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Carbon materials play a pivo tal role across various advanced applications, yet their synthesis traditionally necessitates inert atmospheres to avert oxidation at high temperatures, thus inflating production costs and resource utilization. Achieving precision synthesis of functional porous carbon materials via air‐pyrolysis remains a formidable challenge. Herein, a streamlined, one‐step lava‐like carbonization approach is introduced enabling the fabrication of porous carbons boasting tailored morphologies (0‐3D), elevated specific surface areas (540.7–1047.6 m2g⁻¹), heteroatom doping, and commendable carbon yields (20‐39.1%) through direct pyrolysis within an air environment. Leveraging recyclable boric acid as a reaction medium, a lava‐like flowing protective barrier above 170 °C is engendered that spontaneously creates an oxygen‐free‐like milieu devoid of high pressure or intricate procedures. This boron‐containing lava serves dually as a template and chemical activator, facilitating pore formation and catalyzing porous carbon production. Notably, the method accommodates a spectrum of carbon sources, encompassing sugars, proteins, graphene oxide, and their metal mixtures. The resultant morphologically customizable carbons exhibit excellent performance in areas as diverse as microwave absorption and electrocatalysis. This work pioneers a novel pathway for large‐scale precision synthesis of high‐quality carbon materials via air‐pyrolysis under mild conditions. [ABSTRACT FROM AUTHOR]

Oriented aerogels, emerging as a new generation of lightweight electromagnetic interference (EMI) materials, often face complex synthesis processes. While creating an orderly oriented microstructure for EMI aerogels through ambient pressure drying (APD) shows promise, it remains a significant challenge. Here, inspired by the directional grown structure of the plant, a new strategy that employs rapid precursor orientation followed by slow cross‐linking to achieve the APD of directional EMI aerogels is proposed. This approach demonstrates that low‐temperature oriented polymerization of polyaniline enables strong cross‐linking with poly(3,4‐ethylenedioxythiophene) and alginate, forming a robust conductive directional skeleton and mitigating surface tension issues during mild drying. The resulting aerogel features high conductivity (48.84 S m−1), excellent flame retardancy, and impressive compressive strength. Notably, its sturdy frame allows for further enhancement with other functional materials, such as Mxene, through re‐processing and re‐drying. The tree‐branch‐like aerogel achieves a significantly improved EMI shielding effectiveness of 50.3 dB across an ultrawideband range of 8.2–40 GHz. This strategy offers a new idea for the straightforward preparation of functional aerogels with programmability and oriented microstructures using ambient drying. [ABSTRACT FROM AUTHOR]

In traditional food industry, the assessment of mushy materials plays an important role in high‐quality food production, which still relies heavily on human tactile perception. In this work, to address this issue for enhancing food production efficiency, a flexible electret tactile sensor that can mimic expert touch is developed. The sensor consists of a pair of electrodes, a microstructural spacer, and a pre‐charged electret. Benefiting from the electrostatic induction‐based working mechanism, the sensor attains high sensitivity and is ideal for precise sensing in actions similar to those of skilled Baijiu distillers. Due to its hermetic and electromagnetic interference‐resistant encapsulation with polypropylene/aluminum/parylene films, the sensor remained durable in vinasse in the real distillery, with its high water and alcohol content, for over 21 days. This demonstrates its long‐term stability in harsh environment. Based on the proposed flexible electret tactile sensor, an automated and intelligent vinasse identification system is built, mimicking the actions of Baijiu distillers in vinasse assessment. Combining tactile sensing data with machine learning, the system can distinguish 8 kinds of vinasses with different ingredient ratios, achieving an accuracy of 98%. This work significantly demonstrates the practical potential of the sensor in the food industry. [ABSTRACT FROM AUTHOR]

