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Resveratrol (Res) has been identified to reduce neurodegeneration. Circular RNAs (circRNAs) are stable noncoding RNAs that are considered to be ideal biomarkers for molecular targeting treatment. Here, this study focused on investigating the function and relationship of circ_0050263 and Res in Alzheimer's Disease (AD). Human neuroblastoma cell line SK‐N‐SH was exposed to amyloid‐β (Aβ) to induce AD cell model in vitro. Cell viability, apoptosis, and inflammatory reaction were evaluated by CCK‐8 assay, flow cytometery, and ELISA analysis. The oxidative stress and endoplasmic reticulum stress (ERS) were determined by detecting related markers. Levels of genes and proteins were detected by qRT‐PCR and Western blot. Dual‐luciferase reporter assay was adopted to verify the binding between miR‐361‐3p and circ_0050263 or PDE4A (Phosphodiesterase 4A). Subsequently, we found that Res treatment alleviated Aβ‐induced apoptosis, inflammatory response, oxidative stress, and ERS in SK‐N‐SH cells. Circ_0050263 is a stable circRNA, which was increased by Aβ, but decreased by Res in SK‐N‐SH cells. Circ_0050263 overexpression reversed Res‐induced neuroprotective effects. Mechanistically, circ_0050263 acted as a sponge for miR‐361‐3p, which targeted PDE4A. Circ_0050263 silencing abated Aβ‐induced neuronal injury, which were counteracted by following PDE4A overexpression. Moreover, PDE4A upregulation could attenuate Res‐mediated neuroprotective effects. In all, Res alleviated Aβ‐induced neuronal apoptosis, inflammation, oxidative stress, and ERS via circ_0050263/miR‐361‐3p/PDE4A axis, providing new insights for AD therapy. [ABSTRACT FROM AUTHOR]

There are various walking pavements in daily life. Slip accidents will happen if required friction for safe walking is greater than available friction between the foot and ground surface. Existing researches mostly focus on horizontal or slope pavements, whereas the cross‐slope walkways are less. A self‐developed gait friction test platform was used to test friction, distribution of plantar pressure and spatiotemporal parameters of human walking under cross‐slope condition. With the increase of cross‐slope angles, the mediolateral friction increases (R2 = 0.972, P < 0.001), the anterior‐posterior friction shows no significant change (R2 = 0.758, P = 0.017), the normal pressure decreases (R2 = 0.915, P = 0.007), and the high foot is more prone to slip and fall than low foot. Therefore, plantar pressure distribution of both feet was shifted to left. The gait cycle was prolonged (P < 0.001), swing period of both feet decreased (P = 0.029) and support period increased (P = 0.015) with the increase of cross‐slope angle. [ABSTRACT FROM AUTHOR]

The plasticized poly(vinyl alcohol) (TPVA) was successfully prepared using poly(vinyl alcohol) (PVA) and 1‐butyl‐3‐methylimidazolium bromide (BMIMBr). Plasticizing effect of the degree of polymerization (DP) on PVA was investigated by differential scanning calorimetry (DSC), thermo gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), and melt flow indexer (MI). It was found that new hydrogen bonds between PVA and BMIMBr were formed, which was confirmed by the‐OH shift of PVA in FT‐IR analysis. XRD analysis showed that the original lattice and more irregular molecular chain structures in the amorphous region of PVA were destroyed effectively, which was conducive to the decrease of degree of crystallinity. Moreover, the plasticizing effect decreased with the increase of DP duo to more molecular entanglements in PVA. TPVA‐1799 possessed the largest thermal processing window and best melt flowability, which was significant for melt spinning in the future. [ABSTRACT FROM AUTHOR]

Sunitinib (Sun), a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, is the standard first‐line treatment against advanced clear cell renal cell carcinoma (RCC), but resistance to therapy is inevitable. Reactive oxygen species production is associated with sensitivity to chemotherapy, but the underlying mechanisms are not completely understood. Here, we investigated the mechanisms contributing to Sun resistance using the RCC cell lines ACHN and 786‐O. We report that Sun‐resistant cells exhibited reduced apoptosis, increased cell viability, increased reactive oxygen species production and disrupted mitochondrial function. Furthermore, chronic Sun treatment resulted in an up‐regulation of Sirt5/isocitrate dehydrogenase 2 (IDH2) expression levels. Knockdown of Sirt5/IDH2 impaired mitochondrial function and partially attenuated Sun resistance. Finally, up‐regulation of Sirt5 enhanced the expression of IDH2 via modulation of succinylation at K413 and promoted protein stability. In conclusion, dysregulation of Sirt5/IDH2 partially contributes to Sun resistance in RCC cells by affecting antioxidant capacity. [ABSTRACT FROM AUTHOR]