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Your search keyword '"Cieslak, Agata"' showing total 3 results
Start Over Author "Cieslak, Agata" Publisher wiley-blackwell
3 results on '"Cieslak, Agata"'

1. Reconstruction of rearranged T‐cell receptor loci by whole genome and transcriptome sequencing gives insights into the initial steps of T‐cell prolymphocytic leukemia.

Author

Patil, Paurnima, Cieslak, Agata, Bernhart, Stephan H., Toprak, Umut H., Wagener, Rabea, López, Cristina, Wiehle, Laura, Bens, Susanne, Altmüller, Janine, Franitza, Marek, Scholz, Ingrid, Jayne, Sandrine, Ahearne, Matthew J., Scheffold, Annika, Jebaraj, Billy M. C., Schneider, Christof, Costa, Dolors, Braun, Till, Schrader, Alexandra, and Campo, Elias

Published
2020
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3. NAP1L1- MLLT10 is a rare recurrent translocation that is associated with HOXA activation and poor treatment response in T-cell acute lymphoblastic leukaemia.

Author

Bond, Jonathan, Touzart, Aurore, Cieslak, Agata, Trinquand, Amélie, Marchand, Tony, Escoffre, Martine, Contet, Audrey, Muller, Marc, Schmitt, Claudine, Fest, Thierry, Asnafi, Vahid, and Macintyre, Elizabeth

Subjects
CHROMOSOMAL translocation, LYMPHOBLASTIC leukemia, HISTONE methyltransferases, HISTONES, MEDICAL genetics
Abstract

The article reports on a study that investigated the incidence of the NAP1L1-MLLT10 translocation in T-acute lymphoblastic leukaemia (T-ALL). It describes the discovery of the NAP1L1-MLLT10 genetic rearrangement as well as the clinical details of NAP1L1-MLLT10 patients. It also discusses the mechanism by which NAP1L1-MLLT10 is likely to recruit the DOT1 ligand histone methyltransferase and to activate the HOXA locus.

Published
2016
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