13 results on '"Ghersetich, I"'
Search Results
2. ORIGINAL ARTICLE The use of pyruvic acid in the treatment of acne.
- Author
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Cotellessa, C., Manunta, T., Ghersetich, I., Brazzini, B., and Peris, K.
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ACNE ,SKIN disease treatment ,PYRUVIC acid ,CHEMICAL peel ,SEBACEOUS gland diseases ,ORGANIC acids ,CHEMOSURGERY - Abstract
Background Acne is one of the most common dermatological diseases, affecting about 50% of adolescents. Different chemical peelings are used in local treatment, either alone or in association with other therapies. Objective To evaluate the efficacy and tolerability of chemical peeling with pyruvic acid for treatment of mild to moderate papulo-pustular acne. Methods We conducted an open-label study in which patients affected by mild to moderate papulo-pustular acne were treated with 40-50% pyruvic acid every 2 weeks for a total of 3-4 months. Forty patients (26 women and 14 men), ranging in age from 18 to 30 years, were enrolled in the study. Evaluations of sebum production and skin hydration were performed before and after treatment in 24 patients. Results Complete remission was observed in 16 patients (40%), partial remission was detected in 20 patients (50%), and no improvement was seen in four patients (10%). No side-effects were observed during or after treatment. Post-treatment evaluation of sebum production in 24 patients revealed a reduction in sebum levels in all patients. Post-treatment values of cutaneous hydration did not vary significantly from pretreatment values in the 24 patients evaluated. Conclusions The results of our study indicate that peeling with pyruvic acid can be considered an effective, safe and well-tolerated procedure in the treatment of patients affected by mild to moderate papulo-pustular acne. [ABSTRACT FROM AUTHOR] more...
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- 2004
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3. Laser treatment of cutaneous vascular lesions: face and leg telangiectases.
- Author
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Hercogova, J, Brazzini, B, Hautmann, G, Ghersetich, I, and Lotti, T
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TELANGIECTASIA ,MEDICAL lasers ,SKIN diseases - Abstract
Editorial. Discusses the treatment of cutaneous vascular lesions of the face and leg using laser technology. Types of lasers used to treat facial and leg telangiectases; Main vascular lesions that can be successfully treated with laser devices. more...
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- 2002
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4. Nd:YAG 1064 nm laser in the treatment of facial and leg telangiectasias.
- Author
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Major, A, Brazzini, B, Campolmi, P, Bonan, P, Mavilia, L, Ghersetich, I, Hercogova, J, and Lotti, T
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ND-YAG lasers ,TELANGIECTASIA ,THERAPEUTICS - Abstract
AbstractBackgroundFacial and leg telangiectasias are a frequent cosmetic concern for both females and males with various skin types and ages. To date the different treatments for these problems, in particular leg telangiectasias, have frequently failed or led to negative side-effects. ObjectiveThis study examines the clinical effects and safety of applications with a 1064-nm Nd:YAG laser system (SmartEpil II, DEKA M.e.l.a., Florence, Italy) to treat vessels on the face and legs. Materials and methodsTwenty-five subjects with facial telangiectasias underwent one treatment at 100 J/cm
2 , 10 ms and 2 Hz repetition rate. Thirty-two subjects with leg telangiectasias, measuring 0.1–3 mm in diameter, were treated at 125–200 J/cm2 , 10–30 ms and 2 Hz repetition rate. Subjects in this group underwent one to five treatment sessions at 8 week intervals. ResultsAll subjects showed visible improvement, with 95–100% clearing of the face telangiectasias after only one treatment, and 50–100% clearing of the lower extremity vessels after three to five treatments. Transitory hypopigmentation was seen in two cases subjected to leg vessel treatment. ConclusionsTreatment of facial and leg telangectasias using a true long pulse 1064 nm Nd:YAG laser is an effective and safe method. The relative lack of discomfort combined with a high degree of individual satisfaction should play a part in the fairly high level of acceptance of this new form of therapy for the treatment of leg and face telangiectasias. [ABSTRACT FROM AUTHOR] more...- Published
- 2001
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5. Laser tissue interaction in epidermal pigmented lesions.
- Author
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Brazzini, B, Hautmann, G, Ghersetich, I, Hercogova, J, and Lotti, T
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MEDICAL lasers ,TISSUE analysis - Abstract
Editorial. Comments on the laser-tissue interaction in epidermal pigmented lesions. Complexity of the interaction; Imposition of a tissue effect by laser light; Estimation of thermal relaxation times of some important skin structures. more...
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- 2001
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6. Chemical peeling: How, when, why?
- Author
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Ghersetich, I., Teofoll, P., Gantcheva, M., Ribuffo, M., and Puddu, P.
