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In the present study, the participation of protein kinase C (PKC) signalling in prothoracicotropic hormone (PTTH)‐stimulated ecdysteroidogenesis in Bombyx prothoracic glands (PGs) is demonstrated and characterized. PTTH stimulated phosphorylation of a 37‐kDa protein in Bombyx PGs both in vitro and in vivo, as recognized by a PKC substrate antibody. Treatment with either A23187 or thapsigargin also stimulated this 37‐kDa protein phosphorylation. PTTH‐stimulated phosphorylation of the 37‐kDa protein was markedly attenuated in the absence of Ca2+. The phospholipase C (PLC) inhibitor, U73122, greatly inhibited PTTH‐stimulated phosphorylation of this protein, indicating the involvement of Ca2+ and PLC. A mitogen‐activated protein kinase/extracellular signal‐regulated kinase (ERK) kinase (MEK) inhibitor (U0126), a phosphoinositide 3‐kinase (PI3K) inhibitor (LY294002) and a chemical activator of adenosine 5′‐monophosphate‐activated protein kinase (AMPK) (5‐aminoimidazole‐4‐carboxamide‐1‐β‐d‐ribofuranoside) did not affect PTTH‐stimulated phosphorylation of the 37‐kDa protein, implying that ERK and PI3K/AMPK are not the upstream signalling pathways for PKC‐dependent protein phosphorylation. The mitochondrial oxidative phosphorylation inhibitors (the uncoupler carbonyl cyanide p‐trifluoromethoxyphenylhydrazone and diphenylene iodonium) inhibited PTTH‐stimulated phosphorylation of the 37‐kDa protein, indicating its redox regulation. Treatment with PKC inhibitors (either calphostin C, chelerythrine C or rottlerin) reduced PTTH‐stimulated phosphorylation of the 37‐kDa protein. PTTH‐stimulated ecdysteroidogenesis was also inhibited by treatment with rottlerin, thus further confirming participation of PKC‐dependent phosphorylation in PTTH signalling. From these results, we demonstrated that redox‐regulated PTTH‐stimulated PKC signalling is involved in ecdysteroid secretion in Bombyx PGs. [ABSTRACT FROM AUTHOR]

It is well known that phosphorylation of extracellular signal‐regulated kinase (ERK) is involved in prothoracicotropic hormone (PTTH)‐stimulated ecdysteroidogenesis in insect prothoracic glands (PGs). In the present study, we further investigated the downstream signalling pathways. Our results showed that PTTH stimulated p90 ribosomal S6 kinase (RSK) phosphorylation at Thr573 in Bombyx mori PGs both in vitro and in vivo. The in vitro PTTH stimulation was stage‐ and dose‐dependent. The absence of Ca2+ reduced PTTH‐stimulated RSK phosphorylation. Stimulation of RSK phosphorylation was also observed after treatment with either A23187 or thapsigargin. A phospholipase C (PLC) inhibitor, U73122, blocked PTTH‐stimulated RSK phosphorylation. These results indicate the involvement of Ca2+ and PLC. Treatment with diphenylene iodonium (DPI), a mitochondrial oxidative phosphorylation inhibitor, blocked PTTH‐regulated RSK phosphorylation, indicating its redox regulation. A mitogen‐activated protein kinase (MAPK)/ERK kinase (MEK) inhibitor, U0126, but not a phosphatidylinositol 3‐kinase (PI3K) inhibitor, LY294002, decreased PTTH‐stimulated RSK phosphorylation, indicating that ERK is an upstream signalling. A protein kinase C (PKC) inhibitor, chelerythrine C, inhibited PTTH‐stimulated RSK phosphorylation, and a PKC activator, phorbol 12‐myristate acetate (PMA) stimulated RSK phosphorylation, indicating the involvement of PKC. BI‐D1870, a specific RSK inhibitor, partly prevented PTTH‐stimulated RSK phosphorylation and significantly inhibited PTTH‐stimulated ecdysteroid secretion, indicating that PTTH‐stimulated RSK phosphorylation is involved in ecdysteroidogenesis. Taken together, these data indicate that PTTH activates RSK phosphorylation which plays important roles in PTTH‐stimulated ecdysteroidogenesis. [ABSTRACT FROM AUTHOR]

