6 results on '"Carneiro, V"'
Search Results
2. Surgery in ovarian cancer - Brazilian Society of Surgical Oncology consensus.
- Author
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Tsunoda, A. T., Ribeiro, R., Reis, R. J., da Cunha Andrade, C. E. M., Moretti Marques, R., Baiocchi, G., Fin, F., Zanvettor, P. H., Falcao, D., Batista, T. P., Azevedo, B. R. B., Guitmann, G., Pessini, S. A., Nunes, J. S., Campbell, L. M., Linhares, J. C., Carneiro, V., Coimbra, F. J. F., da Cunha Andrade, Cem, and Azevedo, Brb
- Subjects
OVARIAN epithelial cancer ,ONCOLOGIC surgery ,ABDOMINAL surgery ,CYTOREDUCTIVE surgery ,TASK forces ,PERITONEUM surgery ,PAIN management ,CANCER relapse ,COMBINED modality therapy ,DIAGNOSTIC imaging ,GENETIC counseling ,HEALTH care teams ,HOSPITALS ,HYSTERECTOMY ,MEDICAL quality control ,MEDICAL protocols ,MEDICAL referrals ,OVARIECTOMY ,OVARIAN tumors ,PALLIATIVE treatment ,TUMOR classification ,PATIENT selection ,SALPINGECTOMY - Abstract
Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall survival and progression-free survival. The Brazilian Society of Surgical Oncology (BSSO) supported a taskforce of experts to reach a consensus: experienced and specialised trained surgeons, in cancer centres, provide the best EOC surgery. Laparoscopic and/or radiological staging prognosticates the possibility of complete cytoreduction (CC0) and helps to reduce unnecessary laparotomies. Surgical techniques were reviewed. Multidisciplinary input is essential for treatment planning. Quality assurance criteria are proposed and require national consensus. Genetic testing is mandatory. This consensus states the final recommendations from BSSO for management of EOC.
Tweetable Abstract: Brazilian Society of Surgical Oncology consensus for surgery in epithelial ovarian cancer patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
3. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population.
- Author
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Queiroz, G. A., Costa, R. S., Alcantara‐Neves, N. M., Nunes de Oliveira Costa, G., Barreto, M. L., Carneiro, V. L., and Figueiredo, C. A.
- Subjects
GENETICS of asthma ,ATOPY ,PUBLIC health ,ENVIRONMENTAL health ,BLOOD testing - Abstract
Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-13 (IL-13). Interleukin-33 (IL-33) appears to be a potent inducer of Th2 immune response. This occurs when IL-33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation. Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans. No study was conducted to replicate such findings in a European and African descendent mixed population. DNA was extracted from peripheral blood from 1223 subjects, and the samples were genotyped using Illumina 2.5 Human Omni Beadchip. We tested for possible associations between SNPs in the IL33 and ST2 with asthma and allergy markers such as specific IgE (sIgE), IL-5 and IL-13 production and skin prick test (SPT). Logistics regressions were performed using PLINK software 1.07. The analyses were adjusted for sex, age, helminth infection and ancestry markers. The G allele of IL33 SNP rs12551256 was negatively associated with asthma (OR 0.71, 95% CI: 0.53-0.94, P = 0.017). In contrast, the A allele of IL1RL1 rs1041973 was positively associated with IL-5 production (OR 1.36, 95% CI: 1.09-1.84, P = 0.044), sIgE levels (OR 1.40, 95% CI: 1.07-1.84, P = 0.013) and positive SPT (OR 1.48, 95% CI: 1.08-2.03, P = 0.014), for Blomia tropicalis mite. The same allele, in atopic subjects, was associated with decreased production of soluble ST2 (sST2) ( P < 0.05). Moreover, expression quantitative trait loci (eQTL) analysis suggests that rs1041973 and rs873022 regulate the expression of IL1RL1 gene. This latest SNP, rs873022, the T allele, was also associated with a lower production of sST2 in plasma of Brazilians. The genetic risk score for rs1041973 and rs16924161 demonstrated a higher risk for SPT positivity against B. tropicalis, the greater the number of risk alleles for both SNPs. Our findings demonstrate a robust association of genetic variants in IL1RL1 and IL33 SNPs with allergy markers and asthma. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
4. Highly reactive light-dependent monoterpenes in the Amazon.
- Author
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Jardine, A. B., Jardine, K. J., Fuentes, J. D., Martin, S. T., Martins, G., Durgante, F., Carneiro, V., Higuchi, N., Manzi, A. O., and Chambers, J. Q.