Solar panels often suffer from dust accumulation, significantly reducing their output, especially in desert regions where many of the world's largest solar plants are located. Here, an autonomous dust removal system for solar panels, powered by a wind‐driven rotary electret generator is proposed. The generator applies a high voltage between one solar panel's output electrode and an upper mesh electrode to generate a strong electrostatic field. It is discovered that dust particles on the insulative glass cover of the panel can be charged under the high electrical field, assisted by adsorbed water, even in low‐humidity environments. The charged particles are subsequently repelled from the solar panel with the significant Coulomb force. Two panels covered with sand dust are cleaned in only 6.6 min by a 15 cm diameter rotary electret generator at 1.6 m s−1 wind speed. Experimental results manifest that the system can work effectively in a wide range of environmental conditions, and doesn't impact the panel performance for long‐term operation. This autonomous system, with its high dust removal efficiency, simplicity, and low cost, holds great potential in practical applications. [ABSTRACT FROM AUTHOR]

Ten compounds, including three new bioflavonoids (1–3) and seven known compounds (4–10), were identified in the ethyl acetate fraction of the 85 % ethanol extract of Selaginella delicatula. The structures of the new compounds were determined through spectroscopic data analysis, and their absolute configurations were established using circular dichroism (CD). All the isolated compounds were tested for their antiproliferative effects on MCF‐7, HepG2, and HEK 293T cells. Compounds 1 and 5 exhibited significant cytotoxicity against MCF‐7 cells, effectively inhibiting their proliferation. Meanwhile, compounds 1, 2, 5, and 7 respectively exhibited strong inhibitory effects on HepG2 cells. Furthermore, when we combined the IC50 values of compounds 3, 5, and 7 on HEK 293T cells, we discovered that they selectively inhibited cell growth. [ABSTRACT FROM AUTHOR]

To better characterize the heterogeneity of transitional shale pore structure and understand its impact on shale gas enrichment, fine characterization of the pore structure of different shale lithofacies was performed by field‐emission scanning electron microscopy, high‐pressure mercury injection, low‐temperature N2 adsorption, and low‐pressure CO2 adsorption. Fractal theory was used to obtain the fractal dimension of the shale pores at different scales and reveal the relationships among the pore structural characteristics, mineral composition, total organic carbon content, and fractal dimension of the shale and their geological significance. The results showed that organic pores, intergranular pores, intragranular pores, and microcracks were generally developed in the transitional shale samples from the study area; elliptic or irregular organic pores were mainly developed in the argillaceous shale lithofacies and siliceous shale lithofacies, and wedge‐shaped or irregular intragranular pores were mainly developed in the calcareous shale lithofacies. The pore size distribution showed a multipeak pattern, and mesopores were the main contributors to the total pore volume (PV), while micropores and macropores contributed little to the total PV. The PV and specific surface area of the siliceous shale were lower than those of the argillaceous shale but higher than those of the calcareous shale, indicating that the change in lithofacies had a significant effect on the shale pores. The common influence of clay minerals, quartz content, and total organic carbon content results in strong heterogeneity and complex pore structure characteristics of shale reservoirs. The pores in the transitional shale from the study area had obvious multiscale fractal characteristics, and the fractal dimension characteristics of different lithofacies and pores at different scales were different, which reflected that the pore structure of the shale had strong heterogeneity. The heterogeneity of the shale pores mainly originated from the macropores and mesopores, while the heterogeneity of micropores was relatively low. The heterogeneity of the pore development and structure at different scales was controlled by the mineral composition matter and organic matter abundance to varying degrees. [ABSTRACT FROM AUTHOR]

Stable isotope chemical labeling methods have been widely used for high‐throughput mass spectrometry (MS)‐based quantitative proteomics in biological and clinical applications. However, the existing methods are far from meeting the requirements for high sensitivity detection. In the present study, a novel isobaric stable isotope N‐phosphorylation labeling (iSIPL) strategy was developed for quantitative proteome analysis. The tryptic peptides were selectively labeled with iSIPL tag to generate the novel reporter ions containing phosphoramidate P−N bond with high intensities under lower collision energies. iSIPL strategy are suitable for peptide sequencing and quantitative analysis with high sensitivity and accuracy even for samples of limited quantity. Furthermore, iSIPL coupled with affinity purification and mass spectrometry was applied to measure the dynamics of cyclin dependent kinase 9 (CDK9) interactomes during transactivation of the HIV‐1 provirus. The interaction of CDK9 with PARP13 was found to significantly decrease during Tat‐induced activation of HIV‐1 gene transcription, suggesting the effectiveness of iSIPL strategy in dynamic analysis of protein‐protein interaction in vivo. More than that, the proposed iSIPL strategy would facilitate large‐scale accurate quantitative proteomics by increasing multiplexing capability. [ABSTRACT FROM AUTHOR]

