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This contribution applies the Q methodology to investigate Chinese public employees' accountability preferences under different accountability relationships in delivering public services. We identify four accountability preferences: a vertically oriented accountability, a network‐style accountability, a style of accountability between market and participatory accountability, and a vertically oriented style of market accountability. Our data show that Chinese public employees hold varied accountability preferences in public service delivery, and hierarchy is a relatively popular one. It is suggested that governors should effectively align different accountability relationships with the aim of better steering the behavior of public employees in public service delivery. [ABSTRACT FROM AUTHOR]

Emotions and joint attention are highly associated and mutually influenced during preschool, the critical period for early emotional and cognitive development. However, few studies have explored the neuropsychological mechanism of joint attention with preschoolers and their partners under different emotions. This study has examined the prefrontal activation under a comprehensive emotional joint attention task in 45 preschoolers (25 boys, Mage = 58 ± 9.02 months) to compare the different influences of partners' positive, neutral, and negative emotions. Analysis of the functional near‐infrared spectroscopy data indicated that the participants' prefrontal activation triggered by joint attention in positive and negative emotions was significantly higher than in neutral emotions. Moreover, their brain synchronization intensity was significantly higher in positive emotions of joint attention than in negative emotions. These findings advance our understanding of the neural mechanism of early childhood emotional processing under joint attention and provide a neural perspective to explain the effects of different emotions on preschoolers' social cognition. Our findings add a new perspective to the influence of emotion on the neural mechanisms of social interaction. We address the gap in the literature using preschoolers to study the neural mechanisms of emotional joint attention and find that participants have significantly higher prefrontal activation triggered by joint attention to positive and negative emotions compared to neutral emotions. [ABSTRACT FROM AUTHOR]

Governance and policy authors are concerned with the effectiveness of crisis management. In this study, the effectiveness of 27 Chinese provinces in addressing COVID‐19 is examined using the QCA approach. The contribution identifies four pathways for explaining effective crisis management and two for explaining ineffective crisis management. Strong analytical capacity is a relatively critical condition for achieving effective crisis management. This study contributes to the existing governance and policy literature through uncovering the mechanisms underlying effective crisis management. [ABSTRACT FROM AUTHOR]

LiNiO2 cathode material for lithium‐ion batteries has the advantages of high specific capacity, abundant resources, and low cost, but it suffers from difficulties in preparation, structural instability, and serious capacity decay. In this work, highly pure and layered structural LiNi0.95AlaTi0.05‐aO2 (a=0, 0.025, 0.05) cathode materials were synthesized by a simply sol‐gel method. The cation mixing of Ni2+ and Li+, structural deterioration, irreversible conversion between H2 and H3 phases and unstable surface and CEI (Cathode‐electrolyte interface) film can be effectively suppressed by co‐doping with Al3+ and Ti4+. A preferred LiNi0.95Al0.025Ti0.025O2 sample provides a discharge specific capacity of 223 mAh g−1 at 0.1 C and 148.32 mAh g−1 at 5 C, a capacity retention of 72.7 % after 300 cycles at 1 C and a Li+ diffusion coefficient of about 2.0×10−9 cm2 s−1. [ABSTRACT FROM AUTHOR]

Coordination is one of the most challenging crisis management issues governments face worldwide. In this contribution, we examine the coordination mechanism applied by Qingdao control command in China to fight against COVID‐19. Its coordination is implemented contingently via five different approaches: achieving compromises through a centralized tiered meeting system, developing standard operating procedures through issuing documents, encouraging pragmatic problem‐solving through improvisation, establishing routines through finding shortcuts, and following commands and suggestions from higher‐up. Two perspectives, the structural‐institutional and cultural perspectives, have been applied to explain the choice of the contingent coordination mechanism. Our study contributes to the existing crisis coordination literature through substantiating the approaches underlying contingent coordination and providing a preliminary explanation of it. [ABSTRACT FROM AUTHOR]

With increasing numbers of environmental conflicts in recent years, Chinese local governments are changing their modes of governance with the aim of addressing these conflicts satisfactorily. Through a case study, we identified shifts in modes of governance from hierarchical to network and from market to hybrid (characterized by a combination of market and hierarchical) in three arenas. Our findings confirm that initiating actors, stakeholder involvement types, rules of interaction, and implementation strategies are useful indicators of shifts in governance modes. Media, protests and policy entrepreneurs in different arenas are important factors in the shift from hierarchical to network governance, while policy entrepreneurs and higher‐level government intervention are crucial factors in the shift from market to a hybrid governance mode. Policy entrepreneurs play an important role in all three arenas. As for theoretical contribution, our research has provided the evidence for non‐hierarchical governance practices in the NIMBY in China. In the future, local governments in China may learn to consider proper governance mode shifts to deal with the NIMBY conflicts in infrastructure planning and construction. [ABSTRACT FROM AUTHOR]

