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1. Daily allergic multimorbidity in rhinitis using mobile technology: a novel concept of the MASK study.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Devillier, P, Anto, J M, Bewick, M, Haahtela, T, Arnavielhe, S, Bedbrook, A, Murray, R, van Eerd, M, Fonseca, J A, Morais Almeida, M, Todo Bom, A, Menditto, E, Passalacqua, G, Stellato, C, Triggiani, M, Ventura, M T, Vezzani, G, Annesi-Maesano, I, Bourret, R, Bosse, I, Caimmi, D, Cartier, C, Demoly, P, Just, J, Portejoie, F, Siroux, V, Viart, F, Bergmann, K C, Keil, T, Klimek, L, Mösges, R, Pfaar, O, Shamai, S, Zuberbier, T, Mullol, J, Valero, A, Spranger, O, Tomazic, P V, Kowalski, M L, Kuna, P, Kupczyk, M, Raciborski, F, Samolinski, B, Toppila-Salmi, S K, Valovirta, E, Cruz, A A, Sarquis-Serpa, F, da Silva, J, Stelmach, R, Larenas-Linnemann, D, Rodriguez Gonzalez, M, Burguete Cabañas, M T, Kvedariene, V, Valiulis, A, Chavannes, N H, Fokkens, W J, Ryan, D, Sheikh, A, Bachert, C, Hellings, P W, Vandenplas, Olivier, Ballardini, N, Kull, I, Melén, E, Westman, M, Wickman, M, Bindslev-Jensen, C, Eller, E, Bosnic-Anticevich, S, O'Hehir, R E, Agache, I, Bieber, T, Casale, T, Gemicioğlu, B, Ivancevich, J C, De Vries, G, Sorensen, M, Yorgancioglu, A, Laune, D, MACVIA working group, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Devillier, P, Anto, J M, Bewick, M, Haahtela, T, Arnavielhe, S, Bedbrook, A, Murray, R, van Eerd, M, Fonseca, J A, Morais Almeida, M, Todo Bom, A, Menditto, E, Passalacqua, G, Stellato, C, Triggiani, M, Ventura, M T, Vezzani, G, Annesi-Maesano, I, Bourret, R, Bosse, I, Caimmi, D, Cartier, C, Demoly, P, Just, J, Portejoie, F, Siroux, V, Viart, F, Bergmann, K C, Keil, T, Klimek, L, Mösges, R, Pfaar, O, Shamai, S, Zuberbier, T, Mullol, J, Valero, A, Spranger, O, Tomazic, P V, Kowalski, M L, Kuna, P, Kupczyk, M, Raciborski, F, Samolinski, B, Toppila-Salmi, S K, Valovirta, E, Cruz, A A, Sarquis-Serpa, F, da Silva, J, Stelmach, R, Larenas-Linnemann, D, Rodriguez Gonzalez, M, Burguete Cabañas, M T, Kvedariene, V, Valiulis, A, Chavannes, N H, Fokkens, W J, Ryan, D, Sheikh, A, Bachert, C, Hellings, P W, Vandenplas, Olivier, Ballardini, N, Kull, I, Melén, E, Westman, M, Wickman, M, Bindslev-Jensen, C, Eller, E, Bosnic-Anticevich, S, O'Hehir, R E, Agache, I, Bieber, T, Casale, T, Gemicioğlu, B, Ivancevich, J C, De Vries, G, Sorensen, M, Yorgancioglu, A, Laune, D, and MACVIA working group

Abstract

BACKGROUND: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. METHODS: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as "Low" burden and VAS levels ≥50/100 as "High" burden. RESULTS: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on "Low" and "High" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. CONCLUSIONS: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

Published
2018

2. Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study.

Author

Bédard, A., Basagaña, X., Anto, J. M., Garcia-Aymerich, J., Devillier, P., Arnavielhe, S., Bedbrook, A., Onorato, G. L., Czarlewski, W., Murray, R., Almeida, R., Fonseca, J. A., Correia da Sousa, J., Costa, E., Morais-Almeida, M., Todo-Bom, A., Cecchi, L., De Feo, G., Illario, M., and Menditto, E.

Subjects
MOBILE health, ALLERGIC rhinitis, POLLEN, MEDICAL masks, MOBILE apps, ACQUISITION of data, ANTIALLERGIC agents, FLUTICASONE
Abstract

Background: The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information including the phenotypic characteristics of the users. Methods: The Allergy Diary–MASK-air–mobile phone app, freely available via Google Play and App, was used to collect the data of daily visual analogue scales (VASs) for overall allergic symptoms and medication use. Fluticasone Furoate (FF), Mometasone Furoate (MF), Azelastine Fluticasone Proprionate combination (MPAzeFlu) and eight oral H1-antihistamines were studied. Phenotypic characteristics were recorded at entry. The ARIA severity score was derived from entry data. This was an a priori planned analysis. Results: 9037 users filled in 70,286 days of VAS in 2016, 2017 and 2018. The ARIA severity score was lower outside than during the pollen season. Severity was similar for all treatment groups during the pollen season, and lower in the MPAzeFlu group outside the pollen season. Days with MPAzeFlu had lower VAS levels and a higher frequency of monotherapy than the other treatments during the season. Outside the season, days with MPAzeFlu also had a higher frequency of monotherapy. The number of reported days was significantly higher with MPAzeFlu during and outside the season than with MF, FF or oral H1-antihistamines. Conclusions: This study shows that the overall efficacy of treatments is similar during and outside the pollen season and indicates that medications are similarly effective during the year. [ABSTRACT FROM AUTHOR]

