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In this study, the effects of the spectral acceleration at the superstructure first‐mode period on the isolator displacement are investigated for far‐field ground motions. For this purpose, two different base‐isolated models are subjected to 165 far‐field ground motions. It is demonstrated that considering the spectral acceleration at the superstructure first‐mode period, besides that at the effective period, improves the estimation accuracy of isolator displacement. ASCE 7‐22 modifies the scaling period range to consider the superstructure first mode period and proposes the new period range from the superstructure first‐mode period to the 1.25 times effective period. In the ASCE 7‐22, the same weight factor is used for the whole period range. However, the present study shows that adding the superstructure first‐mode related period range with appropriate weight factor to the effective period‐based scaling range decreases the dispersion of isolator displacement in the nonlinear response history analyses (NRH). Then, to overcome the spectral shape effects on the fragility curves, a vector‐valued intensity measure parameter is obtained by combining spectral acceleration at the effective period and reduced spectral acceleration at the superstructure first‐mode period. The optimum contribution factor for the spectral acceleration at the superstructure first‐mode period is defined as the ratio of the superstructure first‐mode period to the effective period. The article shows that the proposed parameter is efficient and sufficient to be used as an intensity measure for far‐field ground motions. Furthermore, regression analysis results indicate that this vector‐valued intensity measure parameter correlates well with the isolator displacement. Further, the article shows that using the proposed IM parameter in the fragility curves makes the collapse margin ratio of these curves less sensitive to the spectral shape of the selected ground motions. [ABSTRACT FROM AUTHOR]

Background: For over 50 years, music therapy and breathing exercises have been widely utilized as interventions to help individuals cope with fatigue, stress and pain globally. Aim: To analyse the effects of music and breathing exercises on anxiety and pain in patients undergoing coronary angiography. Study Design: This is a single‐blind, randomized controlled trial. The sample comprised 165 patients: 55 in the control group, 55 in the breathing exercise group and 55 in the music therapy group. Patients in the music group listened to music during angiography, those in the breathing exercise group practised exercises 30 min before the procedure and the control group received standard treatment. Anxiety levels were assessed before and after the procedure, and pain levels were measured post‐procedure. The Consolidated Standards of Reporting Trials (CONSORT) checklist for reporting randomized trials was used to guide reporting. Results: Anxiety scores rose significantly in the control group from 33.9 ± 4.2 pre‐angiography to 37.7 ± 4.9 post‐angiography. Conversely, the breathing group's anxiety scores decreased from 34.3 ± 3.5 before angiography to 31.7 ± 1.5 after angiography, and the music group exhibited a reduction from 32.3 ± 3.6 to 30.8 ± 1.6. Post‐angiography, the control group reported a mean pain score of 64 ± 0.8 mm, while the breathing and music groups had significantly lower scores of 35 ± 0.6 and 29 ± 0.8 mm, respectively. Statistical analysis showed a highly significant difference in pain scores between the intervention and control groups. Conclusions: This study provides support for the beneficial effects of employing breathing exercises and music in alleviating pain and anxiety during coronary angiography procedures. Relevance to Clinical Practice: Integrating these findings into clinical practice could be significant for improving patients' pain experiences and anxiety, enhancing the tolerance of invasive medical procedures. [ABSTRACT FROM AUTHOR]

A questionnaire survey was conducted to identify the factors that are effective in assessing people's attitudes toward e‐waste pollution prevention. Reliability analysis, normality distribution analysis, correlation and regression analysis, independent sample t‐test, and one‐way analysis of variance (ANOVA) were performed on the data obtained through IBM SPSS Statistics 25. In this way, it was determined to what extent the level of public awareness of e‐waste, environmental concerns, empathy, and moral norms toward the environment are affected by socio‐demographic factors. According to the study results, a significant relationship was found between environmental concerns, environmental pollution awareness, environmental responsibility, personal moral norms and educational status, and empathy and moral norms. In addition, limited growth, anthropocentrism, fragility of the balance of nature, educational status, and having children were also found to have a significant relationship with environmental concerns. However, a significant relationship was found between marital status and environmental concerns, empathy and moral norms. A significant relationship was also found between age group and empathy and moral norms. [ABSTRACT FROM AUTHOR]

The article discusses a case report of a 40-year-old female patient diagnosed with both multiple sclerosis (MS) and ankylosing spondylitis (AS) who was successfully treated with ocrelizumab. AS is a systemic inflammatory disorder primarily affecting the axial skeleton, while MS is a chronic demyelinating disorder of the central nervous system. The patient experienced significant improvement in both AS and MS symptoms with ocrelizumab treatment, achieving inactive disease status with no reported adverse effects. This case highlights the potential benefits of ocrelizumab in treating patients with dual diagnoses of AS and MS, although further research is needed to fully understand its safety and efficacy profile. [Extracted from the article]

Hydrothermal synthesis is a straightforward approach for producing high‐yield manganese dioxide (MnO2) nanostructures with efficient morphological control at low temperatures. This study investigates the microstructural dependency of hydrothermally grown α‐MnO2 nanowires (NWs) on pre‐treatment conditions on the substrate surface. Within this scope, α‐MnO2 NWs were synthesized on chemical vapor deposition (CVD)‐based graphene foam (GF) substrates pre‐treated via potassium permanganate (KMnO4) solution as a seeding layer with different concentrations (0.025, 0.050, 0.075, 0.1 M). A direct α‐MnO2 NWs growth (without pre‐treatment) was also performed on GF by hydrothermal method. The seeding layer effect on the NWs growth was elaborated to comprehend the process‐structure correlations by characterizing the resultant graphene foam/α‐MnO2 nanowires (GF/α‐MnO2 NWs) nanocomposites through Scanning Electron Microscopy (SEM), Raman Spectroscopy, X‐Ray Diffraction (XRD), and X‐Ray Photoelectron Spectroscopy (XPS). SEM, XRD, and Raman Spectroscopy revealed the successful acquisition of highly crystalline α‐MnO2 in one‐dimensional nanowire morphology on the high‐quality GF. Moreover, XPS results confirmed that all nanocomposites comprise α‐MnO2 and graphene without chemical degradation. Consequently, slight changes in solution concentration of seeding layers caused a noticeable alteration in the nanowire's structure, which could ensure effective control of nanocomposite properties without sacrificing the high purity of each component. [ABSTRACT FROM AUTHOR]

In this study, Lacticaseibacillus casei and Lactobacillus acidophilus probiotic bacteria were encapsulated using oleaster flour, which is rich in phenolic compounds and has prebiotic properties as potential. The optimum conditions required for the encapsulation of L. casei and L. acidophilus bacteria with maximum efficiency using oleaster flour were determined by central composite design–response surface methodology. As a result of the optimization process, the encapsulation efficiency for L. casei and L. acidophilus capsules was 93.66 ± 2.58% and 74.97 ± 1.34%, respectively. The capsule sizes of L. casei and L. acidophilus encapsulated with oleaster flour were determined by scanning electron microscopy to be 104.8 ± 26.3 and 95.7 ± 12.1 μm, respectively. Fourier transform infrared spectroscopy analyses showed that there was no change in the structure of the encapsulation material, oleaster flour, after encapsulation. Also, the storage stability of free and encapsulated bacteria was investigated, and it was found that the viability losses of encapsulated probiotic bacteria were less than those of free probiotic bacteria. Finally, the effect of encapsulation on bacterial viability during in vitro gastrointestinal digestion was investigated, which is the main purpose of the study. While free probiotic bacteria cannot reach the intestinal environment alive after in vitro gastrointestinal digestion due to pH and enzyme effects, encapsulated L. casei and L. acidophilus bacteria largely preserved their viability, and their postdigestion viability was 39.59 ± 1.50% and 36.28 ± 0.01%, respectively. The results showed successful encapsulation of L. casei and L. acidophilus probiotic bacteria with oleaster flour. [ABSTRACT FROM AUTHOR]

