This article discusses a case of recurrent erythema multiforme (EM) induced by contact dermatitis to nickel. The patient, a 17-year-old female, experienced painful targetoid blisters on her hands, feet, and chest, as well as erosions on her lips. These lesions recurred every other month and were triggered by direct contact with nickel. Biopsies confirmed the diagnosis of EM, and patch testing revealed a strong positive reaction to nickel sulfate. The patient was initially treated with medication and advised to avoid nickel, but experienced intermittent outbreaks. Eventually, she was started on mycophenolate mofetil, which resulted in no recurrence of symptoms. The article suggests that contact dermatitis to allergens, including nickel, should be considered in cases of recurrent EM. [Extracted from the article]