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9. T cell-mediated cytotoxicity against dengue-infected target cells.

Author

Pang T, Devi S, Blanden RV, and Lam SK

Subjects
Animals, Antigens, Ly analysis, Cell Line, Cross Reactions, Cytotoxicity, Immunologic, Encephalitis Virus, Japanese immunology, H-2 Antigens analysis, Mice, Mice, Inbred BALB C, Sindbis Virus immunology, Dengue Virus immunology, T-Lymphocytes, Cytotoxic immunology
Abstract

A cytotoxic T lymphocyte (CTL) response to dengue virus-infected target cells is described. Effector cells were generated in an in vitro secondary culture and appeared to be T cells possessing both the Lyt 1.1 and Lyt 2.1 surface antigens. A stronger CTL response was noted with the H-2k haplotype compared to H-2d, and H-2 compatibility was required between CTL and target cells. CTL generated showed some cross-reactivity with target cells infected with Japanese encephalitis virus (JEV), another flavivirus, but not with target cells infected with an alphavirus, Sindbis. The significance and importance of these findings are discussed.

Published
1988
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