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CHEMICAL peel , *KERATOSIS , *SCARS , *RESORCINOL , *WARTS , *CHEMICALS - Abstract
General description Chemical peeling is a procedure frequently used to treat unaesthetic cutaneous alterations such as photoageing, actinic keratosis, chloasma, senile lentigo and post-acneic scars as well those of a non-strictly aesthetic nature such as seborrhoeic keratosis and flat warts. Several chemical agents are used depending on the depth of peeling to he obtained. The most commonly used agents are: alpha-hydroxy-acids, resorcinol. Jessner's solution, and trichloroacetic acid. In the present study the characteristics of the individual substances, technical procedure and applications are taken into consideration, Finally, the main risks and side-effects, depending on the depth of peeling, are considered. Learning objective The reader will have learned what a chemical peeling is. what chemical agents are available, and how to perform chemical peeling in the office. The mechanism of action of different chemical agents. expectations from this procedure, potential risks and complications are also reviewed with insight into criteria for selecting patients. [ABSTRACT FROM AUTHOR] more...
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- 1997
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7. Circulating Vδ1 + T cells are activated and accumulate in the skin of systemic sclerosis patients.
- Author
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Giacomelli, R., Matucci-Cerinic, M., Cipriani, P., Ghersetich, I., Lattanzio, R., Pavan, A., Pignone, A., Cagnoni, M. L., Lotti, T., and Tonietti, G.
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- 1998
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8. Alternative treatment of psoriasis with balneotherapy using Leopoldine spa water.
- Author
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Tsoureli-Nikita, E, Menchini, G, Ghersetich, I, and Hercogova, J
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PSORIASIS ,BALNEOLOGY - Abstract
Abstract Background Leopoldine spa water is a hypotonic water rich in sulphate that has been used occasionally for balneological treatments in psoriatics. We evaluated the anti-inflammatory effects of this salso-sulphate water on the skin of subjects with psoriasis. Patients and methods We selected 10 volunteer subjects (23–58 years old), who presented symmetrical, bilateral psoriasis involving at least 40% of the body surface. All the subjects were subjected to the following treatment schedule: (i) immersion of both arms in water twice a day [the right arm was immersed in Leopoldine spa water at its natural source temperature (27.2 °C) for 30 min, and the left arm was immersed in double-distilled water for 30 min at a constant temperature of 27 °C]; (ii) both arms were exposed to the sun for 60 min after each immersion; and (iii) vaseline containing moisturizing creams were applied liberally. The treatment was continued for 4 weeks and was well tolerated by all subjects. Response to treatment was assessed by means of the modified Psoriasis Area and Severity Index (PASI). Six of the 10 subjects volunteered to undergo a cutaneous biopsy of lesional skin both before and 4 weeks after treatment to allow for assessment of modifications of the cutaneous infiltrate in the areas treated. Results At the end of 4 weeks the average pretreatment PASI score of the left arms was 5.72 (range 4–9.6) while the right arms had a mean PASI of 5.56 (range of 3.2–9). At the end of the study the average PASI score was 0.78 for the arms treated with Leopoldine spa water and 2.83 for the arms treated with double-distilled water. The mean PASI improvement score for the Leopoldine spa water treated arms was 85.9% while the double-distilled water treated arms showed a PASI improvement score of 50.5%. An immunohistological study showed significant differences between the cutaneous samples taken 4 weeks after treatment and those taken before treatment with... [ABSTRACT FROM AUTHOR] more...
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- 2002
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9. Pityriasis lichenoides et varioliformis acuta during pregnancy.
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Brazzini, B., Ghersetich, I., Urso, C., Cianferoni, L., and Lotti, T.
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LICHENS , *PREGNANCY complications - Abstract
Focuses on the occurrence of the pityriasis lichenoides et varioliformis acuta (PLEVA) during pregnancy. Analysis of the aetiology of PLEVA; Possibility of the involvement of the mucosal membranes of the vagina, cervix and the uterus; Description of PLEVA symptoms. more...
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- 2001
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10. Therapeutic Hotline: Facial skin rejuvenation in a patient treated with photodynamic therapy for actinic keratosis.
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Bruscino N, Rossi R, Dindelli M, Ghersetich I, and Lotti T
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- Aged, 80 and over, Carcinoma, Squamous Cell prevention & control, Female, Humans, Keratosis, Actinic drug therapy, Skin Aging radiation effects, Skin Neoplasms prevention & control, Aminolevulinic Acid therapeutic use, Keratosis, Actinic radiotherapy, Photochemotherapy methods, Photosensitizing Agents therapeutic use, Rejuvenation
- Abstract
The aim of the most used treatments of actinic keratoses (AKs) is to avoid the conversion into invasive squamous cell carcinoma through the destruction of the lesion; a lot of therapeutic modalities (imiquimod, 5-fluorouracil, electrosurgery with curettage, cryosurgery) are effective and safe in this field, but not many can do it with excellent cosmetic results like treatment with photodynamic therapy (PDT). We have treated with this technique an old patient, whose AK was resistant to other treatments; the most interesting feature of our case comes from the esthetic effects of the PDT employing a methyl-ester of 5-aminolevulinic acid as topical photosensitizer. This kind of therapy has removed not only the lesion but also the photoaging manifestations like the wrinkles and the ugly lines, leaving a smooth skin, as we have proved with 3D-profilometry technique. more...