Three new flavonoids, seladoeflavones G‐I (1–3), together with six known flavonoids, involvenflavone E (4), involvenflavone F (5), unciflavone F (6), 3‐[5,7‐dihydroxy‐2‐(4‐methoxy‐phenyl)‐4‐oxo‐4H‐chromen‐8‐yl]‐4‐methoxy‐ benzoic acid (7), naringenin (8), and eriodictyol (9) were isolated from the petroleum ether and the ethyl acetate fractions of the whole herbs of Selaginella doederleinii. The structures of new flavonoids were established by 1D NMR (1H, 13C and DEPT), 2D NMR (HMBC, 1H‐1H COSY and HSQC), HRMS and electronic circular dichroism (ECD). Compounds 1–7 are apigenin or naringin derivatives with aryl substituents at the C‐8 or C‐3′ positions, in which the new compounds 1 and 2 were identified as S configuration. In addition, compounds 4 and 5 exhibited strong cytotoxicity against human laryngeal cancer cells (Hep‐2 and Fadu) with IC50 values in the range of 1.41‐3.22 μg/mL. The results of this study could enrich the flavonoids diversity and be regarded as some further insight into the chemotaxonomic diversity of natural products in Selaginella. [ABSTRACT FROM AUTHOR]

Acute kidney injury (AKI) is a significant worldwide health problem. The protective effects of norisoboldine (NOR) against ischemia/reperfusion (I/R) induced renal injury in a rat model were evaluated. AKI was induced in rats by I/R. Animals were treated with 20 mg/kg/h propofol, intraperitoneally administered and 10 mg/kg NOR 30 min before inducing renal ischemia. Biomarkers of kidney function, including cytokines and oxidative stress parameters, were measured in serum. The serum levels of creatinine and blood urea nitrogen in propofol‐ and NOR‐treated rats were lower compared to the untreated I/R group. Moreover, treatment with propofol or NOR, alone and in combination, decreased the levels of cytokines and oxidative stress in rats with kidney injury. In conclusion, this study suggested that treatment with NOR potentiated the nephroprotective effects of propofol in rats with I/R‐induced renal injury by ameliorating oxidative stress and apoptosis pathway. [ABSTRACT FROM AUTHOR]

An electron conductive matrix, or collector, facilitates electron transport in an electrochemical device. It is stationary and does not change during the entire operation once it is built. The interface of this matrix and an electrode is constructed at a 2D level at the micro‐scale, and naturally limits the breadth and depth of electrochemical reactions. Herein, the idea of an enhanced electrode coupled with a conducting molecule that can extend interfacial reactions is first introduced. With a spatialized interspace, this electrode can change the present understanding of the electrode process and opens up a new realm of electrode‐based reaction chemistry. A lithium–sulfur (Li–S) battery is used as the target for implementing the enhanced electrode owing to the complex multi‐electron reaction. Through the interaction of π–π stacking between graphite‐based carbon and iron (II) phthalocyanine (FePc), soluble FePc can be decorated on the surface of an electrode that has the capability of transporting electrons. The scanning tunneling microscope break junction characterization and density functional theory indicate that FePc has a strong molecular electronic conductivity. The reactants obtain electrons more easily from the conducting molecule than from the collector directly. As a result, the performance of the corresponding Li–S battery considerably improves. [ABSTRACT FROM AUTHOR]

