1. Prediction scores based on neonatal inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates.
- Author
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Yoshimatsu, Hidetaka, Iwai, Masanori, Kitabatake, Yasuji, Ozono, Keiichi, and Nakamura, Kimitoshi
- Subjects
CHORIOAMNIONITIS ,GESTATIONAL age ,LEUKOCYTE count ,NEWBORN infants ,UMBILICAL cord ,INFLAMMATION - Abstract
Aim: The aim of the study was to examine the predictive value of inflammatory markers for chorioamnionitis and funisitis in extremely low gestational age neonates. Methods: According to the Redline histopathological classification, extremely low gestational age neonates were classified into: (1) maternal inflammatory response ≤1 or ≥2, based on inflammatory findings of the placenta and (2) foetal inflammatory response ≤1 or ≥2, based on inflammatory findings of the umbilical cord. On admission and 12–36 h postnatally, procalcitonin and high‐sensitivity C‐reactive protein levels and white blood cell and neutrophil counts were compared. For both maternal and foetal inflammatory responses ≥2, the predictive value of each inflammatory marker was calculated. Results: On admission, procalcitonin had the best predictive value for maternal and foetal inflammatory response ≥2. The maternal inflammatory response ≥2 prediction score includes procalcitonin level on admission, high‐sensitivity C‐reactive protein level and white blood cell count at 12–36 h postnatally. Foetal inflammatory response ≥2 prediction score includes procalcitonin level and white blood cell count on admission and 12–36 h postnatally. The sensitivities were 96.4% and 96.3%, respectively. Conclusion: Procalcitonin, high‐sensitivity C‐reactive protein levels and white blood cell count provide highly sensitive prediction scores for chorioamnionitis and funisitis in extremely low gestational age neonates. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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