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Objective: To compare the outcomes for laparoscopic vascular hitch (VH) and dismembered pyeloplasty in patients with pelvi‐ureteric junction obstruction (PUJO) secondary to crossing vessels (CV). Patients and Methods: Patients who underwent laparoscopic management of CV at our institution were identified between 2008 and 2020. Baseline characteristics and outcome measures were compared between those who underwent VH and those who underwent dismembered pyeloplasty. Those who underwent VH were selected intraoperatively by identifying CV in the absence of intrinsic obstruction by assessing resolution of hydronephrosis after cranially displacing the CV away from the PUJ, followed by intraoperative fluid bolus and diuretic test. In addition, a systematic search and meta‐analysis were performed in June 2020 (International Prospective Register of Systematic Reviews [PROSPERO] ID CRD42020195833). Results: A total of 20 patients underwent VH and 74 dismembered pyeloplasty. On multivariate analysis, VH was associated with: shorter operative time (P = 0.001; odds ratio [OR] 0.455, 95% confidence interval [CI] 0.294–0.705) and length of stay (P = 0.012; OR 0.383, 95% CI 0.183–0.803), lower use of stents (P < 0.001; OR 0.024, 95% CI 0.004–0.141) and opioid administration (P = 0.005; OR 0.157, 95% CI 0.044–0.567). From our literature search, 194 records were identified and 18 records were included (three comparative and 16 non‐comparative). Meta‐analysis of the comparative studies and our institutional data showed similar success rates (relative risk [RR] 1.77, 95% CI 0.33–9.52) and complication rates (RR 0.75, 95% CI 0.20–2.82). VH was associated with shorter operative time (standardised mean difference [SMD] −1.65, 95% CI −2.58 to −0.72 h) and hospital stay (SMD −1.41, 95% CI −2.36 to –0.47 days). The VH success rates ranged from 87.5% to 100% in the identified studies. Failure of VH was associated with unrecognised concomitant intrinsic obstruction in addition to CV. Conclusions: A VH, for well‐selected patients with CV without concomitant intrinsic obstruction, offers a high success rate with shorter operative times. [ABSTRACT FROM AUTHOR]

Background: There are two main techniques for arterial reconstruction in RT: TA using a stab longitudinal incision which creates an elliptical opening and AP which fashions a circular defect. We hypothesized that AP creates a natural anastomosis lumen, similar to the donor renal artery, which optimizes RT perfusion. Methods: A retrospective review of a single‐institution database was performed between 2000 and 2018. Twenty patients who underwent AP arteriotomy were compared to 40 TA‐matched controls. Data were collected on creatinine (preoperative, nadir, and time to nadir), and DUS RI and PSV at 1 week, 3 months, and 6‐12 months post‐RT. Results: ttNC was shorter in the AP group (5 ± 4 vs 12 ± 13 days; P =.03). PSV at 1 week was lower in the AP group (186 ± 65 cm/s vs 232 ± 89 cm/s; P =.04). There was no difference in nadir creatinine value (P =.26), preoperative creatinine (P =.66), and initial postoperative creatinine (P =.80). RI at week 1 were not different between groups (P =.37). Follow‐up DUS showed the difference in PSV between groups became non‐significant (1 month P =.50 and 6‐12 months P =.53). Conclusions: AP arteriotomy in RT improves early perfusion and function parameters (ttNC and initial PSV) as compared to TA. AP arteriotomy optimizes early allograft reperfusion, which may have important long‐term implications and deserves further evaluation. [ABSTRACT FROM AUTHOR]

This study assesses if perineural invasion (PNI) detected on biopsy with Gleason score (GS) 3 + 4 = 7 prostate cancer (PCa) is associated with upstaging/upgrading of disease after radical prostatectomy (RP). 154 patients with GS 3 + 4 = 7 PCa diagnosed from biopsy who underwent RP were assessed for PNI. The percentage of biopsy sites with PNI (%PNI) was also calculated. Pattern 4 morphologies (ill-defined glands [IDG], fused, cribriform, and glomerulations) were also assessed. Clinical information, GS and stage after RP were retrieved from the medical records. 45 % (69/154) of patients were upstaged (≥pT3) and 29 % (44/154) were upgraded to GS >3 + 4 = 7 after RP. 37 % (57/154) of patients had PNI which was associated with upstaging (RR 1.4; P = 0.04) but not upgrading (RR 0.9; P = 0.7). There was higher %PNI in upstaged patients (12.1 % ± 1.8 vs. 7.1 % ± 1.5, P = 0.03) with a significant correlation between %PNI and ≥pT3 ( r = 0.178, P = 0.027). After multivariate analysis, only cribriform formations were significantly associated with upstaging ( P = 0.009). The presence of PNI in biopsies with GS 3 + 4 = 7 PCa is associated with upstaging at RP but is a weaker predictor of ≥pT3 disease than cribriform morphology. [ABSTRACT FROM AUTHOR]

Objective: To compare the outcomes of pre‐ vs postnatally diagnosed posterior urethral valves (PUV) at two large paediatric centres in North America to ascertain if the prenatal diagnosis of PUV is associated with better outcomes. Patients and Methods: All boys with PUV were identified at two large paediatric institutions in North America between 2000 and 2020 (The Hospital for Sick Children [SickKids, SK] and Children's Hospital of Philadelphia [CHOP]). Baseline characteristics and outcome measures were compared between those diagnosed pre‐ vs postnatally. Main outcomes of interest included progression of chronic kidney disease (CKD), the need for renal replacement therapy (RRT), and bladder function compromise, as determined by need for clean intermittent catheterisation (CIC). Time‐to‐event analyses were completed when possible. Results: During the study period, 152 boys with PUV were treated at the SK (39% prenatal) and 216 were treated at the CHOP (71% prenatal). At the SK, there was no difference between the pre‐ and postnatal groups in the proportion of boys who required RRT, progressed to CKD Stage ≥3, or who were managed with CIC when comparing the timing of diagnosis. The time to event for RRT and CIC was significantly younger for prenatally detected PUV. At the CHOP, significantly more prenatal boys required RRT; however, there was no significant difference in the age this outcome was reached. The proportion of boys managed with CIC was not different but the time to event was significantly earlier in the prenatal group. Conclusion: This study represents the largest multi‐institutional series of boys with PUV and failed to identify any difference in the outcomes of pre‐ vs postnatal detection of PUV. A multidisciplinary approach with standardisation of the treatment pathways will help in understanding the true impact of prenatal/early detection on outcomes of PUV. [ABSTRACT FROM AUTHOR]