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Your search keyword '"Ferry, G."' showing total 72 results
Start Over Author "Ferry, G." Publisher wiley-blackwell
72 results on '"Ferry, G."'

1. Scar formation in mice deafened with kanamycin and furosemide.

Author

Żak, Magdalena, van der Linden, Cynthia A., Bezdjian, Aren, Hendriksen, Ferry G., Klis, Sjaak F.L., and Grolman, Wilko

Abstract

ABSTRACT In mammals, hair cell loss is irreversible and leads to hearing loss. To develop and test the functioning of different strategies aiming at hair cell regeneration, animal models of sensorineural hearing loss are essential. Although cochleae of these animals should lack hair cells, supporting cells should be preserved forming an environment for the regenerated hair cells. In this study, we investigated how ototoxic treatment with kanamycin and furosemide changes the structure of cochlear sensory epithelium in mice. The study also compared different tissue preparation protocols for scanning electron microscopy (SEM). Cochleae were collected from deafened and nondeafened mice and further processed for plastic mid modiolar sections and SEM. For comparing SEM protocols, cochleae from nondeafened mice were processed using three protocols: osmium-thiocarbohydrazide-osmium (OTO), tannic acid-arginine-osmium, and the conventional method with gold-coating. The OTO method demonstrated optimal cochlear tissue preservation. Histological investigation of cochleae of deafened mice revealed that the supporting cells enlarged and ultimately replaced the lost hair cells forming types 1 and 2 phalangeal scars in a base towards apex gradient. The type 3 epithelial scar, flattened epithelium, has not been seen in analysed cochleae. The study concluded that mice deafened with kanamycin and furosemide formed scars containing supporting cells, which renders this mouse model suitable for testing various hair cell regeneration approaches. Microsc. Res. Tech. 79:766-772, 2016. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
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40. Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial.

Author

Ferry, George D., Kirschner, Barbara S., Grand, Richard J., Issenman, Robert M., Griffiths, Anne M., Vanderhoof, John A., Fiedorek, Stephen C., Winter, Harland S., Hassall, Eric G., Watkins, John B., Gryboski, Joyce, Ulshen, Martin H., Daum, Frederic, Perman, Jay A., Thomas, Daniel W., Heubi, James E., Byrne, William J., Jones, Bobbette, Ferry, G D, and Kirschner, B S

Published
1993

45. Photochemistry of HOx in the upper troposphere at northern midlatitudes

Author

Jaeglé, L., Jacob, Daniel James, Brune, W. H., Faloona, I., Tan, D., Heikes, B. G., Kondo, Yasuyuki, Sachse, G. W., Anderson, B., Gregory, G. L., Singh, H. B., Pueschel, R., Ferry, G., Blake, D. R., and Shetter, R. E.

Abstract

The factors controlling the concentrations of HO radicals (= OH + peroxy) in the upper troposphere (8–12 km) are examined using concurrent aircraft observations of OH, HO, HO, CHOOH, and CHO made during the Subsonic Assessment Ozone and Nitrogen Oxide Experiment (SONEX) at northern midlatitudes in the fall. These observations, complemented by concurrent measurements of O, HO, NO, peroxyacetyl nitrate (PAN), HNO, CH, CO, acetone, hydrocarbons, actinic fluxes, and aerosols, allow a highly constrained mass balance analysis of HO and of the larger chemical family HO (= HO + 2 HO + 2 CHOOH + HNO + HNO). Observations of OH and HO are successfully simulated to within 40% by a diel steady state model constrained with observed HO and CHOOH. The model captures 85% of the observed HO variance, which is driven mainly by the concentrations of NO (= NO + NO) and by the strength of the HO primary sources. Exceptions to the good agreement between modeled and observed HO are at sunrise and sunset, where the model is too low by factors of 2–5, and inside cirrus clouds, where the model is too high by factors of 1.2–2. Heterogeneous conversion of NO to HONO on aerosols (γ = 10) during the night followed by photolysis of HONO could explain part of the discrepancy at sunrise. Heterogeneous loss of HO on ice crystals (γ = 0.025) could explain the discrepancy in cirrus. Primary sources of HO from O()+HO and acetone photolysis were of comparable magnitude during SONEX. The dominant sinks of HO were OH+HO (NO50 pptv). Observed HO concentrations are reproduced by model calculations to within 50% if one allows in the model for heterogeneous conversion of HO to HO on aerosols (γ = 0.2). Observed CHOOH concentrations are underestimated by a factor of 2 on average. Observed CHO concentrations were usually below the 50 pptv detection limit, consistent with model results; however, frequent occurrences of high values in the observations (up to 350 pptv) are not captured by the model. These high values are correlated with high CHOH and with cirrus clouds. Heterogeneous oxidation of CHOH to CHO on aerosols or ice crystals might provide an explanation (γ ∼ 0.01 would be needed)., Engineering and Applied Sciences

Published
2000
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