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A ZnO/TiO2@MWCNTs nanocomposite as an effective catalyst was employed for generating quinolinoquinazoline derivatives in high yields. These new compounds were synthesized by using multicomponent reaction of quinoline, isothiocyanate, 6‐amino‐2‐(prop‐1‐en‐2‐yl)‐1H‐indole‐5‐carbaldehyde, primary amines, and dimethyl acetylenedicarboxylate in aqueous media. It should be mentioned that the high performance of nanocatalyst was synthesized by using water extract of Aloe vera, which was utilized in these reactions for many times to confirm the reusability of nanocatalyst. The antioxidant property of new synthesized quinolinoquinazoline was evaluated by two procedures. Also, the antimicrobial activity of newly generated quinolinoquinazoline was evaluated by disk distribution process utilizing two kinds of Gram‐negative bacteria and Gram‐positive bacteria, proving bacterial growth was stopped by using of these compounds. Applied to the preparation of quinolinoquinazoline derivatives, this method has short reaction times, high product yields, and the ability to separate catalyst and product using simple procedures. [ABSTRACT FROM AUTHOR]

The facile procedure allows the synthesis of thiazoles from α-haloketones and dithiocarbamates. [ABSTRACT FROM AUTHOR]