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Grey mould is reported in the vineyards of Castilla y León, Spain, every year. However, the natural populations of the pathogen have yet to be properly characterized. Vineyards from six wine‐producing areas were surveyed in 2002 and 2007, sampling from bunches of grapes with and without symptoms. A total of 283 Botrytis field isolates were selected for physiological and genetic analyses. Botrytis cinerea isolates predominated in the population, although isolates belonging to Botrytis pseudocinerea and Botrytis prunorum were also identified. These two species are recorded for the first time in Spain in this work. In addition, two isolates closely related to Botrytis californica were identified. Physiologically, the B. cinerea population is very diverse, displaying a normal distribution of aggressiveness values in Vitis vinifera leaves, suggesting a quantitative nature for this trait. Several isolates unable to cause infection were identified, most of them belonging to a mycelial morphotype. Population genetic analysis revealed that genotypic diversity is high and that multiple infections of the same bunch of grapes by different genotypes occur frequently. The high genotypic diversity observed, an even distribution of both mating types and the linkage disequilibrium values detected support a mixed mode of reproduction with low levels of clonality. The wine‐producing area in which each isolate was collected imposed a low degree of population differentiation, an effect that does not depend solely on the geographic distances but rather on the management practices used by growers and wine producer associations. [ABSTRACT FROM AUTHOR]

Regular use of marijuana during adolescence enhances the risk of long-lasting neurobiological changes in adulthood. The present study was aimed at assessing the effect of long-term administration of the synthetic cannabinoid WIN55212.2 during adolescence in young adult mice. Adolescent mice aged 5 weeks were subjected daily to the pharmacological action of WIN55212.2 for 3 weeks and were then left undisturbed in their home cage for a 5-week period and finally evaluated by behavioral testing. Mice that received the drug during adolescence showed memory impairment in the Morris water maze, as well as a dose-dependent memory impairment in fear conditioning. In addition, the administration of 3 mg/kg WIN55212.2 in adolescence increased adult hippocampal AEA levels and promoted DNA hypermethylation at the intragenic region of the intracellular signaling modulator Rgs7, which was accompanied by a lower rate of mRNA transcription of this gene, suggesting a potential causal relation. Although the concrete mechanisms underlying the behavioral observations remain to be elucidated, we demonstrate that long-term administration of 3 mg/kg of WIN during adolescence leads to increased endocannabinoid levels and altered Rgs7 expression in adulthood and establish a potential link to epigenetic changes. [ABSTRACT FROM AUTHOR]

Mixtures of the dimethyl esters of adipic acid and 2,3:4,5-di- O-methylene-galactaric acid (Galx) were made to react in the melt with either 1,6-hexanediol or 1,12-dodecanediol to produce linear polycyclic copolyesters with aldarate unit contents varying from 10 up to 90 mole %. The copolyesters had weight-average molecular weights in the ∼35,000-45,000 g mol−1 range and a random microstructure, and were thermally stable up to nearly 300 °C. They displayed Tg in the -50 to -7 °C range with values largely increasing with the content in galactarate units. All the copolyesters were semicrystalline with Tm between 20 and 90 °C but only those made from 1,12-dodecanediol were able to crystallize from the melt at a crystallization rate that decreased as the contents in the two comonomers approached each other. Copolyesters containing minor amounts of galactarate units adopted the crystal structure characteristic of aliphatic polyesters but a new crystal polymorph was formed when the cyclic sugar units became the majority. Stress-strain parameters were sensitively affected by composition of the copolyesters with the mechanical behavior changing from flexible/ductile to stiff/brittle with the replacement of adipate units by the galactarate units. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 [ABSTRACT FROM AUTHOR]

Water repellency is a widespread property of Pinus pinaster and Eucalyptus globulus forest soils in NW Spain and is particularly severe during the summer dry conditions. The aim of this work was to compare actual water repellency at field-moist samples with potential water repellency after drying at 25 and 105 °C in samples collected at different times of year under four forest soils. Also, we investigated whether drying at 25 or 105 °C led to repellency values comparable to the highest levels reached under field conditions in the summer with a view to developing an appropriate sampling protocol towards estimating the maximum possible water repellency of a given soil as a key to establishing its environmental effects. The actual and potential water repellency was determined by using the water drop penetration time (WDPT) and molarity of an ethanol drop (MED) tests. Clear seasonal patterns of water repellency were observed from the results for the four forest soils, peaking in the dry period and disappearing after prolonged wet periods. Water repellency lasts longer in sandy loam soils than in more finely textured soils, and also under eucalyptus than under pine forests. Drying soil samples at 25 or 105 °C increased water repellency, as measured with the WDPT method, in the four soils, but especially in the non-repellent samples collected during the wet period. The increase was more marked in the sandy loam soils than in the more finely textured soils, and also after drying at 105 °C than at 25 °C. MED measurements exposed a common trait in the four soils; thus, the water repellency values obtained under field conditions in summer invariably exceeded those obtained after drying at 25 or 105 °C. In addition, the repellency values for dried samples collected in the wet period were never comparable to the maximum levels observed under field conditions in the summer. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