A boron (B)/nitrogen (N) co‐doped graphene is synthesized via an two‐steps method and used as an interlayer for lithium‐sulfur (Li−S) batteries. Due to the excellent electronic conductivity and dense sheet constructure of graphene, it can improve the conductive network, reduce the pores of polypropylene (PP) membrane, and consequently inhibit the penetration of polysulfide in Li−S batteries. More importantly, the co‐doped B and N atoms play the role of Lewis acid‐base, which have a strong adsorption capacity to lithium ions and as well as sulfur ions during reactions, and thus inhibit the "shuttle effect" and accelerate the conversion reactions of polysulfides. Based on this multifunctional interlayer, the cells exhibit a high initial capacity of 1448 mAh g−1, and achieve a reversible capacity of 578 mAh g−1 under a large rate of 2 C after 350 cycles with a capacity decay of 0.015 % per cycle. These results demonstrate the enormous potential of the B/N co‐doped graphene as the interlayer for high‐performance Li−S batteries. [ABSTRACT FROM AUTHOR]

The copper phthalocyanine and 2,3,5,6‐tetrafluoro‐tetracyano‐quino‐dimethane molecules adsorbed on the copper and single‐layer graphene‐modified copper surfaces have been investigated using Raman and X‐ray photoelectron spectroscopy. The adsorbed amounts for both molecules on the two different substrates are almost comparable as confirmed by the C 1s and N 1s core level X‐ray photoelectron spectra. Raman signal enhancement has been observed for both molecules when they are adsorbed on the graphene surface. The strongest chemical interaction is observed between the 2,3,5,6‐tetrafluoro‐tetracyano‐quino‐dimethane and copper substrate. Based on the Raman and X‐ray photoelectron spectroscopic data, the mechanism of the graphene‐enhanced Raman scattering is discussed, which might greatly rely on the unique electronic properties of graphene. [ABSTRACT FROM AUTHOR]

A novel three‐stage catalytic reactive distillation (RD) column integrated chemical reaction and distillation process for the continuous synthesis of ε‐caprolactone (ε‐CL) was proposed to overcome the disadvantages of previous batch processes. Reaction kinetics according to the two‐step indirect oxidation method was studied firstly, which was essential in reactor design and process optimization as well as lacking in the current literature. Kinetics models obtained by data fitting were tested by residual distribution and model statistics. And then, according to the thermodynamic characteristics and reaction kinetics of this process, a steady‐state simulation of RD column was carried out with the process simulator Aspen Plus. The influence of operation parameters was investigated on process performance. Under the optimal operating conditions, the conversion of cyclohexanone was 97%, and the mass fraction of ε‐CL in the bottom products was 62.31%. The simulation showed that RD column worked with excellent results in respect to conversion and product purity because of integrating the processes of chemical reaction and distillation. [ABSTRACT FROM AUTHOR]

Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common and dose‐limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation in peripheral nervous system, especially in dorsal root ganglion, is a significant mechanism of OIPN. Several specific transporters, including organic cation transporters, high‐affinity copper uptake protein1 (CTR1), ATPase copper transporting alpha (ATP7A) and multidrug and toxin extrusion protein 1 (MATE1), could be associated with this mechanism. This review summarizes the current research progress about the relationship between platinum accumulation and OIPN, as well as suggests trend for the future research. [ABSTRACT FROM AUTHOR]

Anatase‐TiO2/graphene nanosheets (TiO2/GNs) composite with 3D architecture was synthesized via an in‐situ method. The honeycomb‐like structure has a porous nature, high stability and abundant electron/lithium pathways. When the sample was used as an anode material for Li‐ion battery, it showed an excellent electrochemistry performance with superior rate and cyclic performance. The capacity can keep at 184 mA h g−1 at 50 C (16.5 A g−1) after 10000 cycles. While, when the rate increased to as high as 150 C (52.5 A g−1), the reversible capacity can still maintain at above 125 mA h g−1. These results demonstrate the enormous potential of the nanocomposite has great potential applied in long‐life LIBs. [ABSTRACT FROM AUTHOR]

