Search

Objective Methods Results Interpretation To investigate neurologic manifestations of post‐acute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) in post‐hospitalization Neuro‐PASC (PNP) and non‐hospitalized Neuro‐PASC (NNP) patients across the adult lifespan.Cross‐sectional study of the first consecutive 200 PNP and 1,100 NNP patients evaluated at a Neuro‐coronavirus disease 2019 (COVID‐19) clinic between May 2020 and March 2023. Patients were divided into younger (18–44 years), middle‐age (45–64 years), and older (65+ years) age groups.Younger and middle‐age individuals accounted for 142 of 200 (71%) of PNP and 995 of 1100 (90.5%) of NNP patients. Significant age‐related differences in the frequencies of comorbidities and abnormal neurologic findings demonstrated higher prevalence in older patients. Conversely, 10 months from COVID‐19 onset, we found significant age‐related differences in Neuro‐PASC symptoms indicating lower prevalence, and therefore, symptom burden, in older individuals. Moreover, there were significant age‐related differences in subjective impression of fatigue (median [interquartile range (IQR)] patient‐reported outcomes measurement information system [PROMIS] score: younger 64 [57–69], middle‐age 63 [57–68], older 60.5 [50.8–68.3]; p = 0.04) and sleep disturbance (median [IQR] PROMIS score: younger 57 [51–63], middle‐age 56 [53–63], older 54 [46.8–58]; p = 0.002) in the NNP group, commensurate with higher impairment in quality of life (QoL) among younger patients. Finally, there were significant age‐related differences in objective executive function (median [IQR] National Institutes of Health [NIH] toolbox score: younger 48 [35–63], middle‐age 49 [38–63], older 54.5 [45–66.3]; p = 0.01), and working memory (median [IQR] NIH toolbox score: younger 47 [40–53], middle‐age 50 [44–57], older 48 [43–58]; p = 0.0002) in NNP patients, with the worst performance coming from the younger group.Younger and middle‐age individuals are disproportionally affected by Neuro‐PASC regardless of acute COVID‐19 severity. Although older people more frequently have abnormal neurologic findings and comorbidities, younger and middle‐age patients suffer from a higher burden of Neuro‐PASC symptoms and cognitive dysfunction contributing to decreased QoL. Neuro‐PASC principally affects adults in their prime, contributing to profound public health and socioeconomic impacts warranting dedicated resources for prevention, diagnosis and interventions. ANN NEUROL 2024 [ABSTRACT FROM AUTHOR]

An asymmetric zinc phthalocyanine dye (ZnPcT3C), bearing three tetraethylene glycol donor groups and one carboxylic acid anchoring group, was synthesized as a photosensitizer dye for dye‐sensitized solar cells (DSSCs). The tetraethylene glycol (TEG), consisting of four ethoxy units, works as an amphiphilic long‐chain donor group that greatly helped in reducing the molecular aggregation. Carboxylic acid group, on the other hand, an acceptor, together with TEG in ZnPcT3C functions as a 'push–pullʼ system suitable for DSSCs. Absorption spectra of ZnPcT3C in DMSO showed a strong sharp Q band in the infrared region 600–700 nm with (λmax = 682 nm) and a less intense soret band appeared in the region 300–400 nm with λmax = 340 nm. The zinc phthalocyanine (ZnPcT3C) exhibited molar extinction coefficient (ε) of 72,727 L mol−1cm−1. The emission was observed at λem = 695 nm upon excitation at 650 nm and exhibited a fluorescence decay of 2.82 ns. The ZnPcT3C dye sensitised solar cell (c = 1 mM) exhibited the power conversion efficiency (η) of 3.52% in chloroform in I−/I3 electrolyte under simulated 100% brightness. Cosensitization of ZnPcT3C with another auxiliary dye D131 in 1:1 ratio in a cocktail‐type DSSC attained the power conversion efficiency of twice as high as η = 6.27% in an identical condition. A mixture of D131 (λmax = 470 nm) dye with the ZnPcT3C phthalocyanine harvests sunlight across the visible spectra, enabling DSSCs to attain a large photocurrent and photovoltage, enhancing power conversion efficiency. [ABSTRACT FROM AUTHOR]

In our efforts to design mono‐carbonyl analogues of curcumin with potential antiplasmodial activity, diarylidenecyclopentanone (DACP) derivatives, Ia–Iu and II–V, have been synthesized and characterized using 1H NMR, 13C NMR, IR, UV–Vis, and mass spectrometry. Structure of one of these DACPs has been verified by single crystal XRD. At the outset, all 25 DACPs were first screened at 12.5 µM for their in vitro antiplasmodial activity against the chloroquine (CQ)‐sensitive Pf3D7. The three most potent compounds (In, It, and Ik) were further tested at <10 µM concentrations against Pf3D7, PfINDO (CQ resistant), and PfMRA‐1240 (Artemisinin resistant) strains for determination of their IC50s and resistance indices. The drug profile of the DACPs was found to be very promising, with the most active compound It (IC50 1.39 µM against PfINDO) showing a selectivity index of ∼17 tested using HUH‐7 and HEK‐293T mammalian cell lines. Molecular docking studies with Pf pyridoxal synthase showed a good correlation between docking scores of DACPs and in vitro antiplasmodial activity. Further, high conformity with Lipinski's parameters indicates that these DACPs are promising antiplasmodial lead compounds. [ABSTRACT FROM AUTHOR]

Summary: The emergence of kokumi sensation as a flavour enhancer prompted the search for cost effective and the sustainable production of kokumi flavour substances (KS), including small γ‐glutamyl peptides (GGP) and aromatic free amino acids (FAA). We sought to investigate the potential of mechanically deboned meat (MDM) from beef, mutton, lamb and venison for KS production through enzymatic γ‐glutamylation. Liquid chromatography‐mass spectrometry (LC–MS) and in vitro calcium‐sensing receptor (CaSR) activity assays were utilised to identify GGPs and their kokumi intensity, respectively. The enzymatic method significantly increased GGP and FAA in all MDM samples with differences in individual peptides across the species. Notably, all four sources of MDM activated CaSR in a dose‐dependent manner, displaying varying potency and efficacy levels. Beef, lamb and mutton showed a similar range of higher potency, while venison exhibited lower potency but higher efficacy. The thermal stability of γ‐glutamylated beef samples, used as an exemplar, was confirmed at temperatures of 80 °C, 120 °C and 150 °C. Given these findings, MDM represents a promising substrate for KS production and warrants further investigation to assess its practical applicability for enhancing kokumi flavour in the food industry. [ABSTRACT FROM AUTHOR]

Background: Androgen deprivation therapy (ADT) in prostate cancer (PCa) has been associated with development of insulin resistance. However, the predominant site of insulin resistance remains unclear. Methods: The ADT & Metabolism Study was a single‐center, 24‐week, prospective observational study that enrolled ADT‐naive men without diabetes who were starting ADT for at least 24 weeks (ADT group, n = 42). The control group comprised men without diabetes with prior history of PCa who were in remission after prostatectomy (non‐ADT group, n = 23). Prevalent diabetes mellitus was excluded in both groups using all three laboratory criteria defined in the American Diabetes Association guidelines. All participants were eugonadal at enrollment. The primary outcome was to elucidate the predominant site of insulin resistance (liver or skeletal muscle). Secondary outcomes included assessments of body composition, and hepatic and intramyocellular fat. Outcomes were assessed at baseline, 12, and 24 weeks. Results: At 24 weeks, there was no change in hepatic (1.2; 95% confidence interval [CI], −2.10 to 4.43; p =.47) or skeletal muscle (−3.2; 95% CI, −7.07 to 0.66; p =.10) insulin resistance in the ADT group. No increase in hepatic or intramyocellular fat deposition or worsening of glucose was seen. These changes were mirrored by those observed in the non‐ADT group. Men undergoing ADT gained 3.7 kg of fat mass. Conclusions: In men with PCa and no diabetes, 24 weeks of ADT did not change insulin resistance despite adverse body composition changes. These findings should be reassuring for treating physicians and for patients who are being considered for short‐term ADT. In this prospective study of hormone‐naive men who were eugonadal and did not have diabetes, 24 weeks of androgen deprivation therapy (ADT) for prostate cancer (PCa) was not associated with worsening of hepatic or skeletal muscle insulin resistance despite a substantial increase in fat mass. These findings have relevance for both physicians and patients when determining treatment for PCa and suggest that a short course of ADT may not worsen metabolic risk in patients without pre‐existing diabetes. [ABSTRACT FROM AUTHOR]

