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25 results on '"Kufner, Sebastian"'

1. Aspirin loading and coronary no‐reflow after percutaneous coronary intervention in patients with acute myocardial infarction.

Author

Ndrepepa, Gjin, Cassese, Salvatore, Xhepa, Erion, Joner, Michael, Sager, Hendrik B., Kufner, Sebastian, Laugwitz, Karl‐Ludwig, Schunkert, Heribert, and Kastrati, Adnan

Subjects
MYOCARDIAL infarction, PERCUTANEOUS coronary intervention, ASPIRIN, DRUG-eluting stents, BLOOD flow
Abstract

Background: The association of aspirin loading with the risk of coronary no‐reflow (CNR) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has not been investigated. We assessed the association of aspirin loading before PCI with CNR in patients with AMI. Materials and Methods: This study included 3100 patients with AMI undergoing PCI. Of them, 2812 patients received aspirin loading (a single oral [or chewed] or intravenous dose of 150–300 mg) and 288 patients did not receive aspirin loading before PCI. The primary endpoint was CNR, defined as Thrombolysis in Myocardial Infarction blood flow grade of <3 after the PCI. Results: CNR occurred in 130 patients: 127 patients in the group with aspirin loading and 3 patients in the group without aspirin loading before PCI (4.5% vs. 1.0%; odds ratio [OR] = 4.50, 95% confidence interval, [1.42–14.21], p = 0.005). After adjustment, the association between aspirin loading and CNR was significant (adjusted OR = 4.49 [1.56–12.92]; p < 0.001). There was no aspirin loading‐by‐P2Y12 inhibitor (ticagrelor or prasugrel) interaction (pint = 0.465) or aspirin loading‐by‐chronic aspirin therapy on admission (pint = 0.977) interaction with respect to the occurrence of CNR after PCI. Chronic low‐dose aspirin therapy on admission was not independently associated with higher risk of CNR after PCI (adjusted OR = 1.06 [0.65–1.72]; p = 0.824). Conclusion: In patients with AMI undergoing PCI, aspirin loading before the PCI procedure at the guideline‐recommended doses was associated with higher odds of developing CNR. However, due to the limited number of events, the findings should be considered as hypothesis generating. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Iliofemoral artery predilation prior to transfemoral transcatheter aortic valve implantation in patients with aortic valve stenosis and advanced peripheral artery disease.

Author

Alvarez‐Covarrubias, Hector A., Joner, Michael, Cassese, Salvatore, Warmbrunn, Mairead, Lutz, Jannik, Trenkwalder, Teresa, Seguchi, Masaru, Aytekin, Alp, Presch, Antonia, Pellegrini, Constanza, Rheude, Tobias, Patrick Mayr, N., Kufner, Sebastian, Schunkert, Heribert, Kastrati, Adnan, and Xhepa, Erion

Published
2023
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4. Prior Myocardial Infarction and Treatment Effect of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndromes - A Post-hoc Analysis of the ISAR- REACT 5 Trial.

Author

Lahu, Shqipdona, Scalamogna, Maria, Ndrepepa, Gjin, Menichelli, Maurizio, Valina, Christian, Hemetsberger, Rayyan, Witzenbichler, Bernhard, Bernlochner, Isabell, Joner, Michael, Xhepa, Erion, Hapfelmeier, Alexander, Kufner, Sebastian, Sager, Hendrik B., Mayer, Katharina, Kessler, Thorsten, Laugwitz, Karl-Ludwig, Richardt, Gert, Schunkert, Heribert, Neumann, Franz-Josef, and Kastrati, Adnan

Published
2022
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5. Stent Optimization Using Optical Coherence Tomography and Its Prognostic Implications After Percutaneous Coronary Intervention.

Author

Rai, Himanshu, Harzer, Fiona, Tatsuhiko Otsuka, Abdelwahed, Youssef S., Antuña, Paula, Blachutzik, Florian, Koppara, Tobias, Räber, Lorenz, Leistner, David M., Alfonso, Fernando, Nef, Holger, Masaru Seguchi, Aytekin, Alp, Xhepa, Erion, Kufner, Sebastian, Cassese, Salvatore, Laugwitz, Karl-Ludwig, Byrne, Robert A., Kastrati, Adnan, and Joner, Michael

Published
2022
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7. A prospective trial of a novel low‐dose paclitaxel‐coated balloon therapy in patients with restenosis in drug‐eluting coronary stents Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In‐stent REstenosis 3A (ISAR‐DESIRE 3A)

Author

Kufner, Sebastian, Rai, Himanshu, Wiebe, Jens, Altevogt, Felix, Pyxaras, Stylianos, Joner, Michael, Xhepa, Erion, Cassese, Salvatore, Colleran, Roisin, Schunkert, Heribert, Zrenner, Bernhard, Kastrati, Adnan, and Byrne, Robert A.

Published
2022
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8. Prognostic value of haemoglobin drop in patients with acute coronary syndromes.