Coordination of the response to the COVID‐19 crisis may be understood as the multimonth management of a temporary organisation instead of classical crisis management. A key question is how to maintain operational flexibility, that is, an organisation's ability to adapt its day‐to‐day functions to accommodate a changing environment. This contribution describes how a control command established by a Chinese municipality in response to COVID‐19 tried to cope with the problems at hand. Based partially upon participatory observation the following aspects are considered: shifting political attention, adapting interaction frequency, changing organisational structures, improvising routines, and altering priorities. [ABSTRACT FROM AUTHOR]

Using the Weather Research and Forecasting (WRF) model, a series of sensitivity experiments were conducted to study the individual and overall effects of the various topographic uplifts of the Tibetan Plateau (TP) on regional climate variability. The presence of the southern slope of the TP facilitates the maintenance and development of the South Asia High (SAH), which produces a positive cyclic response between local precipitation and SAH, so that the northern branch of the South Asian summer monsoon (SASM) maintains the water vapor supply. At the same time, the southern slope of the TP has a positive effect on the mid‐latitude tropospheric anomalous cyclone and anticyclone systems which promotes the downstream advancement of the East Asian summer monsoon (EASM) and is favourable for the transfer of water vapor and convective clouds downstream. The role of the TP platform is mainly due to the lifting of moisture generated by its local heating, which favours the formation of local convective clouds and precipitation while causing nonadiabatic warming of the troposphere. Water vapor transported from the TP could affect precipitation in central‐eastern China (CEC). However, the supply of water vapor in Southern East China (SEC) mainly comes from the southeast coast of China. The Tibetan Plateau sensitive areas (TPSA) have impacts on the water vapor transport path. Removing the TPSA favours an increase in precipitation and convective clouds in SEC. The removal of topographic disturbances favours the convergence and dispersion of water vapor at mid‐latitudes. The mid‐latitude dynamical anomaly may form a standoff with the low‐latitude dynamical system. This leads to inefficient precipitation and convective generation processes, a weakened monsoon advance over land, and a southward shift in the rainfall belt. [ABSTRACT FROM AUTHOR]

Nitrogen doped carbon materials containing transition metal nanoparticles have attracted much attention as bifunctional oxygen electrocatalysts. In this paper, the template etching method is used to obtain the nitrogen‐doped graphene with abundant macropores embedded with cobalt nanoparticles (Co@N−C). The prepared Co@NC‐800 catalyst has a half‐wave potential (E1/2=0.835 V) close to Pt/C and good stability in excess of Pt/C for oxygen reduction reaction (ORR). At the same time, the catalyst has good oxygen evolution reaction (OER) performance. In addition, zinc‐air batteries (ZABs) based on the Co@NC‐800 catalyst show good cycle stability of up to 200000 s and high power density of 73.5 mW cm−2. The synergistic effect of the integrated component between nitrogen‐doped graphene and cobalt nanoparticles as well as the macroporous structure endow Co@NC‐800 with abundant exposed active sites and mass/electron transfer capacity, thus leading to the high electrocatalytic activity. This work shows potential for practical applications in electrochemistry. [ABSTRACT FROM AUTHOR]

Background & Aims: Disruption of lipid metabolism is largely linked to metabolic disorders, such as hypercholesterolemia (HCL) and liver steatosis. While cholesterol metabolic re‐programmers can serve as targets for relevant interventions. Here we explored the dietary conjugated linoleic acids (CLA)‐induced HCL in mice and the molecular regulation behind it. Methods: A high dose of CLA supplementation in the diet was used to induce HCL in mice and was found to cause a hyper‐activated cholesterol biosynthesis programme in the liver, leading to cholesterol metabolism dysregulation. The effects of a small‐molecule drug targeting PPARα, i.e., GW6471 were studied in vivo in mice fed diets with CLA supplementation for 28 days, and in primary hepatocytes derived from HCL‐mice in vitro. Results: We demonstrate that CLA induced HCL and liver steatosis through multiple pathways. Among which was the PPARα‐mediated cholesterogenesis. It was found to cooperate with SREBP2 via binding to Hmgcr and Dhcr7 (genes encoding key enzymes of the cholesterol biosynthetic pathway) and recruits the histone marks H3K27ac and H3K4me1 and cofactors. PPARα inhibition disrupts its physical association with SREBP2 by blocking cobinding of PPARα and SREBP2 to the genomic DNA response element. We showed that NR RORγ functions as an essential mediator that facilitates the interaction of PPARα and SREBP2 to modulate the cholesterol biosynthesis genes expression. Conclusions: Our study unravels that the small‐molecule compound GW6471 exerts an attractive therapeutic effect for CLA‐induced HCL, involving multiple pathways with the "PPARα‐RORγ‐SREBP2" being a potential complex player in this hepatic cholesterol biosynthesis programming. [ABSTRACT FROM AUTHOR]

