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A 10‐year‐old golden retriever was presented for the evaluation of exercise intolerance. Physical examination and laboratory tests showed no abnormalities except for mild anaemia. Standard transthoracic echocardiography revealed dilated coronary sinus, raising suspicion of a persistent left cranial vena cava, and the persistency of this anomaly was confirmed by agitated‐saline study. Right ventricular echocardiographic parameters did not change significantly, while conventional parameters and global longitudinal strain analysis revealed left ventricular systolic dysfunction. Moreover, post‐systolic shortening and early systolic lengthening were detected by two‐dimensional speckle tracking echocardiography. This report shows that post‐systolic shortening and early systolic lengthening may be useful diagnostic markers indicating regional left ventricular systolic dysfunction. Further studies are needed to elucidate whether persistent left cranial vena cava contributes to left ventricular systolic dysfunction or is an accidental benign finding in dogs. [ABSTRACT FROM AUTHOR]

OBJECTIVES To study changes in serum C-reactive protein, haptoglobin, ceruloplasmin and albumin concentration, total anti-oxidant capacity and paraoxonase-1 and butyrylcholinesterase activity in dogs with parvoviral enteritis of different degrees of clinical severity. METHODS Prospective study of 9 healthy and 43 dogs with parvoviral enteritis that were classified into mildly, moderately and affected groups. RESULTS Dogs with parvoviral enteritis had a significant increase in C-reactive protein compared with healthy dogs, with an increase of higher magnitude in animals with more severe clinical signs. All dogs with parvoviral enteritis had a significant increase in haptoglobin concentration compared with healthy dogs, but with no difference according to disease severity. There was a decrease in paraoxonase-1 activity in parvoviral enteritis. CLINICAL SIGNIFICANCE Major increases of C-reactive protein concentrations in dogs with parvoviral enteritis are a marker of disease severity. In addition, higher values for anti-oxidants in severe cases compared with mild and moderate cases suggest a possible compensatory anti-oxidant mechanism. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the acute-phase protein response in dogs with parvoviral enteritis as predictor of the clinical outcome. Methods: Canine parvovirus infection was diagnosed based on the compatible clinical findings and confirmed by the canine parvovirus antigen test in 43 dogs of less than six months of age. Blood samples for complete blood cell count and acute-phase proteins (C-reactive protein, haptoglobin, ceruloplasmin and albumin) were collected before treatment. Twenty-three dogs died during or after treatment (non-survival) and the rest recovered (survival). Five healthy dogs were enrolled as control. Results: Serum C-reactive protein, ceruloplasmin and haptoglobin levels in dogs with parvoviral enteritis were higher (P<0·001, P<0·01 and P<0·001, respectively), but serum albumin was lower (P<0·001) than those in controls. Mean C-reactive protein and ceruloplasmin values in non-survival were higher (P<0·01) than those for survival dogs. C-reactive protein was found to be superior to ceruloplasmin, haptoglobin and albumin for distinguishing survival from non-survival dogs. Values higher than 92·4 mg/l for C-reactive protein had a sensitivity of 91% to predict mortality. Clinical Significance: The magnitude of the increase in serum acute-phase proteins in dogs with parvoviral enteritis could be a useful indicator of the prognosis of the disease. In acute-phase proteins, C-reactive protein is a potent predictor of mortality in dogs with parvoviral enteritis. [ABSTRACT FROM AUTHOR]