7 results on '"Gorostidi F"'
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2. Human and porcine urothelial stem cells
- Author
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Larsson, H. M., Gorostidi, F., Hubbell, J. A., Barrandon, Y., and Frey, P.
3. Single cell analysis of porcine and human urothelial cells
- Author
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Larsson, H. M., Gorostidi, F., Barrandon, Y., Hubbell, J. A., and Frey, P.
4. Congenital Malformations of the Cricoid Cartilage: Upper Airway Obstruction and Treatment Strategy.
- Author
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Gombert E, Gorostidi F, and Sandu K
- Subjects
- Child, Humans, Cricoid Cartilage surgery, Retrospective Studies, Treatment Outcome, Airway Obstruction etiology, Airway Obstruction surgery, Laryngostenosis etiology, Laryngostenosis surgery, Laryngostenosis diagnosis
- Abstract
Objectives: To review treatment and outcomes in patients with congenital cricoid cartilage malformation., Methods: Retrospective analysis of patients with diagnosis of congenital cricoid malformation (CCM) treated in a single tertiary pediatric referral center between 1985 and 2022. Patients were grouped according to the morphology of the cricoid cartilage that was diagnosed during endoscopy. We reviewed the treatment strategy(s), decannulation rate, complications, and functional outcomes., Results: Twenty-nine patients were grouped into four morphological subtypes of cricoid cartilage: 10 patients had a hypoplastic cricoid, eight had an elliptic shape, five had severe anterior thickening, and six an accentuated V-shape posterior cricoid plate. Twenty-four patients underwent surgery, and five were closely followed up without surgical treatment. Eight patients had a tracheostomy prior to surgery, and the majority had a hypoplastic cricoid. Most patients (20 out of 24) required additional procedures postoperatively to achieve an age-appropriate airway. Thirteen patients needed endoscopic dilatation(s) and granulation tissue removal; four needed more aggressive treatment, and three patients required revision open surgery. Decannulation was achieved after a median of 4.5 months in all previously tracheostomized patients. Endoscopy at the last follow-up showed an age-appropriate airway in 27 patients; 20 patients had normal oral feeding, and 11 patients had a normal voice., Conclusion: Endoscopy is important to diagnose CCM and most of the time patients would need only watchful waiting. In this report, surgery was required for patients who continued to remain symptomatic and had a compromised airway. The type of surgery depends on the type of cricoid malformation and the grade of stenosis., Level of Evidence: 4 Laryngoscope, 133:3185-3191, 2023., (© 2023 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
5. Pediatric vascular anomalies with airway compromise.
- Author
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Gorostidi F, Glasson N, Salati V, and Sandu K
- Subjects
- Child, Female, Humans, Infant, Infant, Newborn, Pregnancy, Esthetics, Dental, Laryngostenosis, Prenatal Diagnosis adverse effects, Tracheotomy, Airway Obstruction etiology, Airway Obstruction surgery, Vascular Malformations
- Abstract
Vascular anomalies are rare lesions of diverse nature that may affect the head and neck region. Any mass in or around the upper airway has the potential to obstruct or compromise it. The absolute priority, before etiologic treatment, is the evaluation of the risk for the airway and its management. Prenatal diagnosis of an upper airway obstruction requires a planned delivery in a center having a specialized team experienced in managing a compromised feto-neonatal airway, and who could perform an ex-utero intrapartum treatment to secure the airway. Even after birth, the airway remains central in the patient's overall management. Signs and symptoms of airway compromise must be evaluated keeping in mind the specific requirements of infants and small children and being aware that rapid worsening may occur. The treatment is then tailored to the patient and his lesion with the goal of improving symptoms while avoiding treatment-related complications. Maintaining reasonable expectations by the patient and families are part of a successful management. Cure is achievable for small and localized lesions, but symptom relief and mitigation of functional, esthetic and psychological impairments is the goal for large and complex lesions. If a tracheotomy was required, decannulation is one of the primary management goals., (© 2022 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
