1. Basophil activation test in cancer patient blood evaluating potential hypersensitivity to an anti‐tumor IgE therapeutic candidate.
- Author
-
Bax, Heather J., Khiabany, Atousa, Stavraka, Chara, Pellizzari, Giulia, Chan Wah Hak, Charleen, Robinson, Alexandra, Ilieva, Kristina M., Woodman, Natalie, Naceur‐Lombardelli, Cristina, Gillett, Cheryl, Pinder, Sarah, Gould, Hannah J., Corrigan, Christopher J., Till, Stephen J., Katugampola, Sidath, Barton, Claire, Winship, Anna, Ghosh, Sharmistha, Montes, Ana, and Josephs, Debra H.
- Subjects
- *
BASOPHILS , *HEMATOLOGIC malignancies , *CANCER patients , *ALLERGIES , *DRUG allergy , *MEDICAL sciences - Abstract
Basophil activation test in cancer patient blood evaluating potential hypersensitivity to an anti-tumor IgE therapeutic candidate Keywords: basophils; BAT; IgE; MOv18; ovarian cancer EN basophils BAT IgE MOv18 ovarian cancer 1 5 5 07/29/20 20200801 NES 200801 To the Editor, Monoclonal anti-tumor IgG antibodies are used widely to treat malignancies. These include superior affinity of IgE for cognate Fc receptors and the presence in tumors of effector cell populations (eg, macrophages and mast cells) known to exert anti-tumor activities when activated by IgE. [Extracted from the article]
- Published
- 2020
- Full Text
- View/download PDF