The electrochemical performances and process mechanisms of Zn/LiFePO4 cells in a slightly acidic 1.9 m Li2SO4–0.5 m ZnSO4 aqueous solution were investigated. The results showed that the hydrogen depletion side reaction on the surface of the zinc sheet led to an increase in pH of the electrolyte and fluctuations in specific capacity of the cells, and that the dissolution of Fe2+ ions and the lamination of LiFePO4 particles resulted in a decrease in the specific capacity of the cells. At pH 5.0, the initial discharge specific capacity of the Zn/LiFePO4 cell was about 120.0 mAh g−1 at 0.25 C, about 64.4 mAh g−1 at 3 C, with about 60.9 % capacity retention rate after 200 cycles at 1 C, and the Li+ ions diffusion coefficient was about 7.75×10−12 cm2 s−1. [ABSTRACT FROM AUTHOR]

Cryptocaryon irritans (Brown, 1951) is an obligate parasite that mainly invades the skin, fins and gills of marine fish and causes marine 'white spot disease'. It is common to aquarium and maricultured fish and causes high mortality due to its widespread geographical distribution, indiscriminate host specificity, short and simple life cycle, and high level of virulence. Numerous physical methods and chemical bath agents are applied to cure this disease in closed, re‐circulating aquaculture systems, but these treatments are not suitable in open environments such as cages and ponds. Fortunately, new measures, such as oral chemical drugs, oral plant components, vaccines and even biological control, are being developed as promising methods to treat and prevent cryptocaryoniasis in open aquaculture systems. Here, we provide a broad overview of C. irritans research, focussing primarily on work conducted in the last decade that may offer new insights into the treatment of disease in a practical setting. [ABSTRACT FROM AUTHOR]

Flow cytometric sorting is a vital tool in biological research and clinical diagnostics. Theoretically, a high‐speed jet‐in‐air sorter is a fluorescent‐activated cell sorting sorter that ideally processes cells with high purity, yield, and viability. However, high‐speed jet‐in‐air sorting is a complex process due to its inherent requirements for high fluidic stability and electronic and timing precision. Here, we report that an additional manual correction of drop delay leads to improved cell yield. Adding 2% FBS to the loading buffer had no significant effect on the fate of sorted cells in 4 h. However, the addition of a suitable concentration of FBS/BSA in the collecting buffer resulted in a notable increase in cell count and proliferation and a significant decrease in cell apoptosis for cell lines and primary cells. Moreover, the level of gene expression remained steady in the 5% FBS collecting buffer. In summary, here we demonstrate techniques that can be easily followed to refine sorted yields of healthy cells. [ABSTRACT FROM AUTHOR]

SUMMARY: The bottle gourd (Lagenaria siceraria, Cucurbitaceae) is an important horticultural crop exhibiting tremendous diversity in fruit shape. The genetic architecture of fruit shape variation in this species remains unknown. We assembled a long‐read‐based, high‐quality reference genome (ZAAS_Lsic_2.0) with a contig N50 value over 390‐fold greater than the existing reference genomes. We then focused on dissection of fruit shape using a one‐step geometric morphometrics‐based functional mapping approach. We identified 11 quantitative trait loci (QTLs) responsible for fruit shape (fsQTLs), reconstructed their visible effects and revealed syntenic relationships of bottle gourd fsQTLs with 12 fsQTLs previously reported in cucumber, melon or watermelon. Homologs of several well‐known and newly identified fruit shape genes, including SUN, OFP, AP2 and auxin transporters, were comapped with bottle gourd QTLs. [ABSTRACT FROM AUTHOR]

