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To address the present need in forensic security perceptions, including the ability to detect latent fingerprints, designing and development of low‐cost fluorescent materials becomes inevitable. This work illustrates the preparation of ZnO and its nanocomposite, Zn−CD with nitrogen doped carbon dots (CD−GC) with all components being generated from a single natural precursor, "Gynura Cusimba". Cell viability experiment carried out on HEK 293T cell line revealed that CD−GC, pure ZnO nanoparticles, and Zn−CD_0.8 were all biocompatible after being suitably evaluated by various analytical methods. Zn−CD_0.8 nanopowder was useful in detecting level 1–3 features of latent fingerprint developed on several substrates, which displayed good contrast and visibility. The work also highlights the application of Zn−CD_0.8 nanopowder for real time detection of latent fingerprints by demonstrating its use to identify aged fingerprints and those immersed in water. The results indicate that the potential of Zn−CD_0.8 to be a reasonably priced alternative to the existing commercial powders. [ABSTRACT FROM AUTHOR]

Communication and collaboration are key science competencies that support sharing of scientific knowledge with experts and non‐experts alike. On the one hand, they facilitate interdisciplinary conversations between students, educators, and researchers, while on the other they improve public awareness, enable informed choices, and impact policy decisions. Herein, we describe an interdisciplinary undergraduate course focused on using data from various bioinformatics data resources to explore the molecular underpinnings of diabetes mellitus (Types 1 and 2) and introducing students to science communication. Building on course materials and original student‐generated artifacts, a series of collaborative activities engaged students, educators, researchers, healthcare professionals and community members in exploring, learning about, and discussing the molecular bases of diabetes. These collaborations generated novel educational materials and approaches to learning and presenting complex ideas about major global health challenges in formats accessible to diverse audiences. [ABSTRACT FROM AUTHOR]

Development of useful products from toxic or hazardous waste is a unique strategy to overcome their disposal. In this work, we report the valorization of the toxic flowers of Thevetia peruviana (TP) into blue fluorescent nitrogen doped carbon dots (N‐CDs) with ∼6.6 % nitrogen doping from a single source of biomass without using any external dopant. The hydrophilic N‐CDs are biocompatible and show excitation‐dependent emission. Cytotoxity studies revealed the N‐CDs are selectively toxic towards the cancerous cells (DU‐145, MDA MB‐231, HepG2, and B16) but more biocompatible with normal CHO‐K1 and HEK‐293 cells. It has been observed that generation of reactive oxygen species in presence of N‐CDs cause DNA damage and the unrepaired cells undergo apoptosis in G2/M phase. To investigate the toxicity to normal cells, we further carried out in‐vitro and in‐vivo genotoxicity studies to reveal its non‐mitotoxic, non‐clastogenic, and non‐aneugenic properties. [ABSTRACT FROM AUTHOR]

Now in its 52nd year of continuous operations, the Protein Data Bank (PDB) is the premiere open‐access global archive housing three‐dimensional (3D) biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership. The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) is funded by the National Science Foundation, National Institutes of Health, and US Department of Energy and serves as the US data center for the wwPDB. RCSB PDB is also responsible for the security of PDB data in its role as wwPDB‐designated Archive Keeper. Every year, RCSB PDB serves tens of thousands of depositors of 3D macromolecular structure data (coming from macromolecular crystallography, nuclear magnetic resonance spectroscopy, electron microscopy, and micro‐electron diffraction). The RCSB PDB research‐focused web portal (RCSB.org) makes PDB data available at no charge and without usage restrictions to many millions of PDB data consumers around the world. The RCSB PDB training, outreach, and education web portal (PDB101.RCSB.org) serves nearly 700 K educators, students, and members of the public worldwide. This invited Tools Issue contribution describes how RCSB PDB (i) is organized; (ii) works with wwPDB partners to process new depositions; (iii) serves as the wwPDB‐designated Archive Keeper; (iv) enables exploration and 3D visualization of PDB data via RCSB.org; and (v) supports training, outreach, and education via PDB101.RCSB.org. New tools and features at RCSB.org are presented using examples drawn from high‐resolution structural studies of proteins relevant to treatment of human cancers by targeting immune checkpoints. [ABSTRACT FROM AUTHOR]

As a fuel, hydrogen may effectively replace the traditional fossil fuels. TiO2 has been in use the most in semiconductors for photocatalytic hydrogen generation, according to a detailed review of the prior art. In our research, we created a photocatalytic system made of an H‐CD/Pt−TiO2 heterostructure, where carbon dots (H‐CD) were derived from a natural plant source called Rhus Semialata and 1 wt% Pt−TiO2 using photo‐deposition technique. After thorough characterization using various techniques including XPS, XRD, UV‐DRS, etc., the nanocomposites as‐prepared as well as the pristine materials were examined for their hydrogen generation capabilities using a 450 W Xe−Hg lamp. Inference from the experimental data showed that 1 wt %‐ Pt/TiO2 nanocomposite with 1 % H‐CD demonstrated a higher rate of hydrogen production (180.7 mmol h−1 g−1cat) than 1 wt%‐ Pt/TiO2. In this work, H‐CD and Pt play the role of photosensitizer and co‐catalyst respectively in enhancing the hydrogen generation of the nanocomposite compared to that of pure anatase TiO2 under similar conditions. [ABSTRACT FROM AUTHOR]

