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Microbiota diversity in patients with Diffuse Large B-Cell Lymphoma and Immune-Privileged Sites Lymphoma There is however still limited knowledge about MB diversity in different lymphoma subtypes especially in large B-cell lymphoma of immune-privileged sites (LBCL-IPS). B Conclusions: b Both lymphoma groups - diffuse large B-cell lymphoma as well as large B-cell lymphoma of immune-privileged sites - are characterized by unique microbiota composition. [Extracted from the article]

Purpose Interleukin-6 (IL-6) and/or its soluble receptor are detected in the vitreous and aqueous humors of patients with uveitis. Inhibition of IL-6 signaling in a murine model of experimental autoimmune uveitis suppresses the development of uveitis. We designed an exploratory Phase 2 study to evaluate the efficacy and safety of sarilumab, a human monoclonal antibody directed against the alpha subunit of the IL-6 receptor complex in the management of posterior segment NIU. Methods SATURN is a 52-week, multicenter, double-masked, placebo-controlled, parallel arm, randomized trial to evaluate the efficacy and safety of sarilumab (200 mg) administered subcutaneously every 2 weeks in patients with posterior NIU, who are treated with systemic steroids (as single therapy or with methotrexate). Efficacy and safety are assessed at each visit. The study primary endpoints are reduction from baseline in vitreous haze or systemic-steroid sparing effects, both measured at week 16. Other key endpoints assessed at week 16 include the change from baseline in: central retinal thickness, best-corrected visual acuity, and percentage of patients with retinal vessel leakage on fluorescein angiography. Results The study has completed enrollment. As of April 6, 2015, 58 patients have been randomized and treated. Conclusions The SATURN study may help clarify the role of IL-6 in the pathogenesis of NIU and the potential for IL-6 inhibition in the management of posterior segment NIU. [ABSTRACT FROM AUTHOR]