Skin sensitization is a key endpoint for safety assessment, especially for cosmetics and personal care products. The adverse outcome pathway for skin sensitization and the chemical and biological events driving the induction of human skin sensitization are now well understood. Several non‐animal test methods have been developed to predict sensitizer potential by measuring the impact of chemical sensitizers on these key events. In this work, we have focused on Key Event 1 (the molecular initiating step), which is based on formation of a covalent adduct between skin sensitizers and endogenous proteins and/or peptides in the skin. There exists three in‐chemico assays approved by the Organization for Economic Co‐operation and Development—(1) Direct Peptide Reactivity Assay (DPRA), (2) Amino Acid Derivative Reactivity Assay (ADRA), and (3) Kinetic Direct Peptide Reactivity Assay (kDPRA) to quantify peptide/amino acid derivative depletion after incubation with test chemicals. However, overestimated depletion of the cysteine‐based peptide/amino acid derivatives is known in such assays because of the dimerization of the thiol group. In this present work, we report the synthesis and structural confirmation of the dimer of N‐(2‐[1‐naphthyl]acetyl)‐L‐cysteine (NAC) from the ADRA assay to allow simultaneous determination of (a) peptide depletion by quantifying NAC monomer and (b) peptide dimerization by quantifying NAC dimer thereby eliminating the overestimation. We present a case study with three chemicals to demonstrate the importance of this approach. Thus, this simultaneous assay gives a more informed view of the peptide reactivity of chemicals to better identify skin sensitizers. Guidelines for skin sensitization addressing Key Event 1 include three in‐chemico methods: DPRA, ADRA, and kDPRA. However, overestimated depletion of the Cysteine‐based peptide/amino acid derivatives is known in such assays because of the dimerization of the thiol group. In this present work, we synthesized NAC dimer from the ADRA assay to allow simultaneous determination of peptide depletion and dimerization, thus eliminating the overestimation. We present a case study with three chemicals to demonstrate the importance of this approach. [ABSTRACT FROM AUTHOR]

This paper reports improvement in the tensile, flexural and interlaminar shear strength (ILSS) properties of ADG‐NH2/Epoxy/CFRP composites at low filler content. Five symmetrical CFRP composite laminates were prepared through wet layup process assisted by vacuum bagging technique with varying wt% proportions (0.25, 0.5, 0.75 and 1) of ADG‐NH2/Epoxy. Tensile tests, short beam shear test and flexural tests were carried out as per ASTM D3039, ASTM D2344 and ASTM 790‐10 respectively to assess the effect of the ADG‐NH2 functionalized nano additives on their mechanical properties. The variation in ILSS were studied for varying temperatures (room temperature, 35, 50, 75, 85, & 100°C for each type of ADG‐NH2/Epoxy wt% (neat, 0.25, 0.5, 0.75 & 1)) of ADG‐NH2/Epoxy/CFRP composites. The ILSS was enhanced up to ∼27% for 0.5 wt% of ADG‐NH2 reinforced CFRP at room temperature but reduced with the higher concentrations (0.75 wt% & 1 wt%). It was observed that ILSS reduced with gradual temperature variations up to 100°C w.r.t room temperature. But an increment was observed up to 0.5 wt% for ADG‐NH2 for all temperature. Form the test results, it has been recorded an improvement in mechanical properties that is, the elastic modulus by ∼18%, ultimate tensile strength by ∼21%, % elongation at break by∼19% and toughness by∼28% for the 0.5 wt% of ADG‐NH2 graphene nano additive reinforced CFRP composite laminates as compared to neat epoxy CFRP laminates. Results also show the augmentation in the Max load by ∼24%, flexural strength by ∼33%, flexural modulus by ∼43%, and flexural strain by ∼26% were observed for the 0.5 wt% of ADG‐NH2 graphene nano additive reinforced CFRP composite laminates as compared to neat epoxy CFRP composite laminates. Fractographic studies of fractured surface using SEM analyses shows better adhesion mechanisms which supports the augmentation in mechanical properties with addition of amine functionalized graphene to CFRP laminate. Highlights: Reinforcement of amine functionalized (ADG‐NH2) graphene in the epoxy matrix and incorporation with carbon fibers to enhance the interfacial and flexural properties.Evaluation of temperature effects on interlaminar shear strength properties of amine functionalized CFRP compositesImprovements in tensile, ILSS and flexural properties observed for a low percentage (0.5 wt%) of ADG‐NH2 graphene reinforced CFRP composite laminates.Use of aerospace grade epoxy and resin with amine functionalized graphene for further use in aerospace industry applications. [ABSTRACT FROM AUTHOR]

We analyze the generalized Hamiltonian structure of a system of first‐order ordinary differential equations for the Jenner et al. system (Letters in Biomathematics 5 (2018), no. S1, S117–S136). The system of equations is used for modeling the interaction of an oncolytic virus with a tumor cell population. Our analysis is based on the existence of a Jacobi last multiplier and a time‐dependent first integral. Suitable conditions on the model parameters allow for the reduction of the problem to a planar system of equations, and the time‐dependent Hamiltonian flows are described. The geometry of the Hamiltonian flows is also investigated using the symplectic and cosymplectic methods. [ABSTRACT FROM AUTHOR]

Multifunctionality, integration, and miniaturization are the mainstream trends in modern device development. However, optical display and depth perception, essential for innovative applications like intelligent driving and mixed reality, are typically achieved separately in complex and bulky optical systems. Metasurfaces, ultrathin artificial optical surfaces with strong light–matter interaction capabilities at the nanoscale, offer a versatile platform for creating multifunctional, highly integrated, and miniaturized devices by fully exploring spatial multiplexing and utilizing variables like location, polarization, and frequency. In this study, a multifunctional metasurface that integrates meta‐holography with Dammann gratings is presented. By engineering the phase profile, the device can display specific holographic images in the Fresnel region while simultaneously producing a high‐density spot cloud with over 37 000 spots covering the entire half space. As a proof‐of‐concept, a projection and reconstruction experiment is performed to elaborate its potential for retrieving three‐dimensional (3D) spatial information of real scenarios. The simultaneous generation of display and point cloud holds significant promise for applications in cutting‐edge imaging technologies such as intelligent driving and robot vision. [ABSTRACT FROM AUTHOR]

Single‐molecule localization microscopy (SMLM), which has revolutionized nanoscale imaging, faces challenges in densely labelled samples due to fluorophore clustering, leading to compromised localization accuracy. In this paper, we propose a novel convolutional neural network (CNN)‐assisted approach to address the issue of locating the clustered fluorophores. Our CNN is trained on a diverse data set of simulated SMLM images where it learns to predict point spread function (PSF) locations by generating Gaussian blobs as output. Through rigorous evaluation, we demonstrate significant improvements in PSF localization accuracy, especially in densely labelled samples where traditional methods struggle. In addition, we employ blob detection as a post‐processing technique to refine the predicted PSF locations and enhance localization precision. Our study underscores the efficacy of CNN in addressing clustering challenges in SMLM, thereby advancing spatial resolution and enabling deeper insights into complex biological structures. [ABSTRACT FROM AUTHOR]