Hollow titanium nitride (TiN) microspheres were synthesized using a simple and template‐free method. Compared to other approaches via templates, the way we reported is simpler and more economical. Meanwhile, the surface porous structure could form simultaneously. The TiN microspheres with an average diameter of about 1 μm are composed of tens of nanoscale spherical particles (40‐60 nm), which are first applied in cathode as a host material for lithium‐sulfur (Li−S) batteries. Due to the hollow and porous architecture and the N−Ti‐N bonding unit, the TiN spheres resist the volume changes during charge/discharge, effectively reduce the "shuttle effect", and catalyze the sulfur conversion reaction as well. The cell with TiN microsphere cathode exhibits a large discharge capacity of 692 mAh g−1 at 1st cycle under a high rate of 5 C, releases the reversible capacity of 740 mAh g−1 under a rate of 1 C after 400 cycles with a capacity decay of 0.006 % per cycle. These results demonstrate the enormous potential of the TiN microspheres as the host material for high‐performance Li−S batteries. [ABSTRACT FROM AUTHOR]

We present strategies to tune the redox properties of polyoxometalate clusters to enhance the electron‐coupled proton‐buffer‐mediated water splitting process, in which the evolution of hydrogen and oxygen can occur in different forms and is separated in time and space. By substituting the heteroatom template in the Keggin‐type polyoxometalate cluster, H6ZnW12O40, it is possible to double the number of electrons and protonation in the redox reactions (from two to four). This increase can be achieved with better matching of the energy levels as indicated by the redox potentials, compared to the ones of well‐studied H3PW12O40 and H4SiW12O40. This means that H6ZnW12O40 can act as a high‐performance redox mediator in an electrolytic cell for the on‐demand generation of hydrogen with a high decoupling efficiency of 95.5 % and an electrochemical energy efficiency of 83.3 %. Furthermore, the H6ZnW12O40 cluster also exhibits an excellent cycling behaviour and redox reversibility with almost 100 % H2‐mediated capacity retention during 200 cycles and a high coulombic efficiency >92 % each cycle at 30 mA cm−2. [ABSTRACT FROM AUTHOR]

Introduction Although HIV antibody tests have been widely accepted in clinical diagnosis of HIV infection, they may not be sufficient to diagnose all subjects with HIV infection. Except negative result of antibody test in the well-known' acute window phase', in rare cases, patients do not develop HIV antibodies despite demonstrable infection. Primary pulmonary Kaposi sarcoma (KS) without mucocutaneous involvement accounts for only 0-15% of all AIDS-related KS. KS is rare among Chinese subjects, especially in persons of Han descent. Methods A case of seronegative AIDS with primary pulmonary Kaposi sarcoma (KS) was reported. It's a 46-year-old Chinese man presented with sore throat, hemoptysis, fever, dyspnea and multiple lung nodules. The lung lesions grew over a 5-month period so as the symptoms worsened. The possibility of AIDS was discounted by his physicians because of the repeatedly negative HIV antibodies tests despite the ELISA tests or Western blot tests. Histopathologic diagnosis of fine needle lung biopsy in local hospital was undetermined. After admission, HIV infection was eventually confirmed by plasma HIV RNA testing. Histopathologic diagnosis of Lung Kaposi sarcoma was made through repeated fine needle aspiration biopsy as well as the review of former one. Multiple antibiotics and chemotherapy were administrated with no clinical effect due to advanced stage and the patient passed away soon after diagnosis. Results This is the first case of seronegative HIV-1 infection with presentation of primary pulmonary KS. Conclusion This case underscores the importance of plasma RNA test in conjunction with HIV antibody test for some rare patients with HIV infection who present with severe immunodeficiency and opportunistic infections or malignancy. [ABSTRACT FROM AUTHOR]

We consider the implications of platform price discrimination in the context of card platforms. Despite the platform's ability to price discriminate, we show that it will set fees for card usage that are too low, resulting in excessive usage of cards. We show this bias remains even if card fees (or rewards) can be conditioned on each type of retailer that the cardholder transacts with. We use our model to consider the European Commission's objection to the rules card platforms have used to sustain differential interchange fees across European countries. [ABSTRACT FROM AUTHOR]