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), funded by the US National Science Foundation, National Institutes of Health, and Department of Energy, has served structural biologists and Protein Data Bank (PDB) data consumers worldwide since 1999. RCSB PDB, a founding member of the Worldwide Protein Data Bank (wwPDB) partnership, is the US data center for the global PDB archive housing biomolecular structure data. RCSB PDB is also responsible for the security of PDB data, as the wwPDB‐designated Archive Keeper. Annually, RCSB PDB serves tens of thousands of three‐dimensional (3D) macromolecular structure data depositors (using macromolecular crystallography, nuclear magnetic resonance spectroscopy, electron microscopy, and micro‐electron diffraction) from all inhabited continents. RCSB PDB makes PDB data available from its research‐focused RCSB.org web portal at no charge and without usage restrictions to millions of PDB data consumers working in every nation and territory worldwide. In addition, RCSB PDB operates an outreach and education PDB101.RCSB.org web portal that was used by more than 800,000 educators, students, and members of the public during calendar year 2020. This invited Tools Issue contribution describes (i) how the archive is growing and evolving as new experimental methods generate ever larger and more complex biomolecular structures; (ii) the importance of data standards and data remediation in effective management of the archive and facile integration with more than 50 external data resources; and (iii) new tools and features for 3D structure analysis and visualization made available during the past year via the RCSB.org web portal. [ABSTRACT FROM AUTHOR]

With a huge upsurge in the energy requirements all over the world, development of energy storage devices with high safety standards without compromising the ecological aspects has become the need of the hour, that propelled the scientific community to search for alternative yet promising sources of energy that would prevent the exhaustion of natural resources. Numerous attempts have been undertaken to utilize the renewable biopolymers in the evolution of solid‐ state electrolytes, as a substitute for liquid electrolytes which are prone to cause leakage leading to hazardous accidents. Despite strenuous efforts, it is still challenging to strike a right balance between the biopolymer elements and the conducting additives. In this review, we aim to lay out a recap on the progress achieved in recent times by employing biopolymers as electrolyte components and its future prospects, that would assist the researchers across the globe to inch one step closer in their quest to find the best electrolyte system for flexible electronics. [ABSTRACT FROM AUTHOR]

Industrial pollutants are one of the many contributing factors towards deterioration of nature, urging the scientific community around the globe to look for ways in which they can be eliminated. In this regard, we have developed and optimized an efficient photocatalytic system comprising of liquid exfoliated graphene quantum dots (GQDs) and TiO2, by carrying out a thorough study with different morphologies of TiO2; namely, nanotubes, nanorods and nanoparticles. The nanocomposites were duly characterized using various techniques such as FT‐IR, TGA, FESEM, UV‐vis spectroscopy etc. Among the as‐prepared range of nanocomposites, the photocatalyst containing 2 wt% of GQDs and TiO2 nanotubes was found to exhibit a higher degradation efficiency of 96.7 % towards methylene blue (MB) under visible light irradiation of 120 min. Further, we have also repeated the photocatalytic study of this nanocomposite up to four cycles to understand the reusability of the photocatalyst. Band gap of GQDs, pristine TiO2 and the nanocomposite determined from Tauc plot was found to be 2.26, 2.92 and 2.86 eV respectively. We also underline that the "metal‐free" GQDs, synthesized via our approach, play the role of a photosensitizer by providing an edge of extending the visible light absorption in the case of nanocomposites via enhanced electron‐hole (e–h) separation and lowering of band gap. [ABSTRACT FROM AUTHOR]

Abstract: The Protein Data Bank (PDB) was established in 1971 as a repository for the three dimensional structures of biological macromolecules. Since then, more than 85000 biological macromolecule structures have been determined and made available in the PDB archive. Through analysis of the corpus of data, it is possible to identify trends that can be used to inform us abou the future of structural biology and to plan the best ways to improve the management of the ever-growing amount of PDB data. [Copyright &y& Elsevier]

The title compounds, 1-cyano-2-hydroxy- N-[4-(methylsulfon­yl)phenyl]but-2-en­amide, C12H12N2O4S, PHI492, 1-cyano-2-hydroxy- N-[3-(methyl­sulfonyl)­phenyl]­but-2-en­amide, C12H12­N2O4S, PHI493, and N-[3-bromo-4-(trifluoro­methoxy)­phenyl]-1-cyano-2-hydroxybut-2-en­amide, C12H8Br­F3N2O3, PHI495, are potent inhibitors of Bruton's tyrosine kinase (BTK). The molecular structures of these compounds are similar and they display similar hydrogen-bonding networks and crystal packing. Examination of the crystal-packing interaction in the three compounds reveals an alternating direction of adjacent mol­ecules in the crystalline lattice due to intermolecular cyano-amide hydrogen bonding. PHI492, a positional isomer of PHI493, does not form intermolecular O-H⃛O hydrogen bonds between mol­ecules and crystallizes in a space group different from that of PHI493 and PHI495. The aromatic ring and the amide group of each mol­ecule form a conjugated π-system which ensures planarity, with further stabilization gained from intramolecular O-H⃛O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the title compound, C21H17N3O2, the dihedral angles between the central pyrazole and the substituent pyridine, hydroxyphenyl and benzene rings are 48.58 (1), 5.2 (1) and 84.73 (1)°, respectively. [ABSTRACT FROM AUTHOR]

In the title compound, C21H16FN3O2, the pyridine ring is nearly coplanar with the plane of the fused bicyclic ring system [dihedral angle = 4.1 (2)°], while the 4-fluoro­phenyl ring forms a dihedral angle of 67.7 (3)° with the fused bicyclic ring system. [ABSTRACT FROM AUTHOR]

The structure of the title compound, C25H22ClN3O2·C2H6O, displays N—H⋯O, O—H⋯O, O—H⋯N, C—H⋯Cl, C—H⋯O hydrogen bonding. [ABSTRACT FROM AUTHOR]