A green and efficient method for the preparation of spirooxindole‐linked fused pyrans has been developed utilizing a catalyst‐free visible‐light‐driven one‐pot multicomponent reaction strategy. The reaction was performed in a water and ethanol mixture, using the combination of isatin, malononitrile, and cyclic 1,3‐dicarbonyls such as 4‐hydroxy‐1‐methyl‐2(1H)‐quinolone, 4‐hydroxycoumarin, 4‐hydroxythiocoumarin, or barbituric acid derivatives. This catalyst‐free, environmentally friendly, visible‐light‐driven, and room temperature method is a valuable addition to the synthetic toolbox for constructing complex heterocyclic scaffolds under one‐pot conditions. It holds promise for future applications in medicinal chemistry and drug discovery. [ABSTRACT FROM AUTHOR]

The integration of health monitoring and wearable antenna technologies has enhanced patient assessment and the provision of healthcare. Traditional health monitoring methods have evoked a surge in interest toward embroidered antennas as a viable solution for constant physiological monitoring in a noninvasive way. This study examines the performance of an embroidered wearable textile (EWT) antenna intended for breathing rate applications. The antenna is seamlessly integrated into a commercially available T‐shirt, extending the confines of "smart" textiles. The compact (45 mm × 26 mm) EWT antenna operates in 2.4 and 5.8 GHz with gains of 2.07 and 5.85 dBi, respectively. Crumpling and stretching analysis have also been investigated to ensure antenna's mechanical stability and reliability. Subsequently a specific absorption rate analysis has also been performed to quantify the radiation within specified limits. [ABSTRACT FROM AUTHOR]

Bacterial keratitis (BK) is an infection that causes inflammation of the cornea and, if severe, can result in blindness. Topical fluoroquinolones combined with corticosteroids have been shown to be useful in the treatment of BK. A rapid, selective, and sensitive bioanalytical method for simultaneous quantification of Gatifloxacin (GAT) and Dexamethasone (DEX) has been developed and validated using tandem mass spectrometry (LC–MS/MS). Optimal separation was accomplished in under 5 min using an Agilent Zorbax C18 column (100 mm × 4.6 mm, 3.5 μm). The mobile phase was composed of a blend of 0.2% formic acid in triple distilled water and methanol with a flow rate of 0.65 mL/min in isocratic mode. GAT and DEX were detected in positive electrospray ionization multiple reaction monitoring mode (MRM), and the retention time was found to be at 1.64 and 2.93 min, respectively. The linearity of GAT and DEX was found to be in the range of 1.56–400 ng mL−1 with good precision and accuracy. The method was validated according to USFDA regulatory guidelines. The validated method was effectively utilized for preclinical pharmacokinetic analysis of GAT and DEX in rabbit tear fluid following the topical application of a commercial formulation. [ABSTRACT FROM AUTHOR]

Transfer hydrogenation of N‐heteroarenes was successfully achieved using a water‐soluble half‐sandwich Cp*Ir‐based catalyst containing a uracil‐based bifunctional abnormal NHC ligand, using HCOOH/HCOONa buffer solution as the hydrogen source. Reduction of N‐heteroarenes was shown to be highly pH‐dependent, and an acidic pH = 3.0 was found to be suitable for the best activity. The catalyst showed excellent functional group compatibility and high turnover number (up to 10,400), with catalyst loadings as low as 0.005 mol%. Finally, we demonstrated the catalyst's efficacy and applicability toward reusable and repetitive transfer hydrogenation using liquid/liquid extraction methodology, which underscored the significance of sustainable usage of noble metal catalysts in such transformations. [ABSTRACT FROM AUTHOR]

Summary: Radio frequency (RF) energy harvesting (EH) for wireless networks provides a green and sustainable solution and offers an energy‐efficient system. It is most crucial for fulfilling the power requirement of the rising number of low‐powered wireless devices and achieving sustainable development goals (SDG). It ensures the longevity of devices in the network even at inaccessible remote locations. Such RF‐EH‐based mechanisms are utilized in simultaneous wireless information and power transfer (SWIPT) systems. Most of the prevailing studies have analyzed the SWIPT system over conventional fading channels. However, due to the higher rate requirements, the current paradigm shift in frequency usage shifts towards the GHz band, which also offers better EH efficiency. Hence, SWIPT system analysis over the channel that is suitable for mm‐wave signal propagation is dealt with in this study. This study evaluates SWIPT performance over fluctuating two‐ray (FTR) fading channel that is crucial since it provides the best fit for characterizing GHz signal and also provides a generalized framework for most of the conventional fading channels. This study presents new analytical results assuming time switch relaying (TSR) protocol with (i) amplify and forward (AF) and (ii) decode and forward (DF) relaying. The results are also analyzed for H branches maximal ratio combining (MRC) diversity technique and evaluated the diversity gain for both AF and DF relays. The effectiveness of the system is measured in terms of system outage probability (SOP) to envisage the reliability of SWIPT based system. This work presents the simulation and modeling of such system and its obtained results are validated by Monte Carlo simulations for their accuracy. [ABSTRACT FROM AUTHOR]

This study aims to investigate the effect of ultrasound conditions on the germination kinetics and drying characteristics of a germinated Bengal gram at different drying temperatures. Ultrasound treatment was given to the Bengal gram seeds at two different conditions, that is, before (US) and after soaking (SU), which was then followed by germination. This study also determines mass transfer parameters at drying temperatures of 45°C, 55°C, and 65°C and assesses the influence on the physicofunctional characteristics of a germinated Bengal gram. The germination rate behavior was effectively predicted using a zero‐order kinetic model with the highest R2 value of 0.7974–0.8857 in each nontreated (S) and treated (SU, US) Bengal gram seed, respectively. This study showed that the ultrasound treatment effectively enhanced the germination rate in both conditions, and the highest germination rate was found in pretreated ultrasound Bengal gram samples. The logarithmic thin layer drying model, with the highest average R2 of 0.9954 and the lowest average RMSE value of 0.0160, is the best‐fitted model to predict the changes in moisture ratio in both treated and nontreated conditions. The moisture diffusivity values at drying temperatures ranging from 45°C to 65°C were found in treated (US, SU) and nontreated (S) germinated samples ranging from 3.34 × 10−8 to 4.03 × 10−8 m2/s, 1.30 × 10−8 to 2.01 × 10−8 m2/s, and 6.6 × 10−9 to 8.06 × 10−9 m2/s, respectively. The protein content increased in the ultrasound‐treated sample between 12.37% and 13.50%. The solubility ranged from 8% to 10.36% throughout the treated and nontreated germinated Bengal gram flour. This study provides a unified approach to utilizing ultrasound‐treated germinated Bengal gram seeds as an alternative option to develop a functional product with better nutritional and functional properties. [ABSTRACT FROM AUTHOR]

In this paper, we argue that, while it is necessary to modify existing policy using the lessons learned from disaster events (i.e., reactive learning), this approach is insufficient on its own for dealing with ongoing and emerging climate‐induced disaster risks. Rather, we assert that policymakers must also adopt a proactive and anticipatory learning approach that would enable policy learning and policy evolution in the absence of a major disaster event. We examine drivers, actors, and processes of change in disaster‐management policy paradigms in Bangladesh. A longitudinal learning perspective is applied. We categorize disaster management (DM) policy regimes into three learning episodes: (i) reactive, (ii) transitional, and (iii) proactive. The roles of reactive and proactive learning in shifting DM policy paradigms within these learning episodes are particularly determined. Finally, five interrelated factors that triggered proactive policymaking are identified, which are: risk‐oriented policymaking; cross‐scale (i.e., lesson drawing and policy transfer) and cross‐level (i.e., from local, regional, and national experience) learning; participation of multiple stakeholders; research‐informed and knowledge‐based policymaking; and the presence of a strong advocacy group and a participatory policy process. [ABSTRACT FROM AUTHOR]

