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Background: The null phenotype in P1PK blood group, known as "p," is extremely rare in the whole world. Individuals of p phenotype spontaneously form anti‐PP1PK isoantibody. Here, we report a case of p phenotype with naturally occurring anti‐PP1PK isoantibodies in a Chinese individual. Study Design and Methods: Serology tests, containing alloantibodies screening and identification, were conducted to demonstrate the phenotype in P1PK blood group. The genotype of A4GALT gene was identified by haplotypes separation and sequencing. Results: The serological assay demonstrated the p phenotype of the proband, presenting with 1:64 titer of anti‐PP1PK. The sequencing data revealed a compound heterozygote consisting of A4GALT*P1.01 with c.343A>T and a novel allele based on A4GALT*01N.05 with an addition polymorphism c.100G>A. The sequence of the novel allele has been submitted to GenBank and the accession number OM912503 was assigned. Conclusion: Our study demonstrates a case of naturally occurring anti‐PP1Pk in a Chinese individual with p phenotype, which is based on compound heterozygosity including one novel allele. As the proband is a young lady, monitoring the titer of anti‐PP1PK and early initiation of medical intervention are essential after her pregnancy. [ABSTRACT FROM AUTHOR]

A novel variant of HLA‐DQB1*03 differs from DQB1*03:02:01:01 by one nucleotide substitution in Exon 2. [ABSTRACT FROM AUTHOR]

HLA‐DPB1*1104:01 differs from HLA‐DPB1*540:01 by a single nucleotide change in exon 2. [ABSTRACT FROM AUTHOR]

HLA‐A*30:140 differs from HLA‐A*30:01:01 by one nucleotide change in exon 2 at position 341 (C > A). [ABSTRACT FROM AUTHOR]

The HLA‐DPA1*02:33 allele differs from DPA1*02:02:02:04 by two nucleotide change in exon 4. [ABSTRACT FROM AUTHOR]

B*46:01:33 differs from B*46:01:01:01 by one nucleotide change at nucleotide 105 in exon 2 from C to T. [ABSTRACT FROM AUTHOR]

HLA‐A*24:02:78 differs from HLA‐A*24:02:01:01 in exon 3 by a single nucleotide. [ABSTRACT FROM AUTHOR]

HLA‐DQB1*06:01:22 differs from HLA‐DQB1*06:01:01:01 by one nucleotide substitution in codon 189 in exon 4. [ABSTRACT FROM AUTHOR]

The novel KIR2DL4*036 allele differs from the closest allele KIR2DL4*00102 by a single missense mutation. [ABSTRACT FROM AUTHOR]

The novel KIR3DL1*00702 allele differs from the closest allele KIR3DL1*00701 by a single silent mutation. [ABSTRACT FROM AUTHOR]

The novel KIR2DS2*022 allele differs from the closest allele KIR2DS2*00101 by a single nonsynonymous mutation. [ABSTRACT FROM AUTHOR]

One nucleotide substitution in codon 189 of HLA‐C*01:02:01:01 results in a novel allele, HLA‐C*01:179. [ABSTRACT FROM AUTHOR]

The novel KIR2DL4*038 allele differs from the closest allele KIR2DL4*00102 by a single missense mutation. [ABSTRACT FROM AUTHOR]

The novel KIR2DL4*037 allele differs from the closest allele KIR2DL4*00501 by a single missense mutation. [ABSTRACT FROM AUTHOR]

The novel KIR2DL4*00603 allele differs from the closest allele KIR2DL4*00602 by a silent mutation. [ABSTRACT FROM AUTHOR]

The novel KIR3DL3*063 allele differs from the closest allele KIR3DL3*04802 by a single missense mutation. [ABSTRACT FROM AUTHOR]

The novel KIR3DL3*02602 allele differs from the closest allele KIR3DL3*02601 by a single silent mutation. [ABSTRACT FROM AUTHOR]

The novel KIR3DL3*062 allele differs from the closest allele KIR3DL3*02602 by a single missense mutation. [ABSTRACT FROM AUTHOR]