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Your search keyword '"Dubrova, Yuri"' showing total 6 results
Start Over Author "Dubrova, Yuri" Publisher wiley-blackwell
6 results on '"Dubrova, Yuri"'

3. Paternal Exposure to Ethylnitrosourea Results in Transgenerational Genomic Instability in Mice.

Author

Dubrova, Yuri E., Hickenbotham, Peter, Glen, Colin D., Monger, Karen, Hiu-Pak Wong, and Barber, Ruth C.

Subjects
GENOMICS, MOLECULAR genetics, IONIZING radiation, RADIOACTIVITY, GERM cells, CANCER, ALKYLATING agents, DNA adducts, MUTAGENS, ANIMAL experimentation
Abstract

The article presents a study which shows that the paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice. It states that recent findings on this concern identify that the effects of ionizing radiation are not confined to the directly exposed parental germ cells, but can also appear in their non-exposed offspring resulting in heightened mutation rates and cancer predisposition. In this study, the effects of paternal treatment by ethylnitrosourea, an alkylating agent which is identified to form some types of DNA adducts, on the transgenerational effects in the first-generation offspring of exposed CBA/Ca and BALB/c male mice were analyzed.

Published
2008
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