A new species of nemacheilid loach, Schistura sonarengaensis sp. nov., is described from three cave‐dwelling populations (Barak–Surma–Meghna drainage) in the South Garo Hills district of Meghalaya, India. The new species possesses prominent eyes but is easily distinguished from all the congeners of the genus Schistura from Barak–Surma–Meghna and adjacent rivers drainages of northeast Indian (except S. syngkai) in having 13–26 vertically elongated to circular mid‐lateral black blotches (brownish in life) overlayered on a grayish‐black mid‐lateral stripe on a dull white or pale‐beige (golden brown in life) body. However, it can be easily distinguished from S. syngkai in having a complete (vs. incomplete) lateral line with more 72–89 (vs. 19–42) lateral‐line pored scales, greater pre‐dorsal length (48.5–53.1 vs. 41.9–44.1 %SL), a wider body at dorsal‐fin origin (11.3–16.7 vs. 9.4–10.3 %SL), greater dorsal (18.1–21.1 vs. 15.1–17.0 %SL) and lateral (20.9–24.1 vs. 17.4–18.9 %SL) head length, a wider head (14.5–18.5 vs. 11.6–13.3 %SL), and moderately forked (vs. emarginated) caudal fin. Further, molecular analysis confirms the distinctiveness of S. sonarengaensis sp. nov. from its congeners found in northeast India by significant divergences with uncorrected genetic distance ranging from 3.7% to 17.3% in the mitochondrial cytochrome c oxidase subunit I (COI) gene dataset. The phylogenetic position of the new species with its sister species was evaluated using maximum likelihood and Bayesian analysis. The species delimitation approaches assemble species by automatic partitioning (ASAP) and Poisson tree processes (PTP) utilized for testing species assignments consistently identified our test group as a distinct species from its sister species. Although the new species lacks typical morphological adaptations usually associated with a subterranean life, such as complete absence (or vestigial presence) of eyes and pigmentation, it exhibits a reduction of pigmentation when compared to the epigean congeners. [ABSTRACT FROM AUTHOR]

Herein we first report the unprecedented synthesis of tetrazene‐based cobalt complexes using unusual coupling of amines via dehydrogenation. These cobalt complexes were employed for dehydrogenative coupling reactions to synthesize N‐heterocycles (quinoline, and quinazolinone). Based on control experiments and IR identification of intermediates, we proposed a plausible reaction mechanism. Synthesis protocols were utilized for preparative scale synthesis and biologically active molecule (±)‐galipinine synthesis. [ABSTRACT FROM AUTHOR]

Cytotoxic CD8+ T cells plays a pivotal role in the adaptive immune system to protect the organism against infections and cancer. During activation and response, T cells undergo a metabolic reprogramming that involves various metabolic pathways, with a predominant reliance on glycolysis to meet their increased energy demands and enhanced effector response. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Recent reports indicates that exosomes may transfer biologically functional molecules to the recipient cells, thereby facilitate cancer progression, angiogenesis, metastasis, drug resistance, and immunosuppression by reprogramming the metabolism of cancer cells. This study sought to enlighten possible involvement of cancer‐derived exosomes in CD8 + T cell glucose metabolism and discover a regulated signalome as a mechanism of action. We observed reduction in glucose metabolism due to downregulation of AKT/mTOR signalome in activated CD8 + T cells after cancer derived exosome exposure. In‐vivo murine breast tumor studies showed better tumor control and antitumor CD8 + T cell glycolysis and effector response after abrogation of exosome release from breast cancer cells. Summarizing, the present study establishes an immune evasion mechanism of breast cancer cell secreted exosomes that will act as a foundation for future precision cancer therapeutics. [ABSTRACT FROM AUTHOR]

Harnessing CO2 in conjunction with inexpensive reusable H2 for catalytic hydrogenation is a viable method for lowering the environmental impact of industrial operations while producing useful chemicals and fuels. To make the process more sustainable, particular emphasis was paid to the heterogeneous catalyst system in this regard. Intending to profit from both homogeneous and heterogeneous catalysis in real‐world circumstances for the CO2 hydrogenation reaction, heterogenized molecular catalysts are receiving a lot of attention among heterogeneous catalysts. This review is devoted to significant developments in single‐site heterogenized molecular catalysts for CO2 hydrogenation reactions. Attempting to illustrate the state‐of‐the‐art developments in this domain, the present work meticulously summarizes several recently reported heterogenized molecular catalysts for the CO2 hydrogenation process producing formic acid/formate, N‐formamide, and methanol. The fundamental structure–activity relationships and mechanistic understanding are given particular attention since they offer solid foundations for sensible catalyst architectural design. Important variables that influence catalytic activity are also emphasized, such as electron density, metal dispersion, porous nature, surface area, a robust backbone, and coordination environment of metal sites. Finally, a short assessment is given as potential directions for further research. [ABSTRACT FROM AUTHOR]

In this research, we endeavour to demonstrate the potential of Aqueous Extract of Dillenia indica (AEDI) pseudosepals in catalyzing tetrahydrobenzo[b]pyran and spirooxindole derivatives, thereby paving the way for greener and more sustainable chemical synthetic strategies. The reactions proceed smoothly with AEDI as the catalyst in water at room temperature to afford high to near quantitative yields in a short duration of 15–45 minutes, making it a green and environmentally friendly alternative to existing protocols. This synthetic pathway satisfies several green chemistry principles such as avoiding the use of any toxic or hazardous metal catalyst and other external additives/promoters, the use of a biodegradable catalyst obtained from natural resources, auxiliary solvent conditions, and reusability of the catalyst. The protocol reported here offers remarkable attributes like wide substrate scope, high to near quantitative yields of products and the scale up viability along with ecological safety, straightforward work‐up procedure and excellent values of green chemistry metrics as compared to other reported approaches. [ABSTRACT FROM AUTHOR]

This work reports a practical approach for C−O and C−C bond formation reactions catalysed by Pd nanoparticles supported on Luffa sponge (PdNPs@LS).PdNPs@LS were prepared via a green route in‐situ by using ethanol as solvent, and lignin content present in the luffa sponge could work as an effective reducing reagent to reduce Pd(II) to Pd(0) without any harsh chemical used for reduction. The bio‐based support used i. e. Luffa sponge extracted from the waste feedstock of Luffa guard in a simple filtration method is a cheap, biodegradable, abundant and renewable source with netting‐like three‐dimensional porous structure. Without significant loss of its activity the PdNPs@LS could be easily recovered and recycled for at least three times. The catalyst is characterized by FT‐IR, TGA, SEM‐EDX, TEM, and XPS analyses. [ABSTRACT FROM AUTHOR]

