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Abstract: In this chapter, we describe the legal parameters in which sexual misconduct adjudication processes take place and highlight both noteworthy pitfalls and promising practices. [ABSTRACT FROM AUTHOR]

Phosphorylation of l-serine-containing enkephalin analogs has been explored as an alternative to glycosylation in an effort to increase blood-brain barrier permeability and CNS bioavailability of peptide pharmacophores. Two enkephalin-based peptides were modified for these studies, a set related to DTLES, a mixed μ/δ-agonist, and one related to DAMGO, a highly selective μ-agonist. Each unglycosylated peptide was compared to its phosphate, its mono-benzylphosphate ester, and its β- d-glucoside. Binding was characterized in membrane preparations from Chinese hamster ovary cells expressing human μ, δ and κ-opiate receptors. Antinociception was measured in mice using the 55 °C tail-flick assay. To estimate bioavailability, the antinociceptive effect of each opioid agonist was evaluated after intracerebroventricular (i.c.v.) or intravenous administration (i.v.) of the peptides. Circular dichroism methods and high-field nuclear magnetic resonance were used in the presence and absence of sodium dodecylsulfate to understand how the presence of a membrane might influence the peptide conformations. [ABSTRACT FROM AUTHOR]

A series of μ-agonist DAMGO analogs were synthesized and pharmacologically characterized to test the ‘biousian’ hypothesis of membrane hopping. DAMGO was altered by incorporating moieties of increasing water solubility into the C-terminus via carboxamide and simple glycoside additions. The hydrophilic C-terminal moieties were varied from glycinol in DAMGO ( 1) tol-serine amide ( 2),l-serine amide β-d-xyloside ( 3),l-serine amide β-d-glucoside ( 4), and finally tol-serine amide β-lactoside ( 5). Opioid binding and mouse tail-flick studies were performed. Antinociceptive potency (intravenous) increased, passing through a maximum (A50 ≈ 0.2 μmol/kg) for 2 and 3 as membrane affinity versus water solubility became optimal, and dropped off (A50 ≈ 1.0 μmol/kg) for 4 and 5 as water solubility dominated molecular behavior. Intravenous A50 values were plotted versus hydrodynamic values (glucose units, g.u.) for the glycoside moieties, or the hydrophilic/hydrophobic Connolly surface areas (A50 versus e−Awater/Alipid), and provided either a V-shaped or a U-shaped curve, as predicted by the ‘biousian’ hypothesis. The μ-selective receptor profile was maintained ( Ki’s = 0.66–1.3 nm) upon modifications at the C-terminus. The optimal ‘degree of glycosylation’ for the DAMGO peptide message appears to be between 1.25 and 1.75 g.u. (hydrodynamic g.u.), or 0.75 and 0.90 in terms of the surface-derived amphipathicity values. [ABSTRACT FROM AUTHOR]

An increasingly litigious environment, combined with a renewed interest in spirituality, makes it imperative for higher education officials to be cognizant of the legal implication of two competing fundamental rights. [ABSTRACT FROM AUTHOR]

This chapter examines the Millennial generation's implications for the design and delivery of student affairs programs and services. The unique characteristics of the Millennial students offer insights into the programs and services that this generation of college students will want and need. [ABSTRACT FROM AUTHOR]

Investigates the development of communities which are based on the mutual principles of justice and personal responsibility, in higher education in the United States. Benefits of community-based movements; Improvement of personal responsibility; Discussion on the campus judicial systems.