Nonalcoholic‐fatty‐liver‐disease (NAFLD) is the result of imbalances in hepatic lipid partitioning and is linked to dietary factors. We demonstrate that conjugated linoleic acid (CLA) when given to mice as a dietary supplement, induced an enlarged liver, hepatic steatosis, and increased plasma levels of fatty acid (FA), alanine transaminase, and triglycerides. The progression of NAFLD and insulin resistance was reversed by GW6471 a small‐molecule antagonist of peroxisome proliferator‐activated receptor α (PPARα). Transcriptional profiling of livers revealed that the genes involved in FA oxidation and lipogenesis as two core gene programs controlled by PPARα in response to CLA and GW6471 including Acaca and Acads. Bioinformatic analysis of PPARα ChIP‐seq data set and ChIP‐qPCR showed that GW6471 blocks PPARα binding to Acaca and Acads and abolishes the PPARα‐mediated local histone modifications of H3K27ac and H3K4me1 in CLA‐treated hepatocytes. Thus, our findings reveal a dual role of PPARα in the regulation of lipid homeostasis and highlight its druggable nature in NAFLD. [ABSTRACT FROM AUTHOR]

The concept of risk has received scholarly attention from a variety of angles in the social, technical, and natural sciences. However, public policy scholars have not yet generated a comprehensive overview, shared understanding and conceptual framework of the main problem‐solving approaches applied by governments in coping with risks. In this regard, our main aim is to examine existing perspectives on prevailing risk coping strategies, find a common denominator among them and contribute to current policy and risk science literature through providing a conceptual framework that systematically spans the spectrum of risk coping strategies and incorporates the essence of the most relevant insights. To this end, we first examine the concept of risk in‐depth by exploring various definitions and types of risk. We then review different approaches proposed by different strands of research for addressing risk. Finally, we assess current knowledge and develop an amalgamated perspective for examining how risks can be addressed by classifying them into six general types of response (no response; prevention; control; precaution; toleration; and adaptation) as well as indicators to identify these responses. We argue that these strategies can function as a heuristic tool for decisionmakers in designing appropriate policies to cope with risks in decision‐making processes. [ABSTRACT FROM AUTHOR]

Epsilon toxin (ETX) is a 33‐kDa pore‐forming toxin produced by type B and D strains of Clostridium perfringens. We previously found that ETX caused haemolysis of human red blood cells, but not of erythrocytes from other species. The cellular and molecular mechanisms of ETX‐mediated haemolysis are not well understood. Here, we investigated the effects of ETX on erythrocyte volume and the role of the putative myelin and lymphocyte (MAL) receptors in ETX‐mediated haemolysis. We observed that ETX initially decreased erythrocyte size, followed by a gradual increase in volume until lysis. Moreover, ETX triggered phosphatidylserine (PS) exposure and enhanced ceramide abundance in erythrocytes. Cell shrinkage, PS exposure and enhanced ceramide abundance were preceded by increases in intracellular Ca2+ concentration. Interestingly, lentivirus‐mediated RNA interference studies in the human erythroleukaemia cell line (HEL) cells confirmed that MAL contributes to ETX‐induced cytotoxicity. Additionally, ETX was shown to bind to MAL in vitro. The results of this study recommend that ETX‐mediated haemolysis is associated with MAL receptor activation in human erythrocytes. These data imply that interventions affecting local MAL‐mediated autocrine and paracrine signalling may prevent ETX‐mediated erythrocyte damage. [ABSTRACT FROM AUTHOR]

It has been reported that the proliferation and apoptosis of mammary epithelial cells affect milk production. Therefore, ensuring adequate mammary epithelial cells is expected to enhance milk production. This study is devoted to studying the effects of kisspeptin‐10 (Kp‐10), a peptide hormone composed of 10 amino acids, on bovine mammary epithelial cell (bMEC) proliferation and exploring the underlying mechanism of its action. bMECs were treated with various concentrations of Kp‐10 (1, 10, 100, and 1,000 nM), and 100 nM Kp‐10 promoted the proliferation of the bMECs. Kp‐10 promoted the cell cycle transition from G1 to the S and G2 phases, increased the protein levels of Cyclin D1 and Cyclin D3, and reduced the expression levels of the p21 gene. This study also showed that inhibition of G protein‐coupled receptor 54 (GPR54), AKT, mTOR, and ERK1/2 reduced the proliferation of the bMECs that had been induced by Kp‐10. In addition, Kp‐10 decreased the complexes formed by Rb and E2F1 and increased the expression levels of the E2F1 target genes. These results indicate that Kp‐10 promotes bMEC proliferation by activating GPR54 and its downstream signaling pathways. [ABSTRACT FROM AUTHOR]

