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Start Over Author "Dun, Karen" Publisher wiley-blackwell
2 results on '"Dun, Karen"'

1. Variant acute promyelocytic leukaemia with novel NAB2::RARA fusion shows clinical all‐trans retinoic acid and arsenic trioxide sensitivity.

Author

Ng Liet Hing, Melissa, Ryland, Georgina L., Nguyen, Tamia, Tiong, Ing Soo, Dun, Karen, Ninkovic, Slavisa, Nedumannil, Rithin, Westerman, David A., Blombery, Piers A., Chan, Kah Lok, and Bajel, Ashish

Subjects
ACUTE promyelocytic leukemia, TRETINOIN, REVERSE transcriptase polymerase chain reaction, CHRONIC leukemia
Abstract

Variant acute promyelocytic leukaemia with novel NAB2::RARA fusion shows clinical all-trans retinoic acid and arsenic trioxide sensitivity Acute promyelocytic leukaemia (APL) is characterised by reciprocal translocation between the promyelocytic leukaemia ( I PML i ) gene at chromosome 15q24 and the retinoic acid receptor alpha ( I RARA i ) gene at chromosome 17q21. (E) Metaphase FISH using PML:RARA dual fusion translocation probe (Metasystems), which is negative for PML:RARA fusion but displays 3 RARA (green) signals, indicating the presence of a variant RARA translocation. [Extracted from the article]

Published
2023
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