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The article focuses on a study that assesses the age-dependent sensitivity to nephrotoxicant cisplatin in multi-aged rat models. It reports the cisplatin-induced nephrotoxicity in the said rats. It mentions that the level of Kim-1 tissue mRNA and urinary protein is correlated to each other and to the severity of renal lesions. It notes that the multi-age rat model can be used in demonstrating the different age-related sensitivities to renal injury.

The article presents a study which evaluates the use of cytochrome c (cyt c) as a non-invasive biomarker of drug-induced liver injury. It states that the study was undertaken to emphasize the need for additional tools in detecting human toxicity. The study used the urine of adult rats treated with hepatoxins as subject of the experiment and employed serum diagnostic tests, immunohistochemistry, and urinary analysis for cyt c. Results indicated histomorphological changes and TUNEL staining in liver coherent with hepatocellular necrosis, apoptosis, and inflammation and showed that the liver is the primary source of cyt c. It shows that cyt c is a useful indicator of hepatic injury when used as a potential urinary biomarker.