the mechanistic differences compared to Co‐N4 in sulfur reduction/oxidation. This configuration enhances the electron transfer with Li2S6, where the electrons tend to aggregate between P and Li atoms as two separate parts rather than a single merged zone as observed in symmetric Co‐N4 SACs. This process facilitates polysulfide decomposition and promotes Li2S nucleation/oxidation. Furthermore, the CoPNC interlayer effectively suppresses cell self‐discharge and Li anode corrosion due to polysulfide shuttling. Li‐Li symmetrical cell incorporated with the CoPNC interlayer achieves a prolonged lifespan exceeding 1000 h, and Li‐S full cell delivers a discharge capacity of more than 1500 mAh g−1. This research provides insights into how the geometric configuration of SACs influences the performance of conversion‐type batteries. [ABSTRACT FROM AUTHOR]

Cytochrome P450 enzyme (CYP)‐catalyzed functional group transformations are pivotal in the biosynthesis of metabolic intermediates and products, as exemplified by the CYP‐catalyzed C7‐hydroxylation and the subsequent C7‐C8 bond cleavage reaction responsible for the biosynthesis of the well‐known antitumor monoterpene indole alkaloid (MIA) camptothecin. To determine the key amino acid residues responsible for the catalytic selectivity of the CYPs involved in MIA biosynthesis, we characterized the enzymes CYP72A728 and CYP72A729 as stereoselective 7‐deoxyloganic acid 7‐hydroxylases (7DLHs). We then conducted a comparative analysis of the amino acid sequences and the predicted structures of the CYP72A homologs involved in camptothecin biosynthesis, as well as those of the CYP72A homologs implicated in the pharmaceutically significant MIAs biosynthesis in Catharanthus roseus. The crucial amino acid residues for the catalytic selectivity of the CYP72A‐catalyzed reactions were identified through fragmental and individual residue replacement, catalytic activity assays, molecular docking, and molecular dynamic simulations analysis. The fragments 1 and 3 of CYP72A565 were crucial for its C7‐hydroxylation and C7‐C8 bond cleavage activities. Mutating fragments 1 and 2 of CYP72A565 transformed the bifunctional CYP72A565 into a monofunctional 7DLH. Evolutionary analysis of the CYP72A homologs suggested that the bifunctional CYP72A in MIA‐producing plants may have evolved into a monofunctional CYP72A. The gene pairs CYP72A728‐CYP72A610 and CYP72A729‐CYP72A565 may have originated from a whole genome duplication event. This study provides a molecular basis for the CYP72A‐catalyzed hydroxylation and C‐C bond cleavage activities of CYP72A565, as well as evolutionary insights of CYP72A homologs involved in MIAs biosynthesis. [ABSTRACT FROM AUTHOR]

The application prospects of ZnS stress luminescent materials cover many fields such as high‐precision structural monitoring, smart materials, biomedical imaging, and new sensor technologies, which bring broad application prospects and significance to them in the fields of engineering, medicine, and scientific research. In this article, the electronic structure and optical properties of ZnS materials are successfully regulated by applying pressure and doping rare earth metals (Re), and it is found that the regulation of the luminescence properties of ZnS is the result of stress and doping interactions. Specifically, when pressure is applied or Re metal doping, the lattice structure is deformed and the atomic spacing is adjusted, which affects the electronic energy level distribution and optical properties of ZnS materials. Computational analysis of density functional theory (DFT) reveals the microscopic mechanisms behind these changes, including changes in lattice parameters, adjustment of bond length, and changes in band structure. This study provides theoretical guidance for the design and synthesis of high‐performance and high‐stability ZnS light‐emitting materials, and is of great significance for expanding the application of ZnS in the field of lasers and sensors. [ABSTRACT FROM AUTHOR]