Background: Maternal mortality ratio is one of the significant indicators of a country's healthcare quality and development. In recent years, Türkiye has made significant advancements in maternal and child health services. However, it has been discussed that stagnation has been observed in recent years, and the migration from Syria and the COVID‐19 pandemic have significantly overshadowed this success. The purpose of this study is to evaluate the current situation of the maternal mortality level in the country based on the experiences and views of experts working in this area. Methods: Key informant interviews were conducted with a purposive sample of academics, representatives of public institutions, and NGOs to understand the mechanisms of success in maternal mortality in the 1990s. Thematic analysis was used to understand the reasons for the stagnation of the decline in maternal mortality and to develop recommendations for reducing maternal mortality. Results: Twenty‐five key informant interviews were conducted. Positive developments contributing to the success of maternal mortality, problems and obstacles hindering further progress and suggestions/recommendations are the themes of this research. The key informants highlighted the health transformation policies, the lack of data on the impact of COVID‐19, recent migration on maternal mortality, inadequate education and training on sexual and reproductive health (SRH), the absence of rights‐based policies, and gender equality as critical issues in current policies. Conclusion: The outcomes of this study underline the importance of the availability, accessibility, and quality of SRH services and empowering women, girls, families, and communities to eliminate preventable maternal mortality levels. [ABSTRACT FROM AUTHOR]

This study aimed to retrospectively evaluate the baseline and follow‐up viral loads and viral clearance times in cases followed for asymptomatic and symptomatic congenital cytomegalovirus (cCMV) infection between August 2010 and August 2022. Among 93 cases, they had asymptomatic (n: 55) and symptomatic (n: 38). The median baseline blood viral load detected in the symptomatic cCMV (ScCMV) infection (13 054 IU/mL) was significantly higher than that of asymptomatic cCMV (AcCMV) infection (4636 IU/mL) (p < 0.013). There was no difference in median viral clearance times (75 and 90 days, respectively) in baseline viremic cases in the ScCMV and AcCMV infection groups. There were no differences in median baseline blood viral load (6930 IU/mL and 14 268 IU/mL, respectively) and median viral clearance times (75 and 85 days, respectively) between the 6‐week and 6‐month antiviral treatment group. No correlation was found between baseline blood viral load, clinical severity, and the number of systems involved. However, in initial viremic cases, the viral load threshold for a symptomatic case was 8856 IU/mL, with 85.7% sensitivity and 54.5% specificity. [ABSTRACT FROM AUTHOR]

Aim Background Methods Results Discussion and conclusion Implications for nursing and health policy To evaluate the effect of the fear of violence of nurses working in Turkey on their intention to migrate and to examine the mediating role of psychological well‐being on this effect.Many countries are concerned about nurses’ fear of violence and their intention to migrate. The fear of violence at work may influence nurses’ intention to migrate. Additionally, psychological well‐being may impact this process. However, the impact of the fear of violence at work on the intention to migrate, as well as the moderating effect of psychological well‐being in a nursing context, is not well understood.We conducted this cross‐sectional study on a sample of 221 nurses from two public hospitals. We collected survey data between November 2022 and January 2023 using three scales. We analyzed the data using SPSS, AMOS, and HAYES. We followed the STROBE statement guidelines for cross‐sectional studies.Nurses reported a moderate intention to migrate and a moderate to high level of fear of violence and psychological well‐being. Fear of violence is positively associated with the intention to migrate. Mediation analyses indicated that the association between fear of violence and intention to migration was mediated by psychological well‐being.The fear among nurses of being exposed to violence increases their intention to migrate. However, high psychological well‐being can reduce this intention.Nursing managers, policymakers, and decision‐makers need to take serious precautions against the fear of violence in the future and make necessary improvements for nurses who witness violence. To achieve this, it can begin by paying attention to the high psychological well‐being of each nurse. [ABSTRACT FROM AUTHOR]

Summary: Whey and sunflower meals are primary by‐products of dairy cheese and vegetable oil production, respectively. Due to their widespread abundance, their valorisation could enable the generation of various value‐added food ingredients or products. In this study, an effort was made to utilise enzymatic pectinolysis along with other pre‐treatments to generate mixtures from whey and sunflower meal (SFM). The increasing presence of SFM increased the critical denaturation temperature of the mixtures and induced less protein structural changes. In addition, the presence of complex carbohydrates in SFM enhanced water and oil holding capacities. In general, pectinase and ultrasonication led to enhanced foaming of the mixtures, although the foams were relatively short‐lived. SFM inclusion limited foaming and emulsification capacities of the blends. In most cases, increasing the ratio of SFM to protein resulted in lower total reducing sugars (TRS), suggesting a more limited enzymatic activity. On the other hand, heating temperature or ultrasonication improved the extent of pectinolysis. Pre‐treatments and pectinolysis improved the functional properties of SFM and whey protein concentrate blends and are promising as an alternative protein source in new product applications. [ABSTRACT FROM AUTHOR]

Visual system is crucial to autobiographical memory. Research tended to show that blind adults may compensate for the loss of visual information in retrieval of their autobiographical memories. Much less is known about how blind children's autobiographical memory develops in the absence of visual information. Using cue‐word methodology, 36 sighted and 33 blind early teenagers were asked to recall memories and subsequently rated phenomenological qualities of their memories. Retrieval latency, the number of prompts provided, episodic and non‐episodic details reported for each memory were coded. In terms of memory accessibility, the blind group recalled comparable number of memories with comparable latency to retrieve memories, but they needed more prompting. Blind participants recalled similar number of episodic details; however, they reported more extraneous details, decreasing specificity. Blind early teenagers reported higher auditory imagery, a propensity to remember events from the first‐person perspective, and a tendency to remember events as coherent stories. [ABSTRACT FROM AUTHOR]

The coronavirus 2 (SARS‐CoV‐2), a positive‐sense RNA virus that causes severe acute respiratory illness, is the cause of Coronavirus Disease 2019 (COVID‐19) and Monkeypox is a zoonotic viral disease caused by a double‐strand enveloped DNA virus, a member of the Poxviridae family under the umbrella of the Orthopoxvirus genus. These viruses have harmed global health, societal stability, and global economy prompting the development of new therapeutic options. The purpose of this study was to analyze the potency of hazelnut‐derived bioactive peptides for usage in preventive measures against SARS‐CoV‐2 and Monkeypox infections. Since SARS‐CoV‐2 entry into the host cell takes place through angiotensin‐converting enzyme (ACE) receptors, an in silico attempt was made here to analyze the previously characterized ACE‐inhibitory hazelnut peptides for their anti‐COVID potential. First of all, peptide sequences with PeptideRanker values >0.5 were determined, where 43 of 256 hazelnut peptides met this condition. BIOPEP tools were used to calculate their ACE‐inhibitory characteristics. VPHW and DENPRHF demonstrated the strongest ACE‐inhibitory activity based on BIOPEP analysis. The binding potentials of VPHW (p < 0.001) and DENPRHF (p < 0.001) peptides to ACE were statistically significant based on PepSite2 analysis. The hazelnut‐derived peptides were docked with ACE, spike proteins, SARS‐CoV‐2 proteases, host cell receptors, and Monkeypox 2022 membrane proteins using HPEPDOCK and CABS‐dock. The in silico findings pointed out potential inhibition of SARS‐CoV‐2 main protease in the host cell and Monkeypox 2022 membrane protein and demonstration of multiple bioactivities. [ABSTRACT FROM AUTHOR]

