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Background: Platelet derived growth factors (PDGF)‐D and the expression of its receptor increase in neoplastic progression of cancer. Co‐silencing of growth factor and receptor can be suggested as an important strategy for effective cancer therapy. In the present study, we hypothesized that suppression of PDGF‐D signaling pathway with small interfering RNAs (siRNAs) targeting both PDGF‐D and PDGF receptor (PDGFR)‐β is a promising strategy for anticancer therapy. Methods: Chitosan nanoplexes containing dual and single siRNA were prepared at different weight ratios and controlled by gel retardation assay. Characterization, cellular uptake, gene silencing and invasion studies were performed. The effect of nanoplexes on breast tumor growth, PDGF expression and apoptosis was investigated. Results: We have shown that downregulation of PDGF‐D and PDGFR‐β with chitosan/siRNA nanoplex formulations reduced proliferation and invasion in breast cancer cells. In the in vivo breast tumor model, it was determined that the intratumoral administration of chitosan/siPDGF‐D/siPDGFR‐β nanoplexes markedly decreased the tumor volume and PDGF‐D and PDGFR‐β mRNA and protein expression levels and increased apoptosis. Conclusions: According to the results obtained, we evaluated the effect of PDGF‐D and PDGFR‐β on breast tumor development and showed that RNAi‐mediated inhibition of this pathway formulated with chitosan nanoplexes can be considered as a new breast cancer therapy strategy. [ABSTRACT FROM AUTHOR]

Objective. To evaluate the protective effects of glycyrrhetinic acid (GA) and chrysin (CH) on experimental ischemia-reperfusion (I/R) injury in rat ovaries using tissue oxidative stress marker levels, hormone levels, and histopathological scores. Methods. Sixty healthy rats were randomly divided into six equal groups: control, I/R, I/R + CH (50 mg/kg/day), I/R + GA (100 mg/kg/day), CH (50 mg/kg/day), and GA (100 mg/kg/day). Biochemical, hormonal, and histopathological evaluations were performed on blood and tissue samples 14 days after CH and GA treatment. Results. The antioxidant defense system parameters were significantly higher in the ovarian tissues of the I/R + CH and I/R + GA groups than in those of the I/R group. Serum follicle-stimulating hormone levels were significantly reduced, and serum anti-Müllerian hormone levels were significantly increased in rats treated with CH and GA compared with those in the I/R group. Additionally, the histopathological scores of the I/R + CH and I/R + GA groups were significantly improved compared with those of the I/R group. Conclusions. The significant improvements in tissue oxidative stress parameters, serum hormone levels, and histological scores observed in this study indicate that treatment with CH or GA may be a conservative approach to prevent I/R injury in adnexal torsion cases after the ovarian detorsion procedure. [ABSTRACT FROM AUTHOR]

Seven of the patients had hypopigmented MF, and five of these seven patients responded well to NBUVB treatment.6 In conclusion, in addition to pityriasis alba and atopic dermatitis, hypopigmented MF should be considered as a preliminary diagnosis, especially in pediatric patients presenting with chronic hypopigmented lesions which do not respond optimally to treatment. We would like to take this opportunity to present a patient whom we followed up with a diagnosis of hypopigmented MF and successfully treated using NBUVB therapy. We read the article titled "Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management" by Kothari et al.1 with great interest. [Extracted from the article]

Due to the presence of superficial and raised areas, both PYL and Er:YAG laser treatment were planned. Keywords: Er:YAG laser; lymphangioma; pro-yellow laser EN Er:YAG laser lymphangioma pro-yellow laser 3631 3632 2 08/09/22 20220801 NES 220801 Dear Editor, We read with interest the recent article "Evaluation of the efficacy of pro-yellow laser in the management of vascular skin disorders" by Sarac and Onder.1 In this article, the effect of pro-yellow laser in vascular skin diseases such as facial telangiectasia, erythematotelangiectatic rosacea, port-wine stain, spider angioma, venous lake, scrotal angiokeratoma, and cherry angioma was evaluated. Commentary on "Evaluation of the efficacy of pro-yellow laser in the management of vascular skin disorders": Lymphangioma circumscriptum treated with 577-nm pro-yellow laser and Er:YAG laser. [Extracted from the article]