Despite being one of the most prevalent RNA modifications, the role of N6‐methyladenosine (m6A) in amyotrophic lateral sclerosis (ALS) remains ambiguous. In this investigation, we explore the contribution of genetic defects of m6A‐related genes to ALS pathogenesis. We scrutinized the mutation landscape of m6A genes through a comprehensive analysis of whole‐exome sequencing cohorts, encompassing 508 ALS patients and 1660 population‐matched controls. Our findings reveal a noteworthy enrichment of RNA binding motif protein X‐linked (RBMX) variants among ALS patients, with a significant correlation between pathogenic m6A variants and adverse clinical outcomes. Furthermore, Rbmx knockdown in NSC‐34 cells overexpressing mutant TDP43Q331K results in cell death mediated by an augmented p53 response. Similarly, RBMX knockdown in ALS motor neurons derived from induced pluripotent stem cells (iPSCs) manifests morphological defects and activation of the p53 pathway. Transcriptional analysis using publicly available single‐cell sequencing data from the primary motor cortex indicates that RBMX‐regulated genes selectively influence excitatory neurons and exhibit enrichment in ALS‐implicated pathways. Through integrated analyses, our study underscores the emerging roles played by RBMX in ALS, suggesting a potential nexus between the disease and dysregulated m6A‐mediated mRNA metabolism. [ABSTRACT FROM AUTHOR]

Depression is a prevalent mental disorder, but the side effects of antidepressants also make depressed patients resistant. Effective and safe antidepressants should be developed from traditional herbs, with the aim of reducing the side effects of antidepressants and improving the efficacy of drugs. In this study, the new macamide compound‐4 (NMC‐4) was synthesized for the first time, addressing the problem of difficult extraction, isolation, and low content of natural macamide. NMC‐4 was characterized using mass spectrometry, nuclear magnetic resonance, and infrared spectroscopy. The protective effect of NMC‐4 against cell injury was demonstrated to be stronger than that of natural macamide (N‐benzylhexadecanamide, XA) using a PC12 cell injury model. The study explored the effects of NMC‐4 on chronic unpredictable mild stress (CUMS)‐induced depressive symptoms. NMC‐4 significantly improved depressive‐like behaviors. NMC‐4 ameliorated CUMS‐induced depressive‐like behaviors by mitigating neuroinflammation and modulating the NF‐κB/Nrf2 and BDNF/PI3K/Akt pathways. [ABSTRACT FROM AUTHOR]

To unveil the charge storage mechanisms and interface properties of electrode materials is very challenging for Na‐ion storage. In this work, we report that the novel layered perovskite Bi2TiO4F2@reduced graphene oxides (BTOF@rGO) serves as a promising anode for Na‐ion storage in an ether‐based electrolyte, which exhibits much better electrochemical performance than in an ester‐based electrolyte. Interestingly, BTOF@rGO possesses a prominent specific capacity of 458.3–102 mAh g−1/0.02–1 A g−1 and a high initial coulombic efficiency (ICE) of 70.3%. Cross‐sectional morphology and depth profile surface chemistry indicate not only a denser reactive interfacial layer but also a superior solid electrolyte interface film containing a higher proportion of inorganic components, which accelerates Na+ migration and is an essential factor for the improvement of ICE and other electrochemical properties. Electrochemical tests and ex situ measurements demonstrate the triple hybridization Na‐ion storage mechanism of conversion, alloying, and intercalation for BTOF@rGO in the ether‐based electrolyte. Furthermore, the Na‐ion batteries assembled with the BTOF@rGO anode and the commercial Na3V2(PO4)2F3@C cathode exhibit remarkable energy densities and power densities. Overall, the work shows deep insights on developing advanced electrode materials for efficient Na‐ion storage. [ABSTRACT FROM AUTHOR]

Previous studies found that histamine H2 receptor antagonists (H2RAs) had blood pressure lowering and cardioprotective effects, but the impact of H2RAs on the survival outcomes of critically ill patients with essential hypertension is still unclear. The aim of this study was to investigate the association of H2RAs exposure with all‐cause mortality in patients with essential hypertension based on Medical Information Mart for Intensive Care III database. A total of 17,739 patients were included, involving 8482 H2RAs users and 9257 non‐H2RAs users. Propensity score matching (PSM) was performed to improve balance between 2 groups that were exposed to H2RAs or not. Kaplan–Meier survival curves were used to compare the cumulative survival rates and multivariable Cox regression models were performed to evaluate the association between H2RAs exposure and all‐cause mortality. After 1:1 PSM, 4416 pairs of patients were enrolled. The results revealed potentially significant association between H2RAs exposure and decreased 30‐day, 90‐day, and 1‐year mortalities in multivariate analyses (HR = 0.783, 95% CI: 0.696‐0.882 for 30‐day; HR = 0.860, 95% CI: 0.778‐0.950 for 90‐day; and HR = 0.883, 95% CI: 0.811‐0.961 for 1‐year mortality, respectively). Covariate effect analyses showed that the use of H2RAs was more beneficial in essential hypertension patients with age ≥ 60, BMI ≥ 25 kg/m2, coronary arteriosclerosis, stroke, and acute kidney failure, respectively. In conclusion, H2RAs exposure was related to lower mortalities in critically ill patients with essential hypertension, which provided novel potential strategy for the use of H2RAs in essential hypertension patients. [ABSTRACT FROM AUTHOR]

