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We examined the efficacy and adverse events of continuous l‐asparaginase administration in dogs with large cell lymphoma of presumedgastrointestinal (GI) origin. We retrospectively reviewed medical records of dogs with large cell lymphoma of presumed GI origin treated with continuous l‐asparaginase administration from 2009 to 2018. We collected information on the signalment, lesion site, complete blood count, serum biochemical profile, diagnostic imaging findings, cytological and histopathological findings, immunophenotype, l‐asparaginase administration frequency, treatment response, adverse events, rescue protocol, and patient outcomes. Clinical outcomes were assessed using medical records or by contacting the owner or referring veterinarian. Thirty‐two dogs with large cell lymphoma of presumed GI origin received weekly l‐asparaginase administration. The median number of l‐asparaginase injections was seven (range: 1–30). Although two of the 32 dogs had GI toxicity of grade 3 or higher, none developed a hypersensitivity reaction. The response rate based on ultrasonographic findings was 18/32 (56%) and that based on clinical signs was 30/32 (94%). The median overall progression‐free survival was 50 days (range: 2–214 days), and median overall survival was 147 days (range: 2–482 days). Adverse events associated with continuous l‐asparaginase administration were rare. Clinical signs at diagnosis improved in most cases. Based on these results, continuous l‐asparaginase administration appears to be a reasonable treatment option for dogs with large cell lymphoma of presumed GI origin. [ABSTRACT FROM AUTHOR]

A 9‐month‐old intact crossbred female cat was presented with jaundice, intermittent anorexia and lethargy, increased hepatic enzyme activities, and hyperammonemia. Abdominal ultrasound and computed tomographic examinations determined that the liver had a rounded and irregular margin, and histopathological examination identified excessive accumulation of copper hepatocytes in the liver. Concentrations of both blood and urine copper were higher than in healthy cats. The patient responded well to treatment with penicillamine. Clinicopathological abnormalities and clinical signs improved within 2 months, and the patient was alive for >9 months after starting treatment. Genetic examination determined that the patient and its littermate had a single‐nucleotide variation (SNV, p. T1297R) that impaired the function of the ATP7B gene product; the gene that is mutated in patients with Wilson's disease (WD). Hepatic copper accumulation was believed to be associated with the SNV of the ATP7B gene, and the patient had a genetic disorder of copper metabolism equivalent to WD in humans. [ABSTRACT FROM AUTHOR]

Background Stroke volume ( SV) in trained athletes continuously increases with progressive exercise intensity. We studied whether physical training affected left ventricle ( LV) function response to exercise using 3D echocardiography and tissue Doppler imaging ( TDI). Methods Eleven male university athletes and 12 male university nonathletes were enrolled in this study. After baseline data were collected, subjects performed a symptom-limited supine bicycle ergometer exercise test. Initial workload was 25 Watts (W) and increased 25 W every 3 minutes. At rest and every exercise stage, LV end-systolic and diastolic volume index ( LVEDVI and LVESVI), SV index ( SVI), cardiac index ( CI), LV ejection fraction ( LVEF), and early lateral mitral flow velocity (Ea) were evaluated. Heart rate ( HR), and systolic and diastolic blood pressure ( SBP and DBP) were continuously recorded. Results Nonathletes showed a slow increase in CI, and SVI reached a plateau value at a HR of 90 beats per minute (bpm). In contrast, CI and SVI increased progressively and continuously in athletes. Both CI and SVI were significantly higher in athletes than in nonathletes at HRs of 100, 110, and 120 bpm. LVEDVI kept increasing in athletes while it plateaued in nonathletes. In contrast, LVESV decreased continuously during exercise in both groups. There was no significant difference in LVEF, Ea, SBP, or DBP at rest and during exercise between the two groups. Conclusion LV responses to exercise in athletes were different from those of in nonathletes; thus, habitual physical training may play an important role in the increase in both SVI and CI in young individuals. [ABSTRACT FROM AUTHOR]