Mastitis, an inflammation of mammary gland, is a serious disease that affects the health of dairy cows around the world. Myricetin, a flavonoid from Bayberry, has been reported to suppress various inflammatory response. The aim of this study was to evaluate the effect of myricetin on lipopolysaccharide (LPS)‐induced in vivo and in vitro mastitis model and clarify the underlying mechanism. In vivo experiments, myricetin attenuated the severity of inflammatory lesion and neutrophil infiltration. Moreover, myricetin pretreatment induced a significant decrease in the activity of myeloperoxidase (MPO) and the production of TNF‐α, IL‐6, and IL‐1β triggered by LPS. Myricetin pretreatment could also increase the integrity of the blood–milk barrier and upregulate the tight junction proteins in LPS‐induced mice mastitis. In vitro, myricetin inhibited LPS‐induced inflammatory response in mice mammary epithelial cells (mMECs). In the further mechanism studies, we found that the anti‐inflammatory effect of myricetin was mediated by inhibiting LPS‐induced phosphorylation of AKT, IKK‐α, IκB‐α, and P65 in vivo and in vitro. Collectively, these data suggested that myricetin effectively ameliorated the inflammatory response by inhibiting the AKT/IKK/NF‐κB signaling pathway and repairing the integrity of blood–milk barrier in LPS‐induced mice mastitis. [ABSTRACT FROM AUTHOR]

Abstract: Individual differences in young children's frustration responses set the stage for myriad developmental outcomes and represent an area of intense empirical interest. Emotion regulation is hypothesized to comprise the interplay of complex behaviors, such as facial expressions, and activation of concurrent underlying neural systems. At present, however, the literature has mostly examined children's observed emotion regulation behaviors and assumed underlying brain activation through separate investigations, resulting in theoretical gaps in our understanding of how children regulate emotion in vivo. Our goal was to elucidate links between young children's emotion regulation‐related neural activation, facial muscular movements, and parent‐rated temperamental emotion regulation. Sixty‐five children (age 3–7) completed a frustration‐inducing computer task while lateral prefrontal cortex (LPFC) activation and concurrent facial expressions were recorded. Negative facial expressions with eye constriction were inversely associated with both parent‐rated temperamental emotion regulation and concurrent LPFC activation. Moreover, we found evidence that positive expressions with eye constriction during frustration may be associated with stronger LPFC activation. Results suggest a correspondence between facial expressions and LPFC activation that may explicate how children regulate emotion in real time. [ABSTRACT FROM AUTHOR]

In recent years, governing environmental conflicts concerning the planning, construction, and operation of urban facilities has increasingly become a challenge for Chinese local governments. Chinese governments seek adequate responses to deal with these conflicts, for instance by ignoring criticism and sticking to initial decisions, by suppressing protests, or by compromising. In this article, by analysing 10 cases of conflict in China using crisp-set qualitative comparative analysis ( csQCA), we aim to investigate which combinations of diverse conditions lead to changes in local governments' decisions. Four contextualized paths to explain both the presence and the absence of these changes are identified. These findings increase our understanding of the mechanisms underlying the governance of environmental conflicts in China and may inform Chinese governments and non-state actors who are seeking ways to deal adequately with them. [ABSTRACT FROM AUTHOR]

Many studies have investigated the association between CYP1A1 rs1048943 and rs4646903 polymorphisms and laryngeal cancer risk, but their results have been inconsistent. The PubMed and CNKI were searched for case-control studies published up to 01 July 2015. Data were extracted and pooled odds ratios ( OR) with 95% confidence intervals ( CI) were calculated. In this meta-analysis, we assessed 10 published studies involving comprising 748 laryngeal cancer cases and 1558 controls of the association between CYP1A1 rs1048943 and rs4646903 polymorphisms and laryngeal cancer risk. For CYP1A1 rs1048943 of the homozygote G/G and G allele carriers (A/G + G/G) versus A/A, the pooled ORs were 1.77 (95% CI = 1.28-2.81, P = 0.007 for heterogeneity) and 1.86 (95% CI = 1.45-2.40, P = 0.000 for heterogeneity). For CYP1A1 rs4646903 of the homozygote G/G and G allele carriers (A/G + G/G) versus A/A, the pooled ORs were 1.53 (95% CI = 1.31-2.21, P = 0.012 for heterogeneity) and 1.33(95% CI = 1.04-1.71, P = 0.029 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were found among Asians for both the G allele carriers and homozygote G/G. However, no significant associations were found in Caucasian population all genetic models. These results from the meta-analysis suggest that CYP1A1 rs1048943 and rs4646903 polymorphisms contribute to risk of laryngeal cancer among Asian populations. [ABSTRACT FROM AUTHOR]

