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Quantum dot light‐emitting diodes (QLEDs) is one of the most important components in the display field, and different structures have a certain impact on the final performance of the device. Previous QLEDs mainly use ZnO nanocrystals as the electron transport layer (ETL), but the chemical activity of ZnO nanocrystals under electric fields and moisture is not stable enough. To solve this problem, this paper studies the effects of TiO2 films with different thicknesses on the luminescence, current density and external quantum efficiency of QLED devices by using magnetron sputtered TiO2 as a new ETL. The experimental results show that the 50nm TiO2 film achieves the highest external quantum efficiency while maintaining favorable current density and brightness. [ABSTRACT FROM AUTHOR]

This paper introduces a flexible and uniformly‐dispersed quantum dot (QD) color filter (QDCF) fabricated for micro‐LED by photolithography. We studied the condition of PET films and concentration of QDs, the optimized QDCF exhibited high quantum yield (QY) up to over 70%, and a high optical density (OD) over 1.2. The QY increased and then decreased with the increase of the concentration. [ABSTRACT FROM AUTHOR]

In this report, ZnSeTe‐based blue bottom‐emitting quantum dot light‐emitting diodes (QLEDs) with optical microcavity design were demonstrated. The microcavity is formed by the top reflective Ag electrode and the bottom semi‐transparent multilayer electrode, ITO/Ag/ITO. The conventional normal QLED device structure is sandwiched between microcavity. The results show the full width at half maximum (FWHM) of the device emission spectrum is reduced to 50% compared to the device without microcavity, and the tail at longer emission wavelengths is notably suppressed. [ABSTRACT FROM AUTHOR]

Quantum dot light‐emitting diodes (QLEDs) have recently demonstrated great potential for next‐generation displays. By optimizing the device structure and film thicknesses, we achieved top‐emitting QLED devices with good performance metrics, including high brightness, efficiency, and low turn‐on voltage. Furthermore, we successfully fabricated single‐color active‐matrix quantum dot light emitting diode (AMQLED) micro display devices by integrating QLED with a Complementary Metal–Oxide– Semiconductor (CMOS) backplane. These devices exhibit high resolution, brightness, and image quality, underscoring the significant commercial value of QLED micro display devices in head‐mounted augmented reality/virtual reality (AR/VR) systems. [ABSTRACT FROM AUTHOR]

We report a 0.39‐in. quantum dot light‐emitting diode (QLED) microdisplay with full high‐definition (FHD, 1920 × 1080) resolution by integrating a red top‐emitting QLED on a complementary metal–oxide–semiconductor (CMOS) backplane. By optimizing the microcavity structure and constructing a suitable energy‐level structure for the QLED devices, the performance of the large‐area (4.9 × 8.7 mm2) top‐emitting device with normal structure reached 13,936 cd/m2 of brightness at 5‐V bias with 13.3% external quantum efficiency (EQE). Notably, the optimal device showed a low turn‐on voltage of 1.7 V, which matched well the voltage output of the CMOS backplane. Our work demonstrates the great promise of QLED microdisplays for applications in head‐mounted augmented reality/virtual reality (AR/VR). [ABSTRACT FROM AUTHOR]

Inkjet printing as an effective patterning deposition technology is very suitable for the fabrication of quantum dot light‐emitting diodes in next‐generation displays. However, there are still many challenges in achieving high efficiency and stability of the printed device. Herein, we reported the inkjet‐printed quantum dot light‐emitting diodes with an external quantum efficiency of over 20% and half lifetime at 1000 cd/m2 of 27,000 h for the first time. Such excellent performance is owing to the successfully optimal thickness (seven monolayers) of the extra ZnS shell, which improves the balance of the carries injection to suppress the nonradiative process for inkjet‐printed devices. Overall, this performance from inkjet‐printed quantum dot light‐emitting diodes accelerates the printed device to meet the requirements of practical display and lighting applications. [ABSTRACT FROM AUTHOR]

This article discusses the aging behavior of Quantum Dot Light-Emitting Diodes (QLEDs) that use sputtered TiO2 as the Electron Transport Layer (ETL). The authors explain that while there have been advancements in improving the efficiency and lifetime of QLEDs, controlling and predicting device characteristics during storage and operation remains challenging. To address this issue, the authors introduced a sputtered TiO2 film as an alternative ETL, which offers promise in resolving these challenges. The findings indicate that devices incorporating a sputtered TiO2 film as the ETL exhibit a controllable and predictable aging curve, with a lower acceleration factor compared to conventional QLEDs. [Extracted from the article]

