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Dry/wet conditions are one of the key constituents of climate change. The understanding of dry/wet variability is vital for production and water resources management. In this research, the temporal variations of 12‐month timescale standardized precipitation evapotranspiration (SPEI) over 2021–2100 under the SSP1‐2.6, SSP2‐4.5, SSP3‐7.0 and SSP5‐8.5 scenarios in seven subregions and China's mainland were investigated over the baseline period of 1961–2000. The run theory was used to project the variations of dry/wet frequency, duration and severity at different levels during 1961–2000, 2021–2060 and 2061–2100 based on the estimated SPEI. The results showed that dry tendency would occur in northwest China. The linear trend for SSP1‐2.6, SSP2‐4.5, SSP3‐7.0 and SSP5‐8.5 were −0.056, −0.031, 0.009 and −0.072 per decade, respectively. While wet tendency would occur in the other regions over 2021–2100. The mild, moderate and severe dry/wet duration and severity over 2021–2060 and 2061–2100 would gradually decrease. Except for northwest China and Qinghai‐Tibetan Plateau, the extreme drought duration and severity would increase in the other subregions, while the extreme wet duration and severity would increase in most regions of China. The drought frequency in north China would range from 0 to 14 times and be smaller than the other regions over 2021–2060 and 2060–2100. However, the wet frequency in south China would be larger than that in the other regions. The dry/wet frequency duration and severity for the SSP5‐8.5 scenario would be the largest among the four scenarios. The projected dry/wet conditions can provide useful information for future water resources management. [ABSTRACT FROM AUTHOR]

Aim: To explore the effects of protein phosphatase 2 regulatory subunit B''Alpha (PPP2R3A) on the proliferation and migration of liver cancer cells. Methods: Expression of PPP2R3A in tumor tissues of hepatocellular carcinoma (HCC) patients was detected by immunohistochemistry and western blotting. In two liver cancer cell lines (HepG2 and HuH7), PPP2R3A expression was silenced and then overexpression with PPP2R3A lentiviral vectors, and the effects of PPP2R3A knockdown or overexpression on the proliferation, cell cycle, migration, and invasion of HCC cells were determined in vitro. In a xenograft cancer model in nude mice, the in vivo effects of PPP2R3A knockdown on tumor growth and cancer cell proliferation were evaluated. Results: PPP2R3A expression was found in tumor foci in six of eight HCC samples, at a level higher than that in the adjacent para‐tumor tissues. PPP2R3A expression was observed primarily in the cytoplasm of the cancer cells. Knockdown of PPP2R3A resulted in significant inhibition of hepatoma cell proliferation (P <.05), migration (P <.01), and invasion (P <.01) as well as a significant delay in the G1/S transition in both liver cancer lines (P <.05) and increased p53 expression. Conversely, overexpression of PPP2R3A promoted the proliferation (P <.05) and altered cell cycle progression (P <.05) of both liver cancer cell lines. In vivo, PPP2R3A knockdown in liver cancer cells led to significant reductions in the tumor volume (P <.001) and the expression of Ki‐67 in tumor tissues (P <.05). Conclusion: PPP2R3A may play a role in liver cancer via the regulation of tumor cell proliferation and invasion. [ABSTRACT FROM AUTHOR]

To solve multiple attribute decision‐making problems with attribute values or decision values characterized by trapezoidal intuitionistic fuzzy numbers (TIFNs), we define a trapezoidal intuitionistic fuzzy induced ordered weighted arithmetic averaging (TIFIOWA) operator, which is an extension of the induced ordered weighted arithmetic averaging operator. We derive and prove some related properties and conclusions of the TIFIOWA operator. To compare the TIFNs, we define possibility degrees of the TIFNs. Based on the possibility degrees of the TIFNs and the TIFIOWA operator, we construct a new method to determine the order of alternatives in multiple attribute decision making and to choose the best alternative. Finally, a numerical example shows that the developed method is feasible and effective. [ABSTRACT FROM AUTHOR]

Background. Organ transplantation is considered the best treatment for end-stage organ failure. However, the lack of available organs for transplantation and the increasing number of patients waiting for transplants are primary issues facing the transplant community. Thus, developing strategies to increase the number of donors, especially for liver transplantation, has become a priority. The use of organs acquired from donors who suffered cardiac related deaths has increased the pool of potential liver donors. However, donation after cardiac death (DCD) livers increases the risk of primary graft dysfunction. Methods. In the current study, we conducted transcriptome sequencing using livers from a DCD rat to assess the short-term feasibility and functional efficacy of DCD livers. RNA sequencing (RNAseq) data showed that the liver transcriptome varied greatly in rat livers subjected to 15 minutes of cardiac arrest. Results. The livers used in the current study had a significant loss of normal function before transplantation. Functional and network analyses consistently indicated that transcription and translation processes were inhibited after approximately 15 minutes of cardiac arrest. Moreover, the transcriptomic sequencing data provides significant insight for identifying functional genes and testing additional biological questions in DCD liver transplantation in future studies. [ABSTRACT FROM AUTHOR]