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The article offers information on thioguanine-resistant lymphocytes induced by in vivo irradiation of mice. It is found that the frequency of Hprt-deficient lymphocytes vary as a function of time elapsed after exposure and irradiation dose. It is said that mice were exposed to single doses of 0-400 cGy from cesium-137 or to eight daily doses of 50 cGy. It is mentioned that the fractionation effect and the curvilinearity of the early dose-response curve suggested that saturation of repair increased the yield of mutations at higher acute doses.