Nowadays, there is an increasing demand of healthier plant calcium supplements. Moringa oleifera leaves (MOL) are rich in calcium and thus are promising candidates for developing efficient calcium supplements. Here, using fermentation‐based approaches, we developed a Moringa oleifera leaf ferment (MOLF), which contents higher levels of calcium. The therapeutic potential of the MOLF was also examined both in vitro and in vivo. Nine lactic acid bacteria and four yeasts were tested for better fermentation of MOL. Calcium‐deficient rats were used for evaluating the therapeutic effects of MOLF. The results of liquid fermentation showed that the mixture of Lactobacillus reuteri, Lactobacillus acidophilus, and Candida utilis elevated the content of MOL calcium most strikingly, with the content of calcium increased nearly 2.4‐fold (from 2.08% to 4.90%). The resulting MOLF was then subjected to cell experiments and animal experiments. The results showed that calcium absorption in Caco‐2 cells in MOLF group was higher than that in CaCl2 group significantly. Interestingly, in calcium‐deficient rats, MOLF treatment significantly increased the thickness of cortical bone, rat body weight, wet weight of the femur, and the femur bone density, whereas it decreased osteoclast numbers. These results indicate that microbial fermentation increased calcium bioavailability of MOL, promote the growth and development of calcium‐deficient rats, bone calcium deposition, and bone growth; enhance bone strength; reduce bone resorption; and prevent calcium deficiency. [ABSTRACT FROM AUTHOR]

Using blue Micro‐LED back light and red‐green quantum dot (QD) color converter (QDCC) is a full color display technology with great potential to achieve high resolution, color purity and luminous efficiency. In this work, we try a new method of ligands exchange, using 3‐Mercaptopropionic acid (MPA) ligands with two functional groups to treat QDs in the liquid phase. The modified QDs can be sufficiently dispersed in the negative‐tone molecular resists. In our current process, the pixel size can be reduced to 5 fim and the large‐area ultra‐high‐resolution QDCC with great uniformity is realized. [ABSTRACT FROM AUTHOR]

Hepatic veno-occlusive disease (HVOD), one serious complication following hematopoietic stem cell transplantation (HSCT), is mainly initiated by the damage to sinusoidal endothelial cells and hepatocytes. Long non-coding RNAs (lncRNAs) play an important role in the proliferation of hepatocytes and liver regeneration. lncRNAs profile in hepatocytes post-HSCT remains unclear. The aim of this study is to evaluate the profile of lncRNAs in hepatocytes of mice after HSCT. Mice HSCT model was established through infusion of 5 × 106 bone marrow mononuclear cells. On day 7, 14 and 33 after HSCT, mice were sacrificed for analysis of liver pathology, function and index. Total RNA was extracted from hepatocytes of mice on day 14 for microarray analysis of the expression profiles of lncRNAs by Arraystar Mouse lncRNA Microarray v2.0. Obvious edema and spotty necrosis of hepatocytes with inflammatory cells infiltration were observed post-HSCT. Meanwhile, increased levels of alkaline phosphatase, aspartate transaminase, and total bilirubin, as well as elevated liver index were also found. 2,918 up-regulated and 1,911 down-regulated lncRNAs in hepatocytes were identified. Some of differentially expressed mRNAs had adjacent lncRNAs that were also significantly dysregulated, with the same dysregulation direction. T-cell receptor (up-regulation) and VEGF signaling pathway (down-regulation) were identified as one of the most enriched pathways. Dysregulated lncRNAs might be involved in hepatocytes damage after HSCT, suggesting targeting them might be a novel approach in amelioration of hepatocytes damage. © 2016 IUBMB Life, 68(3):232-241, 2016 [ABSTRACT FROM AUTHOR]

Relapsed/refractory multiple myeloma patients with extramedullary disease (EMD) have unfavorable prognosis and lack effective therapy. Chimeric antigen receptor (CAR) T-cell activities in EMD have yet to be determined; how EMD-specific microenvironment influences the clinical outcomes of CAR T-cell therapy remains of great interest. In this prospective cohort study, patients with histologically confirmed extra-osseous EMD were enrolled and treated with combined anti-BCMA and anti-CD19 CAR T-cell therapy from May 2017 to September 2023. Thirty-one patients were included in the study. Overall response occurred in 90.3% of medullary disease and 64.5% of EMD (p = .031). Discrepancies in treatment response were noted between medullary and extramedullary diseases, with EMD exhibiting suboptimal and delayed response, as well as shortened response duration. With a median follow-up of 25.3 months, the median progression-free and overall survival were 5.0 and 9.7 months, respectively. Landmark analysis demonstrated that progression within 6 months post-infusion is strongly associated with an increased risk of death (HR = 4.58; p = .029). Compared with non-EMD patients, patients with EMD showed inferior survival outcomes. Unique CAR-associated local toxicities at EMD were seen in 22.6% patients and correlated with the occurrence and severity of systemic cytokine release syndrome. To the cutoff date, 65% treated patients experienced EMD progression, primarily in the form of BCMA + progression. The pretherapy EMD immunosuppressive microenvironment, characterized by infiltration of exhausted CD8 + T cells, was associated with inferior clinical outcomes. CAR T cells have therapeutic activity in relapsed/refractory EMD, but the long-term survival benefits may be limited. EMD-specific microenvironment potentially impacts treatment. Further efforts are needed to extend EMD remission and improve long-term outcomes., (© 2024 Wiley Periodicals LLC.)