This study examines an unexpected and extreme positive ionospheric response to a minor magnetic storm on August 5, 2019 by using global ionosphere specification (GIS) 3D electron density profiles obtained by assimilating radio occultation total electron content (TEC) measurements of the recently launched FORMOSAT-7/COSMIC-2 satellites, and ground-based global navigation satellite system (GNSS) TEC. The results reveal ~300% enhancement of equatorial ionization anomaly (EIA) crests, appearing over 200-300 km altitudes, and a much intense localized density enhancement over the European sector. These are the most intense ionospheric response that has ever been detected for a small magnetic storm with Dst ~ -53 nT (SYM-H ~ -64 nT). The enhancements are validated by using global ionosphere map (GIM) TEC and ground-based GNSS TEC. The GIS vertical electron density structures during the storm are examined to understand the physical processes giving rise to such an intense ionosphere response during deep solar minimum conditions when the background electron density is very low. Altitude variations and poleward shifts of the locations of the EIA crests indicate that prompt penetration electric fields (PPEF) play an important role in producing the observed positive storm responses, with the storm-induced equatorward circulation supporting the plasma accumulation against recombination losses. Additional physical mechanisms are required to fully explain the unexpected electron density enhancements for this minor storm event. [ABSTRACT FROM AUTHOR]

While not specifically designed as a planetary mission, NASA's Parker Solar Probe (PSP) mission uses a series of Venus gravity assists (VGAs) in order to reduce its perihelion distance. These orbital maneuvers provide the opportunity for direct measurements of the Venus plasma environment at high cadence. We present first observations of kinetic scale turbulence in the Venus magnetosheath from the first two VGAs. In VGA1, PSP observed a quasi‐parallel shock, β ∼ 1 magnetosheath plasma, and a kinetic range scaling of k−2.9. VGA2 was characterized by a quasi‐perpendicular shock with β ∼ 10, and a steep k−3.4 spectral scaling. Temperature anisotropy measurements from VGA2 suggest an active mirror mode instability. Significant coherent waves are present in both encounters at sub‐ion and electron scales. Using conditioning techniques to exclude these electromagnetic wave events suggests the presence of developed sub‐ion kinetic turbulence in both magnetosheath encounters. Key Points: Observations from Parker Solar Probe reveal kinetic scale turbulence in the Venus magnetosheathDifferences in kinetic range spectral indices between flyby‐encounters are possibly due to shock geometry and kinetic plasma instabilities [ABSTRACT FROM AUTHOR]

Identification of modal parameters of a bridge from its earthquake responses is crucial for performing damage assessment of the structure. However, all the input base excitations of the bridge may not be measured because of economic concerns and sensor malfunctions. Consequently, evaluating the modal parameters of a bridge under the consideration of incomplete input measurements is a challenging and important task. An approach that combines the continuous Cauchy wavelet transform with an autoregressive time‐varying moving average with exogenous input (AR‐TVMA‐X) model is proposed in this study to identify the modal parameters of a multispan bridge under multiple support earthquake excitations with incomplete measurements. The efficiency and efficacy of the proposed approach are first validated using numerically simulated responses of a three‐span continuous beam subjected to multiple support nonstationary excitations. A standard procedure of using the proposed approach to identify the modal parameters is established according to comprehensive studies on the effects of noise in the data, the number of supports whose excitations are used in the AR‐TVMA‐X model, and the orders of the AR‐TVMA‐X model on the accuracy of identifying the modal parameters. This procedure is further applied to process the earthquake responses of a two‐span cable‐stayed 510‐m‐long bridge to demonstrate the engineering applicability of the proposed approach. [ABSTRACT FROM AUTHOR]

A set of Observing System Simulation Experiments (OSSEs) are performed to assess the impact of assimilating Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) electron density profiles and ground-based Global Navigation Satellite System (GNSS) total electron content (TEC) observations in a whole atmosphere data assimilation system. The OSSEs are performed using the Whole Atmosphere Community Climate Model with thermosphere-ionosphere eXtension (WACCMX) with data assimilation provided by the Data Assimilation Research Testbed (DART) ensemble adjustment Kalman filter. Results from the OSSEs demonstrate that the assimilation of ionosphere observations improves the short-term (1 hr) forecasts and analyses. The OSSEs show that the short-term forecasts and analyses are further improved when the ionosphere observations adjust the thermosphere neutral composition and temperature in addition to the ionosphere electron density. Based on an initialized forecast experiment, we find that adjusting the thermosphere neutral composition and temperature also leads to improved forecast skill in the ionosphere on longer time scales (i.e., beyond 1 hr). Additionally, it is shown that using a 1 hr data assimilation cycle, and removal of second-order divergence damping inWACCMX+DART significantly improves tidal amplitudes, which were previously found to be too small. These initial results represent the first whole atmosphere data assimilation system with capabilities to assimilate observations from the troposphere to the ionosphere-thermosphere. [ABSTRACT FROM AUTHOR]