Pulsed vacuum drying (PVD) is a novel vacuum drying method that has demonstrated significant potential in improving energy efficiency and product quality in the drying of foods and agricultural products. The current work provides a comprehensive analysis of the latest advancements in PVD technology, including its historical development, fundamental principles, and mechanistic aspects. The impact of periodic pulsed pressure changes between vacuum and atmospheric pressure on heat and moisture transfer, as well as structural changes in foods at micro‐ and macro‐scales, is thoroughly discussed. The article also highlights the influential drying parameters, the integration of novel auxiliary heaters, and the applications of PVD across various fruits, vegetables, and herbs. Furthermore, the review examines the current status and needs for mathematical modeling of PVD processes, identifying key challenges, research opportunities, and future trends for industrial application. The findings suggest that PVD not only enhances drying efficiency and reduces energy consumption but also preserves the nutritional value, color, and texture of dried products better than traditional methods. Future research should focus on optimizing process parameters and integrating advanced control systems to further improve the scalability and applicability of PVD technology in the food industry. [ABSTRACT FROM AUTHOR]

The policy actions of countries reflect adaptive responses of local components within the system to the dynamic global risk landscape. These responses can generate interactions and synergy effects on alleviating the evolution of global risks. Adopting a network perspective, the study proposes a theoretical framework that connects three structural characteristics of policy synergy, namely, synergy scale, alignment intensity, and timing synchronization. Focusing on the Covid‐19 pandemic as a typical global risk context, the study finds that policy synergy with a larger scale, stronger alignment intensity, and more synchronized timing has a positive impact on mitigating global risks. The effect of alignment intensity is particularly pronounced when polycentric governance involves 20 countries facing severe risks, whereas the effect of timing synchronization is more significant when the multicenter group comprises more countries. Building upon the concept of an efficient scale of polycentric governance in various dimensions, this study develops a policy synergy index model. Through multiple empirical analyses, this study validates the causal relationship between policy synergy and the future evolution of global pandemic risk. Policymakers can leverage the dynamic changes in the policy synergy to predict future risk situations and implement well‐rounded and appropriate policy actions, thereby enhancing the efficacy of the synergy effect of multi‐country policy actions for risk governance. [ABSTRACT FROM AUTHOR]

In enhancing oversight within China's capital markets, it has become imperative to investigate the economic ramifications of corporate transgressions in the banking sector. This study applied the tenets of the insurance effect theory to scrutinize the transmission mechanism delineating the impact of corporate violations on bank debt costs, with a specific focus on the ameliorative role played by corporate social responsibility (CSR). The findings underscored a positive correlation between corporate violations and bank debt costs, while CSR emerged as a mitigating factor in this relationship. Notably, organizations demonstrating proactive engagement in CSR activities exhibited a capacity to attenuate the adverse influence of violations on bank debt costs. However, it was discerned that the insurance effect of CSR diminished when companies recurrently breached regulatory norms. These outcomes contribute substantively to fortifying capital market supervision, urging enterprises to conscientiously fulfill their social responsibilities to engender a more cautious approach from financial institutions. [ABSTRACT FROM AUTHOR]

Dental anatomy education for dental technology students should be developed in alignment with digital dental laboratory practices. We hypothesized that a virtually assisted sketching‐based dental anatomy teaching module could improve students' acquisition of skills essential for digital restoration design. The second‐year dental technology curriculum included a novel virtual technology‐assisted sketching‐based module for dental anatomy education. Pre‐ and post‐course assessments evaluated students' skill sets and knowledge bases. Computer‐aided design (CAD) scores were analyzed after one year to assess how the skills students developed through this module impacted their subsequent CAD performance. Participants who undertook the dental sketching‐based teaching module demonstrated significantly improved theoretical knowledge of dental anatomy, dental aesthetic perception, and spatial reasoning skills. A partial least squares structural equation model indicated that the positive effects of this module on subsequent CAD performance were indirectly mediated by dental aesthetic perception, spatial reasoning, and practice time. A virtually assisted sketching‐based dental anatomy teaching module significantly improved students' acquisition of skills and knowledge and positively mediated dental technology students' CAD performance. [ABSTRACT FROM AUTHOR]