The aim of the study was to investigate the relationship between PD-1 expression on the surface of CD4+ T cells and prognosis of patients with diffuse large B-cell lymphoma (DLBCL). Sixty patients who were newly diagnosed with DLBCL and 39 healthy controls were enrolled. In CD4+ T cells of DLBCL patients, the median MFI of PD-1 were 541.5 (range: 348.25-758.75), significantly higher than 250 (range: 211-326) in healthy controls ( P < 0.001). The ZAP70, PI3K, and NFAT mRNA expression levels of patients were 0.47, 0.47, and 0.62 times, respectively, of those of the healthy controls ( P < 0.05). In patients with the percentage of PD-1 on CD4+ T cells ≥30.25%, their EFS and OS were significantly lower than patients with PD-1+ CD4+ T cells <30.25% ( P < 0.05). The possible explanation is that high PD-1 expression on CD4+ cells of DLBCL patients may impair T-cell function and thus contribute to poor prognosis. There was no relationship between PD-1 surface expression on CD4+ T cells and PD-1 expression within the biopsy of tumor microenvironments from DLBCL patients. [ABSTRACT FROM AUTHOR]

This paper examines the impact of analyst coverage on the financial reporting quality of firms as reflected by modified audit opinions (MAOs). Using a sample of Chinese listed firms between 2003 and 2009, we find that analyst coverage, which serves as an external governance mechanism, helps to enhance the financial reporting quality of Chinese listed firms. The effect is more pronounced for non-state-owned enterprises (i.e., private firms), in that they are more dependent on external equity capital and, therefore, under greater pressure from analysts to provide high-quality accounting information. Furthermore, analysts play a more effective role for firms with stronger incentives to manipulate financial reports. Our findings are robust to the control of endogeneity issue. [ABSTRACT FROM AUTHOR]

2,4,5-Trifluorobromobenzene is a valuable intermediate with important application in the synthesis of biologically active peptides and fluorescent reagents. A continuous-flow system has been successfully developed for the synthesis of 2,4,5-trifluorobromobenzene in a microreactor using FeBr3 as a catalyst, which is steadily generated in situ from the reaction of Br2 and Fe. The procedure is efficient and easy-to-handle, and 2,4,5-trifluorobromobenzene can be obtained within minutes in high yields. [ABSTRACT FROM AUTHOR]

Laser treatment has emerged as a common treatment modality for acquired bilateral nevus of Ota-like macules ( ABNOM). To identify the ratio of melasma induction and exacerbation before and after laser therapy for ABNOM and to observe the risk factors related to the induction and exacerbation of melasma by laser therapy, we analyzed related factors of 1268 adult Chinese patients who underwent 1064-nm Q-switched neodymium:yttrium-aluminum-garnet (Nd: YAG) laser ( QNYL) treatment using case series and case-control studies. Overall, 24.0% of the ABNOM patients had mixed melasma. Among the ABNOM patients without melasma, after laser therapy the development of melasma was more frequently noted in patients older than 35 years ( P < 0.0001), as well in patients whose ABNOM was less than 10 cm2 ( P = 0.027), ABNOM were light (similar to yellow-brown) in color ( P = 0.021) and skin types were closer to type IV ( P < 0.0001). New melasma lesions also appeared most frequently in the zygomatic region ( P < 0.0001). Among the ABNOM patients with melasma, 89.5% experienced worsening of their melasma, irrespective of their related factors above. We concluded that the risk of inducing melasma is great after 1064-nm QNYL treatment in ABNOM patients, and particularly in the patients with both ABNOM and melasma. ABNOM patients should be treated as early as possible and before the age of 35 years. [ABSTRACT FROM AUTHOR]

We report a falling film microreactor (FFMR) based gas-liquid continuous microflow process, which features an efficient gas-liquid reaction in a microreactor for the generation of the ethynyl-Grignard reagent directly from acetylene gas and ethylmagnesium bromide (EtMgBr). The successful implement of this process leads to an expeditious flow synthesis of propargylic alcohols and analogues with high selectivity. [ABSTRACT FROM AUTHOR]