Published
2020
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3. Work productivity in rhinitis using cell phones: The MASK pilot study.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Arnavielhe, S, Mathieu-Dupas, E, Murray, R, Bedbrook, A, Caimmi, D P, Vandenplas, Olivier, Hellings, P W, Bachert, C, Anto, J M, Bergmann, K C, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bouchard, J, Canonica, G W, Chavannes, N H, Cruz, A A, Dahl, R, Demoly, P, De Vries, G, Devillier, P, Fink-Wagner, A, Fokkens, W J, Fonseca, J, Guldemond, N, Haahtela, T, Hellqvist-Dahl, B, Just, J, Keil, T, Klimek, L, Kowalski, M L, Kuna, P, Kvedariene, V, Laune, D, Larenas-Linnemann, D, Mullol, J, Pereira, A M, Carreiro-Martins, P, Melén, E, Morais-Almeida, M, Nogueira-Silva, L, O'Hehir, R E, Papadopoulos, N G, Passalacqua, G, Portejoie, F, Price, D, Ryan, D, Samolinski, B, Sheikh, A, Simons, F E R, Spranger, O, Bom, A Todo, Tomazic, P V, Triggiani, M, Valero, A, Valovirta, E, Valiulis, A, van Eerd, M, Wickman, M, Young, I, Zuberbier, T, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J, Bewick, M, Arnavielhe, S, Mathieu-Dupas, E, Murray, R, Bedbrook, A, Caimmi, D P, Vandenplas, Olivier, Hellings, P W, Bachert, C, Anto, J M, Bergmann, K C, Bindslev-Jensen, C, Bosnic-Anticevitch, S, Bouchard, J, Canonica, G W, Chavannes, N H, Cruz, A A, Dahl, R, Demoly, P, De Vries, G, Devillier, P, Fink-Wagner, A, Fokkens, W J, Fonseca, J, Guldemond, N, Haahtela, T, Hellqvist-Dahl, B, Just, J, Keil, T, Klimek, L, Kowalski, M L, Kuna, P, Kvedariene, V, Laune, D, Larenas-Linnemann, D, Mullol, J, Pereira, A M, Carreiro-Martins, P, Melén, E, Morais-Almeida, M, Nogueira-Silva, L, O'Hehir, R E, Papadopoulos, N G, Passalacqua, G, Portejoie, F, Price, D, Ryan, D, Samolinski, B, Sheikh, A, Simons, F E R, Spranger, O, Bom, A Todo, Tomazic, P V, Triggiani, M, Valero, A, Valovirta, E, Valiulis, A, van Eerd, M, Wickman, M, Young, I, and Zuberbier, T

Abstract

Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to assess the impact of uncontrolled rhinitis assessed by visual analogue score VAS on work productivity using cell phone data collection. A mobile phone app Allergy Diary, Android and Apple stores collects daily visual analogue scales VAS data for overall allergic symptoms VAS-global measured, nasal VAS-nasal, ocular VAS-ocular, asthma symptoms VAS-asthma and work VAS-work. A combined nasal-ocular score is calculated. Allergy Diary is available in 20 countries. The App includes the Work Productivity and Activity Impairment Allergic Specific Questionnaire WPAI:AS questionnaire in 6 EU countries. All consecutive users who filled the VAS-work from June 1 to October 31, 2016 were included in the study. A total of 1,136 users filled in 5,818 days of VAS-work. Symptoms of allergic rhinitis were controlled VAS-global<20 in approximately 60% of days. In users with uncontrolled rhinitis, approximately 90% had some work impairment and over 50% had severe work impairment VAS-work>50. There was a significant correlation between VAS-global calculated and VAS-work Rho=0.83, p<0.00001, Spearman rank test. In 144 users, there was a significant correlation between VAS-work and WPAI:AS Rho=0.53, p<0.0001. This article is protected by copyright. All rights reserved.

Published
2017

4. Paving the way of systems biology and precision medicine in allergic diseases : the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

5. Paving the way of systems biology and precision medicine in allergic diseases

Author

University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

6. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

Author

Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, Xu, C, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J, Anto, J M, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Palkonen, S, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohman, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C, Albang, R, Anastasova, V, Anderson, N, Bachert, C, Ballereau, S, Ballester, F, Basagana, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, Gerhard, B, Hammad, H, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kerkhof, M, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, McEachan, R, Mäkelä, M, Mestres, J, Minina, E, Mowinckel, P, Nadif, R, Nawijn, M, Oddie, S, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, A, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, De Vocht, J, Wenger, K, Wieser, S, and Xu, C

Published
2016

7. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis) : the new generation guideline implementation

Author

Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, M., Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Sarabia, A. M. Cepeda, Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia de Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Wagner, A. Fink, Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Moesges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schoell, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, A., Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, J., Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, M., Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Sarabia, A. M. Cepeda, Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia de Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Wagner, A. Fink, Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Moesges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schoell, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, A., Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.

Published
2015

8. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis

Author

Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Carlsen, K. Lodrup, van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., Gehrig, U., Guerra, S., Heinrich, J., Koppelman, G. H., Kowalski, M. L., Lambrecht, B., Lupinek, C., Maier, D., Melen, E., Momas, I., Palkonen, S., Pinart, M., Postma, D., Siroux, V., Smit, H. A., Sunyer, J., Wright, J., Zuberbier, T., Arshad, S. H., Nadif, R., Thijs, C., Andersson, N., Asarnoj, A., Ballardini, N., Ballereau, S., Bedbrook, A., Benet, M., Bergstrom, A., Brunekreef, B., Burte, E., Calderon, M., De Carlo, G., Demoly, P., Eller, E., Fantini, M. P., Hammad, H., Hohman, C., Just, J., Kerkhof, M., Kogevinas, M., Kull, I., Lau, S., Lemonnier, N., Mommers, M., Nawijn, M., Neubauer, A., Oddie, S., Pellet, J., Pin, I., Porta, D., Saes, Y., Skrindo, I., Tischer, C. G., Torrent, M., von Hertzen, L., Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Carlsen, K. Lodrup, van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., Gehrig, U., Guerra, S., Heinrich, J., Koppelman, G. H., Kowalski, M. L., Lambrecht, B., Lupinek, C., Maier, D., Melen, E., Momas, I., Palkonen, S., Pinart, M., Postma, D., Siroux, V., Smit, H. A., Sunyer, J., Wright, J., Zuberbier, T., Arshad, S. H., Nadif, R., Thijs, C., Andersson, N., Asarnoj, A., Ballardini, N., Ballereau, S., Bedbrook, A., Benet, M., Bergstrom, A., Brunekreef, B., Burte, E., Calderon, M., De Carlo, G., Demoly, P., Eller, E., Fantini, M. P., Hammad, H., Hohman, C., Just, J., Kerkhof, M., Kogevinas, M., Kull, I., Lau, S., Lemonnier, N., Mommers, M., Nawijn, M., Neubauer, A., Oddie, S., Pellet, J., Pin, I., Porta, D., Saes, Y., Skrindo, I., Tischer, C. G., Torrent, M., and von Hertzen, L.

