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The MC-3 species was induced using 5 mM SP-3 and GSH in equimolar concentration in deuterated acetonitrile/phosphate buffered saline (PBS, 1X, pH 7.4) (1:1 v/v)Figure S19.13C NMR of GSH-stabilized MC-3. The MC-2 species was induced using 15 mM SP-2 and GSH in equimolar concentration in deuterated acetonitrile/phosphate buffered saline (PBS, 1X, pH 7.4) (1:1 v/v)Figure S10.13C NMR of GSH-stabilized MC-2. Investigating the interaction between merocyanine and glutathione through a comprehensive NMR analysis of three GSH-stabilized merocyanine species Comprehensive NMR characterization of GSH-stabilized merocyanines could aid in the identification of stereochemistry of the GSH-stabilized merocyanine species and may help in providing improved understanding of the sensing mechanism of these photoswitches for GSH. [Extracted from the article]

Recent advances in the coordination chemistry of Eu2+ are reviewed. Common synthetic routes for generating discrete Eu2+-containing complexes reported since 2000 are summarized, followed by a description of the reactivity of these complexes and their applications in reduction chemistry, polymerization, luminescence, and as contrast agents for magnetic resonance imaging. Rapid development of the coordination chemistry of Eu2+ has led to an upsurge in the utilization of Eu2+-containing complexes in synthetic chemistry, materials science, and medicine. [ABSTRACT FROM AUTHOR]

Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of methadone, is being withdrawn from the United States market because its use waned after a black box warning was issued to require electrocardiographic monitoring. Therefore, methadone and buprenorphine are the only opioids available for the treatment of heroin addiction. To our knowledge, the cardiac safety of buprenorphine in patients with methadone-related QTc prolongation has not been described. We report a patient who developed torsade de pointes while receiving high-dose methadone and was successfully inducted onto buprenorphine under close medical supervision. No clinically important QTc prolongation was observed in the acute setting or during follow-up. This observation suggests that buprenorphine may be a safe alternative to oral methadone in patients with opioid addiction who develop torsade de pointes. [ABSTRACT FROM AUTHOR]

Review: 94 refs. [ABSTRACT FROM AUTHOR]