11 results on '"Dragan, I."'
Search Results
2. Impact of scientific and technological advances.
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Dragan, I. F., Dalessandri, D., Johnson, L. A., Tucker, A., and Walmsley, A. D.
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DENTAL education , *MEDICAL school curriculum , *TECHNOLOGICAL innovations , *BIOMATERIALS , *LEARNING - Abstract
Abstract: Advancements in research and technology are transforming our world. The dental profession is changing too, in the light of scientific discoveries that are advancing biological technology—from new biomaterials to unravelling the genetic make‐up of the human being. As health professionals, we embrace a model of continuous quality improvement and lifelong learning. Our pedagogical approach to incorporating the plethora of scientific‐technological advancements calls for us to shift our paradigm from emphasis on skill acquisition to knowledge application. The 2017 ADEE/ADEA workshop provided a forum to explore and discuss strategies to ensure faculty, students and, ultimately, patients are best positioned to exploit the opportunities that arise from integrating new technological advances and research outcomes. Participants discussed methods of incorporating the impact of new technologies and research findings into the education of our dental students. This report serves as a signpost of the way forward and how to promote incorporation of research and technology advances and lifelong learning into the dental education curriculum. [ABSTRACT FROM AUTHOR]
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- 2018
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3. Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 30-34 weeks' gestation.
- Author
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Wright, D., Dragan, I., Syngelaki, A., Akolekar, R., and Nicolaides, K. H.
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PREECLAMPSIA diagnosis , *GESTATIONAL age , *PLACENTAL growth factor , *PREGNANCY , *UTERINE artery , *PROTEIN-tyrosine kinases , *MANAGEMENT , *DOPPLER ultrasonography , *ARTERIES , *CELL receptors , *FETAL ultrasonic imaging , *LONGITUDINAL method , *PREECLAMPSIA , *THIRD trimester of pregnancy , *PREDICTIVE tests , *RECEIVER operating characteristic curves , *BLOOD - Abstract
Objective: To estimate the patient-specific risk of pre-eclampsia (PE) at 30-34 weeks' gestation by a combination of maternal characteristics and medical history with multiples of the median (MoM) values of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PlGF) and serum soluble fms-like tyrosine kinase-1 (sFlt-1), and stratify women into high-, intermediate- and low-risk management groups.Methods: This was a prospective observational study in women attending a third-trimester ultrasound scan at 30-34 weeks as part of routine pregnancy care. Patient-specific risks of delivery with PE at < 4 weeks from assessment and at < 40 weeks' gestation were calculated using the competing-risks model to combine the prior risk from maternal characteristics and medical history with MoM values of MAP, UtA-PI, PlGF and sFlt-1. On the basis of these risks, the population was stratified into high-, intermediate- and low-risk groups. Different risk cut-offs were used to vary the proportion of the population stratified into each risk category and the performance of screening for delivery with PE at < 4 weeks from assessment and delivery with PE from 4 weeks after assessment and up to 40 weeks' gestation was estimated.Results: The study population of 8128 singleton pregnancies included 234 (2.9%) that subsequently developed PE. Using a risk cut-off of 1 in 50 for PE delivering at < 4 weeks and a risk cut-off of 1 in 150 for PE delivering at < 40 weeks' gestation, the proportion of the population stratified into high, intermediate and low risk was about 3%, 26% and 71%, respectively. The high-risk group contained 90% of pregnancies with PE at < 4 weeks and 40% of those with PE at 4 weeks from assessment to 40 weeks' gestation. The intermediate-risk group contained a further 49% of women with PE at 4 weeks from assessment to 40 gestational weeks. In the low-risk group, none of the women developed PE at < 4 weeks and only 0.3% developed PE at 4 weeks to 40 gestational weeks.Conclusion: The study presents risk stratification of PE by the combined test at 30-34 weeks, aiming to identify a high-risk group in need of intensive monitoring from the time of the initial assessment and up to 40 weeks' gestation and an intermediate-risk group in need of monitoring from 4 weeks after the initial assessment and up to 40 weeks' gestation. All pregnancies would need to be reassessed at 40 weeks' gestation. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2017
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4. Development of pre-eclampsia within 4 weeks of sFlt-1/PlGF ratio > 38: comparison of performance at 31-34 vs 35-37 weeks' gestation.
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Dragan, I., Wright, D., Fiolna, M., Leipold, G., and Nicolaides, K. H.