Published
2015

9. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts : an allergic comorbidity cluster

Author

Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagana, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Ranciere, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., Koppelman, G. H., Postma, D. S., Berdel, D., Koletzko, S., Kerkhof, M., Gehring, U., Wickman, M., Melen, E., Hallberg, J., Bindslev-Jensen, C., Eller, E., Kull, I., Carlsen, K. C. Lodrup, Carlsen, K. -H., Lambrecht, B. N., Kogevinas, M., Sunyer, J., Kauffmann, F., Bousquet, J., Anto, J. M., Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagana, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Ranciere, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., Koppelman, G. H., Postma, D. S., Berdel, D., Koletzko, S., Kerkhof, M., Gehring, U., Wickman, M., Melen, E., Hallberg, J., Bindslev-Jensen, C., Eller, E., Kull, I., Carlsen, K. C. Lodrup, Carlsen, K. -H., Lambrecht, B. N., Kogevinas, M., Sunyer, J., Kauffmann, F., Bousquet, J., and Anto, J. M.

Published
2015

10. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Author

Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, M., Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Sarabia, A. M. Cepeda, Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia de Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Wagner, A. Fink, Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Moesges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schoell, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, A., Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, J., Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Lodrup Carlsen, K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghe, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, M., Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Sarabia, A. M. Cepeda, Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., Correia de Sousa, J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Wagner, A. Fink, Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioglu, B., Gereda, J. E., Gonzalez Diaz, S., Gotua, M., Grouse, L., Guzman, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O. B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melen, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Moesges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schoell, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Pontal, F. Radier, Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Roman Rodriguez, M., Romano, A., Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.

Published
2015

11. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

Author

Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagana, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Ranciere, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., Koppelman, G. H., Postma, D. S., Berdel, D., Koletzko, S., Kerkhof, M., Gehring, U., Wickman, M., Melen, E., Hallberg, J., Bindslev-Jensen, C., Eller, E., Kull, I., Carlsen, K. C. Lodrup, Carlsen, K. -H., Lambrecht, B. N., Kogevinas, M., Sunyer, J., Kauffmann, F., Bousquet, J., Anto, J. M., Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagana, X., Smit, H. A., Siroux, V., Just, J., Momas, I., Ranciere, F., Keil, T., Hohmann, C., Lau, S., Wahn, U., Heinrich, J., Tischer, C. G., Fantini, M. P., Lenzi, J., Porta, D., Koppelman, G. H., Postma, D. S., Berdel, D., Koletzko, S., Kerkhof, M., Gehring, U., Wickman, M., Melen, E., Hallberg, J., Bindslev-Jensen, C., Eller, E., Kull, I., Carlsen, K. C. Lodrup, Carlsen, K. -H., Lambrecht, B. N., Kogevinas, M., Sunyer, J., Kauffmann, F., Bousquet, J., and Anto, J. M.

Published
2015

12. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis

Author

Epi Infectieziekten Team 1, Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Carlsen, K. Lodrup, van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., Gehrig, U., Guerra, S., Heinrich, J., Koppelman, G. H., Kowalski, M. L., Lambrecht, B., Lupinek, C., Maier, D., Melen, E., Momas, I., Palkonen, S., Pinart, M., Postma, D., Siroux, V., Smit, H. A., Sunyer, J., Wright, J., Zuberbier, T., Arshad, S. H., Nadif, R., Thijs, C., Andersson, N., Asarnoj, A., Ballardini, N., Ballereau, S., Bedbrook, A., Benet, M., Bergstrom, A., Brunekreef, B., Burte, E., Calderon, M., De Carlo, G., Demoly, P., Eller, E., Fantini, M. P., Hammad, H., Hohman, C., Just, J., Kerkhof, M., Kogevinas, M., Kull, I., Lau, S., Lemonnier, N., Mommers, M., Nawijn, M., Neubauer, A., Oddie, S., Pellet, J., Pin, I., Porta, D., Saes, Y., Skrindo, I., Tischer, C. G., Torrent, M., von Hertzen, L., Epi Infectieziekten Team 1, Cardiometabolic Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Carlsen, K. Lodrup, van Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi-Maesano, I., Bindslev-Jensen, C., Cambon-Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia-Aymerich, J., Gehrig, U., Guerra, S., Heinrich, J., Koppelman, G. H., Kowalski, M. L., Lambrecht, B., Lupinek, C., Maier, D., Melen, E., Momas, I., Palkonen, S., Pinart, M., Postma, D., Siroux, V., Smit, H. A., Sunyer, J., Wright, J., Zuberbier, T., Arshad, S. H., Nadif, R., Thijs, C., Andersson, N., Asarnoj, A., Ballardini, N., Ballereau, S., Bedbrook, A., Benet, M., Bergstrom, A., Brunekreef, B., Burte, E., Calderon, M., De Carlo, G., Demoly, P., Eller, E., Fantini, M. P., Hammad, H., Hohman, C., Just, J., Kerkhof, M., Kogevinas, M., Kull, I., Lau, S., Lemonnier, N., Mommers, M., Nawijn, M., Neubauer, A., Oddie, S., Pellet, J., Pin, I., Porta, D., Saes, Y., Skrindo, I., Tischer, C. G., Torrent, M., and von Hertzen, L.

Published
2015

13. Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study.

Author

Bousquet, J., Devillier, P., Anto, J. M., Bewick, M., Haahtela, T., Arnavielhe, S., Bedbrook, A., Murray, R., van Eerd, M., Fonseca, J. A., Morais Almeida, M., Todo Bom, A., Menditto, E., Passalacqua, G., Stellato, C., Triggiani, M., Ventura, M. T., Vezzani, G., Annesi‐Maesano, I., and Bourret, R.