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- 2010
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11. The neuro-immuno-cutaneous-endocrine network: relationship between mind and skin.
- Author
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Brazzini B, Ghersetich I, Hercogova J, and Lotti T
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- Humans, Skin Physiological Phenomena, alpha-MSH physiology, Endocrine System physiology, Neuroimmunomodulation physiology, Skin Diseases physiopathology
- Abstract
Brain-body(skin) influences are bi-directional and skin should be considered as an active neuro-immuno-endocrine interface, where effector molecules act as common words used in a dynamic dialogue between brain, immune-system and skin. It has been widely demonstrated that stimuli received in the skin can influence the immune, endocrine and nervous systems at both a local and central level. However, the brain can also modulate inflammatory conditions locally induced in the skin. It has been experimentally demonstrated that intracerebral administration of the tridecapeptide alpha-MSH or even its COOH-terminal tripeptide can in fact inhibit cutaneous inflammation induced by the application of topical irritants and intradermal injection of cytokines. The skin can therefore alter the pharmacology of the CNS by releasing large amounts of NPs which obviously do work locally in the skin and beyond the skin. Alpha-MSH may represent a key molecule for understanding this aspect of cutaneous-immune-neuro-endocrine-mental biological communication, being it is also generated in the skin. This molecule may in the future be used as a potent anti-inflammatory agent in clinical dermatology, and preclinical trials are presently in progress. more...
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- 2003
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12. Balneology today.
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Ghersetich I, Freedman D, and Lotti T
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- Free Radicals, Humans, beta-Endorphin metabolism, Baths, Mineral Waters, Skin Diseases therapy
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- 2000
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13. Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients.
- Author
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Giacomelli R, Matucci-Cerinic M, Cipriani P, Ghersetich I, Lattanzio R, Pavan A, Pignone A, Cagnoni ML, Lotti T, and Tonietti G
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- Adult, Aged, Humans, Lymphocyte Activation physiology, Male, Middle Aged, Scleroderma, Systemic pathology, T-Lymphocytes metabolism, T-Lymphocytes pathology, Blood Cells metabolism, Receptors, Antigen, T-Cell, gamma-delta metabolism, Scleroderma, Systemic blood, Scleroderma, Systemic metabolism, Skin pathology, T-Lymphocytes physiology
- Abstract
Objective: An increased percentage of Vdelta1+/gamma/delta T cells has been detected both in the peripheral blood and bronchoalveolar lavage fluid of patients with systemic sclerosis (SSc). This study evaluated the subset distribution, activation status, and expression of cellular adhesion molecules, such as intercellular adhesion molecule 1 (CD54), very late activation antigen alpha4 (CD49d), and lymphocyte function-associated antigen 1alpha (CD11a), on circulating gamma/delta T cells, as well as their presence in the skin of SSc patients., Methods: We studied 12 patients with SSc and 16 healthy volunteer donors. The distribution, activation status, and expression of cellular adhesion molecules were studied by flow cytometry; their presence in SSc patient skin was evaluated by immunohistochemistry., Results: We found that the percentages and absolute numbers of peripheral blood gamma/delta T cells, CD16, CD8, CD45RO, CD25, HLA-DR, CD54, and CD11a coexpression did not differ significantly from those of the controls. CD49d gamma/delta T cells were significantly increased in SSc patients (2.3%) compared with controls (0.5%). A marked increase in the ratio of Vdelta1+ cells to gamma/delta cells was observed in the patients (72%) compared with the controls (31%). The Vdelta1+ subset showed a significant expression of both HLA-DR (83% of total Vdelta1+ cells) and CD49d (90% of total Vdelta1+ cells) compared with the controls (20.5% and 60%, respectively). In the skin, the absolute numbers of gamma/delta T cells were found in striking amounts in perivascular areas, particularly in the early edematous phase of SSc (22.58 in patients and 0 in controls); the majority of gamma/delta T cells were Vdelta1+ (19 in patients and 0 in controls). In the advanced phase of SSc, Vdelta1+ T cells were also increased compared with controls (3.5 versus 0)., Conclusion: Our results show that Vdelta1+ T cells express both adhesion molecules and activation markers, and strongly support gamma/delta T cell homing to sites of inflammation. The increase in the Vdelta1 subset suggests a selective V gene subset expansion. more...
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- 1998
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