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PREECLAMPSIA , *PROTEIN-tyrosine kinases , *PLACENTAL growth factor , *GESTATIONAL age , *THIRD trimester of pregnancy , *DIAGNOSTIC ultrasonic imaging , *PREECLAMPSIA diagnosis , *CELL receptors , *COMPARATIVE studies , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *PRENATAL diagnosis , *RESEARCH , *EVALUATION research , *PREDICTIVE tests , *BLOOD - Abstract
Objective: To compare the performance of screening by soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) ratio > 38 for the prediction of delivery with pre-eclampsia (PE) at < 1 week and < 4 weeks from assessment when the test is carried out at 31-34 vs 35-37 weeks' gestation.Methods: This was a prospective observational study in women attending a third-trimester ultrasound scan as part of routine pregnancy care; the visit was at 30-34 weeks' gestation in the first phase of the study and at 35-37 weeks in the second phase. Serum sFlt-1 and PlGF were measured and their ratio calculated. We estimated the detection rate (DR) and false-positive rate (FPR) of sFlt-1/PlGF ratio > 38 for predicting delivery with PE at < 1 week and < 4 weeks after assessment and compared the performance of screening when the test was carried out at 31 + 0 to 33 + 6 vs 35 + 0 to 36 + 6 weeks' gestation.Results: The study population included 8063 singleton pregnancies that were examined at 31-34 weeks and 3703 at 35-37 weeks. Delivery with PE occurred at < 1, < 4 and ≥ 4 weeks from assessment in five (0.1%), 29 (0.4%) and 202 (2.5%) women assessed at 31-34 weeks, respectively, and in seven (0.2%), 39 (1.1%) and 21 (0.6%) of those assessed at 35-37 weeks. In women without PE, the median sFlt-1/PlGF ratio increased with gestational age at screening and a ratio of 38 was just below the 99th percentile at 32 weeks' gestation and just below the 90th percentile at 36 weeks. In the two gestational windows, the DR of PE delivering < 4 weeks from assessment was similar (75.9% (95% CI, 56.5-89.7%) vs 79.5% (95% CI, 63.5-90.7%)), but the FPR was substantially lower at 31-34 weeks than at 35-37 weeks (1.7% (95% CI, 1.4-2.0%) vs 9.6% (95% CI, 8.7-10.6%)). The number of cases with PE delivering < 1 week from assessment was small, but similarly, in the two gestational windows, the DR was comparable (80.0% (95% CI, 28.4-99.5%) vs 85.7% (95% CI, 42.1-99.6%)), and the FPR was substantially lower at 31-34 weeks than at 35-37 weeks (1.9% (95% CI, 1.6-2.2%) vs 10.2% (95% CI, 9.3-11.3%)).Conclusion: The performance of sFlt-1/PlGF ratio > 38 in the prediction of delivery with PE at < 1 and < 4 weeks from assessment is substantially different when the assessment is at 31-34 weeks' gestation compared to at 35-37 weeks. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Screening for pre-eclampsia using sFlt-1/PlGF ratio cut-off of 38 at 30-37 weeks' gestation.
- Author
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Dragan, I., Georgiou, T., Prodan, N., Akolekar, R., and Nicolaides, K. H.
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PLACENTAL growth factor , *PROTEIN-tyrosine kinases , *PREECLAMPSIA diagnosis , *ULTRASONIC imaging , *THIRD trimester of pregnancy , *DELIVERY date (Obstetrics) , *CELL receptors , *LONGITUDINAL method , *MEMBRANE proteins , *PREECLAMPSIA , *PREDICTIVE tests - Abstract
Objective: To evaluate a soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio cut-off of 38 for the prediction of pre-eclampsia (PE) in routine assessment in singleton pregnancies at 30-37 weeks' gestation.Methods: This was a prospective observational study in women attending a third-trimester ultrasound scan at 30-37 weeks as part of routine pregnancy care. Serum sFlt-1 and PlGF were measured and their ratio was calculated. We estimated the detection rate (DR), false-positive rate (FPR), positive predictive value (PPV) and negative predictive value (NPV) of sFlt-1/PlGF ratio >38 for the prediction of delivery with PE at < 1, < 4 and ≥ 4 weeks after assessment.Results: The study population of 12 305 singleton pregnancies was examined at a median of 32.4 (range, 30.0-36.9) weeks and included 14 (0.11%), 77 (0.63%) and 227 (1.84%) cases that subsequently delivered with PE at < 1, < 4 or ≥ 4 weeks' after assessment, respectively. The DR, FPR, PPV and NPV of sFlt-1/PlGF ratio > 38 in the prediction of delivery with PE at < 1 week were 78.6%, 4.5%, 1.9% and 99.97%, respectively; the values for delivery with PE at < 4 weeks were 76.6%, 4.1%, 10.4% and 99.85% and for delivery with PE ≥ 4 weeks were 20.7%, 4.3%, 8.3% and 98.47%.Conclusion: In routine screening of singleton pregnancies, the performance of a sFlt-1/PlGF ratio > 38 is modest for the prediction of delivery with PE at < 1 and at < 4 weeks after assessment and poor for the prediction of delivery with PE at ≥ 4 weeks after assessment. A sFlt-1/PlGF ratio > 38 predicted 79% of cases delivering with PE at < 1 week after assessment, at a FPR of 4.5%; consequently, a policy of hospitalizing patients with a ratio > 38 would potentially lead to unnecessary hospitalization in 4.5% of pregnancies and a ratio of ≤ 38 would falsely reassure one fifth of women who will deliver with PE within 1 week of assessment. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2017
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6. Wideband multilayer directional coupler with tight coupling and high directivity.