Subjects
PATHOGENIC microorganisms, COMORBIDITY, IMMUNOTHERAPY, QUALITY of life, ASTHMA
Abstract

Abstract: Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1‐year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis‐driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra‐individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity. [ABSTRACT FROM AUTHOR]

Published
2018
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14. The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults.

Author

Siroux, V., Ballardini, N., Soler, M., Lupinek, C., Boudier, A., Pin, I., Just, J., Nadif, R., Anto, J. M., Melen, E., Valenta, R., Wickman, M., and Bousquet, J.

Subjects
ASTHMA in children, PEDIATRIC respiratory diseases, RHINITIS treatment, COMORBIDITY, IMMUNOGLOBULIN E, ALLERGENS
Abstract

Abstract: Background: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. Methods: IgE reactivity to 64 micro‐arrayed aeroallergen molecules was determined with the MeDALL‐chip in samples from the French EGEA study (n = 840, age = 40.7 ± 17.1) and the Swedish population‐based birth cohort BAMSE (n = 786, age = 16 ± 0.26). The age‐ and sex‐adjusted associations between the number of IgE‐reactive allergen molecules (≥0.3 ISU) and the asthma‐rhinitis phenotypes were assessed using a negative binomial model. Results: Groups representing 4 phenotypes were identified: no asthma‐no rhinitis (A−R−; 30% in EGEA and 54% in BAMSE), asthma alone (A+R−; 11% and 8%), rhinitis alone (A−R+; 15% and 24%) and asthma‐rhinitis (A+R+; 44% and 14%). The numbers of IgE‐reactive aeroallergen molecules significantly differed between phenotypes (median in A−R−, A+R−, A−R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE). As compared to A−R− subjects, the adjusted ratio of the mean number of IgE‐reactive molecules was higher in A+R+ than in A+R− or A−R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE). Conclusion: The A+R+ phenotype combined the sensitization pattern of both the A−R+ and A+R− phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms. [ABSTRACT FROM AUTHOR]

Published
2018
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15. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly ( MACVIA- ARIA) - EIP on AHA Twinning Reference Site ( GARD research demonstration project).

Author

Bousquet, J., Agache, I., Aliberti, M. R., Angles, R., Annesi‐Maesano, I., Anto, J. M., Arnavielhe, S., Asayag, E., Bacci, E., Bedbrook, A., Bachert, C., Baroni, I., Barreto, B. A., Bedolla‐Barajas, M., Bergmann, K. C., Bertorello, L., Bewick, M., Bieber, T., Birov, S., and Bindslev‐Jensen, C.

Subjects
ALLERGIC rhinitis, RESPIRATORY allergy, ATOPY, ASTHMA, AGING
Abstract

The overarching goals of the European Innovation Partnership on Active and Healthy Ageing ( EIP on AHA) are to enable European citizens to lead healthy, active and independent lives whilst ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study was to transfer innovation from an app developed by the MACVIA-France EIP on AHA reference site ( Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology ( ICT) tools (i.e. the Allergy Diary and CARAT: Control of Allergic Rhinitis and Asthma Test) in 22 Reference Sites or regions across Europe. This will improve the understanding, assessment of burden, diagnosis and management of rhinitis in the elderly by comparison with an adult population. Specific objectives will be: (i) to assess the percentage of adults and elderly who are able to use the Allergy Diary, (ii) to study the phenotypic characteristics and treatment over a 1-year period of rhinitis and asthma multimorbidity at baseline (cross-sectional study) and (iii) to follow-up using visual analogue scale ( VAS). This part of the study may provide some insight into the differences between the elderly and adults in terms of response to treatment and practice. Finally (iv) work productivity will be examined in adults. [ABSTRACT FROM AUTHOR]

Published
2018
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16. Work productivity in rhinitis using cell phones: The MASK pilot study.

Author

Bousquet, J., Bewick, M., Arnavielhe, S., Mathieu ‐ Dupas, E., Murray, R., Bedbrook, A., Caimmi, D. P., Vandenplas, O., Hellings, P. W., Bachert, C., Anto, J. M., Bergmann, K. C., Bindslev ‐ Jensen, C., Bosnic ‐ Anticevich, S., Bouchard, J., Canonica, G. W., Chavannes, N. H., Cruz, A. A., Dahl, R., and Demoly, P.

Subjects
LABOR productivity, RHINITIS, CELL phones, ALLERGIC rhinitis, MOBILE apps
Abstract

Allergic rhinitis often impairs social life and performance. The aim of this cross-sectional study was to use cell phone data to assess the impact on work productivity of uncontrolled rhinitis assessed by visual analogue scale ( VAS). A mobile phone app ( Allergy Diary, Google Play Store and Apple App Store) collects data from daily visual analogue scales ( VAS) for overall allergic symptoms ( VAS-global measured), nasal ( VAS-nasal), ocular ( VAS-ocular) and asthma symptoms ( VAS-asthma) as well as work ( VAS-work). A combined nasal-ocular score is calculated. The Allergy Diary is available in 21 countries. The app includes the Work Productivity and Activity Impairment Allergic Specific Questionnaire ( WPAI: AS) in six EU countries. All consecutive users who completed the VAS-work from 1 June to 31 October 2016 were included in the study. A total of 1136 users filled in 5818 days of VAS-work. Symptoms of allergic rhinitis were controlled ( VAS-global <20) in approximately 60% of the days. In users with uncontrolled rhinitis, approximately 90% had some work impairment and over 50% had severe work impairment ( VAS-work >50). There was a significant correlation between VAS-global calculated and VAS-work (Rho=0.83, P<0.00001, Spearman's rank test). In 144 users, there was a significant correlation between VAS-work and WPAI: AS (Rho=0.53, P<0.0001). This pilot study provides not only proof-of-concept data on the work impairment collected with the app but also data on the app itself, especially the distribution of responses for the VAS. This supports the interpretation that persons with rhinitis report both the presence and the absence of symptoms. [ABSTRACT FROM AUTHOR]

Published
2017
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17. Increased risk of asthma in overweight children born large for gestational age.