This work was undertaken for two main purposes. One was to examine spatial and temporal variability in surface water repellency under field conditions in sandy loam forest soils of NW Spain, and its relationship to weather and soil moisture conditions. The other purpose was to get further inside in the dynamics of soil water repellency by studying a wetting-drying cycle under controlled laboratory conditions. Both for the field and laboratory study, water repellency was determined using the Water Drop Penetration Time test. Soil water repellency under field conditions was found to exhibit a seasonal pattern, i.e. it peaked during the summer and was absent between November and May. The time required for repellency to become re-established during the spring was shorter under eucalyptus than under pine. Spatial variability peaked at an early stage of soil drying and was minimal during the wet period when soils were hydrophilic as well as at the end of the summer, when repellency was strongest. Spatial and temporal variability in water repellency was found to be negatively correlated with soil moisture and, to a lesser extent, with antecedent rainfall. The moisture range of the so-called transition zone (below which the soil is hydrophobic and also above which it is hydrophobic) differed for the pine (21-50%) and eucalyptus plantations (17-36%). The lower and upper bounds of the transition zone agreed well with the soil moisture contents at the permanent wilting point and at field capacity, respectively. The laboratory results with samples in the wetting phase confirmed those of the field tests. Water repellency increased slightly during the drying phase, but not so much as in the field. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The article discusses findings of a study which examined the effect of wildfire on soil erodibility for common woodlands in Galicia, Spain. Several definitions of soil erodibility are presented. The criteria for the selection of locations burned by a wildfire included parent material, vegetation and presence of reference sites. Based on the results of the study, there were no significant changes in the particle size distribution of soil found on the burned sites. Another observation from the study was less effect of fire on aggregate stability.

This article discusses water repellency in soils from Spain as related to land use and vegetation patterns. Water repellency was determined by using the water drop penetration time test on field-moist samples collected during summer and was compared with the values for dried samples. Different land uses including maize crops, grassland, Pinus pinaster forest and Eucalyptus globulus forest were evaluated in various geological soils. The influence of vegetation on water repellency was found to be related to the content and type of soil organic matter. Water repellency persistence decreased with increasing soil depth. Forest soil samples were found to be the most water repellent.

In this paper an investigation is made of the properties and use of two aggregate measures of forecast bias and accuracy. These are metrics used in business to calculate aggregate forecasting performance for a family (group) of products. We find that the aggregate measures are not particularly informative if some of the one-step-ahead forecasts are biased. This is likely to be the case in practice if frequently employed forecasting methods are used to generate a large number of individual forecasts. In the paper, examples are constructed to illustrate some potential problems in the use of the metrics. We propose a simple graphical display of forecast bias and accuracy to supplement the information yielded by the accuracy measures. This support includes relevant boxplots of measures of individual forecasting success. This tool is simple but helpful as the graphic display has the potential to indicate forecast deterioration that can be masked by one or both of the aggregate metrics. The procedures are illustrated with data representing sales of food items. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Focuses on three adjacent sites in steeply sloping woodland in Galicia (Northwest Spain), at which surface runoff and associated erosion under simulated rainfall were measured on five occasions between June 1998 and July 1999. How two of the three sites had recently been deforested and topsoil added, and one of these two had been sown with grass, which was germinating at the onset of the study; Impact of deforestation on runoff and erosion rates; Why all three soils were very hydrophobic, which led to higher runoff rates than expected, especially during dry periods; Suggestion that great structural stability prevented there being a significant correlation between runoff rate and soil erosion.

Research in the areas of both manufacturing and marketing/sales have advocated the integration of several important interrelated decisions between the two functions (i.e. product development, process development, marketing/sales planning, and manufacturing planning decisions). The process of managing the strategic alignment between a firm's business strategy, external environment, and the integration of manufacturing and marketing/sales decisions is very complex phenomenon that requires a level of analysis that has not occurred previously. This study examined the moderating effects of business strategy and demand uncertainty on the relationship between the integration of manufacturing and marketing/sales-based decisions and organizational performance. The study found general support for the proposed model, suggesting that the impact of the integration of manufacturing and marketing/sales decision on organizational performance is moderated by a firm's business strategy and demand uncertainty. [ABSTRACT FROM AUTHOR]

This article presents the results of applying multicriteria ABC analysis to maintenance inventories. A large service organization and a consumer goods manufacturer participated in the study. The managers in both organizations used cost and noncost criteria for developing the ABC categories for inventory management. The study shows that managers can develop noncost criteria and classify the inventory items in ways that combine the criteria types. Specific policies were defined for managing the items in the industrial finn. Once the benefits of the methodology were demonstrated, a yearlong program for implementing the system was developed. The project is estimated to cost less than 10 to 15% of the available storeroom clerk manhours and provide substantially greater benefits. [ABSTRACT FROM AUTHOR]

The paper reports results of an experiment conducted to evaluate subjective versus objective combination of forecasts. The subjects were undergraduate students at Texas A&M. The students forecasted two different types of time series. The results found show that the subjective combination of forecasts improves their accuracy as compared with individual efforts. Four ex-ante weighting methods were also used to combine the forecasts. They all improve the accuracy of the forecasts. The best results, though, were from the subjective combination of forecasts. [ABSTRACT FROM AUTHOR]

While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3-microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics., (© 2021 The Authors. Published under the terms of the CC BY 4.0 license.)

Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further., (© 2017 The Authors. Published under the terms of the CC BY 4.0 license.)