Summary: Freeze‐dried white cheese powder was produced using WPI (Whey protein isolate) and CMC (carboxymethyl cellulose) and applied in bread production. The optimal formulation ratio of WPI and CMC in freeze‐dried white cheese powder was determined as 5% and 1% (w/w) based on powder properties. Quality characteristics of bread were examined by replacement of white flour with white cheese powder at 10%, 15% and 20%. The addition of CMC provided a significant increase in centrifugal stability (97.18%) and kinetic stability (97.25%) of white cheese emulsions. In powders, CMC reduced water activity, potentially contributing to quality preservation during shelf‐life. The powder with CMC indicated a lighter colour and incorporating the powder into bread formulations resulted in lower L* values and higher a* values compared to the control bread. Texture properties of bread were significantly affected by amount of the powder. The study indicated that white cheeses approaching expiration date can be used in the food industry by converting them into a value‐added product, white cheese powder, using the freeze‐drying technique. [ABSTRACT FROM AUTHOR]

With the global rise in populism over the last decade, there has been an increase in political commentaries (PC) by leaders that criticize their central banks and argue for lower interest rates. We analyse the effects of PCs on exchange rates, bond yields, and the risk premium for six countries that are subject to political pressures. Utilizing a specification with time‐varying parameters, we show that PCs affect the level and the volatility of exchange rates, bond yields and the risk premium in Turkey. The response increases over time. In other countries, there is a significant impact on exchange rate volatility. [ABSTRACT FROM AUTHOR]

Background: Chewing difficulty, poor oral health, inadequate and imbalanced nutrition are serious health problems in individuals with intellectual disabilities. The participants' chewing abilities, oral health and nutritional status were analysed in this study. Methods: Forty‐five adult participants with intellectual disabilities were included. Anthropometric measurements, oral health assessments, chewing ability evaluations and dietary intake analyses were conducted. Results: A 56.8% of the participants were classified as overweight or obese. Teeth grinding was reported in 33.3% of the participants, while 40.0% experienced drooling. All participants with Down syndrome and 58.6% of the participants with developmental delay had chewing difficulties. Inadequate nutrient intake was observed and the fibre, vitamins B1, B3, B9, sodium, phosphorus and iron intakes were significantly lower than reference values in those with chewing difficulty (p <.05). Conclusions: Chewing difficulties were associated with lower intake of certain nutrients, highlighting the importance of addressing oral health and dietary counselling in this population. [ABSTRACT FROM AUTHOR]

Transient perivascular inflammation of the carotid artery (TIPIC) is a rare vascular disease characterized by inflammation of the carotid artery, leading to thickening of the carotid wall and unilateral carotidynia. This case report presents a 48-year-old woman who was diagnosed with TIPIC syndrome in a rheumatology outpatient clinic. The patient experienced right neck pain and numbness in the right hand, accompanied by local tenderness and increased arterial pulse. Laboratory tests showed no abnormalities, and imaging studies revealed inflammatory processes in the carotid artery. TIPIC syndrome is a self-limiting condition with a good prognosis and can be treated with nonsteroidal anti-inflammatory drugs. It is important for healthcare providers to be aware of this syndrome to prevent unnecessary treatment and to differentiate it from systemic vasculitis. [Extracted from the article]

Aim: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection may have a more severe course in patients with underlying disease or who have had immunosuppression. In this study, it was aimed to determine the frequency of coronavirus disease 2019 (COVID‐19) and the mortality rates related to COVID‐19 among patients with rheumatic disease. Methods: The patients who were followed up with rheumatic disease in the rheumatology outpatient clinic in a tertiary hospital were retrospectively assessed if they had COVID‐19 infection or not between March 2020 and January 2022. Results: A total of 10 682 patients were evaluated. There were 2928 (27.4%) COVID‐19‐positive and 7754 (72.6%) COVID‐19‐negative patients. The mean age of COVID‐19‐positive patients was 46.2 ± 14.6 years, and 65.8% were female. Forty‐two (1.4%) patients died due to COVID‐19. Among COVID‐19‐negative patients, 192 patients died. The most common rheumatic disease among patients with COVID‐19 was spondyloarthritis (SpA) (30.4%). Corticosteroids were the most common treatment agent in COVID‐19‐positive patients regardless of mortality. Thirty‐one (73.8%) patients were receiving corticosteroids, and 35 (83.3%) patients were receiving immunosuppressive agents among patients with mortality. According to the logistic regression analysis, older age, male gender, and receiving corticosteroid, hydroxychloroquine, mycophenolate mofetil, tofacitinib, rituximab, and cyclophosphamide were found to be related to increased mortality. Conclusion: COVID‐19 is a serious infection and the current study emphasized that patients with rheumatic diseases had increased mortality rates, particularly in patients who were old, male, and on immunosuppressive treatments. [ABSTRACT FROM AUTHOR]

Direklerarası, the core of Ramadan entertainment in late Ottoman Istanbul, rose to prominence toward the end of the nineteenth century at about the same time as entertainment hubs in Paris, Berlin, Tokyo, and New York. Thanks to the legitimacy provided by the Holy Ramadan, which played a positive role in reducing public suspicion and uneasiness among Muslim families towards the products of early mass culture, Direklerarası seems to draw a larger children's audience compared to Pera and Galata, the epicenter of European‐style entertainment and a location where non‐Muslims were heavily populated. As a result, many children were introduced to emerging modern mass culture at Direklerarası, which offers a large variety of shows and spectacles grouped under the name of lubiyat in the Ottoman world, including theater, musical plays, juggling, circus, concerts, shadow theater and cinema. This article focuses on childhood experiences at Direklerarası using a wide range of primary sources from archival documents and official regulations to Ottoman periodicals and memoirs. It aims to discuss the moral and aesthetic concerns arising from the fact that the spheres of adults and children were not yet clearly separated from each other, as well as how this experience at Direklerarası was remembered later as a childhood memory. [ABSTRACT FROM AUTHOR]

Anatomy instructional methods varied widely during the COVID‐19 pandemic and programs are assessing innovations for retention. Learning preferences were assessed among medical students dichotomized as elective dissectors (ED) or non‐dissectors (ND) during the COVID‐19 partial re‐opening in 2020 (preclinical) and again in 2022 after clinical exposure (post‐clinical) to assess the viability of elective dissection post‐pandemic. A mixed‐method approach was used for the assessment of test scores, learning preference surveys, learning activities rankings, and thematic analyses. No significant differences occurred in anatomy examination scores. Dissection was considered useful by both preclinical groups but significantly more so by ED, while the presence of an instructor was significantly preferred by ED although a majority of ND agreed. Elective dissection was significantly preferred by ND but also by a large minority of ED students. Pre‐ and post‐clinical ND believed that elective dissection offered more academic flexibility, did not hinder clinical learning, and did not negatively impact medical education. The corresponding ED stated that confidence improved, clinical experiences were enhanced, and dissection was irreplaceable. Preclinical ND preferred self‐learning, while ED students preferred online learning, but these differences largely disappeared post‐clinically. Learning activity rankings were not significantly different among all groups (ND, ED, preclinical, and post‐clinical). A hybrid laboratory with a virtual learning environment ranked highest across groups and preferences increased over time suggesting that students benefited from this instructional method during clinical exposure. The absence of laboratory experience ranked lowest, and preference decreased over time suggesting that anatomy dissection is valued. [ABSTRACT FROM AUTHOR]