Author

Pinto, L. A., Guerra, S., Anto, J. M., Postma, D., Koppelman, G. H., Jongste, J. C., Gehring, U., Smit, H. A., and Wijga, A. H.

Subjects
RISK of childhood obesity, ASTHMA in children, GESTATIONAL age, BIRTH weight, OVERWEIGHT children, ATOPY, HEALTH, ASTHMA risk factors
Abstract

Background Being born large for gestational age ( LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children. Objective We investigated the association of being LGA with the prevalence of asthma at age 8 in atopic and non-atopic children and the role of overweight in this association. Methods Complete data on asthma, anthropometry and atopy at age of 8 years, and potential confounders were available for 1608 participants of the PIAMA birth cohort. Odds ratios for the association between LGA and asthma in atopic and non-atopic children were estimated by logistic regression analysis adjusting for potential confounders. Overweight was assessed as a potential modifier of the association between LGA and asthma. Results Being born LGA was not significantly associated with asthma at age of 8 in atopic and non-atopic children. However, overweight at age of 8 years modified the association between asthma at age of 8 and LGA. In non-atopic children, children who were born LGA and were overweight at age of 8 years had a significantly increased odds of asthma compared to non- LGA, non-overweight children (adj OR 7.04; 95% CI 2.2-24). Conclusions We observed that non-atopic children born LGA, who were overweight by 8 years have an increased risk of asthma. If confirmed, these findings suggest that non-atopic children born LGA may be identified early in life as a high-risk group for asthma. [ABSTRACT FROM AUTHOR]

Published
2017
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18. Google Trends terms reporting rhinitis and related topics differ in European countries.

Author

Bousquet, J., Agache, I., Anto, J. M., Bergmann, K. C., Bachert, C., Annesi‐Maesano, I., Bousquet, P. J., D'Amato, G., Demoly, P., De Vries, G., Eller, E., Fokkens, W.J., Fonseca, J., Haahtela, T., Hellings, P. W., Just, J., Keil, T., Klimek, L., Kuna, P., and Lodrup Carlsen, K. C.

Subjects
RHINITIS, EPIDEMIOLOGY, ALLERGIES, DATA
Abstract

Google Trends ( GT) searches trends of specific queries in Google and reflects the real-life epidemiology of allergic rhinitis. We compared Google Trends terms related to allergy and rhinitis in all European Union countries, Norway and Switzerland from 1 January 2011 to 20 December 2016. The aim was to assess whether the same terms could be used to report the seasonal variations of allergic diseases. Using the Google Trend 5-year graph, an annual and clear seasonality of queries was found in all countries apart from Cyprus, Estonia, Latvia, Lithuania and Malta. Different terms were found to demonstrate seasonality depending on the country - namely 'hay fever', 'allergy' and 'pollen' - showing cultural differences. A single set of terms cannot be used across all European countries, but allergy seasonality can be compared across Europe providing the above three terms are used. Using longitudinal data in different countries and multiple terms, we identified an awareness-related spike of searches (December 2016). [ABSTRACT FROM AUTHOR]

Published
2017
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19. Paving the way of systems biology and precision medicine in allergic diseases: the Me DALL success story.

Author

Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D.S., Valenta, R., Wickman, M., Cambon‐Thomsen, A., Haahtela, T., Lambrecht, B. N., Lodrup Carlsen, K. C., Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi‐Maesano, I., Arno, A., Bindslev‐Jensen, C., and De Carlo, G.

Subjects
*IGA glomerulonephritis, *IMMUNOGLOBULIN E, *IMMUNOTHERAPY, *MOLECULAR biology, *DISEASES
Abstract

Me DALL (Mechanisms of the Development of ALLergy; EU FP7- CP- IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. Me DALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: Me DALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, Me DALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. Me DALL has deployed translational activities within the EU agenda. [ABSTRACT FROM AUTHOR]

Published
2016
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20. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The Me DALL hypothesis.

Author

Bousquet, J., Anto, J. M., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Lodrup Carlsen, K., Hage, M., Akdis, C., Bachert, C., Akdis, M., Auffray, C., Annesi‐Maesano, I., Bindslev‐Jensen, C., Cambon‐Thomsen, A., Carlsen, K. H., Chatzi, L., Forastiere, F., Garcia‐Aymerich, J., and Gehrig, U.

Subjects
*IMMUNOGLOBULIN E, *ATOPIC dermatitis, *RHINITIS, *ASTHMA, *STAPHYLOCOCCUS aureus, *IMMUNOREGULATION
Abstract

Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are associated with allergen-specific IgE and nonallergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono- and polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE-mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal type 2 signalling. Asthma, rhinitis and AD are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This study proposes a new classification of IgE-mediated allergic diseases that allows the definition of novel phenotypes to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis and (iii) propose novel strategies of treatment and prevention. [ABSTRACT FROM AUTHOR]

Published
2015
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21. Prevention and control of childhood asthma and allergy in the EU from the public health point of view: Polish Presidency of the European Union.

Author

Samoliński, B., Fronczak, A., Kuna, P., Akdis, C. A., Anto, J. M., Bialoszewski, A. Z., Burney, P. G., Bush, A., Czupryniak, A., Dahl, R., Flood, B., Galea, G., Jutel, M., Kowalski, M. L., Palkonen, S., Papadopoulos, N., Raciborski, F., Sienkiewicz, D., Tomaszewska, A., and Mutius, E.

Subjects
ASTHMA in children, PUBLIC health, ALLERGY in children, RESPIRATORY diseases, PREVENTION
Abstract

The leading priority for the Polish Presidency of the Council of the European Union was to reduce health inequalities across European societies, and, within its framework, prevention and control of respiratory diseases in children. This very important paper contain proposal of international cooperation on the prevention, early detection and monitoring of asthma and allergic diseases in childhood which will be undertaken by the EU member countries as a result of EU conclusion developed during the Polish Presidency of the Council of the European Union. This will result in collaboration in the field of chronic diseases, particularly respiratory diseases, together with the activity of the network of national institutions and NGOs in this area. Paper also contains extensive analysis of the socio-economic, political, epidemiological, technological and medical factors affecting the prevention and control of childhood asthma and allergy presented during Experts presidential conference organized in Warsaw-Ossa 21-22 September 2011. [ABSTRACT FROM AUTHOR]

Published
2012
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22. Quality-of-life and asthma-severity in general population asthmatics: results of the ECRHS II study.