Background: Endless loop tachycardia (ELT) is the commonest pacemaker mediated tachycardia (PMT) encountered among patients with cardiac implantable electronic devices (CIEDs). Despite being enabled with various preventive algorithms, we encountered several cases having recurrent, long, and symptomatic ELT. Materials and Methods: We retrospectively analyzed consecutive device checkups at device clinic at a single center of eastern India between January 2019 to March 2023. Results: There were 20 cases of confirmed and sustained ELT among 4520 device checks. Although mostly benign, in two cases ELT led to clinical worsening in patients having left ventricular (LV) systolic dysfunction. Even with good ventricular function, ELT resulted in improper atrioventricular (AV) synchrony leading to disabling symptom in one case. The differentiation of ELT from sinus tachycardia and atrial tachycardia (AT) was not always easy. Magnet application is certainly useful to differentiate. The situations that provoked ELT in this study were—long AV delays, VIP (ventricular intrinsic preferences)/MVP (managed ventricular pacing), atrial non‐capture, atrial under/over sensing, premature ventricular contractions (PVCs)/couplets, premature atrial contractions (PAC) and slower ventriculo‐atrial (VA) conduction. Rate responsive shortening of post‐ventricular atrial refractory period (PVARP) also promoted its occurrence and hindered troubleshooting. When ELT occurred despite post‐PVC extension of PVARP, lowering the atrial sensitivity, switching to bipolar sensing and manual setting of longer PVARP after measuring VA conduction time were useful. "Rate responsive PVARP" had to be turned off in a few cases to prevent ELT. On the contrary, an over aggressive prolongation of PVARP led to repetitive non‐reentrant ventriculo‐atrial synchrony (RNRVAS) in two cases. Checking VA conduction during implantation and noninvasive program stimulation (NIPS) during follow up were useful to check the tendency for ELT. Conclusion: Clinically significant ELT is rare but not uncommon among devices having in‐built preventive algorithms. Manual adjustments are often useful to troubleshoot the same. [ABSTRACT FROM AUTHOR]

This research presents an analytical study of magnetohydrodynamics (MHD)‐free convective heat and mass transfer flow of a nanofluid bounded by a semi‐infinite flat plate. A magnetic field of strength (B0)$({{B}_0})$ is applied throughout the fluid region. The plate is moving with a constant velocity (U0)$({{U}_0})$, temperature, and the concentration are assumed to be fluctuating with time harmonically from a constant mean at the plate. The frontier equations are assumed to be of an oscillatory nature and cracked analytically using the perturbation technique. The novelty of the present work is to examine the heat and mass transfer MHD flow for Cu‐water and TiO2‐water nanofluids in the presence of thermal radiation. The influence of physical parameters on the flow domain is described in the discussions by graphically and in tabular form. It was found that the fluid temperature and skin friction were reduced with the increased values of the radiation parameters for Cu‐water and TiO2‐water nanofluids. Also, it is noticed that the concentration boundary layer thickness decreases with an increase in chemical reaction parameters. [ABSTRACT FROM AUTHOR]

Summary: This paper presents a low‐voltage ride‐through capability (LVRT) solution for the photovoltaic (PV) grid‐connected inverters compliant with the Indian grid code. The LVRT strategy ensures the uninterrupted connection of solar energy to the grid, safeguarding against system shutdown in the event of various grid faults. During this time, the inverter supplies reactive power to the utility grid, effectively utilizing converter capacity and aiding the restoration of the voltage profile at the point of common coupling (PCC). The system used in this study involves a two‐stage grid‐interfaced solar PV setup with a boost converter that tracks the maximum power point (MPP) and an inverter that maintains the DC‐link voltage. A modified dynamic braking chopper control (MDBCC) has also been implemented to minimize the DC‐link voltage oscillations during asymmetrical faults while simultaneously injecting the sinusoidal current into the grid. To improve grid synchronization in the presence of unbalanced abnormalities, a modified dual second‐order generalized integrator phase‐locked loop (DSOGI‐PLL) has been employed to track the grid voltage angle precisely. Furthermore, a new control system has been developed in conjunction with the LVRT approach. The suggested system is simulated in MATLAB/Simulink to validate the efficacy of the LVRT control method during symmetrical and asymmetrical faults using a 100‐kW two‐stage grid‐interfaced solar PV facility. Finally, for experimental validation, a real‐time test bench (RTS) OPAL‐RT 4510 is used to implement the setup with its control, and the practical results are compared with the simulation outcomes. [ABSTRACT FROM AUTHOR]

Summary: This article describes a generalized single‐phase multiwinding step‐up transformer‐based multilevel converter with optimized device count. The proposed topology comprises of a single dc source, eight switches (four unidirectional and four bidirectional) and a single high‐frequency multiwinding transformer. Phase disposition pulse width modulation (PDPWM) is used for the level creation. The proposed converter is examined qualitatively and quantitatively using the total number of transformers, PWM control method, switch count, voltage stress, and the number of gate drivers, all of which are favorable. All elements of transformer selection, winding requirements, and comparative study have been thoroughly examined. A thorough Lagrange multiplier method has been applied to minimize the copper losses and optimize the multiwinding transformer (MWT) winding. The proposed converter simulations are performed using the MATLAB/SIMULINK environment. Further, the validation of the result is confirmed by a hardware setup of 0.9 kW. [ABSTRACT FROM AUTHOR]

The sub‐mountainous tea gardens of the Dooars region of West Bengal, which contribute approximately 25% of the national tea yield, are constantly fighting with diminishing soil fertility. Inorganic alternatives like chemical fertilizers can provide easier yet short‐term solutions, as their prolonged and indiscriminate usage leaches the soil, devouring its productivity, increasing the soil's heavy metal contents, and subsequently accumulating those heavy metals in leaves. A plausible substitution in this scenario could be the use of organic alternatives like composting or biofertilizer. Although references to such alternative means are found in the literature, a holistic approach targeting plant growth promotion along with mitigating soil metal toxicity is lacking. Keeping this background in mind, this pilot study was designed to optimize the dosage of novel biofertilizers (using resident and alien flora) that can reduce heavy metal loads and residual toxicity in soil, thereby improving overall soil health and tea production. Two potential metallophilic plant growth‐promoting strains of Bacillus sp. (previously reported) were selected and applied to potted tea plants of two different varieties of tea: TV9 and TV25. Among the two modes of treatment tested: solid treatment (compost amended with bacterial culture) and liquid treatment (cell pellets mixed in water suspension), the water suspension‐based direct application of resident soil bacteria showed the highest physiological growth with reduced metal toxicity. Based on physiological data and physico‐chemical data collected, it was observed that direct application of bacteria showed better results in both plant and soil health improvement in comparison to regular compost amended with beneficial microflora. Therefore, this small‐scale pilot study aimed to optimize the dosage and mode of application of novel biofertilizers for improved soil and plant health. [ABSTRACT FROM AUTHOR]

Background: Adrenal insufficiency (AI) is a life‐threatening condition which requires long term glucocorticoid replacement. The insulin tolerance test (ITT) is the current gold standard test for diagnosis of secondary AI, but the widely accepted cut‐off value of a peak cortisol of less than 500 nmol/L assumes that anyone who does not reach this value has AI and thus requires full replacement. The cut‐off used to diagnose AI is also founded on outdated assays. Use of this cut‐off in an era of more specific immunoassays therefore risks misdiagnosis, subsequent unnecessary glucocorticoid exposure and associated adverse effects with increased mortality risk. Design, Patients and Measurements: This retrospective analysis assessed 300 ITT cortisol responses using the Abbott Architect and Alinity analyser platforms in patients with suspected AI over a period of 12 years (August 2010 to January 2022), at a tertiary centre. Results: Patients were classified as having AI or not, based on a comprehensive clinical review of electronic patient records from the point of test to the present day by a panel of pituitary and adrenal specialists. Using the current institutional cut‐off value of 500 nmol/L, receiver operating characteristic analysis identified a 100.0% sensitivity and 43.6% specificity (area under the curve 0.979). Using a lower cortisol threshold value of 416 nmol/L on the Abbott analyser platform maintained a sensitivity of 100.0% and improved the specificity to 86.7%. Conclusion: This data supports lowering the Abbott analyser ITT peak cortisol threshold to 416 nmol/L. Use of this improved cut‐off avoids unnecessary glucocorticoid replacement therapy in 104 (34.7%) of individuals in this study. All patients remained well with at least 1 year longitudinal follow up of glucocorticoid replacement. [ABSTRACT FROM AUTHOR]