- Published
- 2015
- Full Text
- View/download PDF
5. Ectopic calcification among families in the Azores: clinical and radiologic manifestations in families with diffuse idiopathic skeletal hyperostosis and chondrocalcinosis.
- Author
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Bruges-Armas J, Couto AR, Timms A, Santos MR, Bettencourt BF, Peixoto MJ, Colquhoun K, McNally EG, Carneiro V, Herrero-Beaumont G, and Brown MA
- Abstract
OBJECTIVE: Twelve families that were multiply affected with diffuse idiopathic skeletal hyperostosis (DISH) and/or chondrocalcinosis, were identified on the island of Terceira, The Azores, potentially supporting the hypothesis that the 2 disorders share common etiopathogenic factors. The present study was undertaken to investigate this hypothesis. METHODS: One hundred three individuals from 12 unrelated families were assessed. Probands were identified from patients attending the Rheumatic Diseases Clinic, Hospital de Santo Espírito, in The Azores. Family members were assessed by rheumatologists and radiologists. Radiographs of all family members were obtained, including radiographs of the dorsolumbar spine, pelvis, knees, elbows, and wrists, and all cases were screened for known features of chondrocalcinosis. RESULTS: Ectopic calcifications were identified in 70 patients. The most frequent symptoms or findings were as follows: axial pain, elbow, knee and metacarpophalangeal (MCP) joint pain, swelling, and/or deformity, and radiographic enthesopathic changes. Elbow and MCP joint periarticular calcifications were observed in 35 and 5 patients, respectively, and chondrocalcinosis was identified in 12 patients. Fifteen patients had sacroiliac disease (ankylosis or sclerosis) on computed tomography scans. Fifty-two patients could be classified as having definite (17%), probable (26%), or possible (31%) DISH. Concomitant DISH and chondrocalcinosis was diagnosed in 12 patients. Pyrophosphate crystals were identified from knee effusions in 13 patients. The pattern of disease transmission was compatible with an autosomal-dominant monogenic disease. The mean age at which symptoms developed was 38 years. CONCLUSION: These families may represent a familial type of pyrophosphate arthropathy with a phenotype that includes peripheral and axial enthesopathic calcifications. The concurrence of DISH and chondrocalcinosis suggests a shared pathogenic mechanism in the 2 conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
- View/download PDF
6. Surgery in ovarian cancer - Brazilian Society of Surgical Oncology consensus.
- Author
-
Tsunoda AT, Ribeiro R, Reis RJ, da Cunha Andrade C, Moretti Marques R, Baiocchi G, Fin F, Zanvettor PH, Falcao D, Batista TP, Azevedo B, Guitmann G, Pessini SA, Nunes JS, Campbell LM, Linhares JC, Carneiro V, and Coimbra F
- Subjects
- Brazil, Chemotherapy, Adjuvant, Cytoreduction Surgical Procedures, Diagnostic Imaging, Female, Genetic Carrier Screening, Genetic Counseling, Hospitals, High-Volume, Humans, Hysterectomy, Neoplasm Recurrence, Local, Neoplasm Staging, Ovarian Neoplasms pathology, Ovariectomy, Pain Management, Palliative Care, Patient Care Planning, Patient Care Team, Patient Selection, Peritoneum surgery, Quality of Health Care, Referral and Consultation, Salpingectomy, Surgical Oncology, Ovarian Neoplasms surgery
- Abstract
Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall survival and progression-free survival. The Brazilian Society of Surgical Oncology (BSSO) supported a taskforce of experts to reach a consensus: experienced and specialised trained surgeons, in cancer centres, provide the best EOC surgery. Laparoscopic and/or radiological staging prognosticates the possibility of complete cytoreduction (CC0) and helps to reduce unnecessary laparotomies. Surgical techniques were reviewed. Multidisciplinary input is essential for treatment planning. Quality assurance criteria are proposed and require national consensus. Genetic testing is mandatory. This consensus states the final recommendations from BSSO for management of EOC., Tweetable Abstract: Brazilian Society of Surgical Oncology consensus for surgery in epithelial ovarian cancer patients., (© 2018 Royal College of Obstetricians and Gynaecologists.)
- Published
- 2018
- Full Text
- View/download PDF
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