Author

Siroux, V., Boudier, A., Anto, J. M., Cazzoletti, L., Accordini, S., Alonso, J., Cerveri, I., Corsico, A., Gulsvik, A., Jarvis, D., de Marco, R., Marcon, A., Marques, E. A., Bugiani, M., Janson, C., Leynaert, B., and Pin, I.

Subjects
HEALTH surveys, ASTHMATICS, OBSTRUCTIVE lung diseases, HOSPITAL care, MEDICAL care
Abstract

Background:  Health-related quality-of-life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma-severity were assessed among 900 asthmatics enrolled in the European Community Respiratory Health Survey. Methods:  Among asthmatics, 864 completed the short form-36 (SF-36) questionnaire and 477 also completed the Asthma Quality-of-life Questionnaire (AQLQ). A 4-class asthma-severity scale, combining clinical items, forced expiratory volume in 1 s and the level of treatment and the different asthma-severity components (each of the clinical items and hospitalization) were studied in relation to HRQL. Results:  Mean SF-36 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores (45.5 and 48.8 respectively) were lower than expected in a general population. The mean total AQLQ score was 5.8. The AQLQ score and to a lesser extent the PCS score were significantly related to the 4-class asthma-severity scale, although the risk of having a lower HRQL score did not vary proportionally across the levels of severity. Asthma-severity had no impact on the MCS score. Asthma attack frequency and hospitalization were associated with both total AQLQ and PCS scores, whereas nocturnal symptoms and lung function were more strongly related to the AQLQ and PCS score respectively. Conclusion:  In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL. [ABSTRACT FROM AUTHOR]

Published
2008
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23. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project.

Author

Bousquet, J., Anto, J. M., Bachert, C., Bousquet, P. J., Colombo, P., Crameri, R., Daëron, M., Fokkens, W., Leynaert, B., Lahoz, C., Maurer, M., Passalacqua, G., Valenta, R., van Hage, M., and Van Ree, R.

Subjects
*ALLERGENS, *IMMUNOGLOBULIN E, *ALLERGIES, *ALLERGIC rhinitis, *RHINITIS, *RESPIRATORY allergy, *ASTHMA
Abstract

The synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono- vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (Fc ℇRI) and other factors regulating the activation of Fc ℇRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper. [ABSTRACT FROM AUTHOR]

Published
2006
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24. The association between atopy and asthma in a semirural area of Tanzania (East Africa).

Author

Sunyer, J., Torregrosa, J., Anto, J. M., Menendez, C., Acosta, C., Schellenberg, D., Alonso, P. L., and Kahigwa, E.

Subjects
ATOPIC dermatitis, ASTHMA, IMMUNOGLOBULIN E, DERMATOPHAGOIDES pteronyssinus, DISEASES in women
Abstract

Background: Atopy is consistently associated with asthma, except in a study in Africa. We assessed the association between atopy and asthma in women from a semirural area of Tanzania (East Africa). Methods: All pregnant women delivering at the district hospital during a 1-year period were recruited (n=658, 60.6% of those selected). Asthma was investigated by a standard questionnaire and atopy by specific IgE (immunoglobulin E) antibodies to Dermatophagoides pteronyssinus (Der p 1) and cockroach. Results: The prevalence of wheezing chest was 10.7%; of asthma, 3.5%. Levels of specific IgE of >0.35 kU/l (73%) and high levels of total IgE (62% higher than 1000 kU/l) were highly prevalent. Specific IgE antibody levels in sera were not associated with asthma (3.8% of women with negative specific IgE to any antigen had asthma in comparison to 4.0% of women with positive specific IgE; odds ratio [OR]=1.06, 0.35–3.22). Total IgE was not different between women with asthma and women without asthma (P=0.36). Conclusions: In tropical regions, the association between allergy and asthma is complex, and specific IgE reactivity to environmental allergens may not be related to asthma. [ABSTRACT FROM AUTHOR]

Published
2000
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25. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.