Aim To evaluate the role of endoscopic ultrasound ( EUS) in restaging and predicting response after neoadjuvant chemotherapy in patients with advanced gastric cancer. Methods In all, 48 advanced gastric cancer patients were recruited from June 2007 to December 2010 after providing their written, informed consent. All patients underwent an EUS before and after three cycles of neoadjuvant chemotherapy ( FOLFOX 6), and then a radical resection was performed 3-4 weeks after chemotherapy. The results of EUS were compared to the pathological results of the resected specimens. Results After chemotherapy, the overall sensitivity of EUS for T classification was 63 percent ( T2: 44%, T3: 68%, T4: 90%), and overstaging (31%) was more frequent than understaging (6%). The sensitivity and specificity of EUS for N classification were 56 and 50 percent, respectively ( N0: without lymph node metastasis, N1: with lymph node metastasis), with 15 percent overstaged and 32% understaged. EUS revealed that T and/or N downstaging occurred in 46 percent (22/48) of patients after chemotherapy, most of whom had a favorable pathological response to the chemotherapy compared with other patients without T and/or N downstaging. No T or N upstaging was observed after neoadjuvant chemotherapy. Conclusions The accuracy of restaging by EUS for T and N classification was not as good as pathological data for locally advanced gastric cancer patients after neoadjuvant chemotherapy. However, T and/or N downstaging confirmed by EUS correlated well with the degree of pathological response to chemotherapy. [ABSTRACT FROM AUTHOR]

A series of novel symmetrical trans-bis-Schiff bases ( 11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC50=6.35 μg/mL), which is higher than that of the clinical drug 5-fluorouracil (IC50=8.48 μg/mL). Complete assignments had been achieved for the title compounds by spectroscopic techniques, and their have been studied. [ABSTRACT FROM AUTHOR]

To research on the of our designed neonicotinoid compounds, a series of novel cis-configuration nitenpyram analogues with benzoyl hydrazines were designed and synthesized. The structures of all compounds were confirmed by IR, 1H NMR, MS, and elemental analysis. Preliminary bioassays indicated that all the analogues exhibited good insecticidal activities against Nilaparvata legen and Aphis medicagini at 500 mg L−1. [ABSTRACT FROM AUTHOR]

A series of novel neonicotinoids analogs were designed by modifying the pharmacophore of imidacloprid to 1,3,5-hexahydrotriazine conjugated to nitroimine (NNO2) and introducing the phenyl or arylmethyl at the 5-position, and their insecticidal activities were evaluated. Introducing a heterocyclic methyl at 5-position increased the insecticidal activities, whereas other phenyl, phenylmethyl or phenylethyl substituents were unfavorable to activities. Molecular docking study was also performed to clarify the interactions of the most potent analog 1-((6-chloropyridin-3-yl)methyl)-5-(3-pyridylmethyl)-1,3,5-hexahydrotriazine-2-( N-nitro) imine ( 7s) with the target nicotinic acetylcholine receptor, which explained the structure-activity relationships observed in vitro, and revealed further possibilities for insecticide development. J. Heterocyclic Chem., (2011). [ABSTRACT FROM AUTHOR]

Space‐vector pulse‐width modulation (SVPWM) and carrier‐based PWM (CBPWM) of eight‐switch three‐phase inverters (ESTPIs) which are the post‐fault reconfigured topologies for the three‐level neutral‐point‐clamped inverter with an open‐circuit fault in a leg are introduced. On the basis of the PWM regular sampling method, the modulating functions of CBPWM which are equivalent to SVPWM of ESTPIs are derived, therefore the relationship between SVPWM and CBPWM of ESTPIs is revealed. The validity of the theoretical analysis is verified by experimental results. [ABSTRACT FROM AUTHOR]

In the title compound, C(11)H(15)ClN(6)O(4)S, which belongs to the neonicotinoid class of insecticidally active heterocyclic compounds, the six-membered triazine ring adopts an opened envolope conformation. The planar nitro imine group [dihedral angle between nitro and imine groups = 1.07 (7)°] and the thia-zole ring are oriented at a dihedral angle of 69.62 (8)°. A classical intra-molecular N-H⋯O hydrogen bond is found in the mol-ecular structure. Moreover, one classical inter-molecular N-H⋯N and four non-classical C-H⋯O and C-H⋯N hydrogen bonds are also present in the crystal structure. Besides inter-molecular hydrogen bonds, the Cl atom forms an inter-molecular short contact [3.020 (2) Å] with one of the nitro O atoms.