1. Deciphering the factors determining the differentiation of autoreactive thymocytes into regulatory T cells.
- Author
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Benito‐Villalvilla, Cristina, Angelina, Alba, and Martín‐Cruz, Leticia
- Subjects
- *
REGULATORY T cells , *THYMOCYTES , *FORKHEAD transcription factors , *CD25 antigen - Abstract
This article discusses the factors that determine the differentiation of autoreactive thymocytes into regulatory T cells (Tregs). Tregs are a subset of CD4+ T cells that play a crucial role in maintaining peripheral tolerance and immune homeostasis. The majority of Tregs are generated in the thymus upon recognition of self-antigens, while others can be generated in specialized peripheral tissues. The differentiation of Tregs is influenced by factors such as T-cell receptor signaling, co-stimulation, and the presence of TGF-β and retinoic acid. The study also highlights the role of late agonist signaling and the disruption of TCR signaling in the generation of Tregs. The findings contribute to our understanding of thymocyte selection and central tolerance, and may have implications for future therapeutic interventions involving Tregs. [Extracted from the article]
- Published
- 2024
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