Author

Bousquet J, Melén E, Haahtela T, Koppelman GH, Togias A, Valenta R, Akdis CA, Czarlewski W, Rothenberg M, Valiulis A, Wickman M, Akdis M, Aguilar D, Bedbrook A, Bindslev-Jensen C, Bosnic-Anticevich S, Boulet LP, Brightling CE, Brussino L, Burte E, Bustamante M, Canonica GW, Cecchi L, Celedon JC, Chaves Loureiro C, Costa E, Cruz AA, Erhola M, Gemicioglu B, Fokkens WJ, Garcia-Aymerich J, Guerra S, Heinrich J, Ivancevich JC, Keil T, Klimek L, Kuna P, Kupczyk M, Kvedariene V, Larenas-Linnemann DE, Lemonnier N, Lodrup Carlsen KC, Louis R, Makela M, Makris M, Maurer M, Momas I, Morais-Almeida M, Mullol J, Naclerio RN, Nadeau K, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos NG, Passalacqua G, Patella V, Pawankar R, Pham-Thi N, Pfaar O, Regateiro FS, Ring J, Rouadi PW, Samolinski B, Sastre J, Savouré M, Scichilone N, Shamji MH, Sheikh A, Siroux V, Sousa-Pinto B, Standl M, Sunyer J, Taborda-Barata L, Toppila-Salmi S, Torres MJ, Tsiligianni I, Valovirta E, Vandenplas O, Ventura MT, Weiss S, Yorgancioglu A, Zhang L, Abdul Latiff AH, Aberer W, Agache I, Al-Ahmad M, Alobid I, Ansotegui IJ, Arshad SH, Asayag E, Barbara C, Baharudin A, Battur L, Bennoor KS, Berghea EC, Bergmann KC, Bernstein D, Bewick M, Blain H, Bonini M, Braido F, Buhl R, Bumbacea RS, Bush A, Calderon M, Calvo-Gil M, Camargos P, Caraballo L, Cardona V, Carr W, Carreiro-Martins P, Casale T, Cepeda Sarabia AM, Chandrasekharan R, Charpin D, Chen YZ, Cherrez-Ojeda I, Chivato T, Chkhartishvili E, Christoff G, Chu DK, Cingi C, Correia de Sousa J, Corrigan C, Custovic A, D'Amato G, Del Giacco S, De Blay F, Devillier P, Didier A, do Ceu Teixeira M, Dokic D, Douagui H, Doulaptsi M, Durham S, Dykewicz M, Eiwegger T, El-Sayed ZA, Emuzyte R, Fiocchi A, Fyhrquist N, Gomez RM, Gotua M, Guzman MA, Hagemann J, Hamamah S, Halken S, Halpin DMG, Hofmann M, Hossny E, Hrubiško M, Irani C, Ispayeva Z, Jares E, Jartti T, Jassem E, Julge K, Just J, Jutel M, Kaidashev I, Kalayci O, Kalyoncu AF, Kardas P, Kirenga B, Kraxner H, Kull I, Kulus M, La Grutta S, Lau S, Le Tuyet Thi L, Levin M, Lipworth B, Lourenço O, Mahboub B, Martinez-Infante E, Matricardi P, Miculinic N, Migueres N, Mihaltan F, Mohammad Y, Moniuszko M, Montefort S, Neffen H, Nekam K, Nunes E, Nyembue Tshipukane D, O'Hehir R, Ogulur I, Ohta K, Okubo K, Ouedraogo S, Olze H, Pali-Schöll I, Palomares O, Palosuo K, Panaitescu C, Panzner P, Park HS, Pitsios C, Plavec D, Popov TA, Puggioni F, Quirce S, Recto M, Repka-Ramirez MS, Robalo Cordeiro C, Roche N, Rodriguez-Gonzalez M, Romantowski J, Rosario Filho N, Rottem M, Sagara H, Serpa FS, Sayah Z, Scheire S, Schmid-Grendelmeier P, Sisul JC, Sole D, Soto-Martinez M, Sova M, Sperl A, Spranger O, Stelmach R, Suppli Ulrik C, Thomas M, To T, Todo-Bom A, Tomazic PV, Urrutia-Pereira M, Valentin-Rostan M, Van Ganse E, van Hage M, Vasankari T, Vichyanond P, Viegi G, Wallace D, Wang DY, Williams S, Worm M, Yiallouros P, Yusuf O, Zaitoun F, Zernotti M, Zidarn M, Zuberbier J, Fonseca JA, Zuberbier T, and Anto JM

Subjects
Humans, Allergens, Multimorbidity, Rhinitis diagnosis, Rhinitis epidemiology, Rhinitis complications, Asthma diagnosis, Asthma epidemiology, Asthma etiology, Rhinitis, Allergic complications
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Published
2023
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26. Treatment of allergic rhinitis using mobile technology with real-world data: The MASK observational pilot study.

Author

Bousquet J, Devillier P, Arnavielhe S, Bedbrook A, Alexis-Alexandre G, van Eerd M, Murray R, Canonica GW, Illario M, Menditto E, Passalacqua G, Stellato C, Triggiani M, Carreiro-Martins P, Fonseca J, Morais Almeida M, Nogueira-Silva L, Pereira AM, Todo Bom A, Bosse I, Caimmi D, Demoly P, Fontaine JF, Just J, Onorato GL, Kowalski ML, Kuna P, Samolinski B, Anto JM, Mullol J, Valero A, Tomazic PV, Bergmann KC, Keil T, Klimek L, Mösges R, Shamai S, Zuberbier T, Murphy E, McDowall P, Price D, Ryan D, Sheikh A, Chavannes NH, Fokkens WJ, Kvedariene V, Valiulis A, Bachert C, Hellings PW, Kull I, Melen E, Wickman M, Bindslev-Jensen C, Eller E, Haahtela T, Papadopoulos NG, Annesi-Maesano I, Bewick M, Bosnic-Anticevich S, Cruz AA, De Vries G, Gemicioglu B, Larenas-Linnemann D, Laune D, Mathieu-Dupas E, O'Hehir RE, Pfaar O, Portejoie F, Siroux V, Spranger O, Valovirta E, VandenPlas O, and Yorgancioglu A

Subjects
Adult, Combined Modality Therapy, Disease Management, Drug Prescriptions statistics & numerical data, Female, Global Health, Humans, Male, Medication Adherence, Middle Aged, Pilot Projects, Prospective Studies, Randomized Controlled Trials as Topic, Research Design, Rhinitis, Allergic epidemiology, Rhinitis, Allergic prevention & control, Young Adult, Mobile Applications, Rhinitis, Allergic therapy
Abstract

Background: Large observational implementation studies are needed to triangulate the findings from randomized control trials as they reflect "real-world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real-life treatment of allergic rhinitis (AR) using mobile technology., Methods: A mobile phone app (Allergy Diary, freely available in Google Play and Apple App stores) collects the data of daily visual analog scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular, and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries., Results: A total of 2871 users filled in 17 091 days of VAS in 2015 and 2016. Medications were reported for 9634 days. The assessment of days appeared to be more informative than the course of the treatment as, in real life, patients do not necessarily use treatment on a daily basis; rather, they appear to increase treatment use with the loss of symptom control. The Allergy Diary allowed differentiation between treatments within or between classes (intranasal corticosteroid use containing medications and oral H1-antihistamines). The control of days differed between no [best control], single, or multiple treatments (worst control)., Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing everyday use and practice in AR. This pilot observational study uses a very simple assessment (VAS) on a mobile phone, shows novel findings, and generates new hypotheses., (© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)

Published
2018
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27. The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study.

