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Aim: To promote preventive care among older individuals dwelling on an isolated, doctor‐less island, we investigated the feasibility and the efficacy of a home‐based exercise program, depending on their functional status and health‐related quality of life. Methods: A total of 23 older (mean age 72.6 years) participants were assigned to a home‐based exercise program (intervention group), and 34 older (mean age 74.2 years) participants were assigned to a group without any intervention (control group). The participants of the intervention group attended the exercise program three times a week for 3 months. The exercise program consisted of various exercises involving stretching, muscle strengthening, balance retraining and walking. The physical performance, Functional Independence Measure and Short‐Form 36‐item health survey were used to assess the physical and the mental wellbeing of the participants. Results: There was no significant difference between the changes in physical performance at baseline and post 3 months in both groups. However, the motor and the cognitive Functional Independence Measure scores significantly improved in the intervention group post 3 months. The domains of the Short‐Form 36‐item health survey improved post 3 months; particularly, significant improvement was observed in the physical functions, general health, vitality, mental health and mental component summary. Conclusions: Although an isolated island has several problems to support preventive care services, such as a lack of medical resources and availability of only a few healthcare workers, the present study provides evidence on the feasibility and efficacy of nurse‐led home‐based exercise programs for improving the physical and mental health of the older people dwelling on an isolated, doctor‐less island. Geriatr Gerontol Int 2018; 18: 1313–1317. [ABSTRACT FROM AUTHOR]