Thermospheric density is one of the main sources of uncertainty in the estimation of satellites' position and velocity in low‐Earth orbit. This has negative consequences in several space domains, including space traffic management, collision avoidance, re‐entry predictions, orbital lifetime analysis, and space object cataloging. In this paper, we investigate the prediction accuracy of empirical density models (e.g., NRLMSISE‐00 and JB‐08) against black‐box machine learning (ML) models trained on precise orbit determination‐derived thermospheric density data (from CHAMP, GOCE, GRACE, SWARM‐A/B satellites). We show that by using the same inputs, the ML models we designed are capable of consistently improving the predictions with respect to state‐of‐the‐art empirical models by reducing the mean absolute percentage error (MAPE) in the thermospheric density estimation from the range of 40%–60% to approximately 20%. As a result of this work, we introduce Karman: an open‐source Python software package developed during this study. Karman provides functionalities to ingest and preprocess thermospheric density, solar irradiance, and geomagnetic input data for ML readiness. Additionally, it facilitates developing and training ML models on the aforementioned data and benchmarking their performance at different altitudes, geographic locations, times, and solar activity conditions. Through this contribution, we offer the scientific community a comprehensive tool for comparing and enhancing thermospheric density models using ML techniques. Plain Language Summary: Accurately modeling the density of the thermosphere is pivotal for spacecraft operations such as collision avoidance, re‐entry prediction, and orbital lifetime analysis. In this study, our aim is twofold. First, we want to study and compare the performance of data‐driven machine learning (ML) models in predicting thermospheric density data against standard empirical models used in the field, which are used as baseline. By training ML models using precise orbit determination‐derived satellite data, we show that they can achieve significant performance improvement compared to empirical models, with a reduction of 61% in the mean absolute percentage error. Second, we also provide the community with a shared software framework that supports the ingestion of solar irradiance, geomagnetic, and thermospheric density data, as well as a training and benchmarking framework to develop ML models. This framework allows researchers and operators to both train their ML models and to compare them at different periods of the solar cycle, geomagnetic storm conditions, geographical locations, and times. Key Points: Machine learning (ML) models can significantly outperform existing physics‐based thermospheric neutral density models on exactly the same inputsML models can improve over NRLMSISE‐00 and JB‐08 empirical density models by 61% and 39% respectively in the mean absolute percentage errorThe software allows the creation of ML‐ready data for training and benchmarking new models, supporting solar irradiance and geomagnetic data [ABSTRACT FROM AUTHOR]

Coenzyme Q (CoQ) is essential for mitochondrial respiration and required for thermogenic activity in brown adipose tissues (BAT). CoQ deficiency leads to a wide range of pathological manifestations, but mechanistic consequences of CoQ deficiency in specific tissues, such as BAT, remain poorly understood. Here, we show that pharmacological or genetic CoQ deficiency in BAT leads to stress signals causing accumulation of cytosolic mitochondrial RNAs and activation of the eIF2α kinase PKR, resulting in activation of the integrated stress response (ISR) with suppression of UCP1 but induction of FGF21 expression. Strikingly, despite diminished UCP1 levels, BAT CoQ deficiency displays increased whole-body metabolic rates at room temperature and thermoneutrality resulting in decreased weight gain on high-fat diets (HFD). In line with enhanced metabolic rates, BAT and inguinal white adipose tissue (iWAT) interorgan crosstalk caused increased browning of iWAT in BAT-specific CoQ deficient animals. This mitohormesis-like effect depends on the ATF4-FGF21 axis and BAT-secreted FGF21, revealing an unexpected role for CoQ in the modulation of whole-body energy expenditure with wide-ranging implications for primary and secondary CoQ deficiencies. [ABSTRACT FROM AUTHOR]

This article introduces the concept of cognitive social structures to public administration and policy scholars. Cognitive social structures are the perceptions, or mental maps, actors hold of the relationships that exist among the members of their network. These perceptions and their accuracy have implications for actor behavior, decisions, and outcomes. The literature on network cognitions has developed in the fields of psychology and organization studies but has yet to be applied in public administration and policy. We provide an overview of cognitive social structure research. We then demonstrate the theoretical and practical implications cognitive social structures hold for our field by examining applications in two research areas—implementation and leadership. We argue that using a network cognition perspective can help researchers and practitioners to better explain and pursue important organizational and interorganizational phenomena. We hope this article fosters new dialogue on the role of network cognitions in public administration and policy. [ABSTRACT FROM AUTHOR]

Dravet syndrome and genetic epilepsy with febrile seizures plus (GEFS+) are both epilepsy syndromes that can be attributed to deleterious mutations occurring in SCN1A, the gene encoding the pore‐forming α‐subunit of the NaV1.1 voltage‐gated sodium channel predominantly expressed in the central nervous system. In this research endeavor, our goal is to expand our prior cohort of Turkish patients affected by SCN1A‐positive genetic epilepsy disorders. This will be accomplished by incorporating two recently discovered and infrequent index cases who possess a novel biallelic (homozygous) SCN1A missense variant, namely E158G, associated with Dravet syndrome. Furthermore, our intention is to use computational techniques to predict the molecular phenotypes of each distinct SCN1A variant that has been detected to date within our center. The correlation between genotype and phenotype in Dravet syndrome/GEFS+ is intricate and necessitates meticulous clinical investigation as well as advanced scientific exploration. Broadened mechanistic and structural insights into NaV1.1 dysfunction offer significant promise in facilitating the development of targeted and effective therapies, which will ultimately enhance clinical outcomes in the treatment of epilepsy. [ABSTRACT FROM AUTHOR]

This paper examines the evolution of regional disparities within the present‐day borders of Turkey since 1913. Based on our estimates for 58 provinces, we find β‐convergence, an inverse U, and more recently, the beginnings of an N‐shaped pattern for value added per capita. We also find that regional disparities in Turkey exhibit a number of special features that do not easily fit the well‐studied pattern of the early industrializers. First, while per capita value added in other regions moved towards country averages, the differences between the East and the rest of the country persisted and even increased until recently. Second, spatial distribution of economic activity became more concentrated over time due to continued migration to the megacity of Istanbul. Third, we find that regional disparities in per capita value added in Turkey and other developing countries have been higher than those experienced by the early industrializers. These findings raise questions about the extent to which the regional disparities experiences of Turkey and other developing countries have been different than those of the early industrializers. [ABSTRACT FROM AUTHOR]

Background: Clinical data used to train deep learning models are often not clean data. They can contain imperfections in both the imaging data and the corresponding segmentations. Purpose: This study investigates the influence of data imperfections on the performance of deep learning models for parotid gland segmentation. This was done in a controlled manner by using synthesized data. The insights this study provides may be used to make deep learning models better and more reliable. Methods: The data were synthesized by using the clinical segmentations, creating a pseudo ground‐truth in the process. Three kinds of imperfections were simulated: incorrect segmentations, low image contrast, and artifacts in the imaging data. The severity of each imperfection was varied in five levels. Models resulting from training sets from each of the five levels were cross‐evaluated with test sets from each of the five levels. Results: Using synthesized data led to almost perfect parotid gland segmentation when no error was added. Lowering the quality of the parotid gland segmentations used for training substantially lowered the model performance. Additionally, lowering the image quality of the training data by decreasing the contrast or introducing artifacts made the resulting models more robust to data containing those respective kinds of data imperfection. Conclusion: This study demonstrated the importance of good‐quality segmentations for deep learning training and it shows that using low‐quality imaging data for training can enhance the robustness of the resulting models. [ABSTRACT FROM AUTHOR]