Abstract: Background: Thermal detection thresholds and thermal pain thresholds are important in quantitative sensory testing. Although they have been well studied for assessing somatosensory function, the investigation of thermal pain tolerance has been insufficient. The aim of this study was to explore the characteristics of thermal pain tolerance and pain ratings in healthy subjects. Methods: Cold pain tolerance (CPTol) and heat pain tolerance (HPTol) were tested in 213 healthy adults aged 18–81 years recruited from the local community. The thermal detection and thermal pain thresholds were also tested to investigate the association with pain tolerance. The visual analogue scale (VAS) was used for assessing pain severity immediately after the thermal pain and tolerance tests. Results: The normality of the CPTol and HPTol was acceptable. Most participants rated the pain induced by the CPTol and HPTol testing as moderate. HPTol was lower in women than in men (p = 0.001), but CPTol did not differ between sexes. The pain ratings of CPTol and HPTol did not differ between sexes, but significant age effects were observed. The association of the tolerance temperature with pain ratings was weak, while those of pain ratings for CPTol and HPTol were strong (r = 0.87). Conclusions: Women were more sensitive to tolerance heat pain stimuli. Younger participants reported more pain for thermal pain and tolerance tests. Significance: Thermal pain tolerance and pain rating for the thermal pain tolerance temperature depend on gender and age. Women are more sensitive to heat temperatures, young people rate more pain, and the pain ratings of heat and cold are strongly correlated. [ABSTRACT FROM AUTHOR]

Abstract: This study proposed a computerized inquiry‐stage‐dependent argumentation assistance and investigated whether this can help improve elementary students' performance in science processes and the construction of quality arguments. Various argumentation assistances were developed and incorporated into each stage of scientific inquiry in a computer‐supported scientific inquiry system. A nonequivalent quasi‐experimental design was adopted to evaluate the effectiveness of this approach. Two intact sixth grade classes (N = 55) participated in this study, and each student used a tablet computer to accomplish the designated inquiry activities. One class of students was arranged to use the stage‐dependent argumentation assistance, and the other used a generic text‐based interface. The findings indicate that students who used the stage‐dependent argumentation assistance could acquire significantly better science process and argument construction skills than those using the generic text‐based interface. [ABSTRACT FROM AUTHOR]

Summary: This study investigates the incidences and predictors of hepatitis B virus (HBV) relapse after tenofovir disoproxil fumarate (TDF) therapy in hepatitis B e antigen (HBeAg)‐positive and ‐negative patients. We retrospectively recruited 143 chronic hepatitis B (CHB) patients without cirrhosis (39 HBeAg‐positive and 104 HBeAg‐negative patients) who were previously treated with TDF and had post‐treatment follow‐up for at least 6 months (median: 55, IQR 36‐85 weeks). All the patients fulfilled the stopping criteria of APASL 2012. The virological and clinical relapse rates at 104 weeks in HBeAg‐positive patients were 66.6% and 59.1%, while they were 72.3% and 55.9%, respectively, in HBeAg‐negative patients. Cox regression analysis revealed that the higher end‐of‐treatment HBsAg levels were an independent factor of virological relapse in HBeAg‐positive and HBeAg‐negative patients. The end‐of‐treatment HBsAg levels of 200 (area under the receiver operating characteristic (AUROC): 0.624) and 80 IU/mL (AUROC: 0.959) were the optimal values for predicting HBV relapse in HBeAg‐positive and HBeAg‐negative patients, respectively. The virological relapse rate at 78 weeks was 14.3% and 19.6% in HBeAg‐positive and HBeAg‐negative patients who achieved HBsAg ≤200 IU/mL and HBsAg ≤80 IU/mL, respectively. Two patients experienced hepatic decompensation upon hepatitis flares, and no patient died after timely retreatment. Seven patients experienced off‐therapy HBsAg loss. The cumulative rates of HBsAg loss at 104 weeks were 45.5% and 59.3% in patients with end‐of‐treatment HBsAg ≤80 IU/mL and ≤50 IU/mL, respectively. In conclusions, the end‐of‐treatment HBsAg levels were a useful marker for predicting HBV relapse in HBeAg‐positive and HBeAg‐negative CHB patients. [ABSTRACT FROM AUTHOR]