Herein, we investigate the effect of the addition of tetra‐needle‐like zinc oxide whisker (T‐ZnOw), a novel reinforcing additive, on the melt crystallization behavior of biodegradable polybutylene adipate terephthalate (PBAT)/polylactic acid (PLA) polymer blends. PBAT and PLA were blended in a Haake mixer at a fixed weight ratio of 70/30, and the contents of T‐ZnOw varied from 0 to 7 wt%. The melt thermal properties and crystallization behavior of PBAT/PLA blends and PBAT/PLA/T‐ZnOw composites were studied using differential scanning calorimetry. The kinetics of melt crystallization have been quantitatively explained using a range of mathematical formalisms. The Avrami equation is adopted to analyze the isothermal crystallization process and kinetics of PBAT/PLA/T‐ZnOw composites. For its nonisothermal crystallization process and kinetics, the Ozawa equation cannot describe the entire process, while the Jeziomy‐modified Avrami equation can only describe the initial stage of its nonisothermal crystallization. Using Mo‐analysis, the impact of T‐ZnOw contents on the composite's nonisothermal crystallization kinetic has been thoroughly examined. Given that the PBAT/PLA blend system's crystal formation may be inhibited by T‐ZnOw, the observation demonstrates that T‐ZnOw only marginally alters this process. The work is of significant scientific value and adds a new concept to the development of sustainable thin film for packaging. Highlights: T‐ZnOw is used as a novel additive for PBAT/PLA polymer blends.The crystallization of PBAT/PLA/T‐ZnOw composite systems is thoroughly examined.T‐ZnOw marginally reduces the kinetics of the crystallization process of PBAT/PLA blends.PBAT/PLA/T‐ZnOw composites follow volume nucleation with mixed 2D/1D growth.The nonisothermal crystallization of PBAT/PLA/T‐ZnOw composites is validated by Mo‐analysis. [ABSTRACT FROM AUTHOR]

Herein we report a platinum‐catalyzed isomerization of cyclopropenes to 1,3‐dienes. Diverse dienylated alcohols were obtained in 42–98 % yield. The synthetic potential of the products was demonstrated by their use in Diels–Alder cycloadditions with various dienophiles. Isotope labelling studies provide strong support for a mechanism involving pericyclic [1,5]‐σ‐bond rearrangement of a vinyl platinum carbene intermediate. [ABSTRACT FROM AUTHOR]

In multiplayer, first‐person shooter games like Counter‐Strike: Global Offensive (CS:GO), coordinated movement is a critical component of high‐level strategic play. However, the complexity of team coordination and the variety of conditions present in popular game maps make it impractical to author hand‐crafted movement policies for every scenario. We show that it is possible to take a data‐driven approach to creating human‐like movement controllers for CS:GO. We curate a team movement dataset comprising 123 hours of professional game play traces, and use this dataset to train a transformer‐based movement model that generates human‐like team movement for all players in a "Retakes" round of the game. Importantly, the movement prediction model is efficient. Performing inference for all players takes less than 0.5 ms per game step (amortized cost) on a single CPU core, making it plausible for use in commercial games today. Human evaluators assess that our model behaves more like humans than both commercially‐available bots and procedural movement controllers scripted by experts (16% to 59% higher by TrueSkill rating of "human‐like"). Using experiments involving in‐game bot vs. bot self‐play, we demonstrate that our model performs simple forms of teamwork, makes fewer common movement mistakes, and yields movement distributions, player lifetimes, and kill locations similar to those observed in professional CS:GO match play. [ABSTRACT FROM AUTHOR]

In vitro capacitation allows for a greater understanding of the mechanisms underlying fertilization and the development of improved reproductive techniques for improving fertility rates in porcine. Tyrodes albumin lactate pyruvate (TALP) and modified Krebs Ringers Broth (m‐KRB) are two medias that are commonly used in research experiments to induce capacitation in boar spermatozoa (Cañón‐Beltrán et al., Theriogenology, 198, 2023 and 231; Oberlender et al., Archivos de Medicina Veterinaria, 44, 2012 and 201; Sahoo et al., International Journal of Biological Macromolecules, 241, 2023 and 124502). Moreover, understanding the morphological and functional changes in boar spermatozoa at different hours of capacitation periods might aid in the development of novel techniques for improving sperm quality and increasing the litter size. This study was carried out to investigate the effect of Tyrode albumin lactate pyruvate and modified Krebs Ringers Broth media on in vitro capacitation of HD‐K75 boar spermatozoa at three different periods of incubation. A total of 24 ejaculate from four clinically healthy, 10–12 months aged HD‐K75 boars, maintained at ICAR‐All India Coordinated Research Project (AICRP) on pig were selected. Semen was collected by 'Simple fist' method using a portable dummy. The semen samples having 200 mL volume, 103 × 106 spermatozoa/ml concentration and 70% initial motility were selected and split into two parts and suspended in TALP and m‐KRB media, respectively, and incubated for 5 h at 37°C. Seminal parameters viz. sperm viability, plasma membrane integrity and acrosomal integrity were estimated in the samples at 0, 3 and 5 h of incubation. This study revealed that there was significant variation between media in live acrosome‐reacted (p <.05) and HOST‐reacted (p <.01) spermatozoa, while between capacitation periods significant (p <.01) variation was observed in hyperactivated spermatozoa, live acrosome‐reacted spermatozoa, HOST‐reacted spermatozoa, FITC‐labelled PSA, extracellular protein and sperm cholesterol. Non‐significant variation was observed in total phospholipid. TALP showed overall better consequence on sperm viability, plasma membrane and acrosomal integrity of boar spermatozoa. From this study, it could be concluded that both TALP and m‐KRB media were virtuous to induce capacitation in HD‐K75 boar spermatozoa. TALP media, however, had a better effect on sperm viability, plasma membrane and acrosomal integrity of boar spermatozoa. Out of the three different periods, 3 h capacitation period resulted in significantly (p <.01) higher incidence of sperm viability, plasma membrane and acrosomal integrity in HD‐K75 boar spermatozoa. [ABSTRACT FROM AUTHOR]

The biggest obstacles in treating cancer with traditional chemotherapy are unpleasant side effects and drug resistance. A growing amount of interest has been exhibited in using aptamers as target ligands for targeted cancer therapy and specific cancer cell identification due to their distinct benefits. Aptamer‐conjugated nano‐materials have recently provided new prospects in cancer treatment with their improved therapeutic efficacy and capability of reducing toxicity. Consequently, they are not perceived as alien substances our body, which allows their comfortable acceptance. Several tumor markers such as nucleolin, mucin, and the epidermal growth factor receptor can be effectively recognized by aptamers. In addition, glycoproteins on the surface of tumor cells can be recognized using aptamers. So surface modification of drug by aptamer are accomplished for enhanced tumor‐specific recognition by which drug‐specific accretion, internalization, and drug retention in tumors increased through specific ligand‐mediated interactions and thus therapeutic index is increased. Here, we highlight some promising classes of aptamer‐conjugated nanoparticles for the specific recognition of cancer cells and targeted drug delivery and the molecular mechanism and immunomodulatory regulation of these aptamer have been focused. [ABSTRACT FROM AUTHOR]

Curiosity‐driven innovations on the design and synthesis of nonplanar polycyclic aromatic/heteroaromatic compounds with new molecular topologies unfold exciting opportunities for harnessing their intriguing supramolecular properties and thereby the development of novel functional organic materials. This work presents such an innovative synthetic concept of a bottom‐up molecular topology engineering through a unique orchestrated octuple C−H activation reaction, toward the rapid synthesis of a novel class of double heptagon‐incorporated nitrogen‐doped laterally‐fused polycyclic compounds with rarely reported wavy structural configuration. The profound impact of the molecular wavy structures of these compounds on their properties is manifested by weak and tunable solid‐state intermolecular interactions controlling the electronic properties of the materials, leading to reversibly switchable fluorochromism in the solid state and thin films with mechanical force and solvent vapors as external stimuli, thereby indicating their potential applicability in rewritable fluorescent optical recording media, security papers, mechanosensors, volatile organic compound (VOC) sensors etc. [ABSTRACT FROM AUTHOR]