This article examines the impact of populism on the rule of law in Hungary and Poland. It argues that political discourse is important in setting the political agenda and is often followed by the criminalization of minorities, Euroskepticism, intervening in the operation of supreme courts, affecting the decisions of the judges, and disregarding international law and/or supranational legal orders. It also highlights how politicization and securitization increasingly operate under populist authoritarian regimes through the legal system and legislative initiatives to increase the power of the government and the ruling party. Discourse analysis is a valuable tool to reveal whether a legislator's intention serves the people or exploits power to change the structure and functioning of the political system. Thus, this article follows the course of politics in Hungary and Poland from discourse to hijacking democracy through instrumentalizing the rule of law. Related Articles: Deegan‐Krause, Kevin, and Tim Haughton. 2009. "Toward a More Useful Conceptualization of Populism: Types and Degrees of Populist Appeals in the Case of Slovakia." Politics & Policy 37(4): 821–41. https://doi.org/10.1111/j.1747‐1346.2009.00200.x. Skowronska, Kaja. 2021. "The Recent Politicization of Immigration in Poland in Light of Preexisting State Practices: Continuity or Change in the Understanding of Citizenship and Nationhood?" Politics & Policy 49(4): 940–67. https://doi.org/10.1111/polp.12424. Zafirovski, Milan. 2022. "Toward a New Political Democracy Index: Construction, Validation, and Calculation for Individual Societies and Types of Society." Politics and Policy 50(4): 663–99. https://doi.org/10.1111/polp.12488. [ABSTRACT FROM AUTHOR]

Computable biomedical knowledge artifacts (CBKs) are software programs that transform input data into practical output. CBKs are expected to play a critical role in the future of learning health systems. While there has been rapid growth in the development of CBKs, broad adoption is hampered by limited verification, documentation, and dissemination channels. To address these issues, the Learning Health Systems journal created a track dedicated to publishing CBKs through a peer‐review process. Peer review of CBKs should improve reproducibility, reuse, trust, and recognition in biomedical fields, contributing to learning health systems. This special issue introduces the CBK track with four manuscripts reporting a functioning CBK, and another four manuscripts tackling methodological, policy, deployment, and platform issues related to fostering a healthy ecosystem for CBKs. It is our hope that the potential of CBKs exemplified and highlighted by these quality publications will encourage scientists within learning health systems and related biomedical fields to engage with this new form of scientific discourse. [ABSTRACT FROM AUTHOR]

Background: A broad spectrum of skin diseases, including hair and nails, can be directly or indirectly triggered by COVID‐19. It is aimed to examine the type and frequency of hair and nail disorders after COVID‐19 infection. Methods: This is a multicenter study conducted on consecutive 2171 post‐COVID‐19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined. Results: The rate of the previous admission in hospital due to COVID‐19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID‐19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID‐19 infection. The mean stress scores during and after getting infected with COVID‐19 were 6.88 ± 2.77 and 3.64 ± 3.04, respectively, in the hair loss group and were 5.77 ± 3.18 and 2.81 ± 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID‐19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4–7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222–7.027]). The most common nail disorders were leukonychia, onycholysis, Beau's lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID‐19 were statistically significantly more common in patients having nail disorders after getting infected with COVID‐19 when compared to the control group (P < 0.05). Conclusion: The development of both nail and hair disorders after COVID‐19 seems to be related to a history of severe COVID‐19. [ABSTRACT FROM AUTHOR]

Mushroom production is highly affected by green mould disease, which causes severe losses worldwide. This study aimed to characterize Trichoderma spp. isolates collected from Agaricus bisporus‐ and Pleurotus ostreatus‐growing facilities based on their molecular features and evaluate their aggressiveness in mushroom production in vitro and in vivo. Fifty‐six Trichoderma isolates from mushroom farms in Aegean and Marmara regions were analysed for molecular characteristics. In a phylogenetic tree constructed based on internal transcribed spacer (ITS) and tef1 sequences, they were classified into five groups, which included Trichoderma spp. such as T. aggressivum, T. europaeum, T. pleuroticola, T. virens, T. harzianum and T. afroharzianum. Phylogenetic analyses revealed that tef1 sequences could distinguish between T. aggressivum f. aggressivum and T. aggressivum f. europaeum more specifically. Consequently, tef1 sequence variation identified 15 T. aggressivum f. europaeum isolates compared with ITS sequence variation. In vitro conditions based on the dual‐culture tests of the mycelial growth of A. bisporus showed growth inhibition between 50% and 75% depending on the isolates. Two Trichoderma isolates with different ITS and tef1 sequences (3/9 and 7/5 isolates, respectively) and more lytic and mycoparasitic activities were analysed further to determine their effects on yield and mushroom quality parameters. Therefore, T. aggressivum f. aggressivum is not the only species that affects mushroom production, and T. aggressivum f. aggressivum and T. aggressivum f. europaeum isolates significantly (p < 0.05) inhibited A. bisporus growth in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Recent technological developments have considerably transformed the supply, storage, and transportation processes of cadavers, creating new and previously unforeseen ethical challenges regarding cadaver usage. In this study, we analyzed two aspects of the cadaver processing system—cadaver supply and its use in research. Thereafter, we highlighted the major ethical concerns underlying these stages and correlated our search results with the ethical principles outlined in the Declaration of Helsinki (DoH), or Helsinki Declaration. To ensure the reliability and continuity of medical progress, human—especially cadaver—research depends on the ethical priorities as outlined in the DoH: respect for autonomy, privacy/confidentiality, risks/burdens/benefits, and the protection of vulnerable groups. According to our ethics analysis, which also corresponds with the ethics guidelines of the Consensus Panel on Research with the Recently Dead, the most ignored values were respect for autonomy and privacy/confidentiality issues. Based on these ethical concerns, we provide recommendations to address these challenges in anatomy research. [ABSTRACT FROM AUTHOR]

The aim of this study was to treat wastewater from washing, cutting or crushing of intermediate bulk containers (IBCs), steel drums and plastic drums, using the sulfate radical‐based oxidation method. In this study, it was planned to make the wastewater suitable for activated sludge treatment by applying neutralization after a sulfate radical‐based oxidation process. Samples were taken from the industry three times to study these treatment processes. To determine the optimum conditions in the study, chemical oxygen demand (COD), removal efficiency was calculated, and optimum temperature, optimum time, and optimum persulfate dose were determined. Since the washing is done with hot water in the industry, the thermal activation method was used for the activation of persulfate. In the results of the study, COD removal efficiency, and total organic carbon (TOC), biochemical oxygen demand (BOD), total nitrogen (TN), total phosphorus (TP), and potentially toxic metal(s) removal efficiency was measured in three wastewater samples. According to the results of the study, the temperature at which the best COD removal efficiency was observed was 70°C, the COD/S2O82− ratio was 1:2, and the contact time was 5 h. As a result of the study, it has been revealed that such wastewater can be given to the activated sludge after sulfate radical‐based oxidation and neutralization in the same existing reactor instead of the existing FeCl3 process. [ABSTRACT FROM AUTHOR]

Purpose: For assessing the severity of tricuspid regurgitation (TR), there is no gold standard. We developed a parameter, the right ventricular systolic force ratio—RIVIERA, using the continious wave Doppler analysis of TR and pulsed‐wave analysis of the right ventricle outflow tract. We hypothesized that the RIVIERA would facilitate the ability to identify severe TR in clinical settings. Materials and Methods: We obtained data from routine transthoracic echocardiograms. All records reporting no or mild TR (n = 732), moderate TR (n = 584), and severe TR (n = 519) TR were reanalyzed to measure vena contracta (VC) width, TR jet area, effective regurgitant orifice (EROA) derived with the proximal isovelocity surface area method, the RIVIERA, and right‐sided chamber volumes. Results: Significant linear trends were demonstrated for right atrial volume index, end‐diastolic volume index, RVOT velocity time integral, TR jet area, TR‐Vmax, TR‐VTI, TR acceleration, VC width, EROA with increasing TR severity. Independent predictors of severe RT included RIVIERA <4.8, VC width ≥0.7 cm, TR jet area > 10 cm2, and EROA ≥0.4 cm2. Conclusion: The RIVIERA is a feasible, effective, and independent predictor of severe TR that enhances established techniques for estimating TR severity. For clinical decision‐making and management, accurate measurement and classification of TR severity are essential. Therefore, it should be thought about include the RIVIERA in the integrative method to assessing TR severity. [ABSTRACT FROM AUTHOR]