Personality traits are the relatively enduring patterns of thoughts, feelings and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have showed that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such as major depressive disorder. Despite considerable efforts over the past several decades, the genetic variants that influence personality are only beginning to be identified. We review these recent and increasingly rapid developments, which focus on the assessment of personality via several commonly used personality questionnaires in healthy human subjects. Study designs covered include twin, linkage, candidate gene association studies, genome‐wide association studies and polygenic analyses. Findings from genetic studies of personality have furthered our understanding about the genetic etiology of personality, which, like neuropsychiatric diseases themselves, is highly polygenic. Polygenic analyses have showed genetic correlations between personality and psychopathology, confirming that genetic studies of personality can help to elucidate the etiology of several neuropsychiatric diseases. [ABSTRACT FROM AUTHOR]

Background and purpose Physical activity is associated with a reduced incidence of first-time stroke. However, few studies have examined the effect of pre-stroke physical activity on post-stroke complications and clinical outcomes. Methods A total of 39 835 cases of stroke registered in the nationwide stroke registry system of Taiwan between 2006 and 2009 were analyzed according to five levels of severity as determined by National Institutes of Health Stroke Scale score upon hospital admission. Pre-stroke physical activity was defined in the Taiwan Stroke Registry as dedicated leisure-time physical activity for at least 30 min/day for 3 days/week for more than 6 months. A Cox model was used to compare complications and outcomes between active and inactive groups. Results The active and inactive groups were similar in age distribution and stroke type distribution, but the active group had better National Institutes of Health Stroke Scale scores upon admission. The active group also had significantly fewer post-stroke complications. Active patients had lower hospital mortality and better functional outcomes upon discharge as per the modified Rankin Scale. Improved functional status in the active group was significant at 1, 3 and 6 months post-stroke. Conclusion Dedicated leisure-time physical activity for at least 30 min/day, at least three times per week for more than 6 months was associated with decreased stroke severity, fewer post-stroke complications, lower mortality and better outcomes. [ABSTRACT FROM AUTHOR]

All-sky camera observations carried out over Taiwan showed intense equatorial plasma bubbles (EPBs) in 630.0 nm airglow images on consecutive nights of 13-16 March 2015 but were absent in the following night of 17 March when St. Patrick's Day magnetic storm occurred. Rate of total electron content (TEC) index by using Global Positioning System (GPS) network data also confirmed the absence of irregularities on the night 17 March. The results, however, revealed strong irregularities over Indian sector on the same night. Flux tube integrated Rayleigh-Taylor instability growth rates computed using the prior (forecast) state of Thermosphere-Ionosphere Electrodynamics General Circulation Model output after assimilating the GPS-TEC measurements also agree with the observations, showing smaller values over Taiwan and larger values over India on the night of 17 March. The ionospheric response to the storm over Taiwan that resulted in the apparent inhibition of EPB is investigated in this study by using the data assimilation output. Results indicate that on the night of the magnetic storm, prereversal enhancement of zonal electric field over Taiwan was weaker when compared to that over India. Further analysis suggests that the absence of enhancement in the zonal electric field could be due to westward penetration electric field in response to rapid northward turning of interplanetary magnetic field that occurred during the dusk period over Taiwan. [ABSTRACT FROM AUTHOR]

We investigated the incidence and predictors of post-treatment hepatitis B virus ( HBV) relapse and hepatitis B surface antigen ( HBsAg) loss. After cessation of nucleoside analogue (NA) treatment in hepatitis B e antigen (HBeAg)-negative patients with cirrhosis. The rates of HBsAg loss and hepatocellular carcinoma ( HCC) development in HBeAg-negative patients with cirrhosis who continued NA treatment were compared with those who discontinued treatment. Patients with compensated cirrhosis who had discontinued NA treatment for at least 12 months (discontinuing group; n=73) and patients who continued entecavir treatment for at least 4 years (continuing group; n=158) were recruited. Serum HBsAg levels were analysed at the end of treatment (discontinuing group) or at 2.5-3 years of treatment (continuing group). In the discontinuing group, the 6-year cumulative incidence of post-treatment virological relapse and HBsAg loss were 56.3% and 46.7%, respectively. The end-of-treatment HBsAg level of 300 IU/mL was a cut-off value for subsequent post-treatment HBsAg loss and sustained response. In the continuing group, HBsAg loss occurred in five of 158 patients. Cox regression analysis showed that HBsAg levels in the discontinuing group were independent predictors for HBsAg loss in all patients and 104 propensity score ( PS)-matched patients. There was no significant difference in HCC development between the groups in all patients and 104 PS-matched patients. Two patients experienced post-treatment alanine aminotransferase flare with hepatic decompensation, and neither of them died after retreatment. In conclusion, HBeAg-negative patients with cirrhosis who discontinued NA treatment might have a higher rate of HBsAg loss and their risk of developing HCC did not increase compared with those who continued entecavir treatment. [ABSTRACT FROM AUTHOR]