As an effective approach to converting carbon oxide (CO2) into value‐added carbonaceous products, the electrochemical CO2 reduction reaction (ECO2RR) has shown considerable potential for carbon neutrality, addressing global pollution and climate issues. Copper (Cu)‐based electrocatalysts (CuECs) are acknowledged as important candidates for the ECO2RR of multi‐carbon products. Nevertheless, the complicated electron transfer and multiple competitive pathways in the multi‐carbon production process raise challenges of product selectivity. While achieving high current density and structural stability, improving the product selectivity of CuECs has become crucial to their practical applications. Herein, an overview of the fundamental thermodynamic and kinetic principles of ECO2RR are presented. Then, the typical strategies are summarized for increasing CuEC selectivity for the formation of multi‐carbon products from CO2, including morphological control, component design, defect design, and interface design. The catalyst design, catalytic performance, and reaction mechanisms involved in these strategies are reviewed. Finally, the major challenges and future prospects for high‐performance electrocatalysts in ECO2RR are discussed. [ABSTRACT FROM AUTHOR]

BACKGROUND: Optimizing biochar application is vital for enhancing crop production and ensuring sustainable agricultural production. A 3‐year field experiment was established to explore the effects of varying the biochar application rate (BAR) on crop growth, quality, productivity and yields. BAR was set at 0, 10, 50 and 100 t ha−1 in 2018; 0, 10, 25, 50 and 100 t ha−1 in 2019; and 0, 10, 25 and 30 t ha−1 in 2020. Crop quality and growth status and production were evaluated using the dynamic technique for order preference by similarity to ideal solution with the entropy weighted method (DTOPSIS‐EW), principal component analysis (PCA), membership function analysis (MFA), gray relation analysis (GRA) and the fuzzy Borda combination evaluation method. RESULTS: Low‐dose BAR (≤ 25 t ha−1 for cotton; ≤ 50 t ha−1 for sugar beet) effectively increased biomass, plant height, leaf area index (LAI), water and fertility (N, P and K) productivities, and yield. Biochar application increased the salt absorption and sugar content in sugar beet, with the most notable increases being 116.45% and 20.35%, respectively. Conversely, BAR had no significant effect on cotton fiber quality. The GRA method was the most appropriate for assessing crop growth and quality. The most indicative parameters for reflecting cotton and sugarbeet growth and quality status were biomass and LAI. The 10 t ha−1 BAR consistently produced the highest scores and was the most economically viable option, as evaluated by DTOPSIS‐EW. CONCLUSION: The optimal biochar application strategy for improving cotton and sugar beet cultivation in Xinjiang, China, is 10 t ha−1 biochar applied continuously. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Monitoring the generation and movement of equatorial plasma bubbles (EPBs) in a large longitude region is crucial important for better understanding their day‐to‐day variability. Using the newly developed Low lAtitude long Range Ionospheric raDar (LARID) at Dongfang (19.2°N, 108.8°E, dip lat. 13.8°N), China, an extremely long‐range experiment for observing EPB irregularities in a range of ±9,600 km to the radar site was first carried out. The results show that EPB irregularities with ranges up to 7,000 and 9,500 km were observed by the east and west beams of LARID, respectively. By incorporating simultaneous observations from GNSS receiver and ionosonde networks, it is demonstrated that the EPBs generated from post‐sunset to sunrise over a very wide longitude of ∼140°, from Pacific to Africa could be observed by LARID. The results, for the first time, demonstrate the possibility for tracing global EPBs in real time using a few low latitude over‐the‐horizon radars. Plain Language Summary: Equatorial plasma bubble (EPB), which can cause severe ionospheric scintillation, is an important space weather phenomenon. The occurrence of EPBs exhibits complex longitude variation characteristics. Due to the fact that most of the equatorial and low latitude region is covered by ocean, it is challenging to monitor the generation and movement of global EPBs. Recently, an over‐the‐horizon (OTH) radar at low latitude, that is, the LARID, has been built for observing EPB irregularities. However, it is not clear that how far an OTH radar at low latitude can observe irregularities. This would be very important in the design of a low latitude OTH radar network for tracing global EPB irregularities. To address this issue, an extremely long‐range experiment covering a wide longitude of about 180° was performed for the first time with LARID. The successful observation of EPB irregularities from Pacific to Africa sectors demonstrates the possibility of monitoring the complex longitudinal variations of EPBs by an OTH radar, even during geomagnetic storms. The results provide meaningful insight for building a low latitude OTH radar network in future, that consists of three to four OTH radars could have the capability to obtain global EPBs in real time. Key Points: First extremely long‐range experiment for observing equatorial plasma bubbles over a large longitude was conductedEquatorial plasma bubbles with ranges as far as 9,500 km were successfully observed by an over‐the‐horizon radarThe results demonstrate the capability for tracing global equatorial plasma bubbles using a few low latitude over‐the‐horizon radars [ABSTRACT FROM AUTHOR]