In this article, high‐frequency stability estimates are explored for the determination of the zeroth‐order perturbation of the biharmonic operator with constant attenuation from the linearized partial Dirichlet‐to‐Neumann map when part of the boundary is inaccessible and flat. The results obtained suggest improvement of the stability with an appropriate choice of frequency. [ABSTRACT FROM AUTHOR]

Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan, and gelatin, alongside synthetic counterparts such as PLGA and PEG, have gained prominence for their biocompatibility and controlled release profiles. Recent strides in polymer conjugation strategies have enabled targeted delivery through ligand integration, facilitating tissue specificity and cellular uptake. This versatility accommodates combined drug delivery, addressing diverse anterior (e.g., glaucoma, dry eye) and posterior segment (e.g., macular degeneration, diabetic retinopathy) afflictions. The review encompasses an in‐depth exploration of each natural and synthetic polymer, detailing their individual advantages and disadvantages for ocular drug delivery. By transcending ocular barriers and refining therapeutic precision, these innovations promise to reshape the management of anterior and posterior segment eye diseases. [ABSTRACT FROM AUTHOR]

Introduction: Community health centers (CHCs) provide historically marginalized populations with primary care, including cancer screening. Previous studies have reported that women living in rural areas are less likely to be up to date with cervical cancer screening than women living in urban areas. However, little is known about rural–urban differences in cervical cancer screening in CHCs and the contributing factors, and whether such differences changed during the COVID‐19 pandemic. Methods: Using 8‐year pooled Uniform Data System (2014‐2021) data and Oaxaca‐Blinder decomposition, the extent to which CHC‐ and catchment area–level characteristics explained rural‐urban differences in up‐to‐date cervical cancer screening was estimated. Results: Up‐to‐date cervical cancer screening was lower in rural CHCs than urban CHCs (38.2% vs 43.0% during 2014–2019), and this difference increased during the pandemic (43.5% vs 49.0%). The rural–urban difference in cervical cancer screening in 2014–2019 was mostly explained by differences in CHC‐level proportions of patients with limited English proficiency (55.9%) or income below the poverty level (12.3%) and females aged 21 to 64 years (9.8%), and catchment area–level's unemployment (3.4%) and primary care physician density (3.2%). However, Medicaid (–48.5%) or no insurance (–19.6%) counterbalanced the differences between rural–urban CHCs. The contribution of these factors to rural–urban differences in cervical cancer screening generally increased in 2020–2021. Conclusions: Rural–urban differences in cervical cancer screening were mostly explained by multiple CHC‐level and catchment area–level characteristics. The findings call for tailored interventions, such as providing resources and language services, to improve cancer screening utilization among uninsured, Medicaid, and patients with limited English proficiency in rural CHCs. The proportion of females who were up to date with cervical cancer screening was lower in rural community health centers (CHCs) than in urban CHCs, both before and during the COVID‐19 pandemic. Several factors contributed to the rural–urban difference, including proportion of patients with limited English proficiency, Medicaid or no health insurance, income below the federal poverty level at the CHC level, and unemployment rate and primary care physician density in the CHC's catchment area. [ABSTRACT FROM AUTHOR]

Nanoclay is considered to be one of the best fillers for reinforcement in structural polymer composites because of its low cost, easy availability, and ability to improve mechanical, thermal, corrosion resistance, barrier properties and nonflammability in corresponding nanocomposites. Pristine nanoclay is hydrophilic and therefore needs surface modification to make it compatible for uniform dispersion with polymer matrix. In the present work, montmorillonite nanoclay was protonated for generating more hydroxyl groups to facilitate silane functionalization and is reinforced to prepare epoxy nanocomposites with a varying content of 0.5 to 20 wt%. Studies are also conducted to investigate the effect of silanization of unprotonated nanoclay on epoxy nanocomposites. Interestingly, uniform highly exfoliated reduced‐size nanoclay platelets are obtained for functionalized protonated nanoclay. This behavior is attributed to the increase in the d‐spacing between the interlayers of the nanoclay during protonation and silanization. Tensile performances are found best with 0.5 wt% of silanized clay with an improvement of ~50%, ~84% and ~177% in strength, modulus and absorbed failure energy compared to neat epoxy. Although flexural and fracture performance are found highest with 2 wt% of silanized protonated clay with an improvement of ~57.5% in flexural strength and a remarkable ~241% and ~964% enhancement in fracture toughness and fracture energy compared to neat epoxy. The toughening mechanism investigation endorses the improvement in interfacial adhesion of the protonated silanized nanoclay that enhances the properties of the interfacial region, which significantly enhances the resistance for in‐panne crack propagation in epoxy nanocomposites. Highlights: Synthesized silanized and silanized protonated montmorillonite clay.Protonation facilitated silane moiety attachment onto nanoclay.Maximum improvement of flexural strength by ~57.5% for ESPrC2.KIC and GIC were highest showing ~1.74 MPam1/2 and ~830.28 J/m2 for ESPrC2.Enhanced interfacial adhesion due to SPrC with the epoxy matrix. [ABSTRACT FROM AUTHOR]

Mechanophoric polymers are an interesting class of smart polymers which contains a special force‐sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the design of a mechanophoric polymer based on epoxy‐functionalized rhodamine via a monomeric approach. In this case, rhodamine (Rh) is modified with glycidyl methacrylate (GMA) through an epoxy–amine reaction to design a vinyl‐functionalized multi‐armed macromonomer (Rh‐GMA), which is reacted with butyl acrylate (BA) to prepare the crosslinked polymeric film. The crosslinked polymeric film demonstrates mechanophoric properties under UV and stretching conditions. [ABSTRACT FROM AUTHOR]

Burnt sugarcane bagasse powder (SCBP), with its low density, accessibility, and renewal, is an economically reinforcing material. This study fabricated composites, i. e., aluminium/alumina/burnt sugarcane bagasse powder, through the powder metallurgy route. The physical, mechanical, microscopic, and chemical characterization of the composites, such as relative density, microhardness, uniaxial compression, scanning electron microscopy, and x‐ray diffraction, has been conducted. There is a gain in relative density, microhardness and ultimate compression strength of about 2.25 %, 48.07 % and 33.34 % respectively, compared to the base composite (aluminium/4 wt.‐% alumina) at 3 wt.‐% burnt sugarcane bagasse powder. The Taguchi methodology is used as a statistical tool to optimise the response variables. An analysis of variance (ANOVA) is used to find the contribution of input parameters to response variables, and the regression models have been developed. The contribution of factors 'burnt sugarcane bagasse powder wt.‐%' and 'time' on relative density is 81.65 % and 13.64 %, respectively, while the contribution of the same factors on microhardness is 95.98 % and 3.377 %, respectively. The results of the Taguchi method reveal that the optimised conditions for the highest relative density and microhardness are 3 wt.‐% burnt sugarcane bagasse powder and 2.5 h, which have confirmed the experimental results. [ABSTRACT FROM AUTHOR]

Summary: Autonomy is becoming a prime requirement for satellite mission control operations. Data‐driven methods like Machine Learning models are playing a key role in bringing in autonomy. Health keeping data from satellite telemetry is a key ingredient in these data‐driven methods. In real‐world satellite operations, the health‐keeping telemetry data gradually drifts due to adverse space weather effects and wear and tear of electronic and mechanical components. The key question that arises is how to detect and quantify the data drift which is generally a gradual phenomenon. This paper discusses a novel statistical method for detecting data drift occurring in satellite telemetry. For the purpose of experimental work in this paper, an actual telemetry data set of the BUS CURRENT sensor which is part of the Electrical Power System of a Low Earth Orbit Satellite was considered. Data drift detection test was carried out using this sensor data using the developed novel statistical method and with Kolmogorov Smirnov test which is a probabilistic method. Both results are analysed and compared. Thereafter novel statical method was used to check its efficacy using a synthetic data set with induced drift. [ABSTRACT FROM AUTHOR]