Author

Ndrepepa, Gjin, Neumann, Franz‐Josef, Menichelli, Maurizio, Holdenrieder, Stefan, Richardt, Gert, Mayer, Katharina, Cassese, Salvatore, Xhepa, Erion, Kufner, Sebastian, Wiebe, Jens, Joner, Michael, Kessler, Thorsten, Laugwitz, Karl Ludwig, Schunkert, Heribert, and Kastrati, Adnan

Subjects
ACUTE coronary syndrome, HEMOGLOBINS, PROGNOSIS, MORTALITY, HOSPITAL admission & discharge
Abstract

Background: The prognostic value of in‐hospital haemoglobin drop in patients with acute coronary syndrome (ACS) undergoing invasive therapy remains insufficiently investigated. Materials and Methods: This observational study included 3838 patients with ACS with admission and in‐hospital nadir haemoglobin values available. Haemoglobin drop was defined as a positive difference between admission and nadir haemoglobin values. The primary endpoint was one‐year all‐cause mortality. Results: In‐hospital haemoglobin drop occurred in 3142 patients (82%). Patients were categorized into 4 groups: no haemoglobin drop (n = 696 patients), <3 g/dl haemoglobin drop (n = 2703 patients), 3 to <5 g/dl haemoglobin drop (n = 344 patients) and ≥5 g/dl haemoglobin drop (n = 95 patients). The primary endpoint occurred in 156 patients: 17 patients (2.5%) in the group with no haemoglobin drop, 81 patients (3.0%) in the group with <3g/dl haemoglobin drop, 37 patients (10.9%) in the group with 3 to <5 g/dl haemoglobin drop and 21 patients (22.2%) in the group with ≥5 g/dl haemoglobin (adjusted hazard ratio [HR] = 1.30, 95% confidence interval 1.17 to 1.45; p <.001 for one g/dl haemoglobin drop). The association of haemoglobin drop with one‐year mortality remained significant after exclusion of patients with in‐hospital overt bleeding (adjusted HR = 1.27 [1.11–1.46]; p <.001 for one g/dl haemoglobin drop). The lowest haemoglobin drop associated with mortality was 1.23 g/dl in all patients (HR = 1.03 [1.02–1.04]) and 1.13 g/dl in patients without overt bleeding (HR = 1.03 [1.01–1.04]). Conclusions: In patients with ACS, in‐hospital haemoglobin drop was associated with higher risk of one‐year mortality even in the absence of overt bleeding. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes.

Author

Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Bernlochner, Isabell, Richardt, Gert, Wöhrle, Jochen, Witzenbichler, Bernhard, Mayer, Katharina, Cassese, Salvatore, Gewalt, Senta, Xhepa, Erion, Kufner, Sebastian, Sager, Hendrik B., Joner, Michael, Ibrahim, Tareq, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, and Kastrati, Adnan

Published
2021
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11. Ten-Year Clinical Outcomes of Biodegradable Versus Durable Polymer New-Generation Drug-Eluting Stent in Patients With Coronary Artery Disease With and Without Diabetes Mellitus.

Author

Lenz, Tobias, Koch, Tobias, Joner, Michael, Xhepa, Erion, Wiebe, Jens, Coughlan, J. J., Aytekin, Alp, Ibrahim, Tareq, Fusaro, Massimiliano, Cassese, Salvatore, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Kastrati, Adnan, Kufner, Sebastian, and ISAR‐TEST 4 (Intracoronary Stenting, Angiographic Results: Test Efficacy of 3 Limus‐Eluting Stents) Investigators †

Published
2021
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20. Long-term prognostic value of risk scores after drug-eluting stent implantation for unprotected left main coronary artery: A pooled analysis of the ISAR-LEFT-MAIN and ISAR-LEFT-MAIN 2 randomized clinical trials.

Author

Xhepa, Erion, Tada, Tomohisa, Kufner, Sebastian, Ndrepepa, Gjin, Byrne, Robert A., Kreutzer, Johanna, Ibrahim, Tareq, Tiroch, Klaus, Valgimigli, Marco, Tölg, Ralf, Cassese, Salvatore, Fusaro, Massimiliano, Schunkert, Heribert, Laugwitz, Karl L., Mehilli, Julinda, and Kastrati, Adnan

Published
2017
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22. Procedure-related bleeding in elective percutaneous coronary interventions.

Author

Ndrepepa, Gjin, Stephan, Tilman, Fiedler, Katrin Anette, Guerra, Elena, Kufner, Sebastian, and Kastrati, Adnan

Subjects
CORONARY disease, HEMORRHAGE, MORTALITY, HEALTH risk assessment, HEART disease complications
Abstract

Background Prognostic impact of procedure-related bleeding in patients with stable coronary artery disease ( CAD) undergoing elective percutaneous coronary intervention ( PCI) remains incompletely investigated. The aim of this study was to investigate the association between peri- PCI bleeding and 1-year outcome of patients with stable CAD. Materials and methods The study included 9035 patients with stable CAD who underwent elective PCI. Bleeding within 30 days of PCI was defined using the Bleeding Academic Research Consortium ( BARC) criteria. The primary outcome was 1-year mortality. Results Bleeding occurred in 844 patients (9·3%). Actionable bleeding ( BARC class ≥ 2) occurred in 442 patients (4·9%). There were 210 deaths (2·3%) at 1 year following PCI: 41 deaths among patients with bleeding and 169 deaths among patients without bleeding [Kaplan-Meier estimates of mortality, 4·9% and 2·1%; odds ratio = 2·41, 95% confidence interval ( CI) 1·73-3·36, P < 0·001]. The association between bleeding and mortality remained significant after adjustment for baseline risk variables (adjusted hazard ratio = 1·87, 95% CI 1·27-2·76, P = 0·002). Bleeding increased the discriminatory power of the model regarding prediction of 1-year mortality (absolute and relative integrated discrimination improvement, 0·006% and 16·3%, respectively, P = 0·001). Conclusions In patients with stable CAD undergoing elective PCI, the occurrence of bleeding within 30 days of the procedure was associated with increased risk of death at 1 year after PCI. These findings suggest that procedure-related bleeding may contribute to less than optimal results of PCI in terms of mortality reduction in patients with stable CAD. [ABSTRACT FROM AUTHOR]

Published
2015
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