Objectives: Urinary incontinence (UI) is a frequent cause of admission to pediatric nephrology outpatient clinics. The aim of this study was to determine whether anatomical changes in lower urinary tract structures (retrovesical angulation [RVA] and bladder neck position [BNP]) are associated with UI in pediatric patients with daytime‐wetting in comparison to healthy children. Methods: In this prospective study, patients with daytime UI diagnosed using the Dysfunctional Voiding Symptom Score of the International Children's Continence Society and 3‐day‐voiding/bowel diary were compared with an age‐ and sex‐matched control group without incontinence. In addition to routine clinical evaluation, RVA and BNP were measured at rest using transabdominal ultrasound (TA‐US). Intra‐rater agreement was estimated. Results: A total of 88 children were included in the study, with 44 children (22 boys, 22 girls) each in patient and control groups. RVA was significantly greater and BNP was significantly lower in the patient group versus control group (RVA: 134.30 ± 10.05 vs 127.94 ± 13.15, P =.013; BNP: 11.88 ± 4.53 vs 17.20 ± 5.55, P <.001, respectively). Irrespective of the presence of incontinence, girls had a significantly greater RVA than boys (P <.001). However, there was no difference between sexes in BNP values (P =.630). Intra‐rater agreement was very strong for RVA (P <.001, r =.897), and strong for BNP (P <.001, r =.774). Conclusions: TA‐US imaging is a non‐invasive and practical procedure routinely performed in pediatric patients presenting with UI complaints. Our study demonstrated anatomical changes in lower urinary tract structures in pediatric patients with UI. These changes should be considered in the diagnosis, follow‐up, and treatment of patients with UI. [ABSTRACT FROM AUTHOR]

In this study, a sensitive electrochemical method was developed for the determination of hydroxylamine (H−A) using a curcumin‐modified pencil graphite electrode prepared with the electropolymerization of curcumin (PolyCurc‐PGE). The PolyCurc‐PGE showed a remarkable electrocatalytic response for H−A oxidation compared with bare PGE. Amperometric and cyclic voltammetric measurements were performed based on the electrocatalytic oxidation of H−A at PolyCurc‐PGE. Some parameters, such as monomer concentration, pH, and cycle number during electropolymerization, were optimized to obtain the best electrochemical response of the modified electrode towards H−A. Results show that the PolyCurc‐PGE gives a linear response towards H−A oxidation in the range from 0.50 μM to 500 μM (R2=0.9984). In addition, the sensitivity and detection limit (LOD) of PolyCurc‐PGE were found to be 5432 μA mM−1 cm2 and 0.15 μM H−A, respectively. The developed amperometric method was successfully applied to determine H−A in pharmaceutical and water samples, and acceptable results were obtained with high accuracy and precision. [ABSTRACT FROM AUTHOR]

Summary: Liver cirrhosis disease is an important cause of death worldwide. Therefore, early diagnosis of the disease is very important. Machine learning algorithms are frequently used due to its high performance in the field of health, as in many areas. In this study, Multilayer Perceptron‐Artificial Neural Networks, Decision Trees, Random Forest, Naïve Bayes, Support Vector Machines, K‐Nearest Neighborhood, and Logistic Regression classification algorithms are used to classify the factors affecting liver cirrhosis. The performances of these algorithms are compared according to the accuracy rate, F measure, sensitivity, specificity and Kappa score on real data obtained from 2000 liver cirrhosis patients, and the factors affecting the disease are classified with the most appropriate algorithm. In addition, more than 50 articles covering both liver disease and classification methods are reviewed and the latest developments are presented in the study. [ABSTRACT FROM AUTHOR]

A recent trend in the use of high‐resolution accurate mass screening (HRAMS) for doping control testing in both human and animal sports has emerged owing to significant improvement in high‐resolution mass spectrometry in terms of sensitivity, mass accuracy, mass resolution and mass stability. Several HRAMS methods have been reported for the detection of multidrug residues in human or equine urine. These improved analytical technologies have led to changes in the use of prohibited substances, and the administration of more than one substance at low concentrations as a "cocktail" has become one of the methods used to alter performance in racehorses. In one of horse urine samples transferred to the analytical laboratory in Turkey for analysis, 5‐hydroxymethyl meloxicam (2.96 ng/ml), etofenamate (2.15 ng/ml), flufenamic acid (108.92 ng/ml) and cobalt (200 ng/ml) were detected. These findings reveal that more than one prohibited substance was used together as a cocktail to alter the racing performance at low doses. In this case report, flufenamic acid was detected as a metabolite of etofenamate along with the parent drug. This case study also supports the advantages of metabolite analysis for anti‐doping laboratories. [ABSTRACT FROM AUTHOR]

The particular dynamics of public health emergencies urge scientists and Ethics Committee (EC) members to change and adapt their operating procedures to function effectively. Despite having previous pandemic experiences, ethics committees were unprepared to adapt to COVID‐19 pandemic challenges. This survey aims to learn and thoroughly discuss the most salient issues for ECs during the COVID‐19 pandemic. The results indicate that the main problems faced by ECs were lack of/insufficient regulations, lack of data/experience/knowledge, sloppy review, poor research design, and poor adaptation to quarantine measures. Coping with factors that threaten the autonomy and independence of ECs, the ethical dilemma regarding maximizing common good versus protecting the rights and well‐being of study participants, comprehending the change in the context of vulnerable populations, and redefining the role of ECs to strengthen trust in science and vaccine confidence were outstanding issues. [ABSTRACT FROM AUTHOR]

Purpose: After the emergence of the pandemic caused by the COVID‐19 virus, vaccination with various vaccines has started to be implemented across the world. To identify dermatological reactions developing after the COVID‐19 vaccines administered in Turkey and determine their clinical features and risk factors that may play a role in their development. Materials and Methods: The study included patients aged ≥18 years, who presented to 13 different dermatology clinics in Turkey between July 2021 and September 2021 after developing dermatological reactions following the administration of the COVID‐19 vaccine. After providing written consent, the patients were asked to complete a standard survey including questions related to age, gender, occupation, comorbidities, the regular medication used, the onset of cutaneous reactions after vaccination, and localization of reactions. Dermatological reactions were categorized according to whether they developed after the first or second dose of the vaccine or whether they occurred after the inactivated or messenger RNA (mRNA) vaccine. The relationship between dermatological reactions and some variables such as gender and comorbidities was also evaluated. Results: A total of 269 patients [116 women (43.1%), 153 men (56.9%)] were included in the study. It was observed that the dermatological diseases and reactions that most frequently developed after vaccination were urticaria (25.7%), herpes zoster (24.9%), maculopapular eruption (12.3%), and pityriasis rosea (4.5%). The rate of dermatological reactions was 60.6% after the administration of the mRNA vaccine and 39.4% after that of the inactivated vaccine. There was a statistically significantly higher number of reactions among the patients that received the mRNA vaccine (p = 0.001). Conclusion: The most common reactions in our sample were urticaria, herpes zoster, and maculopapular eruption. Physicians should know the dermatological side effects of COVID‐19 vaccines and their clinical features. [ABSTRACT FROM AUTHOR]