The onset of osteonecrosis of the femoral head (ONFH) is intimately associated with the extensive administration of glucocorticoids (GCs). Long‐term stimulation of GCs can induce oxidative stress in both osteoclasts (OCs) and osteoblasts (OBs), resulting in the disturbance of bone remodelling. An alkaloid named crebanine (CN) demonstrates pharmacological properties including anti‐inflammation and reactive oxygen species (ROS) modulation. Our objective is to assess the therapeutic potential of CN in treating ONFH and elucidate the associated underlying mechanisms. The network pharmacology analysis uncovered that CN played a role in regulating ROS metabolism. In vitro, CN demonstrated its ability to reduce the dexamethasone (DEX)‐stimulated generation of OCs and suppress their resorptive function by downregulating the level of osteoclast marker genes. Concurrently, CN also mitigated DEX‐induced damage to OBs, facilitating the restoration of osteoblast marker gene expression, cellular differentiation and function. These effects were achieved by CN augmenting the antioxidant system to reduce intracellular ROS levels. Furthermore, in vitro results were corroborated by micro‐CT and histological data, which also showed that CN attenuated MPS‐induced ONFH in mice. This study highlights the therapeutic potential of CN in counteracting GCs‐induced ONFH. [ABSTRACT FROM AUTHOR]

The involvement of inwardly rectifying potassium channel 4.1 (Kir4.1) in neuropathic pain has been established. However, there is limited understanding of the downstream mechanism through which Kir4.1 contributes to orofacial neuropathic pain. The objective of this study was to examine the regulation of Kir4.1 on the expression of pannexin 3 (Panx3) in the trigeminal ganglion (TG) and the underlying mechanism in the context of orofacial neuropathic pain caused by chronic constriction injury of the infraorbital nerve (CCI‐ION). The study observed a significant increase in Panx3 expression in the TG of mice with CCI‐ION. Inhibition of Panx3 in the TG of CCI‐ION mice resulted in alleviation of orofacial mechanical allodynia. Furthermore, conditional knockdown (CKD) of Kir4.1 in the TG of both male and female mice led to mechanical allodynia and upregulation of Panx3 expression. Conversely, overexpression of Kir4.1 decreased Panx3 levels in the TG and relieved mechanical allodynia in CCI‐ION mice. In addition, silencing Kir4.1 in satellite glial cells (SGCs) decreased Panx3 expression and increased the phosphorylation of P38 MAPK. Moreover, silencing Kir4.1 in SGCs increased the levels of reactive oxygen species (ROS). The elevated phosphorylation of P38 MAPK resulting from Kir4.1 silencing was inhibited by using a superoxide scavenger known as the tempol. Silencing Panx3 in the TG in vivo attenuated the mechanical allodynia caused by Kir4.1 CKD. In conclusion, these findings suggest that the reduction of Kir4.1 promotes the expression of Panx3 by activating the ROS‐P38 MAPK signalling pathway, thus contributing to the development of orofacial neuropathic pain. [ABSTRACT FROM AUTHOR]

Decreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is predominantly induced in tubular epithelium of human and mouse fibrotic kidneys, alongside a reduction in renal spermine content in mice. Moreover, renal SMOX expression is positively correlated with kidney fibrosis and function decline in patients with chronic kidney disease. Importantly, supplementation with exogenous spermine or genetically deficient SMOX markedly improves autophagy, reduces senescence, and attenuates fibrosis in mouse kidneys. Further, downregulation of ATG5, a critical component of autophagy, in tubular epithelial cells enhances SMOX expression and reduces spermine in TGF‐β1‐induced fibrogenesis in vitro and kidney fibrosis in vivo. Mechanically, ATG5 readily interacts with SMOX under physiological conditions and in TGF‐β1‐induced fibrogenic responses to preserve cellular spermine levels. Collectively, the findings suggest SMOX/spermine axis is a potential novel therapy to antagonize renal fibrosis, possibly by coordinating autophagy and suppressing senescence. [ABSTRACT FROM AUTHOR]

Background: The comparison between prostaglandin E2 (PGE2) and oxytocin and for induction of labor (IOL) remains controversial. Objective: The present study aimed to determine the safety and efficacy of these two agents in IOL. Search Strategy: PubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov. from the establishment of the database to April 23, 2023. Selection Criteria: A search was conducted with keywords "labor, induction, prostaglandin E2/PGE2/dinoprostone, and oxytocin". Only randomized clinical trials comparing oxytocin and vaginal dinoprostone in women who were at least late preterm (gestational age [GA] ≥34 weeks), singleton pregnant, and had intact membranes were enrolled for further meta‐analysis. Data Collection and Analysis: We conducted both a descriptive analysis and a meta‐analysis. In the meta‐analysis, we utilized the Mantel–Haenszel random effects model to analyze dichotomous data, employing the relative risk (RR) as the effect measure along with 95% confidence intervals (CIs). The study quality was evaluated using Cochrane Collaboration's risk of bias assessment tool (RoB 2). A random‐effects model was applied for the meta‐analysis. Main Results: After screening 3303 articles from five databases, a total of nine randomized controlled studies composed of 1071 patients were included. Our analysis included 534 patients in the PGE2 group and 537 patients in the oxytocin group. The pooled estimate of vaginal deliveries following PGE2 induction stood at 84.2%, while after oxytocin induction, it was 79.8%. The meta‐analysis showed no statistical difference between the two groups in terms of the rate of vaginal delivery (pooled RR, 1.05; 95% CI: 0.95–1.16; P value for Q, 0.001; I2, 71.14%), cesarean section (pooled RR, 0.84; 95% CI: 0.52–1.35; P value for Q, 0.007; I2, 61.69%) and induction‐delivery interval (pooled standard mean difference, 0.09; 95% CI: −0.67 to 0.85; P value for Q, 0.000; I2, 96.45%). Since the results for fetal distress and uterine hyperstimulation were consistent across all enrolled studies, no further meta‐analysis was conducted. Conclusions: When amalgamating the available literature, it implies that oxytocin was found to have similar effects as PGE2 on delivery outcomes and safety concerns in pregnant women with GA ≥36 weeks. Although the uterine cervix was unfavorable, both low and high doses of oxytocin were feasible for IOL. Synopsis: Labor induction medication systemic review and meta‐analysis. [ABSTRACT FROM AUTHOR]

Background Objectives Methods Results and Conclusions Self‐regulated learning (SRL) is a predictive variable in students' academic performance, especially in virtual reality (VR) environments, which lack monitoring and control. However, current research on VR encounters challenges in effective interventions of cognitive and affective regulation, and visualising the SRL processes using multimodal data.This study aimed to analyse multimodal data to investigate the SRL processes (behaviour, cognition and affective states) and learning performance in the VR environment.This study developed a VR‐based immersive learning system that supports SRL activities, and conducted a pilot study in an English for Geography course. A total of 21 undergraduates participated. Face tracker, electroencephalography, and learning logs were used to gather data for learning behaviour, cognition and affective states in the VR environment.First, the study identified three categories of learners (HG, MG and LG) within the VR environment who presented different behavioural engagement and SRL strategies. The HG exhibited the highest level of cognition and affective states, which resulted in superior performance in terms of vocabulary acquisition and retention. The MG, despite possessing a higher level of cognition, performed inadequately in other aspects, leading to no difference in vocabulary acquisition and retention from the LG. By collecting and mining multimodal data, this study helps to enrich the visual analysis of SRL processes. In addition, the results of this study help to dissect the problems of students' SRL in a VR learning environment. Furthermore, this study provides a theoretical basis and reference for the study of SRL development in immersive learning environments. [ABSTRACT FROM AUTHOR]