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Djordjević, Antonije R., Napijalo, Veljko M., Olćan, Dragan I., and Zajić, Alenka G.
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DIRECTIONAL couplers ,PRINTED circuits ,MULTICONDUCTOR transmission lines ,INTEGRATED circuit interconnections ,ELECTRIC circuits ,ELECTRIC resonators - Abstract
A novel, wideband, symmetrical, printed directional coupler is described, which has tight coupling and high directivity. The coupler consists of four interconnected strips printed in two layers. The dimensions of the strips are optimized to minimize the dispersion of propagating modes. Design data are provided for some typical practical cases. The theoretical results are verified experimentally. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2261-2267, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27051 [ABSTRACT FROM AUTHOR]
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- 2012
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7. Modeling and design of milled microwave printed circuit boards.
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Djordjević, Antonije R., Olćan, Dragan I., and Zajić, Alenka G.
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PRINTED circuits , *MIXING , *METALLIC surfaces , *PERFORMANCE evaluation , *SIGNAL processing , *MICROWAVE devices - Abstract
This article investigates the influence of milling process on properties of printed microwave circuits. Furthermore, design guidelines are proposed for optimizing the milling process by leaving large unmilled copper surfaces on the board without deteriorating circuit performance. The proposed concepts are experimentally verified. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:264-270, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25724 [ABSTRACT FROM AUTHOR]
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- 2011
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8. The academic environment: the students’ perspective.
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Divaris, K., Barlow, P. J., Chendea, S. A., Cheong, W. S., Dounis, A., Dragan, I. F., Hamlin, J., Hosseinzadeh, L., Kuin, D., Mitrirattanakul, S., Mo'nes, M., Molnar, N., Perryer, G., Pickup, J., Raval, N., Shanahan, D., Songpaisan, Y., Taneva, E., Yaghoub-Zadeh, S., and West, K.
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DENTAL health education ,DENTAL students ,STUDENT activities ,STRESS management ,PSYCHOLOGICAL stress ,EVALUATION - Abstract
Dental education is regarded as a complex, demanding and often stressful pedagogical procedure. Undergraduates, while enrolled in programmes of 4–6 years duration, are required to attain a unique and diverse collection of competences. Despite the major differences in educational systems, philosophies, methods and resources available worldwide, dental students’ views regarding their education appear to be relatively convergent. This paper summarizes dental students’ standpoint of their studies, showcases their experiences in different educational settings and discusses the characteristics of a positive academic environment. It is a consensus opinion that the ‘students’ perspective’ should be taken into consideration in all discussions and decisions regarding dental education. Moreover, it is suggested that the set of recommendations proposed can improve students’ quality of life and well-being, enhance their total educational experience and positively influence their future careers as oral health physicians. The ‘ideal’ academic environment may be defined as one that best prepares students for their future professional life and contributes towards their personal development, psychosomatic and social well-being. A number of diverse factors significantly influence the way students perceive and experience their education. These range from ‘class size’, ‘leisure time’ and ‘assessment procedures’ to ‘relations with peers and faculty’, ‘ethical climate’ and ‘extra-curricular opportunities’. Research has revealed that stress symptoms, including psychological and psychosomatic manifestations, are prevalent among dental students. Apparently some stressors are inherent in dental studies. Nevertheless, suggested strategies and preventive interventions can reduce or eliminate many sources of stress and appropriate support services should be readily available. A key point for the Working Group has been the discrimination between ‘teaching’ and ‘learning’. It is suggested that the educational content should be made available to students through a variety of methods, because individual learning styles and preferences vary considerably. Regardless of the educational philosophy adopted, students should be placed at the centre of the process. Moreover, it is critical that they are encouraged to take responsibility for their own learning. Other improvements suggested include increased formative assessment and self-assessment opportunities, reflective portfolios, collaborative learning, familiarization with and increased implementation of information and communication technology applications, early clinical exposure, greater emphasis on qualitative criteria in clinical education, community placements, and other extracurricular experiences such as international exchanges and awareness of minority and global health issues. The establishment of a global network in dental education is firmly supported but to be effective it will need active student representation and involvement. [ABSTRACT FROM AUTHOR]
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- 2008
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9. The Influence of Diazepam on Atropine Reversal of Behavioural Impairment in Dichlorvos-Treated Rats.