Author

Bousquet J, Arnavielhe S, Bedbrook A, Fonseca J, Morais Almeida M, Todo Bom A, Annesi-Maesano I, Caimmi D, Demoly P, Devillier P, Siroux V, Menditto E, Passalacqua G, Stellato C, Ventura MT, Cruz AA, Sarquis Serpa F, da Silva J, Larenas-Linnemann D, Rodriguez Gonzalez M, Burguete Cabañas MT, Bergmann KC, Keil T, Klimek L, Mösges R, Shamai S, Zuberbier T, Bewick M, Price D, Ryan D, Sheikh A, Anto JM, Mullol J, Valero A, Haahtela T, Valovirta E, Fokkens WJ, Kuna P, Samolinski B, Bindslev-Jensen C, Eller E, Bosnic-Anticevich S, O'Hehir RE, Tomazic PV, Yorgancioglu A, Gemicioglu B, Bachert C, Hellings PW, Kull I, Melén E, Wickman M, van Eerd M, and De Vries G

Subjects
Adult, Cross-Sectional Studies, Europe, Female, Humans, Male, Pilot Projects, Work Performance, Asthma complications, Mobile Applications, Quality of Life, Rhinitis, Allergic complications, Surveys and Questionnaires
Abstract

Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Users with a score of 3 or 4 had a significant impairment in quality-of-life questionnaires., (© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)

Published
2018
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28. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.

Author

Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yorgancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PA, Camuzat T, Carlsen KH, Carr W, Cepeda Sarabia AM, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fink Wagner A, Fletcher M, Fiocchi A, Forastiere F, Gamkrelidze A, Gemicioğlu B, Gereda JE, González Diaz S, Gotua M, Grouse L, Guzmán MA, Haahtela T, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane JO, Howarth P, Humbert M, Hyland ME, Ivancevich JC, Jares EJ, Johnston SL, Joos G, Jonquet O, Jung KS, Just J, Kaidashev I, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Khaltaev N, Klimek L, Koffi N'Goran B, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LT, Lieberman P, Lipworth B, Li J, Louis R, Magard Y, Magnan A, Mahboub B, Majer I, Makela MJ, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Merk H, Miculinic N, Mihaltan F, Milenkovic B, Mohammad Y, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Mösges R, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Nyembue TD, O'Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schöll I, Palmer S, Panzner P, Papi A, Park HS, Pavord I, Pawankar R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Pohl W, Popov TA, Portejoie F, Postma D, Potter P, Price D, Rabe KF, Raciborski F, Radier Pontal F, Repka-Ramirez S, Robalo-Cordeiro C, Rolland C, Rosado-Pinto J, Reitamo S, Rodenas F, Roman Rodriguez M, Romano A, Rosario N, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Serrano E, Schmid-Grendelmeier P, Sheikh A, Simons FE, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Strandberg T, Sunyer J, Thijs C, Todo-Bom A, Triggiani M, Valenta R, Valero AL, van Hage M, Vandenplas O, Vezzani G, Vichyanond P, Viegi G, Wagenmann M, Walker S, Wang DY, Wahn U, Williams DM, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, and Mercier J

Subjects
Allergens immunology, Biomarkers, Clinical Decision-Making methods, Clinical Trials as Topic, Comorbidity, Disease Management, Health Planning, Health Policy, Humans, Medical Informatics methods, Practice Guidelines as Topic, Reproducibility of Results, Rhinitis, Allergic epidemiology, Rhinitis, Allergic immunology, Rhinitis, Allergic prevention & control, Web Browser, Rhinitis, Allergic diagnosis, Rhinitis, Allergic therapy
Abstract

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2015
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29. Impact of early diagnosis and control of chronic respiratory diseases on active and healthy ageing. A debate at the European Union Parliament.

Author

Bousquet J, Tanasescu CC, Camuzat T, Anto JM, Blasi F, Neou A, Palkonen S, Papadopoulos NG, Antunes JP, Samolinski B, Yiallouros P, and Zuberbier T

Subjects
Chronic Disease, Early Diagnosis, European Union, Humans, Respiratory Tract Diseases diagnosis, Respiratory Tract Diseases prevention & control
Abstract

A debate at the European Union Parliament was held on 13 November 2012 on the Impact of early diagnosis and control of chronic respiratory diseases on Active and Healthy Ageing (AHA). The debate was held under the auspices of the Cyprus Presidency of the European Union (2012) and represents a follow-up of the priorities of the Polish Presidency of the European Union (2011). It highlighted the importance of early life events on the occurrence of chronic respiratory diseases later in life and their impact on active and healthy ageing. Epidemiologic evidence was followed by actions that should be taken to prevent and manage chronic respiratory diseases in children. The debate ended by practical, feasible and achievable projects, demonstrating the strength of the political action in the field. Three projects will be initiated from this debate: The first will be a meeting sponsored by the Région Languedoc-Roussillon on the developmental origins of chronic diseases and ageing: from research to policies and value creation. The second project is being led by the WHO Collaborating Centre for Asthma and Rhinitis: Prevention of Asthma, Prevention of Allergy (PAPA). The third project is the GA(2)LEN sentinel network., (© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.)

Published
2013
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30. Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project.

Author

Bousquet J, Anto JM, Bachert C, Bousquet PJ, Colombo P, Crameri R, Daëron M, Fokkens W, Leynaert B, Lahoz C, Maurer M, Passalacqua G, Valenta R, van Hage M, and Van Ree R

Subjects
Bacteria immunology, Down-Regulation, Humans, Hypersensitivity, Immediate blood, Hypersensitivity, Immediate diagnosis, Hypersensitivity, Immediate genetics, Polymorphism, Genetic, Receptors, IgE genetics, Receptors, IgE metabolism, Superantigens immunology, T-Lymphocytes immunology, Allergens immunology, Asthma immunology, Hypersensitivity, Immediate immunology, Immunoglobulin E blood, Rhinitis, Allergic, Perennial immunology, Rhinitis, Allergic, Seasonal immunology
Abstract

The synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono- vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (FcepsilonRI) and other factors regulating the activation of FcepsilonRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper.

Published
2006
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