The objective of this study was to determine the usefulness of augmented reality (AR) in teaching. An experiment was conducted to examine children's learning performances, which included the number of errors they made, their ability to remember the content of what they had read and their satisfaction with the three types of teaching materials, including a picture book, physical interactions and an AR graphic book. The three teaching materials were aimed to respectively demonstrate the characteristics of six bacteria with 2D graphics, 3D physical objects, and 3D virtual objects. Seventy-two fifth-grade children were randomly selected to participate in the study, and they were divided into three groups, each of which used the assigned teaching material to learn the name of the six different bacteria in intervals of 1, 2 and 3 min. Results showed that the AR graphic book offers a practical and hands-on way for children to explore and learn about the bacteria. Follow-up interviews indicated that the children liked the AR graphic book the most, and they preferred it to the other materials. Lay Description What is currently known about Augmented Reality and learning? Augmented reality (AR) provides a new perspective for learning by allowing learners to visualize complex spatial relationships and abstract concepts., What the paper adds to the subject matter? AR improves learning performances to a similar extent as the most used teaching materials (both picture books and physical interactions) do., AR not only facilitates learning but also increases learning motivations better than conventional teaching materials do. The implications of study findings for practitioners. If children feel bored about reading textbooks, give them AR (because AR effectively enhances learning and children are more motivated when using AR)., AR teaching material is a good alternative to conventional picture book and physical interactions. [ABSTRACT FROM AUTHOR]

The relationship between androgen deprivation therapy ( ADT) and coronary heart disease ( CHD) remains controversial. Furthermore, the majority of such studies focused on Caucasian populations, and there is still a paucity of studies among Asian populations. This population-based study aimed to investigate the relationship between ADT and CHD in an ethnic Chinese (i.e., Taiwanese) population. We used data sourced from the Taiwan 'Longitudinal Health Insurance Database'. This study included 1278 patients with prostate cancer in the study group and 1278 subjects without prostate cancer in the comparison group. Each patient was individually tracked for a 3-year period to identify those who had subsequently received a diagnosis of CHD. The results showed that the incidence rate of CHD during the 3-year follow-up period was 4.69 (95% CI: 2.99-5.48) per 100 person-years and 2.67 (95% CI: 2.15-3.27) per 100 person-years for the study and comparison cohort, respectively. The Cox proportional hazard regression showed that the hazard ratio for CHD during the 3-year follow-up period for prostate cancer patients was 1.65 (95% confidence interval ( CI) = 1.25-2.16) compared with comparison subjects after adjusting for patients' geographic location, monthly income, urbanization level, hypertension, diabetes, hyperlipidemia, and stroke. However, we failed to find a significant difference in the adjusted hazard of CHD during the 3-year follow-up period between prostate cancer patients who did and those who did not receive ADT (hazard ratio = 1.12, 95% CI = 0.79-1.59). We concluded that prostate cancer but not ADT was significantly associated with CHD. In addition, a common cause of prostate cancer and coronary heart disease could exist. [ABSTRACT FROM AUTHOR]

Facing students' decreasing motivation to pursue scientific study, schools and educators need to coordinate new technologies with pedagogical agents to effectively sustain or promote students' scientific learning and motivation to learn. Although the provision of pedagogical agents in student learning has been studied previously, it is not clear what benefits the strategy might offer with regard to student motivation. This study proposes an agent-based mechanism that integrates problem-solving and inquiry-based instructions to help students better understand complex scientific concepts and to sustain their motivation to learn science. In this study, a quasi-experiment was conducted to evaluate the performance and feasibility of our proposed mechanism. The results revealed that the agent-based mechanism was effective and feasible for enhancing students' learning and motivation to learn. The mechanism was associated with increases in the acquisition of knowledge when compared with the control group. Its effect in promoting and sustaining students' motivation was also statistically significant. Detailed discussions of the findings are provided in this study. [ABSTRACT FROM AUTHOR]

