1. Genetic evidence of a sarcomatoid transformation in Merkel cell carcinoma.
- Author
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Barbieux, Simon, Tallet, Anne, Collin, Christine, Tallegas, Matthias, Delalande, Flore, Bens, Guido, Levy, Annie, Kalampokas, Athanasios, Schrama, David, Houben, Roland, Touzé, Antoine, Garcia, Jeremy, Macagno, Nicolas, Appay, Romain, Samimi, Mahtab, Guyétant, Serge, and Kervarrec, Thibault
- Subjects
CELL transformation ,SQUAMOUS cell carcinoma - Abstract
The sarcomatoid component harbored additional amplifications of the chromosomes 1q, 6q, 9q, 13q, 20, 21, and 22. gl Microscopically, both combined cases showed an MCC component with tumour cells arranged in sheets, with a high nucleocytoplasmic ratio and condensed chromatin associated with in situ (case #1) or invasive conventional SCC (case #2). Merkel cell carcinoma (MCC) is a rare cancer with a 5-year overall survival rate estimated at 40%.[1] About 80% of cases are related to the genomic integration of Merkel cell Polyomavirus (MCPyV).[2] In comparison, the prominent UV signature is a hallmark of MCPyV-negative cases.[1] Interestingly, the cell of origin remains a matter of debate for both MCPyV-negative and MCPyV-positive cases.[[1], [3]] In 5%-10% of cases, MCC is associated with another component, mainly squamous cell carcinoma (SCC). Merkel cell polyomavirus-negative -Merkel cell carcinoma originating from in situ squamous cell carcinoma: a keratinocytic tumor with neuroendocrine differentiation. [Extracted from the article]
- Published
- 2023
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