Governments around the world, when faced with a crisis, struggle to manage various legitimate accountability expectations. Our study investigated how Chinese local governments reconcile social and hierarchical accountability in managing COVID‐19. We found that local governments are generally more responsive to hierarchical than social accountability. Moreover, senior officials are highly unlikely to shirk their duties toward hierarchical accountability when a crisis is severe. Furthermore, crisis severity increases local governments' responsiveness to social accountability. Our study has encircled our understanding regarding the management of multiple accountabilities in crisis. [ABSTRACT FROM AUTHOR]

Leaf‐like V2O5 nanosheets are fabricated by a facile green approach. Used as cathode material for lithium‐ion batteries, this nano‐structured material exhibits superior performance, i.e., high rate capability and good capacity retention upon cycling. Thus, the leaf‐like V2O5 Nanosheets are promising as a cathode material for high power lithium batteries. [ABSTRACT FROM AUTHOR]

A facile and efficient strategy for preparing well dispersed graphene oxide (GO)- co-Poly(phenylene benzobisoxazole) (PBO) copolymer fibers was carried out by direct in situ polycondensation of composite inner salts. The composite inner salts were achieved to improve the dispersivity, solubility, reactivity, and interfacial adhesion of GO in PBO polymer matrix. The structure and morphology of GO- co-PBO copolymer fibers have been characterized. It was demonstrated that GO were covalently incorporated with PBO molecular chains and dispersed considerably well in PBO fiber even the GO reach to 3 wt %. Meanwhile, the tensile modulus, tensile strength and thermal stability of GO- co-PBO copolymer fibers increased considerably with GO. The mechanism and theoretical calculation of GO enhanced PBO fiber were also discussed. The main reasons for the improvement on performance of PBO fiber should be attributed to good dispersion GO in PBO matrix and covalent bonding networks at the interface between GO and PBO molecular chains. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013 [ABSTRACT FROM AUTHOR]

Although the genus Sycophila has broad host preferences, some species are specifically associated with figs as nonpollinator wasps. Because of their sexual dimorphism, morphological plasticity, cryptic mating behaviour and poorly known biology, species identifications are often uncertain. It is particularly difficult to match conspecific females and males. In this study, we employed two molecular markers, mitochondrial COI and nuclear ITS2, to identify Sycophila from six Chinese fig species. Morphological studies revealed 25 female and male morphs, while sequence results for both genes were consistent in supporting the presence of 15 species, of which 13 were host specialists and two used dual hosts. A single species of Sycophila was respectively found on four fig species, but six species were isolated from Ficus benjamina and a same number was reared from Ficus microcarpa. Sequence results revealed three male morphs in one species and detected two species that were overlooked by morphological analysis. [ABSTRACT FROM AUTHOR]

Nanozymes present promising alternatives to natural enzymes, but controlling nanozymes' performance and employing them for selectively removing antibiotics are extremely challenging. Employing theoretical calculations to design the coordination environments of mental and coordination atoms for directing single‐atom nanozymes synthesis emerges as a promising strategy to enhance their efficiency and selectivity in antibiotic elimination. In this study, the peroxidase‐like specificity of iron single‐atom nanozymes (FeSA‐Nx, x = 2,3, and 4) with specific Fe–N coordination numbers is demonstrated based on theoretical calculations. These calculations guide the synthesis of corresponding ultra‐thin FeSA‐Nx, achieving a high degree of consistency between theoretical predictions and experimental results. FeSA‐N3 with a Fe─N3 coordination number proves to be the most effective. The efficient electron transfer from Fe─N3 site to H2O2 reduces the free energy required for •OH generation. Quantitative structure‐activity relationship (QSAR) analysis reveals a strong positive correlation between degradation efficiency of cephalosporins and their electron‐donating capabilities (R2 = 0.820–0.929), realizing selectively eliminating cephalosporins. Integration FeSA‐N3 into ceramic membrane (FeSA‐N3/CM) improves hydrophilicity, achieving continuous and stable removal of cephalosporin. This study provides valuable insights into coordination number regulating nanozyme properties for selective antibiotics removal and offers novel perspectives for FeSA‐N3 application in integrated systems. [ABSTRACT FROM AUTHOR]