In situ and spaceborne studies reveal the prevalence of thin clouds in the major Stratocumulus‐to‐Cumulus Transition (SCT) regions. Using instantaneous satellite and reanalysis data, this study investigates the properties of thin clouds in the Southeast Pacific Ocean and their impact on the cloud radiative effect (CRE). Our findings demonstrate that thin clouds are intrinsic to the SCT. The overcast stratocumulus‐dominated regime exhibits a minimal presence of thin clouds, which become notably prominent after the clouds breakup into the cumulus‐dominated regime. The regime dependence of the occurrence of thin clouds is also observed in terms of the marine cold‐air outbreak parameter and the sea surface temperature. Thin clouds at a given cloud cover significantly modulate the shortwave (SW) and longwave (LW) components of CRE. SW CRE decreases by 46 %–65 % with increasing thin cloud cover. They account for a larger variance in cloud albedo than the combined influence of the liquid water path and effective radius. Furthermore, LW CRE decreases by about 12 %–52 % with thin cloud cover. An increase in the fraction of thin clouds also leads to a larger fraction of negative SW CRE offset by positive LW CRE at a given cloud cover. This LW compensation ranges from approximately 8 % at overcast cloud cover to as much as 19 % at about 50 % cloud cover. These findings elucidate the crucial role of thin clouds, and thus cloud morphology, in modulating CRE and underscore the necessity of their accurate representation in climate models. Plain Language Summary: The eastern regions of major global oceans are primarily covered by low‐altitude clouds. These bright clouds overlay the dark ocean surface, reflecting incoming solar radiation and cooling the Earth. Concurrently, they act as a barrier to the energy emitted by the ocean surface, preventing it from escaping the Earth and thereby contributing to the Earth's warming. Satellite observations reveal the prevalence of thin clouds in these oceanic regions. In contrast to their thicker counterparts, thin clouds are less effective in reflecting solar radiation and blocking surface emissions. This study investigates the impact of thin clouds on radiation using data from various sources. We show that the presence of thin clouds significantly reduces cloud brightness by approximately 46 %–65 %, even when the cloud cover remains constant. Thin clouds have a more substantial effect on a cloud's ability to reflect solar radiation compared to the combined influence of cloud water and cloud droplet size. Furthermore, since thin clouds allow some surface emissions to pass through, their presence at a constant cloud cover reduces their warming effect by up to 52 %. These findings emphasize the crucial role of thin clouds in shaping the contribution of clouds to Earth's energy balance. Key Points: Thin clouds dim cloud brightness by up to 65 percent at a fixed cloud coverThin clouds exert a greater influence on cloud albedo than the combined effects of cloud water and droplet size under constant cloud coverThin clouds reduce longwave warming by up to 52 percent and modulate the balance between longwave warming and shortwave cooling [ABSTRACT FROM AUTHOR]

Owing to its high natural abundance compared to the commonly used transition (precious) metals, as well as its high Lewis acidity and ability to change oxidation state, aluminium has recently been explored as the basis for a range of single‐site catalysts. This paper aims to establish the ground rules for the development of a new type of cationic alkene oligomerisation catalyst containing two Al(III) ions, with the potential to act co‐operatively in stereoselective assembly. Five new dimers of the type [R2Al(2‐py′)]2 (R=Me, iBu; py′=substituted pyridyl group) with different substituents on the Al atoms and pyridyl rings have been synthesised. The formation of the undesired cis isomers can be suppressed by the presence of substituents on the 6‐position of the pyridyl ring due to steric congestion, with DFT calculations showing that the selection of the trans isomer is thermodynamically controlled. Calculations show that demethylation of the dimers [Me2Al(2‐py′)]2 with Ph3C+ to the cations [{MeAl(2‐py')}2(μ‐Me)]+ is highly favourable and that the desired trans disposition of the 2‐pyridyl ring units is influenced by steric effects. Preliminary experimental studies confirm that demethylation of [Me2Al(6‐MeO‐2‐py)]2 can be achieved using [Ph3C][B(C6F5)4]. [ABSTRACT FROM AUTHOR]

This research focuses on studying the effects of heat and mass transfer convective flow passing through an infinite vertical plate embedded in porous media under radiation and chemical reaction with constant heat and mass flux. A magnetic field of strength is functional throughout the fluid region. The novelty of the present work is to examine the heat and mass transfer magnetohydrodynamics flow in the presence of thermal radiation. The equations governing the flow, heat and mass transfer are solved analytically using the perturbation technique. Expressions for velocity, temperature, concentration, skin‐friction, Nusselt, and Sherwood numbers are obtained. The influence of physical parameters on the flow domain is described graphically and in tabular form. It is found that increase in radiation parameter reduces the velocity and temperature. Moreover, internal friction of the plate decreased with increasing values of radiation parameter. [ABSTRACT FROM AUTHOR]

Objective: Dams and reservoirs can alter juvenile growth and survival of migratory salmonids through several physical and biological mechanisms. Juvenile Chinook Salmon Oncorhynchus tshawytscha that are produced upstream of large hydropower dams may have associated passage mortality, but the reservoirs created by these dams can support rapid growth. Characterizing the biotic drivers of growth and mortality in reservoirs may aid in understanding the cumulative effects of river impoundments on migratory salmonid populations. The purpose of this study was to understand how reservoirs facilitate rapid growth in juvenile Chinook Salmon. Methods: We analyzed stomach contents to determine diet composition throughout the summer and fall. We also recorded prevalence of the parasitic nematode Philonema sp. in the coeloms of fish. Result: We found that juvenile Chinook Salmon frequently consumed young‐of‐year centrarchids, which likely contributed to rapid growth. Piscivory was highest from July through October and decreased with surface temperature from November through December. Correspondingly, zooplankton and arthropod consumption increased in November and December. Prevalence of visible Philonema sp. infections in the coelom was high (34.6%), negatively associated with time, and nonlinearly associated with fork length. Conclusion: These findings reveal unique diet patterns and suggest potential parasite‐associated mortality in reservoir‐rearing Chinook Salmon, but more detailed studies across a longer time scale are needed to robustly assess the population‐level effects of this parasite. [ABSTRACT FROM AUTHOR]

A short monodisperse poly(ethylene glycol) (PEG) and a neutral organic rotamer conjugate TEG‐BTA‐2 amphiphile was designed for the construction of a stimuli‐responsive switchable self‐assembled structure for drug encapsulation by noncovalent interaction and targeted controlled delivery. A short PEG, tetraethylene glycol (TEG) was covalently attached with a neutral organic rotamer benzothiazole dye (BTA‐2) affording the neutral TEG‐BTA‐2 (<500 D). The TEG‐BTA‐2 is self‐assembled into a microsphere in an aqueous medium, but remarkably undergoes morphology change switching to a rice‐like microcapsule for curcumin encapsulation. Curcumin‐loaded microcapsules were stable in an aqueous solution, however, were noticed disintegrating upon the addition of BSA protein. This is possibly due to an interaction with BSA protein leading to a protein affinity‐controlled curcumin release in a neutral PBS buffer. Moreover, cell internalization of the neutral amphiphile TEG‐BTA‐2 into A549 cells was observed by fluorescence microscopy, providing an opportunity for application as a molecular vehicle for targeted drug delivery and monitoring. [ABSTRACT FROM AUTHOR]