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To the Editor, Mastocytosis is a complex disease characterized by aberrant expansion and accumulation of clonal mast cells at tissue sites including the skin, bone marrow and gastrointestinal (GI) tract. Seventy per cent of the mastocytosis cohort were female, 75% had characteristic cutaneous lesions of mastocytosis (urticaria pigmentosa), only 3 patients had disease involvement limited to the skin and low tryptase (7.7, 8.4, and 12.5 ng/ml), while the majority (84%) met criteria for indolent systemic mastocytosis (ISM).1 The median tryptase was 41.5 ng/ml (1.1-894, range) and 83% of patients were positive for the D816V KIT mutation. Elevated level of sCD14 and LPS has been reported in patients with HIV and inflammatory bowel disease5 and is reported to be indicative of disease activity and prognosis. [Extracted from the article]