Background/Aim Cerebral white matter changes ( WMC) are commonly observed in magnetic resonance imaging ( MRI) scans of elderly people. Information about the prevalence of WMC is limited, and little is known about site-specific risk factors for the subcortical and periventricular regions in patients with ischaemic stroke. The study aims to analyse the prevalence and severity of WMC and investigate the risk factors of periventricular WMC ( PVWMC) and deep WMC ( DWMC) separately in patients with ischaemic stroke. Methods The data were collected between January and December 2013 from a medical centre in southern Taiwan. Every patient underwent a cerebral MRI scan, and WMC was separately rated as PVWMC and DWMC by using the modified Fazekas scale. Results In total, 527 patients who had experienced ischaemic stroke were included. The mean age of the patients was 67.0 ± 12.5 years (range: 31-94) and 62% of them were men. The mean age was significantly different among the four grades of severity in both the PVWMC ( P < 0.001) and DWMC ( P < 0.001) groups after adjustments for sex and vascular risk factors. Hypertension was independently correlated with severity of DWMC ( P = 0.032) but not with PVWMC ( P = 0.222). In multiple logistic regressions model, hypertension was a significant independent indicator of DWMC (odds ratio = 4.30; 95% confidence interval = 1.70-10.89). Conclusion Our results suggest a region-specific pathogenesis of cerebral white matter in Asian patients with ischaemic stroke that may differ from those in the general population. [ABSTRACT FROM AUTHOR]

Ambient vibration tests are conducted widely to estimate the modal parameters of a structure. The work proposes an efficient wavelet-based approach to determine the modal parameters of a structure from its ambient vibration responses. The proposed approach integrates the time series autoregressive (AR) model with the stationary wavelet packet transform. In addition to providing a richer decomposition and allowing for an improved time-frequency localization of signals over that of the discrete wavelet transform, the stationary wavelet packet transform also has significantly higher computational efficiency than the wavelet packet transform in terms of decomposing time-shifted signals because the former has a time-invariance property. The correlation matrices needed in determining the coefficient matrices in an AR model are established in subspaces expanded by stationary wavelet packets. The formulation for estimating the correlation matrices is shown for the first time. Because different subspaces contain signals with different frequency subbands, the fine filtering property enhances the ability of the proposed approach to identify not only the modes with strong modal interference, but also many modes from the responses of very few measured degrees of freedom. The proposed approach is validated by processing the numerically simulated responses of a seven-floor shear building, which has closely spaced modes, with considering the effects of noise and incomplete measurements. Furthermore, the present approach is employed to process the velocity responses of an eight-storey steel frame subjected to white noise input in a shaking table test and ambient vibration responses of a cable-stayed bridge. [ABSTRACT FROM AUTHOR]

Recent studies have indicated that amino acid (aa) substitutions in the core region and NS5 A interferon sensitivity-determining region ( ISDR) of hepatitis C virus ( HCV) as well as genetic polymorphisms in the interleukin-28 B ( IL-28 B) locus affect the outcome of interferon ( IFN)-based therapies. We aimed to investigate the role of these factors on response to peginterferon plus ribavirin in a prospective study of response-guided therapy. The aa sequences in core region and ISDR and rs12979860 genotypes were analysed in 115 HCV-1 patients. The treatment was 24 weeks for patients achieving a rapid virological response ( RVR), 48 weeks for those with an early virological response ( EVR) and early terminated in those without an EVR. A sustained virological response ( SVR) was achieved in 82% of 34 RVR patients, 45% of 74 EVR patients and 0% of seven non- EVR patients. Logistic regression analysis showed that ISDR mutation (≥2) [odds ratio( OR): 6.024], double core 70/91 mutations ( OR: 0.136), and platelet counts ≥ 15 × 104/μL ( OR: 3.119) were independent pretreatment factors associated with SVR. Apart from rs12979860 CC genotype, low viral load and ISDR mutation (≥2) were significant factors predictive of RVR. Combination of rs12979860 genotype and baseline viral characteristics (viral load and core/ ISDR mutations) could predict RVR and SVR with positive predictive value of 100% and 91%, and negative predictive value of 80% and 54%, respectively. In conclusion, pretreatment screening rs12979860 genotype and aa substitutions in the core region and ISDR could help identifying patients who are good candidates for peginterferon plus ribavirin therapy. [ABSTRACT FROM AUTHOR]

Mass transfer in mass exchangers, such as membrane extractors and dialysers, can be analogous to heat transfer in heat exchangers with correction-factor analysis. In present study, the expressions of mass-transfer rate and correction-factor charts for mass transfer in parallel-flow double-pass rectangular membrane modules were modified by the modified correction-factor analysis, instead of the conventional correction-factor analysis. They are explicit, instead of implicit in the conventional correction-factor analysis. The results can be readily calculated without using trial-and-error method. Experimental results confirm the predicted values for membrane extraction of acetic acid from aqueous solution by methyl isobutyl ketone, as well as for dialysing from aqueous solution, in the double-pass devices. © 2012 Canadian Society for Chemical Engineering [ABSTRACT FROM AUTHOR]

