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Macrodiversity system with macrodiversity SC receiver and three microdiversity MRC (maximum ratio combining) receivers is considered. Independent k-μ short-term fading and correlated Gamma long-term fading are present at the inputs of microdiversity MRC receivers. For this model, the probability density function and the cumulative density function of microdiversity MRC receivers and macrodiversity SC receiver output signal envelopes are calculated. Influences of Gamma shadowing severity, k-μ multipath fading severity, Rician factor and correlation coefficient at probability density function, and cumulative density function of macrodiversity SC receiver output signal envelopes are graphically presented. [ABSTRACT FROM AUTHOR]

The article discusses the use of the Total Tumour Mass score (TM) system in the evaluation of response of inhibitors of B-cell receptor (BCR) to B-cell chronic lymphocytic leukemia (B-CLL). The advantages of the TTM system include understanding of the tumor burden in major tumor cell compartments, the kinetic response of BCR signaling inhibitor monotherapy and the distribution of tumors and lymphocyte. Other benefits of the system are mentioned.

It is proposed that a locally active, intrinsic renin–angiotensin system (RAS) exists in the bone marrow (BM) and plays a role in regulating haematopoiesis. Angiotensin II type I receptor has been detected on erythroid burst-forming unit-derived cells; its antagonist losartan and angiotensin I-converting enzyme (ACE) inhibitors can suppress erythropoiesis. The possible role of ACE/RAS in BM was investigated by evaluating ACE expression in normal BM, several myeloproliferative disorders and myelodysplasia. Immunohistochemical studies showed that erythroid elements expressed ACE protein in both normal and disturbed haematopoiesis. The presence of ACE in erythroid cells suggests another mechanism for direct ACE inhibitor activity in erythropoiesis. [ABSTRACT FROM AUTHOR]