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Savic, Miroslav M., Obradovic, Dragan I., Ugresic, Nenad D., and Bokonjic, Dubravko R.
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DIAZEPAM , *PHARMACODYNAMICS , *ANTICONVULSANTS , *ATROPINE , *RATS , *ANIMAL behavior - Abstract
Acute effects on the behaviour of the organophosphate insecticide dichlorvos and its standard antidotes possessing behavioural activity, atropine and diazepam, were studied separately and in combinations in male Wistar rats. In the spontaneous locomotor activity test, dichlorvos and diazepam decreased, whereas atropine increased performance. The effect of dichlorvos was obtained at a dose (5 mg/kg) that induced overt intoxication, and could not be reversed during first half hour-period after administration of any combination of drugs. In the other two tests, active avoidance learning and rotarod performance, the effective dose of dichlorvos (2 mg/kg) was devoid of somatic signs of intoxication. In these more sensitive tests, the effective atropine dose (40 mg/kg) completely reversed dichlorvos-induced incapacitation. In the rotarod test, diazepam (0.5 mg/kg) contributed to the incapacitating effect of dichlorvos, and impeded desirable influence of atropine as well. In the active avoidance test, diazepam (2.5 mg/kg) contributed to failure to escape; it did not influence the dichlorvos-induced decrease of avoidance performance, nor did it impair the completely reversing effects of atropine. The results point to the possible summation of acute incapacitating effects of organophosphates and diazepam on motor performance, which seems to be, at least partly, antagonized by sufficiently high doses of atropine. However, taking into account the long-term neuroprotective role of the anticonvulsant diazepam, and hence its delayed beneficial influences on behaviour, the immediate testing of atropine/diazepam treatment of organophosphate intoxication in active avoidance paradigm could possess beside sensitivity the predictive value as well. [ABSTRACT FROM AUTHOR]
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- 2003
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10. OP08.06: Assessing quality standards in measurement of uterine artery pulsatility index at 11 to 13+6 weeks of gestation, multicentric study.
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Nemescu, D., Calomfirescu, M., Dragan, I., Iliev, G., Muresan, M., Tudorache, S., Veduta, A., and Zvanca, M.
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UTERINE artery ,UNITS of measurement ,QUALITY standards ,PREGNANCY ,MEASUREMENT errors - Abstract
OP08.06: Assessing quality standards in measurement of uterine artery pulsatility index at 11 to 13+6 weeks of gestation, multicentric study To assess the quality of the measurement of the uterine artery pulsatility index (UtA-PI) at 11 to 13+6 gestational weeks, at the time of pre-eclampsia screening. Centres should routinely monitor the quality of UtA-PI measurements used to estimate the pre-eclampsia screening risk and should provide individualised feedback to sonographers of their measures of central tendency and dispersion to ensure consistent and improved performance. [Extracted from the article]
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- 2019
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11. Applying "think-pair-share" for virtual curriculum retreat.
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Ramesh A, Case A, Stockstill L, and Dragan I
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- Curriculum, Humans, SARS-CoV-2, Schools, Universities, COVID-19
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With coronavirus disease 2019 (COVID-19) leading to ubiquitous changes across the education system, Tufts University School of Dental Medicine took advantage of their new, fast-changing environment to foster engagement among faculty members regarding curricular modifications and their impact on assessment outcomes. A virtual curricular retreat was planned, where adaptations could be discussed through the lens of Miller's Pyramid. The retreat provided an opportunity for faculty to participate in a guided dialogue via a "think-pair-share" activity that resulted in documenting the outcomes of recent curriculum changes while allowing for reflection for future improvement., (© 2021 American Dental Education Association.)
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- 2021
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