LIANG C.-H., YANG C.-Y., LU K.-C., CHU P., CHEN C.-H., CHANG Y.-S., O'BRIEN A.P., BLOOMER M. & CHOU K.-R. (2011) Factors affecting peritoneal dialysis selection in Taiwanese patients with chronic kidney disease. International Nursing Review 58, 463-469 Background: Taiwan has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world with 55 499 ESRD patients on long-term dialysis. Nevertheless, 90.96% of these patients are managed on maintenance haemodialysis (HD), with only 9.03% enrolled in a peritoneal dialysis (PD) programme. Aim: The study aim was to identify the factors affecting Taiwanese patient's selection of PD in preference to HD for chronic kidney disease. Methods: A cross-sectional research design was utilized with 130 chronic renal failure (CRF) patients purposively selected from outpatient nephrology clinics at four separate Taiwan hospitals. Logistic regression was used to identify the main factors affecting the patient's choice of dialysis type. Results: Single-factor logistic regression found significant differences in opinion related to age, education level, occupation type, disease characteristics, lifestyle modifications, self-care ability, know-how of dialysis modality, security considerations and findings related to the decisions made by medical personnel ( P < 0.05). Moreover, multinomial logistic regression after adjustment for interfering variables found that self-care ability and dialysis modality know-how were the two main factors affecting the person's selection of dialysis type. Conclusions: Self-care ability and the person's knowledge of the different types of dialysis modality and how they function were the major determinants for selection of dialysis type in Taiwan based on the results from this study. The results indicate that the education of CRF patients about the types of dialysis available is essential to enable them to understand the benefits or limitations of both types of dialysis. [ABSTRACT FROM AUTHOR]

Please cite this paper as: Chen C-H, Xirasagar S, Lin C-C, Wang L-H, Kou Y, Lin H-C. Risk of adverse perinatal outcomes with antithyroid treatment during pregnancy: a nationwide population-based study. BJOG 2011;118:1365-1373. Objective To compare, using two large nationwide population-based data sets, the risk of adverse pregnancy outcomes (low birthweight [LBW], preterm birth, small for gestational age [SGA] and congenital anomalies) among pregnant women with hyperthyroidism classified into three groups: receiving propylthiouracil (PTU) treatment during pregnancy, receiving methimazole/carbimazole (MMI) treatment, and no antithyroid treatment during pregnancy. Design A matched case-control study. Setting Taiwan. Sample A total of 2830 mothers with hyperthyroidism and 14 150 age-matched randomly selected mothers without hyperthyroidism were included. Methods Conditional logistic regression analyses were performed to examine the risk of adverse pregnancy outcomes (LBW, preterm birth, SGA and major congenital anomalies) among these three groups. Main outcome measures LBW, preterm birth, SGA and major congenital anomalies. Results Women receiving PTU treatment during pregnancy had a higher risk of giving birth to LBW infants than those not receiving antithyroid treatment (odds ratio = 1.40; 95% CI 1.00-1.96), after adjusting for maternal education, anaemia, hyperlipidaemia, pregestational diabetes, pregestational hypertension, hyperemesis gravidarum and infant's gender and birth order. However, children of women receiving MMI treatment did not have increased risks of any adverse fetal outcome relative to mothers not receiving antithyroid treatment. Conclusions Our study finds an increased risk of LBW among babies of mothers with hyperthyroidism receiving PTU treatment during pregnancy relative to untreated mothers with hyperthyroidism. [ABSTRACT FROM AUTHOR]

Oral Diseases (2011) 17, 584-589 Objective: To explore the risk factors of non-syndromic orofacial clefts. Subjects and Methods: A case-control study was conducted in China, 537 infants born with non-syndromic cleft lip with/without cleft palate, 176 infants born with cleft palate (CP), and 221 normal controls were recruited to participate in a questionnaire based study to identify risk factors related to maternal nutrition. Results: Single-factor Chi-square analysis identified 12 factors as significantly related to non-syndromic orofacial clefts ( P < 0.05). Multiple logistic regression showed five of these factors were associated with non-syndromic orofacial clefts, male gender and maternal passive smoking during early pregnancy were risk factors for non-syndromic orofacial clefts (OR = 1.86 and 11.42; 95%CI: 2.28-2.69 and 6.87-19.00, respectively), whereas maternal weight gain during pregnancy and folic acid supplementation during early pregnancy were protective (OR = 0.15 and 0.67; 95%CI: 0.034-0.63 and 0.44-1.00, respectively). Conclusions: Our data may provide references for cleft lip and CP prevention programs, and counseling programs in China. [ABSTRACT FROM AUTHOR]

