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The recent emergence of non-fentanyl-related opioids, for example, isotonitazene and metonitozene, in our jurisdiction also suggests that the illicit NPS trade is still able to subvert analog scheduling as a drug control strategy. Commentary on: Weedn VW, Zaney ME, McCord B, Lurie I, Baker A. Fentanyl-related substance scheduling as an effective drug control strategy. In Cuyahoga County (metropolitan Cleveland), we saw a similar decrease as Miami-Dade County, [1] and the rest of the nation, [2] in 2018 of fentanyl and fentanyl analog overdose deaths. [Extracted from the article]