The efficient removal of low‐concentration endocrine disruptors is crucial for the protection of the aquatic environment. In this study, porous polymer adsorbent materials were modified by nanosecond pulsed discharge plasma to achieve efficient adsorption of low‐concentration bisphenol A (BPA). The removal efficiency of BPA reached 99% after 10 min of plasma modification at a pulse peak voltage of 28 kV, which increased by 25.8% compared to the raw materials. This enhancement was attributed to the increase of active sites and oxygen‐containing functional groups. The adsorption behaviors of the porous polymer materials were primarily dominated by monolayer chemisorption. Subsequently, comparative experiments further verified the high‐efficiency adsorption performance of porous polymer materials after plasma treatment. [ABSTRACT FROM AUTHOR]

Purpose: To explore the microstate characteristics and underlying brain network activity of Ménière's disease (MD) patients based on high‐density electroencephalography (EEG), elucidate the association between microstate dynamics and clinical manifestation, and explore the potential of EEG microstate features as future neurobiomarkers for MD. Methods: Thirty‐two patients diagnosed with MD and 29 healthy controls (HC) matched for demographic characteristics were included in the study. Dysfunction and subjective symptom severity were assessed by neuropsychological questionnaires, pure tone audiometry, and vestibular function tests. Resting‐state EEG recordings were obtained using a 256‐channel EEG system, and the electric field topographies were clustered into four dominant microstate classes (A, B, C, and D). The dynamic parameters of each microstate were analyzed and utilized as input for a support vector machine (SVM) classifier to identify significant microstate signatures associated with MD. The clinical significance was further explored through Spearman correlation analysis. Results: MD patients exhibited an increased presence of microstate class C and a decreased frequency of transitions between microstate class A and B, as well as between class A and D. The transitions from microstate class A to C were also elevated. Further analysis revealed a positive correlation between equilibrium scores and the transitions from microstate class A to C under somatosensory challenging conditions. Conversely, transitions between class A and B were negatively correlated with vertigo symptoms. No significant correlations were detected between these characteristics and auditory test results or emotional scores. Utilizing the microstate features identified via sequential backward selection, the linear SVM classifier achieved a sensitivity of 86.21% and a specificity of 90.61% in distinguishing MD patients from HC. Conclusions: We identified several EEG microstate characteristics in MD patients that facilitate postural control yet exacerbate subjective symptoms, and effectively discriminate MD from HC. The microstate features may offer a new approach for optimizing cognitive compensation strategies and exploring potential neurobiological markers in MD. [ABSTRACT FROM AUTHOR]

A new coordination polymer (CP) with composition [Zn3(bpyp)2(TCB)2(H2O)2]n (1) has been engendered by performing reaction of Zn(II) with 1,3,5‐tris‐(4‐carboxyphenyl)benzene (H3TCB) and 2,5‐bis(pyrid‐4‐yl)pyridine (bpyp) under solvothermal condition. The single crystal X‐ray diffraction analysis for 1 suggests kgd topological behavior having resemblance with a tessellation composed of diamond shapes arranged in a star pattern and represented by the Schläfli symbol {41}2{42·62·81}. This newly designed CP exhibits optical band gap of 2.92 eV and employed as photocatalyst for photodegradation of antibiotics, namely, nitrofurazone (NFZ), chloramphenicol (CAP), sulfasalazine (SLA), oxytetracycline (OXY), and furazolidone (FZD). Among these antibiotics, 1 displays best photocatalytic activity against the photodegradation of NFZ and under optimized conditions viz. photocatalyst dosage of 15 mg, and initial NFZ concentration of 40 ppm, the CP 1 displays best catalytic performance and photo‐decomposed 93.04% NFZ with pseudo first order rate constant k of 0.04502 min−1 in 1 h. The likely photocatalytic mechanism has been evaluated using theoretical calculations. [ABSTRACT FROM AUTHOR]