The fast Fourier transform (FFT) and the power spectrum are still powerful tools for analyzing and measuring both stationary and transient signals in power systems. However, the misapplications of FFT can lead to incorrect results caused by some problems such as aliasing effect, spectral leakage, and picket-fence effect. Measurement errors can be efficiently reduced by understanding fundamentals of FFT as well as loading proper windows. This article develops a distance e-learning environment using a graphical programming tool to help electrical students and engineers for enhancing their signal analysis capability via the Internet Explorer (IE). Critical issues pertaining to engineering education, such as programming design of signal analysis, Internet connection, expected learning outcomes, and course evaluation, are discussed in detail. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 19: 71-80, 2011 [ABSTRACT FROM AUTHOR]

Purpose: Computed tomography angiography (CTA) is increasingly used for the diagnosis of coronary artery disease (CAD). However, CTA is not commonly used for the assessment of ventricular and atrial function, although functional information extracted from CTA data is expected to improve the diagnostic value of the examination. In clinical practice, the extraction of ventricular and atrial functional information, such as stroke volume and ejection fraction, requires accurate delineation of cardiac chambers. In this paper, we investigated the accuracy and robustness of cardiac chamber delineation using a multiatlas based segmentation method on multicenter and multivendor CTA data. Methods: A fully automatic multiatlas based method for segmenting the whole heart (i.e., the outer surface of the pericardium) and cardiac chambers from CTA data is presented and evaluated. In the segmentation approach, eight atlas images are registered to a new patient's CTA scan. The eight corresponding manually labeled images are then propagated and combined using a per voxel majority voting procedure, to obtain a cardiac segmentation. Results: The method was evaluated on a multicenter/multivendor database, consisting of (1) a set of 1380 Siemens scans from 795 patients and (2) a set of 60 multivendor scans (Siemens, Philips, and GE) from different patients, acquired in six different institutions worldwide. A leave-one-out 3D quantitative validation was carried out on the eight atlas images; we obtained a mean surface-to-surface error of 0.94±1.12 mm and an average Dice coefficient of 0.93 was achieved. A 2D quantitative evaluation was performed on the 60 multivendor data sets. Here, we observed a mean surface-to-surface error of 1.26±1.25 mm and an average Dice coefficient of 0.91 was achieved. In addition to this quantitative evaluation, a large-scale 2D and 3D qualitative evaluation was performed on 1380 and 140 images, respectively. Experts evaluated that 49% of the 1380 images were very accurately segmented (below 1 mm error) and that 29% were accurately segmented (error between 1 and 3 mm), which demonstrates the robustness of the presented method. Conclusions: A fully automatic method for whole heart and cardiac chamber segmentation was presented and evaluated using multicenter/multivendor CTA data. The accuracy and robustness of the method were demonstrated by successfully applying the method to 1420 multicenter/multivendor data sets. [ABSTRACT FROM AUTHOR]

Chien W-H, Gau SS-F, Wu Y-Y, Huang Y-S, Fang J-S, Chen Y-J, Soong W-T, Chiu Y-N, Chen C-H. Identification and molecular characterization of two novel chromosomal deletions associated with autism. Autism is a childhood-onset neurodevelopmental disorder with a strong genetic basis in its etiology. Conventional karyotype analysis has revealed that chromosomal structural aberrations such as translocation, inversion, deletion, and duplication play a role in causing autism spectrum disorders (ASD). In addition, recent array-based comparative genomic hybridization (array CGH) studies discovered that submicroscopic deletion and duplication of DNA segments also contributed significantly to the genetic etiology of ASD. Together, these studies indicate that genomic rearrangement is an important genetic mechanism of ASD. Using karyotyping analysis and array CGH technology, we identified a subtelomeric deletion of approximately 6.8 Mb at 4q35.1-35.2 and a terminal deletion of approximately 2.4 Mb at 8p23.2-pter in two autistic boys, respectively. These two deletions were further validated using fluorescent in situ hybridization and real-time quantitative polymerase chain reaction, and their breakpoints were delineated using high-resolution array CGH. The 4q deletion is a rare de novo mutation, while the transmission of 8p deletion is unknown, because the father of the patient was unavailable for study. These two deletions are rare mutations and were not found in the additional 282 patients with ASD and in the 300 control subjects in our population. The identification of these two chromosomal deletions contribute to our understanding of the genetic basis of ASD, and the haploinsufficiency of several genes located at the deleted regions of chromosome 8p and 4q may contribute to the clinical phenotypes of autism. [ABSTRACT FROM AUTHOR]