Educational technologies in veterinary medicine aim to train veterinarians faster and improve clinical outcomes. COVID-19 pandemic, shifted face-to-face teaching to online, thus, the need to provide effective education remotely was exacerbated. Among recent technology advances for veterinary medical education, extended reality (XR) is a promising teaching tool. This study aimed to develop a case resolution approach for radiographic anatomy studies using XR technology and assess students' achievement of differential diagnostic skills. Learning objectives based on Bloom's taxonomy keywords were used to develop four clinical cases (3 dogs/1 cat) of spinal injuries utilizing CT scans and XR models and presented to 22 third-year veterinary medicine students. Quantitative assessment (ASMT) of 7 questions probing ‘memorization’, ‘understanding and application’, ‘analysis’ and ‘evaluation’ was given before and after contact with XR technology as well as qualitative feedback via a survey. Mean ASMT scores increased during case resolution (pre 51.6% (±37%)/post 60.1% (± 34%); p< 0.01), but without significant difference between cases (Kruskal–Wallis H = 2.18, NS). Learning objectives were examined for six questions (Q1–Q6) across cases (C1-4): Memorization improved sequentially (Q1, 2 8/8), while Understanding and Application (Q3,4) showed the greatest improvement (26.7%-76.9%). Evaluation and Analysis (Q5,6) was somewhat mixed, improving (5/8), no change (3/8) and declining (1/8).Positive student perceptions suggest that case studies' online delivery was well received stimulating learning in diagnostic imaging and anatomy while developing visual–spatial skills that aid understanding cross-sectional images. Therefore, XR technology could be a useful approach to complement radiological instruction in veterinary medicine. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate pre‐, peri‐, and postnatal factors, screen time in a group of patients with autism spectrum disorder (ASD) and age and sex‐matched clinical controls to evaluate risk factors specific to ASD. Methods: The study included 211 ASD patients (177 boys, 34 girls; mean age 44.3 ± 13.0 months) and 241 (190 boys, 51 girls; mean age 44.6 ± 14.1 months) age and sex group matched clinical controls. Non‐ASD diagnoses were expressive language disorder (n = 135, 56.0%), intellectual disability (n = 15, 6.2%), attention deficit‐hyperactivity disorder (n = 6, 2.4%), oppositional disorder (n = 6, 2.4%), and other behavioral or emotional problems (no diagnosis; n = 79, 32.8%). A sociodemographic data form was used to collect data regarding pre‐, peri‐, and postnatal factors and total daily screen exposure. Results: According to our findings, maternal severe psychological stress and depression during pregnancy, and maternal postpartum depression were more frequent in the ASD group (p = 0.005, p = 0.035, and p = 0.001 respectively). There was a statistically significant difference between groups with regards to maternal any medication use during pregnancy (p = 0.004). The mean duration of daily screen exposure was higher in the ASD group (9.90 ± 5.10 h) compared to non‐ASD children (4.46 ± 3.40 h; p < 0.001). A ROC curve showed that 8.5 h and above total daily screen exposure (AUC = 0.808 [95% CI: 0.769–0.848], p < 0.001; 55% sensitivity, 90.5% specificity) is likely to be associated with increased risk for ASD. Conclusion: Our study suggests that prenatal maternal psychological stress, prenatal and postpartum depression, and excess exposure to screen might be related to an increased risk for ASD. [ABSTRACT FROM AUTHOR]

In 2005, the R2P was adopted unanimously at the UN World Summit. After the discussions and resolutions, the R2P has been invoked and implemented in several crises. Despite human rights violations and war crimes in Myanmar, the UN Security Council has failed to respond to these crimes and to implement R2P in this case. The passive approach of the UNSC led to atrocity crimes. In 2017, the Myanmar military launched a "clearance operation," thousands of people had to leave the country. Since then, the UNSC has neither adopted a resolution, nor applied sanctions or reminded the R2P to Myanmar government. This article explores the Myanmar crisis and analyzes the UN Security Council's muted response to the Rohingyas crisis. In conclusion, we argue that the veto power of China and Russia restrains the effectiveness of the UNSC in Myanmar case. [ABSTRACT FROM AUTHOR]

Objective: Peripartum cardiomyopathy (PPCM) diagnosis made by excluding identifiable causes of heart failure (HF) and occurs end of the pregnancy or during the postpartum period of five months. It presents a clinical HF spectrum with left ventricular systolic dysfunction. Background: The purpose of this study is to retrospectively evaluate the clinical characteristics, cardiac magnetic resonance (CMR) imaging features, and end‐points consisting of left ventricle recovery, left ventricular assist device implantation, heart transplantation, and all‐cause mortality. Method: Outpatient HF records between 2008 to 2021 were screened. Thirty‐seven patients were defined as PPCM. Twenty‐five patients had CMR evaluation at the time of diagnosis, and six patients were re‐evaluated with CMR. Results: The mean age was 30.5 ± 5.6 years, and the mean LVEF was 28.2% ± 6.7%. In 13(35.7%) patients, LVEF recovered during the follow‐up course. The median recovery time was 281(IQR [78–358]) days. LVEF on CMR was 35.3 ± 10.5, and three patients exhibited late gadolinium enhancement(LGE) patterns. Sub‐endocardial and mid‐wall uptake pattern types were detected. 18(75%) patients met the Petersen left ventricle non‐compaction cardiomyopathy(LVNC) criteria. Patients with NC/C ratio lower than 2.3 had lower LVEDVi and LVESVi (124.9 ± 35.4, 86.4 ± 7.5, p =.003; 86.8 ± 34.6, 52.6 ± 7.6, p =.006), respectively. The median follow‐up time was 2129 (IQR [911–2634]) days. The primary endpoint‐free 1‐year survival was 88.9% (event rate 11.1%), and 5‐year survival was 75.7% (event rate 24.3%). Conclusion: In a retrospective cohort of PPCM patients, 35.7% of patients' LVEF recovered, and the primary end‐point of free‐5‐year survival was 75%. Twenty‐five patients were assessed with CMR; three of four met the Petersen CMR‐derived LVNC at initial evaluation. [ABSTRACT FROM AUTHOR]

Background: Refugee or asylum seekers (RAS) children are at increased risk of physical, developmental, and behavioral health issues. The aim of this study was to evaluate clinical and psychosocial outcomes of hematopoietic stem cell transplantation (HSCT) in RAS children and compare health‐related quality of life (HRQOL) to those of Turkish peers. Methods: This retrospective study included patients who underwent HSCT aged 0–18 years and completed 100‐day post‐transplant. The PedsQL 4.0 Generic Core Scale was used in children over 5 years old to compare HRQOL. Results: A total of 166 RAS patients (M/F: 106 /60) underwent 174 HSCTs (six patients had two, and one had three HSCT) compared to 66 Turkish patients. The mean age of the patients in the RAS group was 7.8 ± 4.9 years and similar to controls. A total of 124 patients (75%) were from Syria, and 49 (25%) were from other countries in the Middle East and Africa. The cause of migration was war in 121 (74%) RAS patients. Complications of HSCT were no different between the groups. However, the rate of neutropenic sepsis was significantly higher in the RAS group (p = 0.004). The total scores of HRQOL were not different between RAS and controls. In the RAS group, ratings of social functioning were lower in patients with consanguinity or non‐malignant disease or who had match‐related donors. Discussion: Identifying areas of difficulty in subscales of HRQOL may help physicians to classify patients who need additional supportive care. Regular monitoring and supporting physical needs may result in better functional outcomes after HSCT. [ABSTRACT FROM AUTHOR]

Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due to rapid industrial development and technology has raised the questions: Is there a relationship between sperm parameters and these substances, and if so, in what extent? Results of studies on the subject reported conflicting results, many of which were not investigated in the seminal plasma. The aim of the current study was to evaluate the relationship between 23 metals and trace elements in human seminal plasma and semen parameters many of which were not investigated before. Levels of 23 metals in human seminal plasma were assessed by inductively coupled plasma mass spectrometry (ICP‐MS). We examined the differences between subjects with normal ejaculate (normozoospermia) and pathologic ejaculate (with at least one abnormal semen parameter) according to the WHO criteria. The only significant difference was detected for Se while the other element's difference was not statistically significant. Se was statistically significantly increased in normal semen group suggesting the positive effect of this element on semen parameters. [ABSTRACT FROM AUTHOR]

This work presents an effective and highly sensitive electrochemical detection of Sunset Yellow (SSY) at poly(Alizarin Red‐S) and functionalized multi‐walled carbon nanotubes composite modified glassy carbon electrode (f‐MWCNTs/poly(ALR‐S)/GCE). The electrochemical response of the f‐MWCNTs/poly(ALR‐S)/GCE towards SSY was examined by cyclic voltammetry (CV) and square wave voltammetry (SWV). Both recorded cyclic voltammograms (CVs) and square wave voltammograms (SWVs) showed that the oxidation/reduction peaks of SSY at f‐MWCNTs/poly(ALR‐S)/GCE were found to be much higher than the bare GCE, f‐MWCNTs/GCE, and poly(ALR‐S)/GCE. Calibration curves obtained from the SWVs indicated that the f‐MWCNTs/poly(ALR‐S)/GCE offers a linear response in the range of 0.50 to 256 μM with a low detection limit (LOD) of 0.16 μM and the sensitivity was found to be 9686 μA mM−1 cm−2. The f‐MWCNTs/poly(ALR‐S)/GCE provides excellent performance for the detection of SSY in daily life samples with high accuracy and precision. [ABSTRACT FROM AUTHOR]

Background and aims: Screening malnutrition, which is the most common complication in hemodialysis patients, is extremely important for these patients. Malnutrition inflammation score (MIS) and geriatric nutritional risk index (GNRI) are malnutrition screening tests used in hemodialysis patients in recent years. The purposes of this study are to evaluate the nutritional status of hemodialysis patients with different screening tests and to determine the cutoff values for this disease‐specific MIS and GNRI. Methods: The study was conducted with 194 adult patients including 98 males and 96 females whose mean age was 53.1 ± 10.96. Subjective global assessment (SGA) and MIS tests were applied, and the GNRI value was calculated for screening malnutrition. MIS and GNRI cutoff values were obtained by adopting the SGA scores as a standard and drawing a receiver operating characteristic curve. The tatistical Package for the Social Sciences‐22.0 package program was used in the analysis. Results: According to SGA, 70.7% of the patients were nourished, 21.1% were mildly‐moderately malnourished, and 8.2% were found to be severely malnourished. The optimal cutoff value predicted for malnutrition was 6.5 points (94.7% sensitivity and 98.5% specificity) for MIS and 86.0 points (64.9% sensitivity and 62.8% specificity) for GNRI. Based on these cutoff values, 28.9% of the patients were determined to be malnourished according to MIS and 45.4% according to GNRI. Conclusion: In conclusion, screening tests are very important in the early identification of malnutrition in hemodialysis patients. This study was conducted to evaluate the malnutrition of hemodialysis patients with different screening tests. At the end of the study, the availability of MIS was found to be high in detecting malnutrition in hemodialysis patients because of its high accuracy and sensitivity of MIS. The cutoff points we identified for both MIS and GNRI are thought to facilitate the determination of malnutrition. [ABSTRACT FROM AUTHOR]

Background: Adult atopic dermatitis (AD), especially adult‐onset type appears to have different clinical manifestations. Dupilumab is an IL‐4 receptor antagonist used in patients with moderate and severe atopic dermatitis, aged 12 years and older and it works by inhibiting the IL‐4 and IL‐13 signaling pathway. The purpose of our study is to retrospectively investigate the side effect profile and drug efficacy of thirteen adult patients who received dupilumab treatment and to evaluate the drug use status and the results during the COVID‐19 pandemicour stuAdult atopic dermatitis (AD), especially adult‐onset type appears to have different clinical manifestations. Dupilumab is an IL‐4 receptor antagonist used in patients with moderate and severe atopic dermatitis, aged 12 years and older and it works by inhibiting the IL‐4 and IL‐13 signaling pathway. The purpose of our study is to retrospectively investigate the side effect profile and drug efficacy of thirteen adult patients who received dupilumab treatment and to evaluate the drug use status and the results during the COVID‐19 pandemicAdult atopic dermatitis (AD), especially adult‐onset type appears to have different clinical manifestations. Dupilumab is an IL‐4 receptor antagonist used in patients with moderate and severe atopic dermatitis, aged 12 years and older and it works by inhibiting the IL‐4 and IL‐13 signaling pathway. The purpose of dy is to retrospectively investigate the side effect profile and drug efficacy of thirteen adult patients who received dupilumab treatment and to evaluate the drug use status and the results during the COVID‐19 pandemicAdult atopic dermatitis (AD), especially adult‐onset type appears to have different clinical manifestations. Dupilumab is an IL‐4 receptor antagonist used in patients with moderate and severe atopic dermatitis, aged 12 years and older and it works by inhibiting the IL‐4 and IL‐13 signaling pathway. The purpose of our study is to retrospectively investigate the side effect profile and drug efficacy of thirteen adult patients who received dupilumab treatment and to evaluate the drug use status and the results during the COVID‐19 pandemic. Materials and Methods: Thirteen patients with clinical and/or histopathological diagnoses of atopic dermatitis who received dupilumab treatment and were subsequently followed up in Bezmialem Vakif University dermatology outpatient clinic between April 2019 and October 2021 were included in our study.Patient files were reviewed, and patients were interviewed in‐person or by phone to learn about the COVID‐19 contagion.Descriptive statistical analysis was performed with Microsoft Excel, and the data obtained were calculated as mean and percentage. Results: All of our patients responded to the treatment after one course of dupilumab injection and also CRP and LDH levels decreased. Conjunctivitis side effect was found at a slightly higher rate than in previous clinical studies. The treatment was continued during the COVID‐19 pandemic in most patients. Meanwhile, four patients had COVID‐19 infection, but one of them was not using dupixent at that time. Conclusion: We can conclude that dupilumab is an effective and safe therapy for patients with severe AD also in cases of severe infections. [ABSTRACT FROM AUTHOR]

Kabuki syndrome (KS) is a rare disorder characterized by distinct face, persistent fingertip pads, and intellectual disability (ID) caused by mutation in KMT2D (56%–76%) or KDM6A (5%–8%). Thirty‐seven children aged 1–16 years who followed for median of 6.8 years were included in this study, which aimed to investigate the genetic and clinical characteristics of KS patients. KMT2D and KDM6A were evaluated by sequencing and multiplex‐ligation‐dependent probe amplification in 32 patients. Twenty‐one pathogenic variants in KMT2D, of which 17 were truncated and nine were novel, one frame‐shift novel variant in KDM6A were identified. The molecular diagnosis rate was 68.7% (22/32). In the whole‐exome sequencing analysis performed in the remaining patients, no pathogenic variant that could cause any disease was detected. All patients had ID; 43.2% were severe and moderate. We observed that facial features that became more prominent with age were enough for a possible diagnosis of KS in infancy. The frequencies of facial features, cardiac and renal anomalies, short stature, microcephaly, and epilepsy did not differ depending on whether they had truncating or nontruncating variants or were in variant‐negative KS‐like group. This study has expanded clinical features of the disease, as well as identified new variants in genes causing KS. [ABSTRACT FROM AUTHOR]