6. Extraluminal biodegradable splint to treat upper airway anterior malacia: A preclinical proof of principle.
- Author
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Gorostidi F, Courbon C, Burki M, Reinhard A, and Sandu K
- Subjects
- Animals, Disease Models, Animal, Endoscopy methods, Female, Prospective Studies, Rabbits, Survival Rate, Trachea surgery, Absorbable Implants adverse effects, Splints adverse effects, Tracheomalacia surgery
- Abstract
Objective: Upper airway malacia highly complicates the treatment of benign laryngotracheal stenosis, and no ideal option is available to date. We here explore the use of extraluminal biodegradable splints in an animal model of long-segment anterior tracheomalacia (TM). We show the efficacy, as well as the tissue tolerance, of a custom-made biodegradable extraluminal device surgically inserted around the trachea., Study Design: Preclinical animal study., Methods: Anterior TM was induced in rabbits through an anterior neck approach by removing eight consecutive anterior tracheal rings without damaging the underlying mucosa. Malacia was corrected during the same surgery by pexy sutures, suspending the tracheal mucosa to an experimental biodegradable device. Symptoms, survival, and tissue reaction were compared to healthy and sham surgery controls., Results: The model induced death by respiratory failure within minutes. Ten animals received the experimental treatment, and those who survived the perioperative period remained asymptomatic with a maximum follow-up of 221 days. Histological studies at programmed euthanasia showed complete degradation of the prosthesis, with significant remnant fibrosis around the trachea. However, the tracheal stiffness of test segments was comparatively less than that of control segments., Conclusion: Extraluminal biodegradable splints rescued animals with a condition otherwise incompatible with life. It was well tolerated, leaving peritracheal fibrosis that was not as stiff as normal trachea. The external tracheal stiffening was sufficient for the test animals to live through the phase of severe acute hypercollapsibility. This represents a valid option to help pediatric patients with laryngotracheal stenosis and associated cartilaginous airway malacia., Level of Evidence: NA. Laryngoscope, 128:E53-E58, 2018., (© 2017 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2018
- Full Text
- View/download PDF
7. External bioresorbable airway rigidification to treat refractory localized tracheomalacia.
- Author
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Gorostidi F, Reinhard A, Monnier P, and Sandu K
- Subjects
- Adult, Airway Obstruction etiology, Airway Obstruction surgery, Child, Child, Preschool, Device Removal, Female, Follow-Up Studies, Humans, Infant, Male, Recurrence, Retrospective Studies, Trachea surgery, Tracheal Stenosis complications, Tracheomalacia complications, Treatment Outcome, Absorbable Implants, Bronchoscopy methods, Laryngoscopy methods, Tracheal Stenosis surgery, Tracheomalacia surgery
- Abstract
Objectives/hypothesis: Our study evaluates the efficacy of extraluminal bioresorbable plates to treat refractory localized airway malacia in patients undergoing corrective surgery for complex multilevel laryngotracheal stenosis., Study Design: Retrospective case series., Methods: Secondary malacic airway segments were characterized (severity, site, type) by a dynamic transnasal flexible laryngotracheobronchoscopy before surgery. Extraluminal bioresorbable plates were used to stabilize the malacic segment through a transcervical approach under intraoperative flexible endoscopic guidance. Results were evaluated subjectively and by a postoperative dynamic endoscopy. We report our experience in seven patients (6 children, 1 adult)., Results: External tracheal stiffening allowed complete or partial resolution of refractory proximal airway malacia in six of seven complex cases described (result in one case is awaited). It allowed quick decannulation in four of seven patients who experienced multiple previous failures. Decannulation failures were due to recurrence of stenosis. With up to 2 years of follow-up, we report no direct complications related to the presence of extraluminal bioresorbable plates around the airway., Conclusion: Extraluminal biodegradable tracheal stiffening represents a valid therapeutic option in select cases of upper airway malacia. It can be highly useful in cases of complex multilevel airway obstructions. External stiffening needs to be planned on a case-to-case basis according to the type of malacia and must be performed under endoscopic guidance., Level of Evidence: 4. Laryngoscope, 126:2605-2610, 2016., (© 2016 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
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