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Accessible summary: We are members of an arts organisation who support the creative talents of people with learning disabilities and autistic people.We have been working on a research project at "The Hub" at Wellcome Collection in a team consisting of academic and nonacademic professionals with diverse abilities.Because of coronavirus, we all had to stay home to stay safe. To carry on with our research project, we participated in 28 creative research meetings on Zoom.In this paper and accompanying video, we will tell you how we did it. We will also tell you how we felt about moving away from "The Hub" and trying to do research remotely from home.We hope our project has shown that people with learning disabilities can transition well to working online when there is trust and mutual respect. Background: As part of "The Hub" project at Wellcome Collection, a team of eight co‐researchers with learning disabilities along academics created an online survey to challenge public understanding of learning disabilities. Using creative and arts‐based methods, co‐researchers remotely co‐analysed the survey results amid COVID‐19 lockdown challenges. Here, we explore our unexpected "transition" journey from the physical "Hub" to the digital space. Methods: We organised 20 sessions at The Hub and used audio/video/photo recordings to capture key moments. With the lockdown, we ensured that every co‐researcher had access to and support for digital technologies. Throughout 2020, we organised 28 Zoom meetings involving all co‐researchers. In June, Lilly (a multi‐media journalist and she lives by the motto striving for equal opportunities for people with disabilities and fairness throughout) and Sue (an independent Leadership Coach and Mentor) conducted Zoom interviews with the co‐research team to reflect on our transition journey. In this creative video‐form submission accompanied by an accessible report, Lilly puts together a story of how we transitioned and felt throughout this process. Findings: We identify that trust and the social bonds established at The Hub are the key components of our transition to the digital environment. There is the tension between longing for in‐person contact and trying to make the most out of the situation to maintain these relationships. At the heart of this is the motivation to "change the world" and strive for social justice. Having time and opportunity to improve, and co‐researchers' steady growth in confidence are equally important. Conclusions: The determination for maintaining friendships among co‐researchers and the motivation to "change the world" overcome COVID‐19‐related challenges in continuing co‐research. [ABSTRACT FROM AUTHOR]

Hepatic cat scratch disease is rarely reported in liver transplant recipients and has never been reported with discrete liver lesions in the graft. A 52-year-old woman was transplanted for hepatitis C cirrhosis and hepatocellular carcinoma. Her posttransplant course was uneventful. She presented 2.7 years after transplantation with fever of unknown origin and went on to develop multiple and diffuse discrete liver lesions. Despite an extensive work-up including percutaneous and laparoscopic biopsies, a subsegmental resection that included one of these masses was required to make the diagnosis of Bartonella henselae infection. Serologic tests were equivocal. Histology was consistent with cat scratch disease of the liver, and polymerase chain reaction (PCR) testing of the resected tissue confirmed the diagnosis. Response to doxycycline was rapid. Fevers resolved within 7 days. Repeat abdominal CT scan showed reduction of the liver masses. Cat scratch disease should be considered in postliver transplant patients presenting with fever and liver lesions, especially if close contact with cats has occurred. Diagnosis by PCR testing of involved tissue is preferred when serologies are equivocal due to immunosuppression. [ABSTRACT FROM AUTHOR]

To evaluate the safety and immunogenicity of unconjugatedHaemophilus influenzaetype b (Hib) polysaccharide (PRP) vaccine and two PRP-protein-conjugated vaccines as a model for the comparison of protein-conjugated versus plain polysaccharide vaccines in the elderly.Randomized, double-blind, prospective study.University-based center for vaccine research and development.A total of 125 adults, aged 64 to 92, who were judged to be in general good health and lacking any significant underlying medical conditions.Subjects were randomized to receive one of three vaccines: Group 1 (n=39), PRP; Group 2 (n=44), PRP conjugated to an outer-membrane protein complex ofNeisseria meningitidis(PRP-OMP); and Group 3 (n=42), PRP conjugated to diphtheria toxoid (PRP-D). Sera were obtained before immunization and 1 and 12 months later.Subjects maintained a diary of injection site and systemic reactions for 3 days after immunization. A radioantigen-binding assay was used to measure total concentrations of serum anticapsular antibody, and an enzyme-linked immunosorbent assay was used to measure immunoglobulin (Ig) G1 and IgG2 anticapsular antibody responses. Antibody functional activity was assessed using a complement-mediated bactericidal assay.Before vaccination, the geometric mean serum anticapsular antibody concentration was 0.8μg/mL, but fewer than 10% of subjects had detectable bactericidal activity (titer>1:4). The magnitude, subclass distribution, and bactericidal activity of antibody responses to unconjugated PRP vaccine were similar to those observed in previous studies of younger adults immunized with PRP. The OMP conjugate, which is highly immunogenic after one dose in 2-month old infants, did not elicit anticapsular antibody responses in the elderly greater than those elicited by PRP vaccine (P=.43). In contrast, the D conjugate, which is poorly immunogenic in 2-month old infants, elicited higher anticapsular antibody responses than PRP vaccine in the elderly (P=.01) and higher levels than the OMP-conjugate 1 year after vaccination (P<.006).Elderly adults develop protective anticapsular antibody responses to unconjugated and conjugated PRP vaccine. The higher anticapsular antibody responses to the D conjugate but not to the OMP conjugate in the elderly, which is the reverse of that observed in immunized infants, implies fundamental differences in the immunological mechanisms by which the two age groups respond to PRP and by which the OMP and D conjugates elicit anticapsular antibody responses. [ABSTRACT FROM AUTHOR]

Deals with the responsibility of the scientific community in providing governments with advice on difficulty problems, especially those involving environmental quality. Objections raised over the renewal of committees that have been important to the nation's health; Origin of the Certainty Principle, a general philosophy of regulation in the U.S.