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Objective: To evaluate the influence of MMR proteins on clinicopathological characteristics and prognosis of salivary gland adenoid cystic carcinoma (ACC). Method: The solid pattern of ACC showed lower expression for MSH2 (p = 0.039). Significant imbalance in MSH2/MSH6 immunostaining was observed in all histological patterns (p < 0.001), and imbalance in PMS2/MLH1 immunostaining was observed in the cribriform pattern (p = 0.011). The presence of capsule was associated with high expression of MSH6 (p = 0.019), MLH1 (p = 0.045) and PMS2 (p = 0.009). The absence of cribriform pattern (p = 0.002) and capsule pattern (p = 0.025), as well as low expression for MSH6 (p = 0.006) and PMS2 (p = 0.037) were associated with lower overall survival. In multivariate analysis, loss of MSH2 (p = 0.039) and MLH1 (p = 0.017) were significantly associated with worse overall survival. Results: Twenty‐four ACC were clinical‐pathologically evaluated and we perform immunohistochemistry for MSH2, MSH6, PMS2 and MLH1. Percentage counting of positive cells was performed in 10 fields of each histological pattern (cribriform, tubular and solid) and the averages of the 30 fields were considered for evaluation with other clinical‐pathological variables (Kruskal‐Wallis/Dunn, Friedman/Dunn, chi‐square, Log‐Rank Mantel‐Cox tests and Cox regression; SPSS v20.0, p < 0.05). Discussion: Salivary glands' ACC shows imbalance of the MMR complex and loss of expression of its components is associated with the overall survival of these patients. [ABSTRACT FROM AUTHOR]

Aims: To analyze the epidemiological profile and quality of life (QoL) of patients with special needs and overload their caregivers. Methods and results: Health‐related QoL was assessed in a quantitative, observational, cross‐sectional study of prospective characteristics using the WHOQOL‐BREF and ZARIT‐22 questionnaires. This study included 122 patients were included; they were divided into patients without caregiver assistance (n = 63) who answered WHOQOL‐BREF, 49 caregivers (n = 49) who responded to ZARIT‐22, and 10 patients were secondarily caregivers of their parents and answered the ZARIT‐22 + WHOQOL‐BREF questionnaires. The WHOQOL‐BREF general score was 71.94 ± 10.58, and patients born in urban areas and married had positive correlations (p <.05) with the QoL scores in the physical and social domains. ZARIT‐22 scores showed an average of 58.63 ± 14.07. Data cross‐checking revealed that patients of white races (p =.030) and who lived in urban regions (p =.003) generated less overload to caregivers. Conclusion: In the WHOQOL‐BREF analysis, family income was a factor with direct impact, and all caregivers referred to moderate‐to‐high overload, with an increase in prevalence as far away from the service the patient resides. [ABSTRACT FROM AUTHOR]